alzheimer s disease ad parkinson s disease pd and sc

Tài liệu Alzheimer’s Disease and Other Dementias doc

Ngày tải lên : 14/02/2014, 18:20

... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... hereditary diseases like Wilson s disease Huntington s disease is an involuntary movement disorder that is often associated with dementia Parkinson s disease is a progressive brain disorder and a ... cerebrovascular and cardiovascular diseases In cerebrovascular disease, the blood vessels that supply the brain with oxygen and nutrients get narrower, and in cardiovascular disease, also called ischemic...

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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

Ngày tải lên : 16/02/2014, 09:20

... microtubule-associated protein that normally serves to assemble and stabilize microtubules Genetics and risk factors implicated in Alzheimer s disease pathogenesis Familial forms of AD, with an autosomal ... models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing animal models discussed, and ... neurites, synaptic loss and gliosis in the adjacent tissue, but not by overt neuronal loss [38,39] Ultrastructural analyses revealed neurons in close proximity to senile plaques and amyloid ﬁbrils...

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Tài liệu Báo cáo khoa học: A facile method for expression and puriﬁcation of the Alzheimer’s disease-associated amyloid b-peptide pdf

Ngày tải lên : 18/02/2014, 13:20

... electron transmission microscope operated at 120 V All reagents were supplied by Electron Microscopy Sciences (Hatﬁeld, PA, USA) Assessement of SEC-isolated peptides by HPLC and SDS-PAGE Samples (100 ... of synthetic peptides, a bacterial expression system allows isotope labeling, which is essential for high-resolution structural analysis of Ab using NMR spectroscopy and allows use of high speciﬁc ... gels (A,C) and 1% agarose gels (B,D), and proteins were visualized by Coomassie stain Lanes HS and LS are molecular mass standards, with the molecular mass in kDa given on the left (E) 1% agarose...

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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx

Ngày tải lên : 05/03/2014, 21:20

... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of the ... cognitive skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores APOE-␧4 was not associated with...

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LifeOut of Focus Alzheimer’s Disease and Related Disorders ppt

Ngày tải lên : 05/03/2014, 23:20

... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS A gradual loss of memory, affecting a person s skills and behavior, characterizes Alzheimer s disease In Helen s case, she slowly lost her ... dementia caused by medical conditions such as head injuries, diseases caused by the human immunodeficiency virus (HIV), Parkinson s disease, and Huntington s disease; and substance-induced persisting ... body and is essential in transmission of nerve impulses through the synapses of the brain and central nervous system (A synapse is the point at 33 LIFE OUT OF FOCUS: ALZHEIMER S DISEASE AND RELATED...

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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx

Ngày tải lên : 05/03/2014, 23:20

... Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive impairment associated ... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... lost in familiar surroundings, the physician can assess visuoconstruction or the ability to copy and produce figures on demand, such as a cross, square, and cube The physician can also assess...

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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

Ngày tải lên : 07/03/2014, 10:20

... enzymes because activity of the enzymes is dependent on optimal metal loading Cu deﬁciency is central to the recessive Menkes and Wilson diseases, and has been implicated in AD Just as excess Cu ... is increased in cerebrospinal ﬂuid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... of AD Identifying these mechanisms will substantially facilitate the development of more effective therapeutic strategies Metal dyshomeostasis and AD Transition metals such as Cu and Fe are essential...

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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc

Ngày tải lên : 08/03/2014, 08:20

... COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected with both constructs ... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... experiments) (Fig 4E) Discussion We have developed a novel GFP-based assay to characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable...

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The Handbook of Alzheimer’s Disease and Other Dementias doc

Ngày tải lên : 14/03/2014, 21:20

... Medical School Massachusetts Alzheimer s Disease Research Center Massachusetts General Hospital, Boston, MA USA Preface This book provides a comprehensive review of Alzheimer s disease and other ... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established with ... to AD is on the rise (Mebane-Sims & Alzheimer s Association, 2009) (Figure 1.1) on-Based Es lati tim pu at es Po Based Estim nicate Cli s Alzheimer s disease (AD) Vascular dementias (VAD) + AD...

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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot

Ngày tải lên : 16/03/2014, 11:20

... Importantly, this complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is signiﬁcant in several tissues, particularly human brain, spinal ... FEBS 1717 RCAN1 in Alzheimer s disease C D Harris et al Fig RCAN1-1 is overexpressed in AD RCAN1-1L and RCAN1-4 protein expression was measured via western blot [a representative blot is shown ... neurons by counting grain density on neurons and subtracting background grain density levels Standard errors were calculated, and Fischer s test was performed to analyze signiﬁcance This shows approximately...

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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc

Ngày tải lên : 16/03/2014, 22:20

... Clinical Diagnosis Braak s Neuroﬁbrillary Staging Control Control Control Control Control Control Control Control Control Control AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD I III IV ... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 (2005)...

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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot

Ngày tải lên : 22/03/2014, 14:20

... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... neurofibrillary tangles in individuals who have not yet developed any overt cognitive dysfunction Abbreviations Ab: b-amyloid; AD: Alzheimer s disease; ADAS-cog: Alzheimer s Disease Assessment Scale; APOE: ... immunoassays according to the instructions provided by the manufacturers ‘Meso Scale Discovery’ (Gaithersburg, MD, USA) and ‘R&D System’ (Minneapolis, MN, USA), respectively For the MMP assays a...

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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt

Ngày tải lên : 23/03/2014, 04:20

... 22q12-q13 AD and sporadic ⁄ early onset PD AR and sporadic ⁄ early onset PD AD ⁄ late onset PD No causative gene identiﬁed AD ⁄ late onset PD Reported in a PD sibling pair AR and sporadic ⁄ early onset ... Duke-NUS Graduate Medical School and SingHealth Services References Gandhi PN, Chen SG & Wilson-Delfosse AL (2009) Leucine-rich repeat kinase (LRRK2): a key player in the pathogenesis of Parkinson s ... M, Guisasola LM, Salvador C, Ribacoba R et al (2005) LRRK2 R1441G in Spanish patients with Parkinson s disease Neurosci Lett 382, 309–311 25 Zabetian CP, Samii A, Mosley AD, Roberts JW, Leis BC,...

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Báo cáo khoa học: Amyloid-b protoﬁbril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx

Ngày tải lên : 23/03/2014, 06:20

... ¨ was used as horseradish peroxidase substrate and the reaction was stopped with m H2SO4 Wells were washed three times between each step after blocking the plates and antibodies and samples were ... models and human disease, it is still interesting and important to reﬂect upon these observations and to try to provide explanations A comparison between APP transgenic models and the human disease ... is widespread and well developed when symptoms begin to appear, but disease severity does not relate to the density of Ab deposits By contrast, in transgenic mice, functional deﬁcits and loss...

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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot

Ngày tải lên : 23/03/2014, 07:20

... Mesulam MM (1993) Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima ... co-localizes with the Ab peptide [48] Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially in Alzheimer s ... acetylcholinesterase is less effective AbGlu22 fi Gln, as well as the Ab1–42 Recent studies indicate that the Ab oligomers instead of the amyloid fibrils ad the real culprit of Alzheimer s disease In this...

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Báo cáo khoa học: Implication of calpain in neuronal apoptosis A possible regulation of Alzheimer’s disease doc

Ngày tải lên : 23/03/2014, 10:21

... caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional loss ... sequential proteolysis results from caspase and calpain activation This work conﬁrms the cross-talk between caspase and calpain and identiﬁes a novel mechanism associated with the proteolysis ... of several MAPs and leading to neuronal apoptosis in AD Conclusion In summary, the ubiquitous expression of calpains in distinct subcellular compartments at different maturational stages and...

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Guideline for Alzheimer’s Disease Management pdf

Ngày tải lên : 23/03/2014, 23:21

... Another assessment instrument, the Columbia University Scale for Psychopathology in Alzheimer s Disease, is brief and effective in assessing psychotic symptoms, but is not appropriate for assessing ... Alzheimer s Disease Management Table A2: Brief Behavioral Assessment Instruments Name of Instrument Description Advantages Disadvantages BEHAVE AD Assessment of 25 behavioral symptoms and a global ... PCP must address caregiver support on an ongoing basis, and assess caregivers’ mental and physical health regularly (see Assessment section) Support groups may be helpful, as both research and...

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ALZHEIMER’S DISEASE AND RELATED DISORDERS ANNUAL doc

Ngày tải lên : 28/03/2014, 22:21

... Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association CERAD = Consortium to Establish a Register for Alzheimer s Disease AIREN = Association Internationale ... class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association Definite and probable AD vs OND Riemenschneider ... gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association Definite and...

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Understanding Alzheimer''''s Disease Edited by Inga Zerr docx

Ngày tải lên : 30/03/2014, 18:20

... by α-secretases, members of the ADAM family of zinc metallo‐ proteases) and sAPPβ (residues 18 to 596; cleaved by β-secretase, an aspartic protease also known as BACE1 in the nervous system and ... caspases pT I T γ ε signaling I or II in excess? G Fe65 _ Tip60 Alzheimer s disease (or CP2/LSF/LBP1) transcription activation in excess? Figure AICD in health and disease Different fates of ... brains of AD patients, it is known that at least βCTF is phosphorylated, whereas this is not the case for αCTF [41] In addition, phos‐ Understanding Alzheimer' s Disease phorylation regulates both...

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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf

Ngày tải lên : 18/06/2014, 22:20

... chimeric virus: (A) Schematic presentation of the rescue strategy of WSN-Ab1-10 chimeric virus (B) SDS-PAGE and coomassie staining of purified chimeric (WSN-Ab1-10) and wild-type (WT) viruses (C) WB ... implications for the pathogenesis and treatment of Alzheimer s disease Proc Nat Acad Sci USA 2001, 98:10273-10278 Schenk D: Opinion: Amyloid-beta immunotherapy for Alzheimer s disease: the end of the beginning ... alone Statistical Analysis Statistical parameters (mean, standard deviation (SD), significant difference, etc.) were calculated using Prism 3.03 software (GraphPad Software, Inc., CA) Statistically...

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