altered microrna regulation in huntingtons disease models
Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
Ngày tải lên :
26/10/2012, 10:04
... in all
cases of Alzheimer disease. These findings not only further define the cell cycle reentry phenotype in Alzheimer
disease but also indicate that the neurofibrillary tangles which define ...
working with other factors to halt the cell cycle and
mediate DNA repair. Interestingly, a much higher
proportion of NFT were labeled in AD cases than in
control cases. These findings hint ... fixed either in 10% buffered formalin or in
methacarn (methanol:chloroform:acetic acid, 6:3:1),
and embedded in paraffin. 6μm sections were depar-
affinized in xylene and rehydrated in graded...
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Cell Cycle Regulation in Mammalian Germ Cells
Ngày tải lên :
25/10/2013, 21:20
... Connexin 43 These intracellular signaling molecules in their absence cause Juneja et al. 1999
impaired folliculogenesis resulting in a germ cell deficiency
within the gonads.
Gja4/Cx37 Connexin 37 Intracellular ... absence of which results in vestigial
element binding protein ovaries with immature oocytes arrested at the pachytene stage.
Dazla Dazla protein (Deleted in RNA binding protein that affects translational ... Chaperone protein involved in protein folding, Dix et al. 1996
70 kDa protein 2 (HSP70-2) leads to spermatogenic arrest at metaphase stage in knockouts.
Cell Cycle Regulation in Mammalian Germ...
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Tài liệu Reading Our Lips: The History of Lipstick Regulation in Western Seats ... doc
Ngày tải lên :
16/01/2014, 22:20
... low in England during the nineteenth century, focusing only on lipstick in England could generate a most misleading
image of lipstick’s global status. For example, during the same period in China, ... Members, 16 Law & Ineq. J. 661 (1998) (pointing out that: “a Marine recruit training
manual used after the Gulf War stated that female recruits would be given ‘instruction in hair care, techniques ... well as the continued complaining of religious writers,
makes clear that lipstick remained at least relatively in use by females and entirely free from regulation of
law.
37
In Spain around 500...
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Tài liệu Emotion Regulation in Couples and Families ppt
Ngày tải lên :
19/02/2014, 04:20
... domain plays
an
important
role
in
maintaining
good
interpersonal
relationships.
Managing
Emotions
Before
we
discuss findings supporting
the
importance
of
managing emo-
tions
in
... are
regulated intrapersonally (within individuals)
than
interpersonally (between
individuals).
Investigators
are
only beginning
to
propose
and
test dyadic
models
specifying
how the
emotion
regulation
... emotions, ranging
from
listening
to
music
to
drinking
caffeinated
beverages
to
withdrawing
from
social interaction.
Parkinson
and
Totterdell (1999)
classified
various emotion regulation...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
Ngày tải lên :
19/02/2014, 18:20
... in
point, formation of huntingtin-containing inclusion
bodies in Huntington’s disease encourages cell survival,
whereas monomers and small inclusion bodies of hunt-
ingtin, a protein possessing ... cells deficient in
desmin, again demonstrating inclusion body construc-
tion independent of intermediate fialments [62]. Inter-
estingly, inclusion body formation is slowed by
aB-crystallin, Hsp27 and ... aB-Crystallin R120 corresponds to aA-crystal-
lin R116 and both are conserved a-crystallin domain
arginines. R120G aB-crystallin permits intermediate fil-
ament self association in vitro, although binding...
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Tài liệu Báo cáo khoa học: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster doc
Ngày tải lên :
20/02/2014, 01:20
... DNA point
mutations in patients with thymidine phosphorylase
deficiency. J Clin Invest 111, 1913–1921.
24 Nishino I, Spinazzola A & Hirano M (1999) Thymidine
phosphorylase gene mutations in MNGIE, ... 1-b-
D-arabinofuranosylcytosine; araG, 9-b-D-arabinofuranosylguanine; araT, 1-b-D-arabin-
ofuranosylthymine; BVaraU, (E)-5-(2-bromovinyl)-1-b-
D-arabinofuranosyluracil; BVDU, (E)-5-(2-bromovinyl)-2¢-deoxyuridine; ... cells
grown under the following different conditions: in normal
culture medium [RPMI containing 10% (v ⁄ v) dialyzed
serum, penicillin and streptomycin], in culture medium con-
taining 1 lm dNs (dAdo,...
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
Ngày tải lên :
06/03/2014, 09:22
... recognition in the normal splicing
process [55]. First, U1snRNP binding to an intronic
splicing processing element has been found to inhibit
pathological pseudoexon inclusion in intron 20 of ... splice-
supporting intronic mutation in the last bp position of
a cryptic exon within intron 6 of the CYBB gene
induces its incorporation into the mRNA causing
chronic granulomatous disease (CGD). ... degradation following its joining to exon 3 (but not exon 2). The levels
of hnRNP H ⁄ F proteins can regulate the extent of NE inclusion. (B) shows that in the NF-1 intron, 30 pseudoexon inclusion levels...
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Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
Ngày tải lên :
07/03/2014, 02:20
... against CD3 (1 lgÆmL
)1
, UCHT1;
BD Pharmingen, Franklin Lakes, NJ, USA) and CD28
(5 lgÆmL
)1
, CD28.2; BD Pharmingen), and maintained in
RPMI-1640 standard medium containing recombinant
human interleukin-2 ... domain of INP54p was cloned into the modi-
fied pEGFP-C1 (Clontech, Mountain View, CA, USA)
vector following the C-terminus of GFP. The first 10 amino
acids of Fyn were engineered in frame N-terminal ... Kiessling S, Sansom OJ, Millar CB,
Maddison K, Bird A, Clarke AR & Frisch SM (2003)
Fas-associated death domain protein interacts with
methyl-CpG binding domain protein 4: a potential link
between...
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EDUCATING TO IMPROVE POPULATION HEALTH OUTCOMES IN CHRONIC DISEASE ppt
Ngày tải lên :
14/03/2014, 20:20
... etc.
Smoking
Smoking
Individual
Individual – Brief interventions in each consultation
Community
Community – Smoke free zones in public buildings
• Conducting education to school kids about smoking
• ... also linked with cultural grouping.
In most fi rst world countries Indigenous people have made signifi cant gains in their health status in the
past twenty years (Ring and Firman, 1998). Indigenous ... This domain includes: core clinical skills, applying
knowledge of chronic conditions to clinical decision-making, physical examination skills,
investigations and the rational use of medicine.
Note:...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... (2002) Increased
huntingtin protein length reduces the number of
polyglutamine-induced gene expression changes in
mouse models of Huntington’s disease. Hum Mol Genet
11, 1939–1951.
72 Cha JH, Kosinski ... gene containing a trinucleotide repeat
that is expanded and unstable on Huntington’s disease
chromosomes. Cell 72, 971–983.
6 Young AB (2003) Huntingtin in health and disease.
J Clin Invest 111, ... progress has been made
in identifying genetic factors contributing to PD in
recent years [135]. Low concordance for clinical disease
in monozygotic twins indicates environmental in uen-
ces on PD...
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Báo cáo khoa học: Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease doc
Ngày tải lên :
16/03/2014, 22:20
... Mochi-
zuki N (2004) A novel actin bundling ⁄ filopodium-form-
ing domain conserved in insulin receptor tyrosine kinase
substrate p53 and missing in metastasis protein. J Biol
Chem 279, 14929–14936.
32 ... equiv-
alent site in the mouse homologue (in a consensus binding motif for 14-3-
3) abolished 14-3-3 binding to d-catenin in vitro and in transfected cells.
d-catenin binds to presenilin-1, encoded ... plakophilin-related arm-repeat protein or neurojungin).
d-Catenin from brain lysates was retained on a 14-3-3 affinity column.
Mutation of serine 1072 in the human protein and serine 1094 in the...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
Ngày tải lên :
22/03/2014, 21:20
... conditions.
Innovative microfinance institutions have had
substantial success in making financial services
accessible to the poor in many parts of the
world, and microfinance is increasingly
provided ... Ethiopia was a leader in Africa in moving to treat MFIs as financial intermediaries, it
has only gradually moved toward promoting financial self-suffic iency. The interest rate was initially fixed ... Union Law.
• The informal financial system covers a range of activities known as susu, including
individual savings collectors, rotating savings and credit associations, and savings and
credit...
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Báo cáo khoa học: Gene regulation by tetracyclines Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes Christian Berens and Wolfgang Hillen pptx
Ngày tải lên :
23/03/2014, 21:20
... and screening systems in
E.coli [104,105] and in S. cerevisiae [88] have lead to a
profound understanding of how DNA binding, inducer
binding and dimerization function in TetR. This informa-
tion ... the inducer-binding and dimerization domain is in dark gray, activation domains are
black boxes, and the silencing domain is stippled. The conformational change leading to the loss of DNA-binding ... disorders. In a conditional model of Hunting-
ton’s disease, mice expressing a mutated huntingtin
fragment in the brain demonstrated that its continuous
supply was needed to maintain the characteristic...
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Better Regulation In Europe Better Regulation In Europe - Austria 2010 pptx
Ngày tải lên :
28/03/2014, 23:20
... responsibility.
Binding guidelines for all federal ministries and the Lände
r relating to the negotiation,
transposition and infringement phases have been in place since 2003. In 2003, the Ministry of ... co-ordination of rule-making is weak in Austria, with regulations being
autonomously conceived within each responsible ministry. As a result forward planning policies vary from
ministry to ministry. ... existing IT systems in the
preparation of regulation including a clear link between public consultation
and the drafting process. Develop a single consultation portal for use by all
ministries...
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