aldosterone receptor blocking agents
Intelligent Software Agents on the Internet: an inventory of currently offered functionality in the information society & a prediction of (near-)future developments
... Practical Aspects of Agents and the Prospects of Agents in a Three Layer Model Intelligent Software Agents Theory Intelligent Software Agents Theory 2.1 Introduction Intelligent software agents are a ... being done into separate agents, such as mail agents, news agents and search agents These are the first step towards more integrated applications, where these single, basic agents are used as the ... offered There are many different kinds of software agents, ranging from Interface agents to Retrieval agents This thesis will be mainly about agents that are used for information tasks (such as...
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Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... and in the absence of protein structure information (30) SiRNA targeting P2X3, δ-opioid receptor and NMDA receptor has been explored as potential means to manage pain (31-33) RNAi primarily acts ... immune response by NMDA receptors has neuropathological consequences J Neurosci 2003; 23: 11094-103 Tanga F.Y., Nutile-McMenemy N., DeLeo J.A The CNS role of Toll-like receptor in innate neuroimmunity ... Rossini C., Granucci F., Giagnoni G., Peri F., Costa B Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice...
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Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits"
... Int J Med Sci 2009, 219 Introduction Chemotherapy, including novel antineoplastic agents, is becoming increasingly effective for cancer and is performed widely, but adverse drug ... drug reactions Among such reactions, phlebitis induced by intravenous infusion of antineoplastic agents reduces the completion of chemotherapy The causative factors of phlebitis include the pH ... may be a useful and specific index to evaluate perivascular tissue damages caused by this kind of agents [15] We have already shown that both rapid administration and dilution of the infusion solution...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... respectively This finding suggests that these two thioglycosides may be promising anti-diabetic agents, based on their strong inhibitory effects on hSGLT Results Inhibition of SGLT transport activity ... kidney through O-glycosides represents a different mechanism of action from other hypoglycemic agents However, until now it has not been applied to clinical practice because absorption of these ... thioglycosides exert this inhibitory effect may be different from that of other oral anti-diabetic agents Studies using rat enterocytes, where the process of glucose transport is very similar to...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... TPO with its receptor on target cells It is well established that serum levels of TPO are regulated by the binding of the ligand to the receptor and the endocytosis of the ligand -receptor complex ... patients on serum levels of TPO and the sIL-6 receptor The latter was chosen since some recent evidence has been presented indicating that high levels of this receptor might be found in MPD and might ... that anagrelide reduces the TPO-mediated intracellular signaling events [10] They suggest reduced receptor binding as a possible mechanism Furthermore, the rise in TPO seen here may be analogous...
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Intelligent Software Agents Theory
... autonomy: agents operate without the direct intervention of humans or others, and have some kind of control over their actions and internal state; 7* social ability: agents interact with other agents ... key values of agents A more advanced agent can interact with other entities such as data, applications, or services Further advanced agents collaborate and negotiate with other agents What exactly ... further by playing with the notion of agents that supersede AI.7 The response of (particularly) these researchers to the pronouncement quoted earlier, that what agents can "can just as well be done...
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Intelligent Software Agents in Practise
... of currently available agents is given to show what is already being done with intelligent software agents As a means of showing what the differences between the mentioned agents are, the (well-known) ... processes more efficient, but also to reduce the cost of human agents Much as in the messaging area (application area in this list), intelligent agents can be used to ascertain, then automate user wishes ... automate handling of their "electronic financial affairs" Intelligent agents can assist in electronic commerce in a number of ways Agents can "go shopping" for a user, taking specifications and returning...
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How Is the Ku Klux Klan Like a Group of Real-Estate Agents
... study of real-estate agents cited above also includes data that reveals how agents convey information through the for-sale ads they write A 66 The Ku Klux Klan and Real-Estate Agents phrase like ... agents are bad people, but that they simply are people—and people inevitably respond to incentives The incentives of the real-estate business, as currently configured, plainly encourage some agents ... suppose that people abuse information only when they are acting as experts or as agents of commerce After all, agents and experts are people too—which suggests that we are likely to abuse information...
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Receptor được hoạt hoá bằng chất tăng sinh peroxisom (PPAR)
... khác Thực tế PPAR đơn độc gắn vào PPRE Giống receptor thyroid acid Retinoic (RAR) receptor Vitamin D (TR), receptor PPAR phải kết hợp với receptor RXR (receptor cis_retinoic acid) dạng heterodimere ... heterodimere RXR với receptor khác gắn vào vùng chức tạo cho receptor chiếm nửa cấu phức hợp RAR_RXR,TR_RXR VDR_RXR gắn vào vùng chức RXR chiếm lĩnh vị trí thuộc đầu 3’,còn receptor (RAR,TR,VDR) ... lĩnh phần thuộc đầu 5’ Do vai trò “đối tác” cho nhiều receptor nội bào khác nên RXR xuất khả tương tác qua lại (cross_talk) hoạt động với receptor Chẳng hạn cạnh tranh để gắn vào vùng chức năng,...
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Tài liệu TỔNG QUAN VỀ MOBILE AGENTS pptx
... cho công nghệ mobile agents [MIL-99] Với tất kết đạt với mobile agents, người ta đạt công nghệ truyền thống Tuy nhiên, vài trường hợp, mobile agents giải pháp tối ưu Mobile agents áp dụng nhiều ... lại thi hành máy đích Hình cho thấy khác biệt Mobile agents so với RPC REV Hình 1: Sự tiến hóa mô hình mobile agents 2.2 Các đặc tính mobile agents Các đặc tính mobile agent bao gồm : Tính tự ... trường khác ỨNG DỤNG CỦA MOBILE AGENTS 3.1 Các lợi mô hình mobile agents Có bảy lợi ích việc ứng dụng mobile agent [LAN-98]: 3.1.1 Giảm tải mạng Kỹ thuật mobile agents cho phép người dùng đóng...
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Tài liệu Causal Agents docx
... S intercalatum are found focally in Southeast Asia and central West Africa, respectively Causal Agents: Schistosomiasis is caused by digenetic blood trematodes The three main species infecting ... especially Thailand and Japan; recently emerged as an important human parasite in Mexico Causal Agents: The trematodes Fasciola hepatica (the sheep liver fluke) and Fasciola gigantica, parasites ... Infections with F gigantica have been reported, more rarely, in Asia, Africa, and Hawaii Causal Agents: The nematode (roundworm) Angiostrongylus cantonensis, the rat lungworm, is the most common...
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Tài liệu Module 3: Configuring Management Agents to Manage Directory Entries doc
... Management Agents to Manage Directory Entries # Creating Management Agents and Connecting to an External Directory Topic Objective To introduce the topics associated with creating management agents ... one of the predefined management agents Creating a management agent involves creating an instance of one of the predefined management agents Predefined management agents contain the capabilities ... Module 3: Configuring Management Agents to Manage Directory Entries Overview of Predefined Management Agents Topic Objective To describe the predefined management agents provided in MMS Novell NDS...
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Tài liệu Color Atlas of Pharmacology (Part 7): Drug-Receptor Interaction doc
... active conformation of receptor protein active Agonist selects active receptor conformation Antagonist selects inactive receptor conformation A Molecular mechanisms of drug -receptor interaction ... 63 64 Drug -Receptor Interaction Receptor Types Receptors are macromolecules that bind mediator substances and transduce this binding into an effect, i.e., a change in cell function Receptors differ ... G-ProteinCoupled Receptors Signal transduction at G-protein-coupled receptors uses essentially the same basic mechanisms (A) Agonist binding to the receptor leads to a change in receptor protein...
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Tài liệu Distributed Network Security Management Using Intelligent Agents pptx
... of agents reflect a set of properties, which common among them and are described below [12]: - Autonomy: is the ability of an agent to operate without direct intervention of humans or other agents ... which is responsible for managing interactions with the other agents and the Social Manager, which holds information about the other agents, support inter-agent communication facilities in the ... Management) It is viewed as a collection of autonomous and intelligent agents located in specific network entities These agents co-operate and communicate in order to perform intrusion detection...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... open-and -shut case? Recent insights into the activation of EGF ⁄ ErbB receptors Mol Cell 12, 541–552 Hynes NE & Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev ... kinase domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, function ... & Yatabe Y (2007) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... anticancer therapy I Okamoto Fig Two different types of EGFR-targeted agents mAbs target the extracellular domain of the receptor, and small-molecule TKIs target the intracellular tyrosine kinase ... The binding of ligand to EGFR induces receptor dimerization and consequent conformational changes that result in activation of the intrinsic tyrosine kinase, receptor autophosphorylation and a transient ... ligand binding to EGFR leads to receptor dimerization, autophosphorylation and activation of downstream signaling pathways Compared with wild-type EGFR, mutant receptors preferentially induce...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... converging, apoptosis signaling pathways: the extrinsic (also called ‘death receptor ) pathway, which is activated by death receptors; and the intrinsic (also called ‘mitochondrial’ or ‘Bcl-2-regulated’) ... adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev 20, 1496–1510 Ji H, Li ... lines correlates with dependence on the epidermal growth factor (EGF) receptor ⁄ extracellular signal-regulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer Ther 3, 465–472...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... proliferator-activated receptor gamma and promotes adipocyte differentiation Cell 83, 813–819 Xu J & Liao K (2004) Protein kinase B ⁄ AKT plays a pivotal role in insulin-like growth factor-1 receptor signaling ... switch’ of adipocyte differentiation Upon ligand binding, PPARc heterodimerizes with the retinoid X receptor, translocates into the nucleus, and activates multiple genes, especially adipogenic genes ... Tobe K et al (2001) The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma Apoptosis induced by TZDs in 3T3-L1 adipocyte...
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Tài liệu ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 docx
... LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER Independent Energy Producers of NJ 868 Independent Insurance Agents of NJ ... 1287 Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION ... 1165 Page of 51 PART III ALPHABETICAL INDEX OF REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION...
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Tài liệu Báo cáo khoa học: Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening docx
... key step in cell death that occurs during hypoxia and other conditions [9] Tumour necrosis factor receptor- associated protein (TRAP1) localizes to the mitochondria and its targeting sequence, which ... novel protein that interacted with the intercellular domain of the type tumour necrosis factor receptor [17] On the basis of the sequence of the homologue, TRAP1 was identified as a member of ... relevant to ischaemic post-conditioning [31] We had also previously demonstrated that adenosine A1 receptor activation reduces hypoxic damage by preventing MPTP opening in rat cardiomyocytes [7]...
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