adaptative immune responses in hiv 1 infection
Báo cáo y học: "Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection" ppt
... cyclosporin-A, and Th2-type cytokines including interleukin-4 and -10 counteract the production of neopterin [ 21] The same is true for anti-inflammatory compounds including certain HMG-CoA reductase inhibitors ... complex The Journal of infectious diseases 19 88, 15 8(5) :10 79 -10 83 Cinque PKI, Gerevini S, Miro JM, Price RW: Progressive multifocal leukoencephalopathy in HIV- 1 infection Lancet Infect Dis 2009, 9:625-636 ... neopterin and virological studies showing that virus detected in CSF likely has at least two origins [47,48] CSF Neopterin in Clinical Management of HIV Infection Given the changes in CSF neopterin...
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Báo cáo y học: "Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapy" pptx
... on the TCR/CD3 complex in human T cells Faseb J 19 98, 12 :5 81- 92 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Page 10 of 11 (page number not for ... therapy HIV Med 2000, 1: 107 -15 French MA, Mallal SA, Dawkins RL: Zidovudine-induced restoration of cell-mediated immunity to mycobacteria in immunodeficient HIV- infected patients Aids 19 92, 6 :12 93-7 ... lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV- 1 disease Lancet 19 98, 3 51: 252-5 Cooney EL: Clinical indicators of immune restoration following highly active...
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Báo cáo y học: " Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection" pdf
... Factors Influencing HIV- 1 Neuroinvasion While interferons (IFNs) are important for an anti-viral immune response, the lasting production of IFN-α and -γ Page of 11 in HIV- 1 infection has been linked ... pathogenesis of HIV- 1 infection J Acquir Immune Defic Syndr 19 99, 22: 413 -429 Orenstein JM, Fox C, Wahl SM: Macrophages as a source of HIV during opportunistic infections Science 19 97, 276 :18 57 -18 61 Alkhatib ... Neurol 19 86, 45:635-646 Everall IP, Luthert PJ, Lantos PL: Neuronal loss in the frontal cortex in HIV infection Lancet 19 91, 337 :11 19 -11 21 Ketzler S, Weis S, Haug H, Budka H: Loss of neurons in the...
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Báo cáo y học: " The macrophage in HIV-1 infection: From activation to deactivation?" potx
... Interference of interleukin -10 with human immunodeficiency virus type Page 13 of 15 13 5 13 6 13 7 13 8 13 9 14 0 14 1 14 2 14 3 14 4 14 5 14 6 14 7 14 8 14 9 15 0 15 1 15 2 15 3 15 4 replication in primary monocyte-derived ... macrophages, in particular macrophages in the gastrointestinal mucosa [18 6 ,18 7 ,19 2], preclude the Page of 15 simple extrapolation from findings in HIV- 1- infected monocytes to HIV- 1 infection of ... Clin Exp Immunol 19 97, 11 0 :10 4 -11 3 Herbein and Varin Retrovirology 2 010 , 7:33 http://www.retrovirology.com/content/7 /1/ 33 19 1 Smith PD, Meng G, Salazar-Gonzalez JF, Shaw GM: Macrophage HIV- 1 infection...
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Báo cáo y học: " Macrophage signaling in HIV-1 infection" pps
... type infection, Page 11 of 13 14 1 14 2 14 3 14 4 14 5 14 6 14 7 14 8 14 9 15 0 15 1 15 2 15 3 15 4 15 5 15 6 15 7 15 8 15 9 beta-chemokine production, and CCR5 expression in CD40Lstimulated macrophages: immune ... CC-chemokines, MIP -1 , MIP -1 and RANTES [12 9 ,13 7 ,14 1 -14 6] An iterative pretreatment of primary macrophages with TNFα prior to HIV infection inhibits HIV- 1 replication in primary macrophages [14 2] ... HIV- 1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion J Immunol 19 91, 14 7:2892-29 01 134 Karsten V, Gordon S, Kirn A, Herbein G: HIV- 1 envelope glycoprotein gp120...
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Báo cáo y học: "Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice" pptx
... Virol 20 01, 75 :11 992 -11 998 doi :10 .11 86 /14 76-5926-9-7 Cite this article as: Naas et al.: Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV ... vaccine in immunized mice using IFN-g ELISPOT assay ELISPOT counts (spot-forming units [SFUs] /1 × 10 6) in response to core, E1 and E2 protein, Core peptides, or vaccinia HCV poly Spot forming ... gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A Gastroenterology 19 96, 11 1:462-4 71 Naas et al Comparative Hepatology 2 010 , 9:7 http://www.comparative-hepatology.com/content/9 /1/ 7...
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Báo cáo y học: "Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot stud" doc
... transitory infection [5,37] and is presumably sustained by infected and susceptible CD4+ T cells trafficking into the meninges and brain In early HIV infection, this type of infection predominates ... antiretroviral therapy against HIV- 1 infection AIDS 2002, 16 (16 ): 214 5- 214 9 Cinque P, Brew BJ, Gisslen M, Hagberg L, Price RW: Cerebrospinal fluid markers in central nervous system HIV infection and AIDS ... system immune activation in HIV- 1 infection AIDS Res Ther 2 010 , 7 :15 12 Navia BA, Jordan BD, Price RW: The AIDS dementia complex: I Clinical features Ann Neurol 19 86, 19 (6): 517 -524 13 Antinori...
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Báo cáo y học: " HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice" potx
... control of HIV- 1 infection and replication [ 21, 22] However, it is the CD8+ cell response that is mainly responsible for controlling the viral infection and suppressing viraemia in HIV- infected individuals ... 0 .1 and 0. 01 indicate a 1: 10 dilution and a 1: 100 dilution, respectively, of VLPs loaded per lane Western blots of Gag p17/p24 (p 41) protein (24-240 ng) loaded per lane is indicated and the intensity ... approved the final manuscript Competing interests The authors declare that they have no competing interests Received: 16 July 2 010 Accepted: 19 November 2 010 Published: 19 November 2 010 References...
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Báo cáo y học: "Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme" pdf
... testing of HIV- 1 inhibition in 1G5 cells S fusiforme inhibits HIV- 1 infection in T cells in a dose dependant manner Next, we investigated S fusiforme ability to inhibit HIV- 1 infection in T cells ... 94 :13 193 -13 197 Page 11 of 12 (page number not for citation purposes) AIDS Research and Therapy 2006, 3 :15 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Chun TW, Carruth L, Finzi D, Shen ... treatment for HIV- 1 infection J Neurovirol 2000, Suppl 1: S8-S13 Volberding PA: Advances in the medical management of patients with HIV- 1 infection: an overview Aids 19 99, 13 Suppl 1: S1-9 Graham...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
... Therapies and Vaccines 2 011 , 9:2 http://www.jibtherapies.com/content/9 /1/ 2 A RMh-8 RSg-8 RUg-8 Group1 250 200 Page of B RAm-9 RHm-9 Group2 15 0 P=0.7556 10 00 10 0 10 10 0 50 0 .1 0. 01 12 19 21 Week Group ... Percentage increase in CD8-CD107a populations in response to overlapping Gag-peptide Lmdd -HIV- gag infiltration into the liver, tissue sections were tested for recombinant Lm harboring the HIV- gag ... final manuscript Competing interests The authors declare that they have no competing interests Received: November 2 010 Accepted: 18 January 2 011 Published: 18 January 2 011 References Belyakov...
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Báo cáo y học: "hytol-based novel adjuvants in vaccine formulation: 2. assessment of efficacy in the induction of protective immune responses to lethal bacterial infections in mice" ppsx
... ± 1. 12 × 10 5 3.64 ± 1. 44 × 10 5 4.0 ± 0.25 × 10 3 1. 54 ± 0.94 × 10 6 1. 23 ± 1. 14 × 10 6 1. 13 ± 2. 31 × 10 6 3 .16 ± 1. 94 × 10 6 1. 80 ± 0.22 × 10 6 8.90 ± 3.20 × 10 5 8.90 ± 1. 12 × 10 4 2N/A 2 .16 ± 1. 10 ... (CFU) 10 6 10 7 10 8 Time 36 hrs post infection 18 hrs post infection 36 hrs post infection 18 hrs post infection 36 hrs post infection 1Control group (nonimmunized) 1PBS 1IFA 1PHIS- 01 1PHYTOL 2N/A ... post infection 18 hrs post infection 36 hrs post infection Control group (nonimmunized) PBS IFA PHIS- 01 PHYTOL 1. 08 ± 0 .14 × 10 6 8.98 ± 1. 94 × 10 6 1. 11 ± 0.20 × 10 8 2N/A 0 0 4.92 ± 0.94 × 10 5...
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Báo cáo y học: " Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells" doc
... described in Figure MOI Cells and peptides 0.005 0. 01 0.05 0 .1 0.5 10 0.05 ± 0. 01 0.06 ± 0. 01 0.09 ± 0. 01 0 .10 ± 0. 01 0 .12 ± 0. 01 0. 51 ± 0.02 1. 02 ± 0.08 1. 53 ± 0.09 1. 68 ± 0 .11 0.67 ± 0.04 1. 34 ± 0 .10 ... ± 0. 41 10.98 ± 0.43 13 .83 ± 0. 61 16.66 ± 0. 71 21. 99 ± 0.94 30 .16 ± 1. 12 WT 0.04 ± 0. 01 0.08 ± 0. 01 0 .17 ± 0.02 0.39 ± 0.03 0.69 ± 0.05 1. 23 ± 0 .10 3.32 ± 0 .14 ΔRev 3.93 ± 0 .17 4.05 ± 0. 21 4.44 ... 2009, 83:79 31- 7947 doi :10 .11 86 /17 43-422X-7 -17 7 Cite this article as: Levin et al.: Peptides derived from the HIV- 1 integrase promote HIV- 1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown...
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Báo cáo y học: " Multiple-infection and recombination in HIV-1 within a longitudinal cohort of women" potx
... Persisted Max No of Possible Initial Prop Visits 1, 5 0.80 44 12 49 50 54 1* 1* 58* env env env pol pol env env* env* env* 1 1 1 1 1, 6 1, 4 ,11 1, 3,5 1, 5 1, 2,8 1, 1, 10 1, 10 1, 3 1 1 1 1 3 2 2 0.80 0.20 0.20 ... 0.50 0.22 39 pol 1, 7 1 1.00 0 43 45 pol env 10 2,3 1, 5,6 ,10 1 1 1. 00 1. 00 15 pol 1, 4 1 0.20 1 20 13 17 55 pol pol env pol 1, 4,9 1, 1, 6 1, 2 1 1 1 1 0.20 0.50 0.80 0.20 Average: Superinfected at last ... Recombinants 27 28 11 10 7 12 12 No of Interstrain Recombinants 28 21 Rate of Intrastrain Recombination/ Ind Rate of Interstrain Recombination/ Ind 0 .14 8 1. 000 0.455 0.700 0.5 71 3.000 0. 417 0.333 1...
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Báo cáo y học: "Association of chemokine receptor gene (CCR2CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians" pdf
... (15 .9) 75 (15 .6) 10 5 (16 .1) HHE 310 (13 .7) 13 8 (12 .2) 17 2 (15 .2) 61 (12 .7) 11 1 (17 .0) HHF *1 128 (5.6) 76 (6.7) 52 (4.6) 24 (5.0) 28 (4.3) HHF*2 480 ( 21. 2) 259 (22.8) 2 21 (19 .5) 99 (20.6) 12 2 (18 .7) ... HHD 16 7 1. 0 0.74 -1. 32 0.983 94 0.9 0.59 -1. 23 0.385 73 1. 2 0.75 -1. 92 0.442 HHE HHD/HHE 15 8 31 1 .1 1.9 0.82 -1. 51 1 .14 -3 .16 0.495 0. 015 85 19 1. 3 2.0 0.86 -1. 87 1. 08-3.57 0.234 0.028 73 12 0.9 1. 7 ... HHA 6 01 (26.5) 305 (26.9) 296 (26 .1) 13 3 (27.7) 16 3 (24.9) HHB HHC 44 (1. 9) 17 8 (7.9) 25 (2.2) 69 (6 .1) 19 (1. 7) 10 9 (9.6) (1. 7) 42 (8.8) 11 (1. 7) 67 (10 .2) HHD 370 (16 .3 19 0 (16 .8) 18 0 (15 .9)...
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Báo cáo y học: "Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro" pdf
... major plasmacytoid (pDC; HLA-DRintCD123hiCD11c-; 77 .1% ); a smaller myeloid (HLA-DRint/hiCD123-CD11clo; 20.4%); and a minor myeloid-related M-DC8+ (HLA-DRint/hiCD123-CD11chiM-DC8+; 2.5%) DC population ... described [15 -17 ,34] Consistent with the findings of another group [15 ], we identified a major HLA-DR int CD11c pDC population, a smaller HLA-DR int CD11c + mDC population and a minor CD11chi DC ... contains IFN-alpha-producing CD11c(-), myeloid CD11c (+), and mature interdigitating dendritic cells J Clin Invest 20 01, 10 7:835-844 16 Schmitt N, Cumont MC, Nugeyre MT, Hurtrel B, Barre-Sinoussi...
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Báo cáo y học: "Decidual soluble factors participate in the control of HIV-1 infection at the" docx
... observed increase in b-chemokine secretion during R5 HIV- 1 infection could therefore be due to HIV- 1 replication Similar b-chemokine upregulation during HIV- 1 infection has also been described in other ... significant (mean 11 .25% p = 0.375) Inhibition of X4 HIV- 1 infection was observed in experiments with out of donors, 10 days post -infection (mean 11 .25% ± 11 .9; p = 0.375)(Figure 6); however, in contrast ... of R5 HIV- 1, while CXCL -12 binds to CXCR4 and thus inhibits X4 HIV- 1 entry In contrast, proinflammatory cytokines such as IL-6, IL -12 and TNF-a stimulate HIV- 1 replication by promoting inflammation...
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Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf
... 89 90 A2 10 0 18 5 91 A2 92 A2 93 94 95 96 97 98 99 10 0 11 0 80 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 A2 10 9 A2 11 0 12 0 75 11 1 11 2 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 1 12 2 12 3 12 1 12 2 12 3 Figure infection) ... 10 0 17 5 91 A2 92 A2 93 94 95 96 97 98 99 10 0 11 0 585 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 A2 10 9 A2 11 0 12 0 11 1 11 2 11 3 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 1 12 2 12 3 12 1 12 2 12 3 Figure 20.3 years post infection) ... CD8 10 00 3000 10 2000 10 00 1 10 12 14 16 3500 10 12 14 16 10 12 14 16 10 0 15 00 12 14 16 10 12 14 16 18 10 12 14 16 18 20 22 10 12 14 16 18 20 10 12 14 16 18 20 22 24 12 14 16 18 20 22 24 26 10 12 ...
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Báo cáo y học: " HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages" doc
... A2/B1 H Weeks Post -Infection 10 10 Donor A1 A2/B1 H Mean hnRNP Expression A1 A2/B1 H Weeks Post -Infection 10 Weeks Post -Infection 10 Donor Relative Expression Relative Expression 0 .1 0 .1 A1 A2/B1 ... remaining Rel at i v e mRNA d13pi 80 10 12 14 16 18 20 22 24 26 28 C d6pi 80 60 d6pi 40 d13pi d20pi 20 d27pi 0. 01 Hours Post-DRB 12 0 PBL Tat1-d3 Tat1-d7 Tat1-d10 Tat1-d14 Nef2-d3 Nef2-d7 Nef2-d10 ... 6000 Tat1 %Tat mRNA rem aining 10 0 4000 2000 d20pi d27pi 60 40 20 Days Post -Infection 0 Hours Post-DRB MDM Tat1-d6 Tat1-d13 Tat1-d20 Tat1-d27 Nef2-d6 Nef2-d13 Nef2-d20 Nef2-d27 0 .1 120 Rev1 10 0 %Rev...
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Báo cáo y học: " Reduced CD4 T cell activation and in vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans" pptx
... susceptibility to in vitro HIV- 1 infection in EUs We evaluated PBMC susceptibility to in vitro infection using two HIV- 1 strains with different tropisms, HIV- 1 NL-4.3 (X4) and HIV- 1 BaL (R5) In order ... CCR5(CD8+)* 13 8.6 ( 61 208) 527.6 (267 – 862) 200 (12 4–285) 370 (19 4–527) 10 41 (475 12 33) 44 .1 (26.9–88.7) 470.2 (298–747) 250.5 (16 4–293) 288.7 ( 217 –403) 269.5 (238– 410 ) 280 .1 (16 5–360) 312 .3 (244–4 41) ... http://www.retrovirology.com/content/3 /1/ 35 taining 10 % FCS, 1% penicillin-streptomycin-neomycin, 1% glutamine and 10 0 U.I of IL2 (Proleukin; Chiron, France) and HIV- 1 replication was monitored by p24 antigen quantification in...
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Báo cáo y học: " Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants" docx
... http://www.retrovirology.com/content/3 /1/ 46 Figure Inhibitory effect of polyanionic compounds against HIV- 1 infection of T-cells Inhibitory effect of polyanionic compounds against HIV- 1 infection of T-cells HIV- 1 BaL (R5, ... against virus binding to DC-SIGN and trans infection of PM -1 cells (Figure 4A) DxS exhibited a lower level of inhibition, demonstrating a maximal 50% inhibition of both binding and trans infection ... anti-viral activity against both HIV- 1 and HSV-2 following in vivo intravaginal application [39], whilst the 4% gel protected against in vivo HSV-2 infection in the cotton rat model [ 41] Although formulated...
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