acr12 putative amino acid sensor proteins in the chloroplast
Báo cáo y học: "Mutation patterns of amino acid tandem repeats in the human proteome" ppt
... M: The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains FASEB J 2000, 14:231-241 Huang H, Winter EE, Wang H, Weinstock KG, Xing ... within the repeat) On the other hand, glutamine, alanine and glutamic acid repeats were the main contributors to the increased number of gap polymorphisms inside the repeats than outside the ... research We investigated the frequency of the different amino acid substitutions in repeats and adjacent sequences, focusing on the eight most common amino acids forming tandem repeats (Table 2) The...
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Báo cáo y học: "Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins" ppt
... (64 amino acids - that is, 30 amino acids either side of the central motif) to define the limits of the repeat, as this is the region containing a significant overrepresentation of the motif in ... structured The amino acids found in tandem repeats tend to be hydrophilic; all the most hydrophilic amino acids [58] are found in the class of common tandem AARs - the only strongly hydrophobic amino acid ... flexible regions of proteins that might have a number of functions, including binding to other proteins and small molecules and providing flexibility in multidomain proteins In an analysis of repeat...
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Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
... Follistatin, Chordin and Noggin [12] These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibiting these signaling molecules from binding to their receptors in ... Other factors affecting the BMP pathway Factors inhibiting BMP2b, other than direct binding proteins such as Noggin and Chordin, also affect dorsoventral patterning One example is found from the ... the extracellular space, thus inhibiting ventralizing activities Of these proteins, Chordin has a long-range effect In Xenopus, expression of the chordin gene is localized to the dorsal marginal...
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Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx
... the proteins of the outer membrane, we set out to determine what proportion was integral and to identify the major protein species To determine whether the major outer membrane proteins were integral ... the proteins present in the aqueous extract (‘Aq’), the detergent phase (‘D’) and the phospholipid-rich pellet (‘P’) Arrowheads designate the size of proteins enriched in the lipid-rich pellet including ... containing peripheral membrane proteins, a detergent-phase in which proteins with a-helical transmembrane domains are soluble and a ‘phospholipid-enriched’ pellet fraction containing proteins...
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... tempting to speculate that the loop is involved in binding one of the (co)substrates of CoaB, indicating that the provided models of the substrate binding sites of human CoaB not give a complete insight ... important for the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in binding of one of the substrates, the amino acid cysteine (Fig 3) However, ... mass information was obtained as described [6], determining the elution volumes of standard proteins and the void volume of the column The Superdex 200 PC 3.2/30 column and the standard proteins...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... 4.13 Tyr Table Amino- acid content of the total proteins of selected mesophiles and hyperthermophiles Calculations were performed using all the open reading frames described in the genomic sequences ... molecules in the aggregate As the aggregate increased in size with inactivation time, more and more soluble enzyme may remain trapped in the insoluble pellet during centrifugation These results ... inactivating at a measurable rate increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor could be the limiting step in BLXI inactivation Higher Ea values of inactivation...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ... occurring C-terminal 100 kDa fragment of filamin, interacting with the motor protein dynein, may exert its inhibitory effect by interfering with interactions between the N- and C-terminal domains, ... LXXAA) both bind to the AR, but the mutant form shows much weaker binding than wild-type a-actinin-2 That is to say, the LXXLL motif in a-actinin-2 has a major role in the interaction with the AR However,...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
... extracellular domains that we have named C1 and C2 C1 defines the domain closest to the amino terminal end and C2 defines the domain closest to the cell membrane A comparison of the inferred amino acid sequence ... of the genes encoding Cg-BMPR1 and Cg-TGFbsfR2 is shown in Fig 2C The serine ⁄ threonine kinase domain in both proteins is encoded by two exons equivalent to kinase subdomains X and XI [22] In ... clarify the binding properties of each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos in...
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Báo cáo khoa học: Molecular dynamics structures of peptide nucleic acidÆDNA hybrid in the wild-type and mutated alleles of Ki-ras proto-oncogene ppt
... deciphering the origin of the destabilization and hence, diminution of the melting temperature (Tm) in the former Base stacking in the vicinity of A C mismatch in PNAÆDNA and DNA duplexes Intra ... interrupted stacking, fluctuating nature of the hydrogen bond and water organization in the vicinity of the mismatch might be the contributing factors for the increase in free energy and diminished stability ... significant variableness in the water interactions surrounding the mismatch Water interaction in the vicinity of A C mismatch Figure 7A–L depicts the nature of water interaction in the neighbourhood...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... protein of 295 amino acids with an N-terminal bZIP DNA-binding domain, a putative transmembrane domain, and a 56 -amino- acid small C-terminal domain (Fig 1A) A truncated form of AtbZIP60 lacking the ... signal peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respectively These mutant proteins are translocated into the lumen of the ER, but remain anchored to the membranes ... pivotal role of the UPR is to maintain ER homeostasis Therefore, the presence of mutated proteins that are unable to fold into their native conformation in the ER induces the UPR in an effort to...
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Báo cáo y học: "Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff" pptx
... present between the lobular elements in the supporting reticular tissue of the bursa and the supraspinatus tendon fibers reaching into the basal portion of the organ, in addition to the dense connective ... staining for AP Note the co-distribution of AP, both the bursa-derived intrinsic enzyme and the C2C12-derived enzyme, with the BMP deposits within the tissue supporting egg maturation [27,28], the ... towards or within the tendon Elements staining positive included reticular fibers, dense connective tissue fibers proximal to the tendon, and the tendon (Figure 2c) Safranin O staining, an indicator...
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Báo cáo y học: " A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein" pdf
... envelope proteins, the fusion protein (F), the hemagglutinin-neuraminidase (HN) protein and the small hydrophobic protein (SH) [23] HN is the major antigenic protein known to elicit neutralizing antibodies ... compared to the activity in MuV-infected cells Because the main receptor binding domain of the MuV HN protein has been proposed to be located at the same site as the neuraminidase activity [34], the ... showed 40% of the hemoglobin concentration in comparison with the hemoglobin detected in MuV-infected cells Furthermore, the HD reaction was not observed in MuV-infected Vero cells or in the pcDNAHN176transfected...
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báo cáo khoa học: " Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach" pptx
... (A) The FAMEs acid content (nmol/ml) in the medium from E coli clones containing the variants listed as determined by Figure total fatty GCMS of (A) The total fatty acid content (nmol/ml) in the ... is 86 where the FatB's always contain a charged residue (21 have lysine, have arginine, has glutamate) while the FatA's always contain the neutral glutamine Because they represent the most dramatic ... valine, glutamine, or histidine at position 141 All other amino acids were represented in the library Agar-plate based screen for TE activity When plated on BTNA agar, there are subtle changes in...
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Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx
... cytokines play a key role in orchestrating inflammatory and structural changes of the airway in asthma by recruiting, activating and promoting inflammatory cells into the airway [38-40] In addition ... suggesting an antiinflammatory role of LPA in a murine model of acute lung injury [26] In addition to its anti-inflammatory effect, LPA regulated E-cadherin intracellular trafficking and airway epithelial ... critical role in pathogenesis of airway inflammatory diseases Therapeutic targeting of LPA2 may be beneficial in reducing allergic inflammatory responses in airway diseases Competing interests The authors...
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Báo cáo khoa học: "Bench-to-bedside review: Treating acid–base abnormalities in the intensive care unit – the role of renal replacement therapy" potx
... disorders and gaining insights into the nature of such disorders and the mechanisms of action of RRT are important In the present review we explore the acid base disorders seen in ARF, the effect of ... clinical setting, the anion gap is not always elevated These findings might lead clinicians to diagnostic and therapeutic confusion In these situations, quantitative analysis using the Stewart– ... hypoalbuminemia Hypoalbuminemia lowered the anion gap and masked the presence of acidifying anions to those clinicians using conventional acid base analysis Effect of renal replacement therapy on acid base...
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Báo cáo khoa học: "Bench-to-bedside review: Treating acid–base abnormalities in the intensive care unit – the role of buffers" ppt
... examining the effects of bicarbonate infusion on intracellular pH are variable, with intracellular [H+] rising [36], falling [37,38,43–48], not changing [4,14,34,35], or either rising or falling ... spectroscopy In one study [51] bicarbonate attenuated the decrease in intracellular muscle pH during exercise induced metabolic acidosis while raising the arterial pH and PCO2 In the other study ... but clinical trials in humans are lacking Competing interests None declared References When should I administer a buffering agent? The lack of evidence supporting buffer therapy in human acidosis...
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Báo cáo y học: "Clinical review: Acid–base abnormalities in the intensive care unit" doc
... whether this is true for other injuries in isolation or combination The interpretation of SBE must therefore incorporate the injury complex into decision-making, perhaps limiting its utility A recent ... identified in some studies that is conspicuously lacking in others? The answer may be found in the timing Much like base excess, the value of the SIG may be related to the time of assay Since the natural ... loading [31–33] Interestingly, metabolic acidosis induced by chloride from normal saline solution loading is associated with impaired coagulation and the need for bicarbonate buffering of the induced...
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Báo cáo y học: "Clinical review: The meaning of acid–base abnormalities in the intensive care unit – effects of fluid administration" potx
... illustrated in Table In either case the SID is reduced to 30 mEq/l, but with a fall in [Cl–] after water dilution Interestingly, hypertonicity makes solutions more acidifying [36] In this case the reduction ... within the cells during correction The net effect of KCl administration is that the retained strong anion (Cl–) stays extracellullar, whereas most of the retained strong cation disappears into the ... membranes with intracellular fluid) This alters extracellular SID and ATOT, the final determinants of metabolic acid base status, toward the SID and ATOT of the infused fluid The CO2TOT of infused fluid...
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Báo cáo khoa học: "Clinical review: The meaning of acid–base abnormalities in the intensive care unit – epidemiolog" ppt
... important The increase in chloride relative to that of sodium reduces the SID, resulting in a reduction in the alkalinity of blood The Na+/Cl– ratio has been proposed as a simple way to delineate the ... addressed in future study designs Without consistency in reporting acid base methodology, conflicting reports will continue Competing interests The author(s) declare that they have no competing interests ... for the albumin level (which, in the critically ill, is usually low) [14-16] The importance of correcting the anion gap for albumin is not limited to the adult population Quite the contrary, there...
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Báo cáo y học: "Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea" pot
... only the PTH11 domain was used to build the tree (the amino- terminal CFEM domain seen in a few proteins was not included), the 13 CFEM domain-containing proteins occurred together in one clade, indicating ... other proteins that were retrieved in the BLAST search, including mPR receptors (mPR_dom, Figure 2d) The proteins containing the PFAM GPCR domains are indicated in Table It is worth noting that the ... glucose-sensing receptors In all the PTH11-related members the region towards the amino terminus was conserved (Figure 2a, PTH11_dom) The extreme amino- terminal and the carboxy-terminal sequences flanking...
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