a special reference to insulin like growth factor ii and raf gene signaling
Báo cáo sinh học: " Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats" doc
... controls IGF -II therapy was able to improve both parameters Effect of IGF -II on caspase and caspase activity Assays for caspase associated activity showed a significant increase of caspase activation ... was obtained at a concentration of 200 pmol/mg Atr Mitochondrial oxidative damage and Total Antioxidant Status (TAS) in isolated liver mitochondria Figure shows intramitochondrial oxidative damage, ... 8%, respectively TAS, as total enzymatic and nonenzymatic antioxidant capability, was evaluated in isolated mitochondria by a colorimetric assay (Randox Laboratories Ltd., Ardmore, Crumlin, UK)...
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báo cáo hóa học:" Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats" pot
... controls IGF -II therapy was able to improve both parameters Effect of IGF -II on caspase and caspase activity Assays for caspase associated activity showed a significant increase of caspase activation ... was obtained at a concentration of 200 pmol/mg Atr Mitochondrial oxidative damage and Total Antioxidant Status (TAS) in isolated liver mitochondria Figure shows intramitochondrial oxidative damage, ... 8%, respectively TAS, as total enzymatic and nonenzymatic antioxidant capability, was evaluated in isolated mitochondria by a colorimetric assay (Randox Laboratories Ltd., Ardmore, Crumlin, UK)...
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Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps
... transducer and activator pathway, which appear to inhibit cytokine and GH signaling as part of a classical negative feedback loop [12] Increased hepatic mRNA of SOCS proteins has been shown to ... CTC CA-3' and 5'-CGG TTA CGG CAC TCC AGT AG-3'; CIS, 5'-GCT TGT CGA GAC CTC GAA TC3' and 5'-CAG GAT CTG GGC TGT CAC TC-3'; IGF-1, 5'TCA GTT CGT GTG TGG ACC AAG-3' and 5'-TCA CAG CTC CGG AAG CAA ... Parramatta, NSW, Australia) and had a catheter aseptically implanted into the right internal jugular vein as described previously [16] A midline laparotomy was performed and a further catheter was inserted...
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Báo cáo khoa học: Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx
... 165-183 +P Sequence Calculated mass (Da) Measured mass (Da) Dmass (Da) HALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNF HALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNF HLMAPSEEDHSILW RVVESLAKAQETSGEEISKF 4660.1 ... Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria Genes Dev 21, 3095–3109 Lang CH, Vary ... metalloproteinase-7 degrades all insulin- like growth factor binding proteins and facilitates insulin- like growth factor bioavailability Biochem Biophys Res Commun 333, 1011–1016 41 Binoux M, Lalou...
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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx
... IGF -II and mutant IGF analogue to rhIGF1R Data were analysed using BIAevaluation software 3.0 and ®tted to a Langmuir : binding model as outlined in Materials and methods The dissociation constant ... quantitatively determines levels of cytoplasmic histone-associated DNA fragments generated during apoptotic DNA fragmentation, was performed according to the manufacturer's instructions, and absorbances ... af®nities to the rhIGF1R than IGF-I (Fig 1F±H and Table 1) The association and dissociation rates of these analogues were too rapid to be accurately measured, and therefore their steady-state af®nities...
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báo cáo hóa học: " Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide" ppt
... Interests: RD has received honoraria from Bristol-Myers Squibb and Lundbeck Laboratories and works as a consultant for Lundbeck Laboratories RD and KWK have received honoraria from Astra-Zeneca Authors’ ... treated animals, performed behavior tests, analyzed data and wrote much of the manuscript SP performed surgery, treated animals, performed behavior tests, analyzed data and did all the PCR analyses ... 2001 Rojo AI, Innamorato NG, Martin-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A: Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease Glia 2010, 58:588-598...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... Changes in the local regulation of insulin- like growth factors I and II and insulin- like growth factor- binding proteins in osteoarthritis of the canine stifle joint secondary to cruciate ligament ... studies Anal Biochem 1986, 154:138-143 37 Bhakta NR, Minerva Garcia A, Frank EH, Grodzinsky AJ, Morales TI: The insulin- like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding ... chondrocytes by insulin- like growth factor- 1 J Biol Chem 2003, 278:36563-36571 Loeser RF, Shanker G: Autocrine stimulation by insulin- like growth factor and insulin- like growth factor mediates chondrocyte...
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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
... Davidson B: Diagnostic and prognostic role of the insulin growth factor pathway members insulin- like growth factor- II and insulin- like growth factor binding protein-3 in serous effusions Hum Pathol 2009, ... University of Maryland, Baltimore Animal Care and Use Committee To compare RIA and CNT-FET assays, Brca1f/f; MMTV-Cre mice and wild type C57Bl/6 mice were euthanized at 3, and 12 months of age to collect ... measured using a RIA kit containing microplates coated with the capture antibody and a I125 labeled detector antibody (Alpco Diagnostic, Salem, NH) The assay was performed according to manufacturer’s...
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Báo cáo y học: "Insulin like growth factor-I in acute subarachnoid hemorrhage: a prospective cohort study" potx
... cerebral artery; AcoA, anterior communicating artery; APACHE, Acute Physiology and Chronic Health Evaluation; ICA, internal carotid artery; MCA, median cerebral artery; SAH, subarachnoid hemorrhage; ... manuscript and revising it critically OR participated in analysis and interpretation of data, drafting the manuscript and revising it critically ER, JRO and VK participated in analysis and interpretation ... 21 Mattila AK, Saarni SI, Salminen JK, Huhtala H, Sintonen H, Joukamaa M: Alexithymia and health-related quality of life in a general population Psychosomatics 2009, 50:59-68 22 Soini E, Rissanen...
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Suitability of insulin like growth factor 1 (IGF1) as a measure of relative growth rates in lingcod
... Swanson, H Fukada, A Hara, and W W Dickhoff 2000 Comparison of extraction methods and assay validation for salmon insulinlike growth factor- I using commercially available components General and ... 27:219–240 Onuma, T A. , K Makino, H Katsumata, B R Beckman, M Ban, H Ando, M Fukuwaka, T Azumaya, P Swanson, and A Urano 2010 Changes in the plasma levels of insulin- like growth factor- I from the ... Perez-Sanchez 2002 Endocrine mediators of seasonal growth in gilthead sea bream Sparus aurata: the growth hormone and somatolactin paradigm General and Comparative Endocrinology 128:102–111 Mittelbach,...
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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx
... Signaling and function of insulin- like peptide in insects Annu Rev Entomol 51, 1–24 Nagasawa H, Kataoka H, Isogai A, Tamura S, Suzuki A, Mizoguchi A, Fujiwara Y, Suzuki A, Takahashi SY & Ishizaki H ... prepared The immunoreactive band was detected using an ECL system (Amersham) and a Polaroid camera (Amersham) Purification of 8K-BLP Animals A racial hybrid of B mori, Kinshu · Showa (Ueda Sanshu, ... of an A- chain and a B-chain, whereas IGFs are singlechain peptides with domains B, C, A and D, and the major function of insulin is to control carbohydrate metabolism, whereas that of IGFs is to...
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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc
... The Authors Journal compilation ª 2006 FEBS A Fanzani et al Insulin- like growth factor signaling A B C D E Fig Neu2-induced differentiation is blocked by PI3 kinase and mammalian target of rapamycin ... of rat cytosolic Neu2, primers 5¢-CCGTCCAGGACCTCACAGAG-3¢ (sense) and 5¢-TC ACTGAGCACCATGTACTG-3¢ (antisense) were used Sialidase assay A confluent 100 mm plate was washed with NaCl ⁄ Pi, and ... Insulin- like growth factor signaling A Fanzani et al the repair of damaged tissue In particular, myoblast proliferation is triggered by activation of the extracellular regulated kinase (ERK)...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... 5¢-GGAUCAAAGAGAACACUGGGGUAUA-AG-3¢; and #1513 sense, 5¢-AGUUCACGUGCAAGAACAAG UUCUG-AG-3¢ The forward sequence of the scrambled RNA was 5¢-GAUCCAAGUAAUACAGAGAUGGGAG AG-3¢ OVISE cells were plated ... matriptase is able to degrade extracellular matrix proteins and to activate urokinasetype plasminogen activator (uPA) [33,39], hepatocyte growth factor (HGF) [39] and protease-activated receptor-2 ... Matriptase siRNAs and a scrambled RNA as a control were designed and synthesized at iGENE (Tsukuba, Japan) The forward sequences of the siRNAs were: #973, sense 5¢-UCAUCACACUGAUAACCAACACUGA-AG-3¢;...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... Rabbit polyclonal to myc tag and mouse monoclonal (CH-19) to pan-cadherin were obtained from abcam (Cambridge, MA, USA) Glutathione S-transferase (GST) antibody was obtained from Bethyl Laboratories ... phosphorylation was detected rapidly and was transient; phosphorylation of ERK1 ⁄ was induced within 10 and phosphorylation was back to basal levels by 60 min, unlike phosphorylation of Akt and S6K1, after ... obtained from Sigma-Aldrich (St Louis, MO, USA) Wortmannin and rapamycin were obtained from Calbiochem (San Diego, CA, USA) U0126 was obtained from LC Laboratories (Woburn, MA, USA) Protein assay...
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HYGIENIC PHYSIOLOGY WITH SPECIAL REFERENCE TO THE USE OF ALCOHOLIC DRINKS AND NARCOTICS BEING A REVISED EDITION OF THE FOURTEEN WEEKS IN HUMAN PHYSIOLOGY ppt
... found by Cuvier to contain considerable animal matter Gelatine was actually extracted from the Cambridge mastodon, and made into glue A tolerably nutritious food might thus be manufactured from ... of Man," an undisputed authority on both sides of the Atlantic, has been adopted as the standard in digestion, respiration, circulation, and the nervous system Leidy's "Human Anatomy," and Sappey's ... Body," and that quaint volume, "Odd Hours of a Physician," have aided the author with facts and fancies The writings of Draper, Dalton, Carpenter, Yalentin, Mapother, Watson, Lankester, Letheby, Hall,...
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BÁO CÁO " ĐA DẠNG DI TRUYỀN GEN INSULIN - LIKE GROWTH FACTOR BINDING PROTEIN 2 TRÊN GÀ " potx
... chicken insulin- like factor binding protein gene associated with chicken growth and carcass traits Poult Sci 84: 1191-1198 Li, Z.H., H Li, H Zhang, S.Z Wang, Q.G Wang, Y.X Wang (2006) Identification ... liquid chromatography Genet Sel Evol 37: 339-360 Rajaram, S., D.J Baylink, S Mohan (1997) Insulinlike growth factor- binding proteins in serum and other biological fluids: Regulation and functions ... thế, tần số cao tìm thấy kiểu gen GG, AG cuối AA quần thể nghiên cứu 39 a dạng di truyền gen Insulin- like growth factor binding protein gà a dạng di truyền gen Insulin- like growth factor binding...
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Nồng độ Hóc Môn "Insulin - Like Growth Factor - I / IGF - I" huyết thanh ở trẻ em Việt Nam - lứa tuổi tiền học đường pot
... levels related to gestational age, birth weighr and day of life Eur J Pediatr 145: 187-189 Juul A, Bang P, Hertel NT et al (1994) Serum insulin- like growth factor- I in 1030 healthly children aldolescent, ... malnutriton Am J Physiol 270 (Endocrinol Metab 33): E646-E653 Robinson H & Picou D (1997) A comparison of fasting plasma insulin and growth hormone concentration in marasmic, kwashiokor, marasmic-kwashiokor ... Maiter D, Adam E, Mulumba N and Ketelslegers JM (1995) Reduced liver insulin- like growth factor- I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone...
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báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx
... Zhu et al have shown that IGFBP-4 has IGF-independent activity as a cardiogenic growth factor, and data suggest that it acts as a competitive inhibitor of the canonical Wnt signaling pathway [26] ... data suggest that IGFBP-7 acts through a negative feedback loop to attenuate MAPK signaling, resulting in cellular senescence in BRAF mutant melanocytes and apoptosis in BRAF mutant melanoma ... Variables Age (y) Mean (± SD) Median Sex Male Female Stage I II Thickness (mm) Mean (± SD) Median Histologic Type Superficial Spreading Nodular Lentigo Maligna Melanoma Anatomic Location Axial...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
... El-Badry OM, Minniti C, Kohn EC, Houghton PJ, Daughaday WH, Helman LJ: Insulin- like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors Cell Growth ... and PDGFRA receptors and may overcome KIT and PDGFRA-dependent imatinib resistance [55] Glycemic derangements related to insulin- like growth factors such as the pro-IGF-IIE and insulin- like growth ... Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y: Gain of function mutations of c-kit in human gastrointestinal...
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Báo cáo sinh học: " Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females" pot
... of a computerized hepatorenal index for sonographic quantification of liver steatosis AJR Am J Roentgenol 2009, 192:909-914 Wasada T, Kasahara T, Wada J, Jimba S, Fujimaki R, Nakagami T, Iwamoto ... HOMA, homeostasis model assessment of insulin resistance; HS, hepatic steatosis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CRP, C-reactive protein; FM%, Fat Mass percentage ... were calculated To avoid multicollinearity, i.e., situations in which the predictors are correlated to each other to some degree, the variance inflation factor and tolerance were set at > 10 and...
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