a rationale for new methods in drug discovery

Advanced Computer-Assisted Techniques in Drug Discoveryedited by Han van de Waterbeemd.Methods pot

Ngày tải lên : 29/06/2014, 09:20

... chemical, biological and medical data are available and are potentially of interest to any drug discovery program Chemical information systems and databases have become essential to handling such ... features and constraints are now within reach Generation of new leads is an important aspect of preclinical research, and database searching is one approach, while blind and targeted screening ... interatomic distances defined by these N atoms The data set is, thus, a matrix containing the conformational minima of all compounds: each row represents a conformation and each column an interatomic...

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In silico methodologies for selection and prioritization of compounds in drug discovery

Ngày tải lên : 08/09/2015, 22:12

... manner Training involves tree construction as well as assigning to each leaf node the class labels stipulated in the training samples for each input item reaching that particular leaf node After ... and shape based matching techniques for the analysis of the interactions of a corporate database against the enzymatic target In the final part of the thesis, a novel application of the Taguchi ... the Random Forest classifier uses Class and Class as training sets in a supervised machine learning approach to generate a similarity score for each compound The similarity scores of Class are...

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Development of database and computational methods for disease detection and drug discovery

Ngày tải lên : 10/09/2015, 09:04

... chemistry information, bioinformatics and chemoinformatics data, system model of pathway, bimolecular interaction data and so on Databases store data in various formats such as relational database tables, ... scheme, integrating data from various resource, designing database interface and implementing database function 2.1.1 Database model and rational schema design A database model is a theoretical foundation ... formats 33 are standardized to have single file format In semantic integration, data from different databases are formalized to have a relational schema which holds relational tables and integrity...

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A time for new ideas innovation in central eastern europe and turkey

Ngày tải lên : 06/12/2015, 23:05

... and retain staff, especially in an innovative small company In our survey, some 35% of local firms said that they had some financial incentives in place for innovation work, a similar level for ... below that relates innovation performance to innovation inputs The patents data are averages for 2003-05, whereas the innovation enablers are indices based on 2003-07 averages All indices are expressed ... COUNTRY DATA: ESTONIA A time for new ideas Innovation in Central Eastern Europe and Turkey Estonia Regulatory and policy framework Innovation inputs and performance ● The Organisation of Research and...

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A Build for Every Check-In

Ngày tải lên : 05/10/2013, 09:20

... containing information that is sent to the build master info/admin contains this Buildbot administrator’s name and e-mail address, while info/host contains a description of the slave The default ... existing installation chdir /usr/local/buildbot/slave/rsreader creating Makefile.sample mkdir /usr/local/buildbot/slave/rsreader/info Creating info/admin, you need to edit it appropriately Creating ... step in gory detail That detailed information is available from each step’s output The information presented in the waterfall display should be understandable at a glance The only step with an...

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Tài liệu Báo cáo khoa học: "A Method for Correcting Errors in Speech Recognition Using the Statistical Features of Character Co-occurrence" pptx

Ngày tải lên : 20/02/2014, 18:20

... ~'¢ ' "Hai arigatou gozaimasu Kyoto Kanko Hoteru yoyaku gakari de gozaimasu", ('l'hank you for calling Kyoto Kanko Hotel reservations.) Input String: -¢, "A hai arigatou gozaimasu e Kyoto Kanko ... the characters before and after "(" Cte") (3) Both the Error-Pattem-Database and String-Database can be mechanically prepared, which reduces the effort required to prepare the databases and makes ... actual utterance (A) No lacking in the meaning of the actual utterance, and with perfect expression (B) No lacking in meaning, but with slightly awkward expression (C) Slightly lacking in meaning...

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Tài liệu Báo cáo khoa học: "A PROGRAM FOR ALIGNING SENTENCES IN BILINGUAL CORPORA" docx

Ngày tải lên : 20/02/2014, 21:20

... (Table 4) for use in lexicography (Klavans and Tzoukermann, 1990) 178 It is remarkable that such a simple approach can work as well as it does An evaluation was performed based on a trilingual corpus ... the distance scores are small, and back off to a lexical approach as necessary Signal Processing ACKNOWLEDGEMENTS We thank Susanne Wolff and and Evelyne Tzoukermann for their pains in aligning sentences ... sentences boundaries The dataset was sufficiently small that it was possible to correct the reznaining mistakes by hand For a larger dataset, such as the Canadian Hansards, it was not possible...

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Báo cáo khoa học: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components ppt

Ngày tải lên : 07/03/2014, 11:20

... seen after 26 days of culture mMCP-6 storage showed similar kinetics as for mMCP-5 In contrast, CPA protein was detected as early as after days of culture, and a maximal plateau of storage was already ... Although b-hexosaminidase activity was already detected at day 0, the intracellular content of this enzyme increased markedly after days of culture, and reached a plateau from about day 12 (Fig 2B) ... metachromatically staining granules seen in mature MCs have been poorly investigated In a recent study, we generated a mouse strain in which the SG gene was targeted [10] We found that, in the absence...

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A Strategy for Cancer Control in Ireland - National Cancer Forum 2006 pdf

Ngày tải lên : 15/03/2014, 00:20

... be a plan for managing and monitoring the screening programme and an agreed set of quality assurance standards • Adequate staffing and facilities for testing, diagnosis, treatment and programme ... capacity of primary care; integrated care pathways and multidisciplinary teams that incorporate palliative care services 36 A formal linkage should be established between the National Cancer Forum ... cancer early, before it has had a chance to spread, remains the best strategy for reducing cancer deaths Examples of early detection include breast awareness, testicular examination and skin inspection,...

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Báo cáo khoa học: "A System for Detecting Subgroups in Online Discussions" pptx

Ngày tải lên : 16/03/2014, 20:20

... of the ACL 2010 Conference Short Papers, pages 263–268, Uppsala, Sweden, July Association for Computational Linguistics Aditya Joshi, Balamurali AR, Pushpak Bhattacharyya, and Rajat Mohanty 2011 ... Canada, October Association for Computational Linguistics Amitava Das and Sivaji Bandyopadhyay 2011 Dr sentiment knows everything! In Proceedings of the ACLHLT 2011 System Demonstrations, pages ... 48th Annual Meeting of the Association for Computational Linguistics, pages 138–147, Uppsala, Sweden, July Andrea Esuli and Fabrizio Sebastiani 2006 Sentiwordnet: A publicly available lexical resource...

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Smart Business, Social Business: A Playbook for Social Media in Your Organization

Ngày tải lên : 17/03/2014, 21:31

... Qantas Airlines jet airliner had crashed on Batam Island in Indonesia Qantas Airlines: No Crash, Despite Lots of Rumors After an emergency landing, rumors of a Qantas Airlines plane crash circulated ... stream does not make a business social Pointing to these accounts in marketing and advertising material also not make a business social So what, then, defines a social business? A social business ... reports from TV and Twitter it’s a Qantas airliner which crash at Batam @smillavtr: Chapter Human Capital, Evolved 17 Reports that a Qantas plane may be involved in a crash in Indonesia http://ow.ly/349sJ...

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Teaching Sexual Health Education: A Primer for New Teachers, A Refresher for Experienced Teachers pot

Ngày tải lên : 22/03/2014, 15:20

... Sexual and Reproductive Health Promotion (Public Health Agency of Canada) Canadian Association of Sexual Assault Centres The Society of Obstetricians and Gynaecologists of Canada Infertility Awareness Association of Canada Canadian Women's Health Network ... It is highly recommended that sexual health education teachers keep parents and guardians informed about all aspects of their sexual health program. For suggested strategies for involving parents and guardians, please refer to the other sections of this booklet. ... It provides basic information about HIV, AIDS and what it is like to live with the disease. The Guelph Conference and Training Institute on Sexuality Canada's leading annual training and education forum for sexual health professionals. With ...

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Auditing for Social Change: A Strategy for Citizen Engagement in Public Sector Accountability docx

Ngày tải lên : 30/03/2014, 02:20

... Financial Management Modern day public auditors perform a variety of audits aimed at satisfying different financial management goals Financial audits assess the accuracy and fairness of both the accounting ... increased, as has the demand for strong, open, and participatory monitoring, evaluation, audit, and information sharing; • Many of the existing standards and norms pertaining to ITA are either outdated ... can the media play in publicizing results of audits and advocating for citizen’s right to information? • What are the advantages and disadvantages of the audit community to adopt a media-shy attitude?...

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Báo cáo hóa học: "A framework for ABFT techniques in the design of fault-tolerant computing systems" pot

Ngày tải lên : 20/06/2014, 22:20

... guarantees that faults representing errors in the processed data will result in notable non-zero values in syndrome sequence Systematic encoding means that the information bits always appear in ... operations at the data-parity level Data processing implementations are protected against Hamidi et al EURASIP Journal on Advances in Signal Processing 2011, 2011:90 http://asp.eurasipjournals.com/content/2011/1/90 ... Huang, JA Abraham, Algorithm-based fault tolerance for matrix operations IEEE Trans Comput C-33, 518–528 (1984) JY Jou, JA Abraham, Fault tolerant matrix arithmetic and signal processing on highly...

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Báo cáo hóa học: " Research Article Extraction of Protein Interaction Data: A Comparative Analysis of Methods in Use" potx

Ngày tải lên : 22/06/2014, 19:20

... way of data capture MANUAL CURATION USING FULL-LENGTH AND ABSTRACT Several databases both in public domain as well as proprietary domain use abstract as the sole source of information Abstracts ... method, and intracellular localization (cytoplasm, membrane, and nucleus) Data is manually entered into PathArt using a curator work bench, a software tool that accepts data in a deﬁned format, and ... 2.1 Manual curation PathArt (proprietary pathway database from Jubilant Biosys Ltd.) is a manually curated database which covers more than 2800 signaling and metabolic pathways across 34 diseases...

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BIOELEC TROMAGNETIC HEALING A RATIONALE FOR ITS USE doc

Ngày tải lên : 29/06/2014, 09:20

... PEMFs also help activate the body’s natural antioxidants to neutralize free radicals rapidly Free radicals have a role in aging, illness, and death Stopping free radicals stops inflammation “Healing ... to perform all of its actions, such as raising a finger or healing a wound.30 Even the Navy and DARPA have contracted with Whelan to start testing the wound-healing LED device More information ... for relieving pain and vibrating female patients who were routinely diagnosed with “hysteria.” Nikola Tesla In 1895, the Niagara Falls Power Company opened for the first time and within a year,...

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Báo cáo toán học: "Some new methods in the Theory of m-Quasi-Invariants" pps

Ngày tải lên : 07/08/2014, 08:22

... result for dihedral groups m-quasi-invariants and the remarkable fact that the freeness result for all m-quasi-invariants follows in a completely elementary manner from one single inequality Namely ... We have seen in section that every m-quasi-invariant in x1 , x2 , x3 is a sum of terms involving (1) An invariant (2) The polynomial x2 x2 Π(x)2m times an invariant (3) An m-quasi-invariant P1 ... combining (2.32) and (2.33) we obtain h = ψ(C) 2 e − e2 + e1 D (2.34) Since ψ(C) is an S3 m-quasi-invariant and e2 − e2 is invariant, this relation forces D to be S3 m-quasi-invariant as well and...

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Báo cáo khoa học: "Choice of a model for height-growth in maritime pine curves" pps

Ngày tải lên : 08/08/2014, 19:21

... functions Seber and Wild (1989, p 118) state that "one advantage of finding stable parameters lies This transformation is made for this practical reasons but, being univariate, it has essentially no ... with a data set containing 44 trees belonging to 13 good growing stands, sampled in the Landes de Gascogne area and aged more than 35 years to get the main part of the curve This selection was made ... Chapman-Richards (Richards, 1959) variableshape functions Both curves have parameters, which have the following meanings: A asymptote; r= related to relative growth rate; m shape parameter; and...

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Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx

Ngày tải lên : 09/08/2014, 01:21

... Nishioka K, Mima T, Ishii T, UmeshitaSasai M, Kobayashi H, Shimizu M, Katada Y, Wakitani S, Murata N, Nomura S, Matsuno H, Katayama R, Kon S, Inobe M, Uede T, Kawase I, Saeki Y: Enhanced local production ... this family serve as adapter proteins that mediate cytokine signaling; in particular, they seem to play a role in tumor necrosis factor and Toll/IL-1 signaling, resulting in activation of transcription ... OPN has also been found in inflamed joints of rheumatoid arthritis patients [28] These observations make OPN an attractive target for anti-inflammatory therapy of MS, and possibly rheumatoid arthritis...

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Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps

Ngày tải lên : 09/08/2014, 06:22

... causes profound bone damage with osteoclast formation and activation, and increased expression of RANK/ RANKL in inflammatory cells, in inflamed synovium, in articular cartilage and at the invading ... differentiation and activation induced by osteoprotegerin ligand Proc Natl Acad Sci USA 1999, 96:3540-3545 Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi ... corresponding to amino acids 317–616 mapping at the carboxy terminus of RANK of human origin [H-300]) or against RANKL (rabbit polyclonal antibody raised against the epitope corresponding to amino acids...

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