a model for stem cell therapy in regenerative medicine
Báo cáo hóa học: " Melanoma: A model for testing new agents in combination therapies" doc
... dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative ... trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b J Clin ... Eggermont AM: Interferon alfa- 2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative...
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Báo cáo y học: "Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes" ppsx
... the families Viperidae (for example, rattlesnakes, and adders) and Elapidae (for example, coral snakes, cobras, and mambas) In addition to these lineages that contain commonly used model research ... comparative data to estimate genomic characteristics of the ancestral amniote genome Page of (or the ancestral squamate genome) would be fascinating, including estimation of ancestral gene family ... Justification and strategies for expansion of snake genomics Research incorporating snakes as model systems is becoming increasingly popular and diverse in its breadth of topics The availability of...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt
... treatment of the brain), and somatic stem cells capable of generating cell types specific for the target rather than the donor organ (e.g., bone marrow mesenchymal stem cells for cardiac repair) ... spermatogonia in the adult human testis, providing another strategy for obtaining genetically identical stem cells Umbilical cord blood stem/ progenitor cells are associated with less graftversus-host ... isolate from other tissues, such as heart and brain Substantial efforts have therefore been devoted to obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps
... not yet clear, and various experimental studies have employed intramyocardial, transendocardial, intravenous, and intracoronary injections In experimental myocardial infarction, functional improvements ... improvements have been achieved after transplantation of a variety of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells ... (Chap 65) Figure 67-1 Strategies for transplantation of stem cells Undifferentiated or partially differentiated stem cells may be injected directly in the target organ or intravenously Stem cells...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot
... Multipotential stem cells also reside within gastric glands and intestinal crypts Thus, hepatic, pancreatic, and/or gastrointestinal precursor cells may be candidates for cell- based therapy of diabetes ... abortuses are an alternative, and a clinical trial of fetal neural stem cells in Batten disease is commencing Transdifferentiation of bone marrow and adipose stem cells into neural stem cells, and ... cells in stroke are also planned Neurologic disorders that have already been targeted for stem cell therapies include spinal cord injury, amyotrophic lateral sclerosis, stroke, traumatic brain...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 4) pot
... organ Imaging techniques are needed to visualize stem cells in vivo after transplantation into humans Fortunately, stem cells can be engineered before transplantation to contain contrast agents ... extraordinary, and disorders such as myocardial infarction, diabetes, Parkinson's disease and many others are attractive targets However, such stem cell based therapies are at a very early stage ... therapeutic applications in regenerative medicine and cancer therapies Clin Pharmacol Ther 82(3):252, 2007 [PMID: 17671448] National Institutes of Health: Stem cell information page URL: http://stemcells.nih.gov/index.asp...
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Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... 909–913 89 Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K & Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53–p21 pathway Nature 460, 1132–1135 ... viral infections [20] Cancer therapy is a principal goal of the current clinical research on hESCs Recently, regression of metastatic melanoma tumors was achieved by transplantation of adaptive ... achieving this by serial reprogramming or by treating iPSCs with chromatinmodifying chemicals has been described [85] An alternative method for avoiding problems associated with partially retained...
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War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? docx
... War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? Summary The high costs of fighting the wars in Iraq and Afghanistan have rekindled congressional interest in ... financial institutions Today, savings bonds are almost always a substitute mechanism for other forms of personal savings Author Contact Information James M Bickley Specialist in Public Finance ... Congressional Research Service War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? Introduction The high costs of fighting the wars in Iraq and Afghanistan have rekindled...
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THE REFORM OF THE SAVINGS BANK SYSTEM IN FRANCE – A MODEL FOR OTHER COUNTRIES? docx
... local savings associations, 34 regional savings banks, National Bank of the savings banks) Tripartite (519 local savings banks, 12 regional state banks, DekaBankDeutsche Girozentrale) Coordinating ... local savings companies at its disposal since 1999 These are not involved in the financial business but are closely associated with the savings banks in a legal and practical sense The local savings ... in France Although not independent institutions, they are invariably attached to the savings bank in the region in which they operate In this way, several savings companies are attached to each...
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Báo cáo khoa học: "A Joint Model for Discovery of Aspects in Utterances" potx
... Domain adaptation with unlabeled data for dialog act tagging In Proc Workshop on Domain Adaptation for Natural Language Processing at the the Annual Meeting of the Association of Computational ... assigns domain/dialog-act/slot labels to each topic at each layer in the hierarchy using labeled data (explained in §4.) We represent domain and dialog act components as meta-variables of utterances ... them For example, in a local domain application, users may require information about a sub-domain (movies, hotels, etc.), and for each sub-domain, they may want to take different actions (find a...
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báo cáo sinh học:" A model for integrating strategic planning and competence-based curriculum design in establishing a public health programme: the UNC Charlotte experience" doc
... Integration, application and practice objectives are one area where practica and capstones (theses or projects) can serve a critical catch-all role, in much the same way as qualifying exams for ... strategic planning approach Assess and align mission The newly created Department of Health Behavior and Administration was charged with administering two existing graduate degree programmes (Master ... program graduates – Program • Define the program’s academic goals and primary objectives Specify educational strategies/approaches • Define key educational strategies and approaches needed to achieve...
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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf
... clinical application) malignant counterparts of embryonic stem cells that originate from the inner cell mass of a blastocyst stage embryo The embryonal carcinoma cells replicate and grow in cell ... post-transplant Kaposi sarcoma [48], skin carcinoma [49] and oral squamous cell carcinoma [50] Notably the incidence of solid tumours is significantly increased in patients that have received a bone marrow ... cells are administrated When transplanted into a homologous species mESC caused highly malignant teratocarcinomas at the site of administration, while xenotransplantation in rats resulted in migration...
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Báo cáo sinh học: "Q&A: What can microfluidics do for stem-cell research" ppsx
... that the stress of manual handling of hESCs is an important factor in their instability over time, and therefore automated techniques for passaging and expansion may be a method for overcoming ... single cell, for example the apical versus basal signals that will be encountered by a polarized cell In traditional mass culture, cells align in random fashion, and although matrix coatings on tissue-culture ... that optimal washing methods in some applications need improvement Engineers have pointed out that the best mathematical framework for handling models, such as differentiation, that start at...
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Báo cáo lâm nghiệp: "A stochastic height-diameter model for maritime pine ecoregions in Galicia (northwestern Spain)" doc
... the thinning; Ga and Gb are the stand basal area after and before thinning, respectively; At is the stand age at thinning; A is the stand age at prediction and α is the parameter to be estimated ... fitted individually for each sample plot; then in a second stage, parameters are explained using stand variables such as number of trees per hectare, basal area, dominant height, etc., as explanatory ... even-aged stands of stone pine (Pinus pinea L.) in Spain, Ann For Sci 60 (2003) 259–269 [8] Cañadas N., Garc a C., Montero G., Relación altura-diámetro para Pinus pinea L en el Sistema central, in: Rojo...
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Báo cáo khoa học: "Choice of a model for height-growth in maritime pine curves" pps
... reducing the parametric nonlinearity, but we did not investigate this point in forcing us to think about those aspects of the model for which the data provide good information and those aspects for ... the dual influence of the shape parameter in this case, which partially explains the high e-correlation For this model, a variable shape parameter between curves will also lead to interpretative ... Chapman-Richards (Richards, 1959) variableshape functions Both curves have parameters, which have the following meanings: A asymptote; r= related to relative growth rate; m shape parameter; and...
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Báo cáo y học: "Outcome of crisis intervention for borderline personality disorder and post traumatic stress disorder: a model for modification of the mechanism of disorder in complex post traumatic syndromes" ppsx
... examine for any associations between the demographic variables and the total score of the BPRS, BSI, and Client Observation Scale General linear model (mixed model analysis of variance (ANOVA)) was ... between and 24 h from the beginning of treatment (that is, from the subject's examination by a psychiatrist and formulation of a treatment plan by the clinical team) Research assistants ('raters'), ... such as when raters were available and did not interfere with the subjects' other commitments All raters had undergone the same training and testing for inter-rater reliability The raters explained...
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Báo cáo khoa học: "Interpreting the variations in xylem sap flux density within the trunk of maritime pine (Pinus pinaster Ait.): application of a model for calculating water flows at tree and stand levels" pdf
... particular individuals in a stand Sap flow data have been used for estimating hourly transpiration and canopy conductances in a range of forest stands [1, 10, 13, 19, 20] The sap flow measurements can ... on each site ’upscaled’ the sap flux values from tree to stand using optically determined leaf area index values (table I), assuming the needles had a semi-cylindrical shape, and calculating ... resisand capacitances are expressed on an all-sided needle area basis The water potential values used in the present paper are corrected for the gravitational gradient The basic equations for each...
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Báo cáo y học: "A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes." ppsx
... microarray data J Am Stat Assoc 2005, 100:764-780 29 Ishwaran H, Rao JS, Kogalur UB: BAMarraytrade mark: Java software for Bayesian analysis of variance for microarray data BMC Bioinformatics ... selected was Bayesian analysis of variance for microarrays [27-29], a Bayesian spike and slab hierarchical model, as implemented in the BAMarray tool (BAMarray 3.0) [27] Using this procedure, transcriptional ... RDC, AR and SI provided material, experimentation, data collection and analysis RDC participated in writing the manuscript LM and ML provided intellectual input for experimentation and data analysis...
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báo cáo khoa học: " Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC" ppt
... sequence reaction 5’-CATGTGGCACCATCTCACAAT-3’ 5’GCTGCGAGCTCACCCAGAATGTCTGG-3’ 62°C 5’-GAATTCGGATGCAGAGCTTCTT-3’ 5’-Biotin-CCCACA CAGCAA AGCAGAAACT-3’ 5’-Biotin-CTTTCTCTTCCGCACCCA 5’-TAAAATTCCCGTCGC-3’ ... Clin Oncol 2011 Tanaka T, Matsuoka M, Sutani A, Gemma A, Maemondo M, Inoue A, Okinaga S, Nagashima M, Oizumi S, Uematsu K, Nagai Y, Moriyama G, Miyazawa H, Ikebuchi K, Morita S, Kobayashi K, Hagiwara ... non-small cell lung cancer: analysis of results in 19 patients Int J Clin Oncol 2008, 13:442-446 Nagai Y, Miyazawa H, Huqun , Tanaka T, Udagawa K, Kato M, Fukuyama S, Yokote A, Kobayashi K, Kanazawa...
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