a man with a watch knows what time it is a man with two watches is never sure
mechanisms of type 2 diabetes
... UKPDS: decreased risk of diabetes-related complications associated with a 1% decrease in A1 C Percentage increase in relative risk corresponding to a 1% rise in HbA1C Observational analysis from UKPDS ... UKPDS study data Any diabetesrelated endpoint Diabetesrelated death All cause Myocardial mortality infarction 14% 21% 21% ** 14% ** Stroke Peripheral vascular disease† Microvascular disease 12% ** ... hypoglycemia potential: – Any patient with low-normal sugars – Long-acting agents combined with decreased oral intake: • Chlorpropamide (Diabinase) • Gliclazide SR (Diamicron MR) – Intermediate agents with...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... Introduction Diabetes mellitus and cardiovascular diseases are challenging medical and social problems Patients with diabetes mellitus are at a higher risk of developing vascular dysfunction and hypertension ... AL, Hawley JA, Febbraio MA Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type diabetes: evidence that insulin resistance is associated with a disturbed ... and diarrhea for seven days The patient was treated with metformin and augmentin Upon examination, the patient was afebrile with stable vital signs, and femoral pulses were present bilaterally...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... Be sure to turn on the datum axis only 25 For Axis alignment, align the axis of shaft A_ 2 with axis of the bushing A_ 2 Select Move tab, and choose Translate Pick eccentric_asm then move it backward ... assembly is shown below 23 CREATE AN TOTAL ASSEMBLY eccentric_mechanism.asm Click , Enter the name of eccentric_mechanism OK Click Then open sub-assembly base_asm.asm and assemble it at default location ... check and make sure there are NO interference 19 Save the assembly CREATE AN SUB-ASSEMBLY arm_asm.asm Click , Enter the name of arm_asm OK 20 Click Then open arm.prt and assemble it at default...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... Lai Chau fault was left-lateral and Sop Cop Lang Chanh was right-lateral one, producing an extensional field, associating secondary faults The secondary faults played a role of the channel system ... also Paleozoic and Triassic granitoids Along the Dien Bien - Lai Chau fault zone, there are some small basins The Dien Bien - Lai Chau basin, located in the south, is the largest one Within Dien ... The Late Neogene basalt erupted as a chain of olivine, pyroxene basalt stretching along the axis of the basin The sample taken from drill hole shows that the mineral composition of basalt mainly...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... of a molecule of b-alanine with a molecule of pantoate in an ATP-dependent manner to form pantothenate [1,2] Pantothenate itself is an important cofactor that is essential for CoA biosynthesis, ... in A thaliana PS, is also unaffected by substrate binding His106 is involved in intersubunit interactions via its side chain, and is in a similar position to Glu132 in A thaliana PS Val111 and ... negative cooperativity for b-alanine when pantoate was present at a high concentration To date, no information is available on the structural basis for this inhibition of this enzyme It is also hypothesized...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... under a linear gradient of NaCl from to m gave a pure tRNAArg transcript, which was precipitated by addition of ethanol Aminoacylation reaction The aminoacylation reaction of tRNA was measured at ... Arg-NHOH is formed and AMP is released The fact that ArgAMP reacts with NH2OH rather than with tRNA shows that, in the ATP–PPi exchange reaction, tRNA stays preferentially in the position suitable ... to activate The fact that kcat and Km for tRNAArg in the aminoacylation reaction not change in the Asn106 fi Ala, Gln111 fi Ala and Phe109 fi Ala mutants of S cerevisiae ArgRS [14] indicates that...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability ... progressing disease Articular cartilage is an avascular tissue that functions at an oxygen tension lower than that of most other tissues Articular cartilage derives both its nutrition and oxygen ... is mediated by a cascade of aspartatespecific cysteine proteases or caspases, and increased caspase expression has been correlated with reduced cell density in human osteoarthritic cartilage [32]...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... 5¢-GGAATTCCATATGGATATTGTATTTATAGAGCA AC-3¢ (forward primer with a Nde I site) and 5¢-CGGGA TCCTTAATTATTTTCTTTCAGATTATTGCC-3¢ (reverse primer with a BamHI site) The expression constructs were transformed ... elucidating the catalytic mechanism of DHNA and developing antimicrobial agents specifically against Gram-positive or Gram-negative bacteria Results NMR analysis Although it is reasonable that the ... are shown in Fig for the SaDHNAcatalyzed reaction The results of the quench-flow analysis are summarized in Fig For SaDHNA, the epimerase activity is insignificant in comparison with its aldolase...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... proton dissociation constant is a thermodynamic parameter, a change in temperature can result in alteration of the pH activity curve The pKa at each temperature was determined and plotted against ... human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity J Biol Chem 274, 8470–8483 Slusher BS, Thomas A, Paul M, Schad CA & Ashby ... aminopeptidases that involves an acidic residue acting as a general acid ⁄ general base and a di-nuclear metal center participating in binding the substrate and stabilizing the transition state [2,14,35–37]...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... procedure Characterization of size distribution, trapped volume and ability to maintain a membrane potential Biochim Biophys Acta 812, 55–65 24 Mishra VK, Palgunachari MN, Segrest JP & Anantharamaiah ... light scattering was measured using a Varian Cary spectrofluorimeter with both excitation and emission monochromators set at 400 nm [24] Data were acquired using excitation and emission slits at 2.5 ... procedures Analysis of the fungicidal effect of viscotoxin A3 Biological materials Fusarium solani f sp eumartii, isolate 3122 (EEA-INTA, Balcarce, Argentina), was grown at 25 °C on potato dextrose agar...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... 5¢-GGAUCAAAGAGAACACUGGGGUAUA-AG-3¢; and #1513 sense, 5¢-AGUUCACGUGCAAGAACAAG UUCUG-AG-3¢ The forward sequence of the scrambled RNA was 5¢-GAUCCAAGUAAUACAGAGAUGGGAG AG-3¢ OVISE cells were plated ... the activity assay The main fraction contained a 75 kDa matriptase as a major component and a few contaminating proteins as analyzed by SDS ⁄ PAGE RNAi experiments with OVISE cells Matriptase ... immunoblotting with the antimatriptase antibody M32 The bar indicates a gelatinolytic band at approximately 80 kDa in lane and a matriptase band at almost the same position in lane Other experimental conditions...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... 5¢-CAGTTGACAATAAGTACAGCG-3¢ (for A7 2L ⁄ F73L); 5¢-CTTTAGGTCGACTCAAATTTTCAGTTGACAATAA GTACAGCG-3¢ (for A7 2L ⁄ F73L ⁄ W78L); 5¢-CCGGCCAG TGTTCATCGATAAATAC-3¢ (for F223H); 5¢-CTTTAGG TCGACTCAAATTTTCAGTTGACAATAAGTACAGCG-3¢ ... Biophys Acta 1625, 291–295 Asawatreratanakul K, Zhang Y-W, Wititsuwannakul D, Wititsuwannakul R, Takahashi S, Rattanapittayapron A & Koyama T (2003) Molecular cloning, expression and characterization ... of radioactivity was analysed with a Fuji BAS 1000 Mac Bioimage Analyzer 11 Acknowledgements We are grateful to Dr A Nakano and Dr M Sato (RIKEN, Japan) for kindly providing the yeast strain...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... cotransformed with pFAB4 and pAN222 (approx 4–8 copies facB) yA2, pabaA1, pdhA1 yA2, pabaA1; pdhB4 yA2, pabaA1; pdhC1 biA1; veA1 yA2, pabaA1; wA3; veA1 pyrG89; DargB::trpCDB; pyroA4; veA1 DmcsA::argB, ... medium Acetate concentrations were determined with citrate synthase and malate dehydrogenase [17] Acetate was activated by an acetyl-CoA synthetase (ACS) from Saccharomyces cerevisiae (Roche) and ... the acetate utilization genes in the Fab4-J3 strain seemed to be suitable to measure mainly the acetate and propionate activating activity of acetyl-CoA synthetase In comparison SMB/ acuA carries...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... GGTGCTgAGCTCAAGTGTGACTTtcGTCTAC SacI CCGGTGGTcGAcTTTGGTTtcACGCCC SalI ACGTACTGCTgTCCGGAAAGtACtCCATGGCCGC ScaI TCCAATCCGTtAGTCTGgCCaTAGAACGCGC MscI GGAGAATGGTgCCAGGGTACATTTcCAATCCGTCA KpnI AATACATCTTaAGGCCGTCGTtGTCGGTGTGG ... pKa 5.9, and that the adjacent Glu180 is negatively charged, raising the pKa of the general acid catalyst [23] It is likely that catalytic residues of IPU adopt a similar catalytic mechanism to ... likely that A niger has a mechanism similar to such amylase synthesis, and IPU may collaborate to produce isomaltose from panose and other branched oligosaccharides with some transglycosidases Since...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... substrate hydrogen exchange reactions catalyzed by 1-methionine-c-lyase Biochenistry 24, 3857–3862 Kainosho, M., Ajisaka, K., Kamisaku, M & Murai, A (1975) Conformational analysis of amino acids and ... exist as a conjugate acid, bearing a positive charge and containing two deuteriums and one hydrogen at the nitrogen atom If rotation around the C–Nbond is not restricted, the statistical factor ... binding is the same for a variety of amino acids It has been established [5] that for a number of amino acid inhibitors bearing nonbranched substituents without functional groups, the hydrophobicity...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... produce a value of 0.20 at neutral pH and 0.25 at basic pH, whereas, Cpd III gives 0.52 at neutral pH In no case is it possible to quantitate accurately Cpd III, as a residual amount of Cpd II is always ... Four unanswered questions Reversibility of Cpd I formation and catalase activity Catalase activity in peroxidases is strictly related with the reversibility of Cpd I formation Although this reaction ... bi-electronically H2O2 fi O2 MPO and LPO share so many structural and functional features that one would expect LPO to display catalase activity as well Nevertheless, a final word on this item has not...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... broblasts treated with the MSSAE monomeric derivative of BS-RNase Cells were treated with 50 lgặmL)1 MSSAE for 75 at 37 C and xed without permeabilization (A) or after a high-salt washing and ... repeats Nature 366, 751756 Papageorgiou, A. , Shapiro, R & Acharya, K (1997) Molecular recognition of human angiogenin by placental ribonuclease inhibitor an X-ray crystallographic study at 20 A resolution ... centrifugation for 20 at 16 000 g, treated with mM dithiothreitol in NaCl/Pi Labelled proteins extracted from plasma membranes and membrane pellets were then analyzed by SDS/PAGE and autoradiography Figure...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... include stationary (nonoscillatory) and oscillatory states In addition, the peroxidaseoxidase system is known to display bistability, that is, two different coexisting dynamic states are simultaneously ... similar initial conditions the reaction may converge on either one of the two stable dynamic regimes Examples are (a) two coexisting steady states [26] and (b) a steady state coexisting with periodic ... bistable domain are approached, the reaction may settle on either one of the two coexisting stable dynamic states Experimentally this means that for exactly the same experimental parameters and...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... performed again Agmatine was added to agmatinase using the same superposition matrix calculated for manganese ions, in order to conserve the ligand-manganese distances RESULTS AND DISCUSSION By site-directed ... B caldovelox arginase (PDB id: 1CEV) as a template and the modelling package WHAT IF [21] An amino-acid sequence identity of 29% was calculated for E coli agmatinase and B caldovelox arginase ... substrate specificity between arginase and agmatinase This aspect is presently under investigation in our laboratory In any case, despite the structural differences between agmatinase and arginase,...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25