a divergent subgroup of the hsp70 family hsp105ais expressed constitutively and induced by various forms of stress
Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
... recombinant allergen after affinity purification using the mAb IG12 [18]. The natural allergen Phl p 1 was also foundto be capable of degrading a synthetic substrate at a papain-cleavage site after ... degradation of the full-length allergen and accumulation of a truncated 15-kDa fragment at about pH 4.5 (Fig. 3A) . This sharpband lacked the N-terminal peptide, as the N-glycosylatedAsn residue ... are one of the earliest lineages of eukaryotic cells, and the Giardia proteaseis the earliest known branch of the cathepsin B family [23].Its phylogeny confirms that the cathepsin B lineage evolvedin...
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Báo cáo khoa học: A structural overview of the PDI family of proteins docx
... reveals interac-tion between ERp57 and the tip of the calreticulinP-domain. Proc Natl Acad Sci USA 99, 1954–1959.53 Satoh M, Shimada A, Keino H, Kashiwai A, Nagai N,Saga S & Hosokawa M ... oxidoreductase activity. The b and b¢domains, although structurally similar to thioredoxin,do not contain catalytically active cysteines. Instead, the b and b¢ domains appear to act as spacers, and areoften ... significant differences in orientation of their a and a domains. The catalytic cysteines (orange) of the 4 °C yeast PDIstructure face each other. (B) The b and b¢ domains (gray) of human PDI are...
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Báo cáo khoa học: Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family pptx
... residue of Ubi-L and the lysine of Bcl-G. The 33.5 kDa Ubi-L adduct wasdigested by V8 protease and subjected to MALDI-MS analysis. The data in the first column are the mass values obtained experimentally,whereas ... 2 and 4contain an aliquot from the hydroxylapatite purification step; lanes 1 and 2, silver-stained; lanes 3 and 4, immunostained with anti-(Ubi-L).Mobilities of the 33.5 kDa Ubi-L adduct and ... third column are those calculated from the V8 protease fragmentation of the gene products of Bcl-G and Ubi-L. The fourth column indicates the number of the first and last amino acid of the identified...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
... shrimpLitopenaeus vannameiKSLILCVLLAGAFA APSRKPTFRRGLNK CAA60129 2,10KSLVLCLLLAGAFA APSRKPTFRRGLNK CAA75310KSLVLCLLLAGAFA APSRKPTFRRGLNK CAA75311Signal crayfishPacifastacus leniusculusMKTLVFCLLLVGALA ... ForwardAll PaTrys Rv 5¢-AGTGACCAGCACAGATAGC-3¢ 220–238 ReversePaTry4 Rv 5¢-GTGGATCCAGTGTTCGTCAT-3¢ ReverseAll PaTrys Fw 5¢-CCGTGCCCATCGTGTCTGA-3¢ 551–569 ForwardEF1 -a Fw 5¢-CCAGTAGACAAACCACTTCG-3¢ ... partial trypsincDNA sequences.Obtaining 5¢ and 3¢ ends by Rapid Amplification of cDNA Ends (RACE)Using total RNA as the template, the 5¢ and 3¢ ends of trypsin mRNAs were amplified using 5¢ and...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... pKT25kan .The DNA fragments encoding tentative middle domain and C-terminal one of human GRP94 were amplified by PCRandtheninsertedinanXbaI/BamHI site of bothpUT18Camp and pKT25kan. The DNA fragment ... Oral and Maxillofacial Surgery and 2Division of Oral Molecular Biology, Department of Developmental and Reconstructive Medicine, Course of Medical and Dental Sciences, Nagasaki University GraduateSchool ... binding activity. The binding activity of the C-terminal domain (100%) or its mutated forms toward the middle-C-terminal domains was quantified as the b-galactosidase activity of the bacterial two-hybrid...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... reductaseSREBP-2NADPHPyruvateAcetyl-CoACitrateacetyl-CoAOxaloacetateOxaloacetateACLACCHMG-CoAHMG-CoA synthaseCitrateMalonyl-CoAPalmitateMalateMitochondriaFASACCSCDFatty acid ... T, Ishikawa M,Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N,Nakakuki M, Hasty AH et al. (2008) Palmitate impairs and eicosapentaenoate restores insulin secretion throughregulation of SREBP-1c ... Yahagi N, Yamamoto T, Ishikawa M,Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y,Kobayashi K, Takahashi A et al. (2008) Cyclin-depen-dent kinase inhibitor, p21WAF1 ⁄ CIP1, is involved inadipocyte...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... novelC-terminal actin-binding domainThirumaran Thanabalu1,2, Rajamuthiah Rajmohan2, Lei Meng2, Gang Ren4,5, Parimala R. Vajjhala4 and Alan L. Munn1,3,4,6*1 Institute of Molecular and Cell ... and growth atelevated temperature, on the one hand, and in corticalactin-patch polarization, on the other hand, are at leastpartially distinct [23]. However, there may still be a functional ... in Table 2. The rabbit polyclonal GFP-spe-cific antiserum was a gift from J. Kahana and P. Silver(Dana Farber Cancer Center, Boston, MA). The anti-actinmAb was MAB1501 from Chemicon International...
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Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
... of the Gq class Ga subunits, namely Gaq and Ga16have a fast rate of degradation. The results impli-cate a prominent role for the proteasome pathway indown regulation and basal turnover of ... representative autoradio-graphies of whole SDS ⁄ PAGE gels loadedwith the 35S immunoprecipitates and the arrowheads indicate the position of Gaq and Ga16. The molecular mass standards areindicated. ... Johansson et al. Proteasome degradation of GqproteinsProteasome involvement in the degradation of the Gq family of Ga subunitsBente B. Johansson, Laura Minsaas and Anna M. AragayDepartment...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... 5¢-ATGAGCTCTGCTTTCCTTCCGGGGA-3¢S1 5¢-ATTGAGCTCACCAGGAGGGCAGGAGG-3¢mEts-R* 5¢-GACACCTGTCGGTAACCCTTAAAGCC-3¢mGATA* 5¢-CGGAGTCGCCTAAGGAGAGATGGAGA-3¢mE-box* 5¢-AGGGTTCCCGATCGGTGTCTGAGAGA-3¢mEts-F* ... 5¢-GTGGTACCAGTAGCAGCCGCCGCAAG-3¢K3 5¢-ATGGTACCGGGCTTTAAGGGTTCCCG-3¢K2 5¢-ATGGTACCGGAAGGAAAGCAGAGCCC-3¢K1 5¢-ATGGTACCTGGTGATCCAGGGCTTGC-3¢Sac 5¢-CCGTTCCGAGCTCCGAGCAC-3¢S3 5¢-ATGAGCTCGGGAACCCTTAAAGCCCG-3¢S2 ... Ltd.(Toyama, Japan). The library was prepared by the cleavage of the cap structures of mRNA with Tobacco acidpyrophosphatase followed by ligation with a syntheticoligoribonucleotide (5¢-GUUGCGUUACAAGGUACGCCACAGCGUAUGAUGCGUAA-3¢)...
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Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity pdf
... Theseinvestigations were supported by the Natural Sciences and EngineeringResearch Council of Canada, the Alberta Heritage Foundation forMedical Research, CanBiocin Ltd (Edmonton, AB), and the CanadaResearch ... structural basis of the inhibition of the antimicrobial activity of CbnB2 by the leader and to assist future analysis of the interaction of preCbnB2 with its ABC transporter protease, it isessential ... N-terminus and C-terminus are indicated, as are the residues at the start and finish of each a- helix. The position of the double glycine motif where cleavage occurs during maturation of the bacteriocin...
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Báo cáo khoa học: Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops docx
... vice versa within the OPA family, the AAT family, the ST3 families and the DAACS1 family. In case of the AAT and DAACS1families, the percentage observed hits and the distribu-tion are as observed ... C-terminalhalves of the OPA, AAT, and DAACS families and the N- and C-ter-minal halves of ST3 (open bars), between the N-terminal halves of ST3 and the C-terminal halves of ST3 (grey bars), and ... N- and C-terminal halves of all the sequences in ST3 and involves blast searches of each sequence in the database against the wholedatabase. Unrelated families of secondary transporters of the...
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Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
... such as dynamin and the antiviral protein, Mx. Because of similarities in the molecular architecture of GBPs and members of the dynamin family, GBPs are classified as a part of the dynamin superfamily. ... Kurosaki M, Kanazawa N,Tanabe Y, Koyama T, Takeda Y, Nakagawa M, Kaki-numa S, Sekine Y et al. (2006) Expressional screening of interferon-stimulated genes for antiviral activityagainst hepatitis ... superfamily: conserved structure and molecularmechanism. Nature 349, 117–127.3 Herrmann C, Martin GA and Wittinghofer A (1995)Quantitative analysis of the complex between p21ras and the Ras-binding...
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Family Life, Reproductive Health, and Population Education: Key Elements of a Health-Promoting School docx
... Health Team and Community Advisory Committee are established, members can start the planningprocess by conducting a situation analysis. It is important to make the analysis manageable and practical ... up-to-date data canhelp ensure that efforts focus on the health and developmental needs of the targetpopulation. Concerns and perceptions vary by age and gender and by demographic and socio-economic ... inadequate and limited services and programmes for males or females, and then take a leadin developing and carrying out actions that address these issues.Case StudyIn 11 African countries, approximately...
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Protecting Children''''s Health In A Changing Environment - Report Of The Fifth Ministerial Conference On Environment And Health.pdf potx
... championed the cause of the environment and health at a time when it was not fashionable, the challenges and responses in this area are now at the centre of the global health agenda. Nevertheless, ... copied in Kazakhstan.• A campaign by students in Austria raised awareness of poor public transport alternatives to the private car, and increased by 50% the number of pupils and teachers who ... RepublicDenmarkEstoniaFinlandFranceGeorgiaGermanyGreeceHungaryIcelandIrelandIsraelItalyKazakhstanKyrgyzstanLatviaLithuaniaLuxembourgMaltaMonacoMontenegroNetherlandsNorwayPolandPortugalRepublic of MoldovaRomaniaRussian FederationSan MarinoSerbiaSlovakiaSloveniaSpainSwedenSwitzerlandTajikistan The former Yugoslav Republic of MacedoniaTurkeyTurkmenistanUkraineUnited...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
... further substantiated by computational interactome data that predict theirinteraction [63]. Interestingly, the observation thatYap4 and Yap6 are induced by a variety of unrelated forms of environmental ... responses are at play [1]. Specific forms of stress such as heat shock and some forms of oxidative stress [2] demand the activation of the heat shock factor(HSF), a modular protein consisting of a helix–turn–helix ... in the thioredoxin and gluta-thione systems, and other antioxidants such as catalase and superoxide dismutase, among others. Yap1 istherefore central to the adaptive response to oxidative stress, ...
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- anatomy and physiology coloring workbook protection of the cns
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- uniform customs and practice for documentary credits of the international chamber of commerce publication 500
- the protection of the marine environment from landbased pollution and activities
- anatomy and physiology coloring workbook protection of the cns answers
- uniform customs and practice for documentary credits of the international chamber of commerce publication 600
- which of the following statements is true glaciers and ice caps are made of saltwater
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25