8— hepatic metabolism of cholesterol bile salts and phospholipids

The syntheses of bis guanidium salts and their applications in asymmetric mukaiyama type SN2 alkylation reactions

Ngày tải lên : 30/09/2015, 10:12

... of Various Bis-Guanidium Salts Chapter The Syntheses of Various Bis-Guanidium Salts Chapt r 1: The Syntheses of Various Bis-Guanidium Salts 11 Chapter The Syntheses of Various Bis-Guanidium Salts ... Bis-Guanidium Salts Since the basic fragments of bis-guanidium salts are the same as those of pentanidium salts, the synthetic procedure is modified from that of pentanidium salts Standard procedure ... Bis-Guanidium Salts Synthesized from Standard Procedure and Its Modified Versions Table 2.1 Order of Lipophilicities of Anions Table 2.2 First Round of Catalyst Screening Results of the Model...

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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"

Ngày tải lên : 25/10/2012, 11:04

... high -cholesterol fed rats Clin Chim Acta 2003; 327: 129-137 Bok SH, Lee SH, Park YB, et al Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl- CoA reductase and ... double-blinded, randomized, placebo-controlled protocol to compare the effects of p-synephrine alone and in combination with different amounts of hesperidin and naringin on: (1) resting metabolism, ... improve insulin sensitivity and glucose tolerance [9], prevent accumulation of triglycerides [9], inhibit cholesterol biosynthesis [10, 11], and serve as antioxidants and anti-inflammatory agents...

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Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx

Ngày tải lên : 18/02/2014, 17:20

... between C20 and C22 [1,14] Another difference between the metabolism of vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs for the metabolism of vitamin D3, ... chain of vitamin D3 Hydroxylation of the side chain of cholesterol at the adjacent carbons C22 and C20, to produce 20a,22R-dihydroxycholesterol as an intermediate, is a prerequisite for cleavage of ... this product (Fig 8A) Metabolism of vitamin D3 by cytochrome P450scc Comparing the major pathways of vitamin D3 and cholesterol metabolism by P450scc, the initial hydroxylation of vitamin D3 at C20...

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Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx

Ngày tải lên : 20/02/2014, 11:20

... determine the effect of chelators on uptake, intracellular distribution and mobilization of NTBI; (c) to assess and compare the activity and toxicity of novel tetradentate and hexadentate pyridinones ... Animal Experimentation Ethics Committee of the University of Western Australia and is in accordance with the Australian Code of Practice for the care and use of animals for scientiﬁc purposes as ... Effect of chelators on uptake of NTBI The effects of the chelators on NTBI uptake by hepatocytes and Q7 hepatoma cells were marked and similar All chelators decreased uptake to 20% or less of the...

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Báo cáo khoa học: Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes pdf

Ngày tải lên : 07/03/2014, 00:20

... polyacrylamide gel in denaturing and reducing conditions, and by western blotting (A) Coomassie-stained bands of isolated Hpt (lane 1), standard ApoE (lane 2), standard ApoA-I (lane 3), and partially puriﬁed ... HRP-conjugated avidin and ECL Coomassiestained bands of VLDL and LDL proteins are shown in lanes and 2, respectively VLDL and LDL proteins, blotted onto the PVDF membrane and incubated with biotinylated ... worsens the onset and the rate of progression of atherosclerosis We evaluated the negative effects of Hpt on LCAT activity and cholesterol uptake by hepatocytes by using molar ratios of Hpt with ApoE...

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Báo cáo khoa học: Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells Soumen Bera1, Theo Wallimann2, Subhankar Ray1 and Manju Ray1 potx

Ngày tải lên : 07/03/2014, 04:20

... 2.5 Estimation of ornithine and GAA The considerable and signiﬁcant activities of AGAT and arginase II in the three types of tumor cells prompted us to measure the level of GAA and ornithine in ... creatine metabolism On the other hand, a high expression of GAMT had been found in the liver and pancreas and other tissues, such as the testes, epididymis and ovary, whereas the expression of both ... prominent up-regulation of the expression and enzymatic activity of both AGAT and GAMT The speciﬁc activity of AGAT in sarcoma tissue reached almost 50% of that observed in the kidney and it was also...

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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulﬁde reductase from Pyrococcus horikoshii Implications for the disulﬁde metabolism of anaerobic hyperthermophiles doc

Ngày tải lên : 07/03/2014, 17:20

... Thermostability and thermoactivity of the CoADR phCoADR is stable for months at both )80 °C and )20 °C, and has half-lives of > 100 and 39 h at 85° and 95 °C, respectively Figure shows the dependence of the ... Addition of a second equivalent of NADPH to the EH2 form of phCoADR results in an increase in absorbance in the regions between 507 and 700 nm and 400 and 500 nm There is also an increase and FEBS ... above Thiols were quantiﬁed by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the CoA and dephospho CoA peaks, as described previously...

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Báo cáo khoa học: Uptake and metabolism of [3H]anandamide by rabbit platelets Lack of transporter? ppt

Ngày tải lên : 08/03/2014, 08:20

... rapid uptake of [3H]anandamide by Ó FEBS 2003 Uptake and metabolism of anandamide by rabbit platelets (Eur J Biochem 270) 3501 Fig Effect of caffeic acid and indomethacin on [3H]anandamide metabolism ... between 100 and 2000 nM was used and the incubation took place at 37 °C The concentration of phenylmethylsulfonyl fluoride used was mM and the preincubation time was 15 Metabolism of [3H] anandamide ... involvement of FAAH on [3H]anandamide uptake and metabolism by rabbit platelets, the effect of phenylmethylsulfonyl fluoride on [3H]anandamide uptake was determined (Fig 5) Preincubation of the platelet...

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The Effects of Inorganic Salts and Precipitated Calcium Carbonate Filler on the Hydrolysis Kinetics of Alkylketene Dimer docx

Ngày tải lên : 09/03/2014, 01:20

... Master of Science and Doctor of Philosophy NOTICE on Colleges degrees of the Southern Association of AND DISCLAIMER The Institute of Paper Science and Technology (IPST) has provided a high standard ... stretchingband of unhydrolyzed AKD and thus can indicatethe active-AKD presentin the mixture The p peak at 1468 cm-’ indicatesthe -CH2- bendingbandof both hydrolyzedand unhydrolyzedAKD, and the ... hydrolysis of AKD at pH 8.3 A, 22 “C, and B, 50 OC 0 Time (h) Figure The pH effect on the hydrolysis of AKD at 50°C 80 60 Time (h) Fig The effect of inorganic salts on the hydrolysis of AKD at 50°C and...

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Báo cáo khoa học: Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate pdf

Ngày tải lên : 22/03/2014, 16:20

... In order to gain insight into the P450 metabolism mechanism of N-Me-cyclo-peptides, the metabolism of a set of molecules composed of TTX (8a), iso-TTX (8b) and dihydrotentoxin (9) was studied in ... retention time and MS cleavage of Ala1-TTX; and (c) the relative amounts of M1 and M2 were different depending on the acidity of the HPLC eluent or on the time elapsed between incubation and analysis ... and characterization of stable carbinol-amide L Perrin et al Table Amounts of metabolites M1 and M2 recovered after 10 incubations of 100 lM tentoxin using lM of rat microsomal preparations and...

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Báo cáo khoa học: Substrate speciﬁcity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase pot

Ngày tải lên : 23/03/2014, 05:22

... Time course of excision of 8-oxoGua (d), FapyGua (s) and FapyAde ( ) by OGG1 (B) Time course of excision of 8-oxoGua (d), FapyGua (s) and FapyAde ( ) by Fpg Means and standard deviations of three ... values of kinetic constants for excision of FapyGua and 8-oxoGua by various forms of OGG1 are 500 400 300 200 100 0 10 15 20 Time (min) Fig Excision of 8-oxoGua and FapyGua by wild-type OGG1 and ... values of kcat and Km for FapyGua excision were Table Km, kcat and ksp values for excision of FapyGua and 8-oxoGua from c-irradiated calf thymus DNA by wild-type and mutant OGG1 proteins Mean ± standard...

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Báo cáo khoa học: A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells doc

Ngày tải lên : 30/03/2014, 04:20

... Glucocorticoid and mineralcorticoid metabolism Glutathione metabolism Glycogen metabolism Steroid biosynthesis Synthesis and degradation of ketone bodies Urea cycle and metabolism nof amino groups ... al Transcriptome in hepatic induction of AT-MSCs analyzed using genmapp software version 2.1 and visualized using ConPath Navigator, a tool that enables viewing and searching of results obtained ... level of human hepatocytes was set to 1.0 induced by hepatic differentiation treatment of ATMSCs A number of genes encoding a blood coagulation factor, a complement component and a component of...

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iec 61131-8 programmable controllers - guidelines for the application and implementation of programming languages

Ngày tải lên : 04/04/2014, 13:46

... of hiding of procedures and data, in which the only knowledge that the user has of a software entity is its external interface and specified functionality Details of internal data structure and ... given in B.1.4 and B.1.3.3 of IEC 61131-3 allows the creation of “anonymous subrange data types” and “anonymous enumerated data types” in the declaration of variables and of elements of structured ... Example of declaration and use of “anonymous array types” 3.1.8 Use of bit-string functions The selection and comparison functions in Tables 27 and 28 of IEC 61131-3 are defined to operate on data of...

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A computer system consists of hardware, system programs, and application programs figs 8

Ngày tải lên : 28/04/2014, 16:35

... master-slave multiprocessor model I/O CPU CPU CPU CPU Runs users and shared OS Runs users and shared OS Runs users and shared OS Runs users and shared OS I/O Memory OS Locks Bus Fig 8-9 The SMP multiprocessor ... Sequence of pages of a book Database query Fig 8-31 Six different types of network service Internet Host Router Message Ethernet header IP TCP Ethernet Headers Fig 8-32 Accumulation of packet ... Headers Fig 8-32 Accumulation of packet headers Message Uni versi of North South ty School of Humanities School of Sciences School of Social Sciences Science Northern University Social sciences...

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Handbook of Reliability, Availability, Maintainability and Safety in Engineering Design - Part 8 doc

Ngày tải lên : 02/07/2014, 10:20

... Reliability of group: R = − Unreliability = − 0.015 = 0.985 With the individual component reliabilities of only 0.9 (i.e ten failures out of 100 events), and of 0.85 (i.e 15 failures out of 100 events), ... some of the critical assemblies and components Consider the overall reliability of these sub- 3.2 Theoretical Overview of Reliability and Performance in Engineering Design 57 Reliability of N ... Probability of failure × Consequence of failure This probability and consequence of systems failure is related to process reliability and criticality at the higher systems levels (i.e process and system...

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Handbook of mathematics for engineers and scienteists part 8 pps

Ngày tải lên : 02/07/2014, 13:20

... multiplication, and division) and the operation of composition (composite functions) The graphs and the main properties of the basic as well as some other frequently occurring elementary functions of the ... any power of x as x → +∞, and it decays faster than any power of 1/x as x → –∞ The graphs of the functions y = 2x and y = (1/2)x are given in Fig 2.3 y y=2 x x y=2 x O Figure 2.3 Graphs of the exponential ... modulus of the logarithmic function tends to inﬁnity slower than any power of x as x → +∞; and it tends to zero slower than any power of 1/x as x → +0 The graphs of the functions y = log2 x and y...

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A textbook of Computer Based Numerical and Statiscal Techniques part 8 doc

Ngày tải lên : 04/07/2014, 15:20

... loge – 12 and 2.6137 Therefore, f(3) and f(4) are of opposite signs Therefore, a real root lies between and For the approximation to the root, taking x0 = 3, x1 = 4, f(x0) = – 4.0986 and f(x1) ... digits using of Falsi Position Sol Let Since and f(x) = tan x + tan h x = f(2.35) = – 0.03 f(2.37) = 0.009 Hence the root lies between 2.35 and 2.37 Let x0 = 2.35 and x1 = 2.37 Using method of Falsi ... root of the equations: (a) x = tan x (b) x2 – loge x – 12 = (c) 3x = cos x + Find the rate of convergence of Regula-Falsi method Find real cube root of 18 by Regula-Falsi method Discuss method of...

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ARNOLD, K. (1999). Design of Gas-Handling Systems and Facilities (2nd ed.) Episode 1 Part 8 doc

Ngày tải lên : 06/08/2014, 02:20

... systems range to 0.65 mole of acid gas per mole of DEA compared to a maximum of 0.4 mole of acid gas per mole of MEA The result of this is that the circulation rate of a DEA solution is slightly ... slurry of rich solution comes off the bottom of the absorber and flows to an atmospheric oxidizer tank where it is regenerated A dense slurry is pumped off the base of the oxidizer to the melter and ... considered: The type of acid contaminants present in the gas stream The concentrations of each contaminant and degree of removal desired The volume of gas to be treated and temperature and pressure at...

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ARNOLD, K. (1999). Design of Gas-Handling Systems and Facilities (2nd ed.) Episode 2 Part 8 docx

Ngày tải lên : 06/08/2014, 02:20

... Design of GAS-HANDLING Systems and Facilities Table 15-2 (Continued) Example Specifications of Pipe, Valves, and Fittings Couplings -in and smaller J4-in Plugs !44n, and smaller 2-in and larger ... with this in mind and, as a minimum, should cover the following: • Opening of equipment or piping, • Lockout and tagout of electrical and mechanical energy sources, « Hot work and other work involving ... response and control measures Assurance of Quality and Mechanical Integrity of Critical Equipment Procedures for assurance of quality in the design, fabrication, installation, maintenance, testing and...

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Báo cáo khoa học: " Degrading of seed quality following 8 months in storage of the rice, maize and soybean basic grade seed" docx

Ngày tải lên : 06/08/2014, 19:20

... rice and maize of the germination rate factor Quality standard of crop seed of the Vietnam (TCVN-1766:2004) (MARD, 2005), germination percentage of basic rice seed must be not less than 80 % and ... Longevity and Deterioration, Plant Sciences 330 Ministry of Agriculture and Rural Development (MARD) (2005) Quality standard of Degrading of seed quality following months in storage of the rice, ... for rice and 17.37% for maize seeds at the eighth month The quality standard of crop seed in Vietnam (TCVN-1766:2004), for basic rice seed is not over 13.5% and the quality standard of crop seed...

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