... neutrophils were washed in phosphate-buffered saline (PBS) and resuspended with 100 µl PBS containing 0.1% NaN3, 10% human AB serum (to prevent nonspecific binding of mAb to Fc receptors) and predetermined ... increased membrane expression of CD69 [ 37] , and this observation was confirmed in the present study This activation molecule is not constitutively expressed on neutrophils but it may be induced on ... manuscript FM conducted the neutrophil functional assays PB conducted the immunofluorescence assays PS -P participated in study design and coordination, and helped to select patients FA helped with...
... unless otherwise stated Comparisons of continuous variables between subjects with exacerbations versus without exacerbations were performed using t tests, and discrete variables were compared using ... Figure (open bars) and without acute exacerbations (gray bars) Changes 2in the SGRQ scores over months in subjects with Changes in the SGRQ scores over months in subjects with (open bars) and without ... scores on the SGRQ than subjects without exacerbations (Table 1) Seventy-nine subjects were on ICS, and acute exacerbations occurred in 26 < /b> of these subjects (32.9%) On the other hand, 77 subjects...
... unless otherwise stated Comparisons of continuous variables between subjects with exacerbations versus without exacerbations were performed using t tests, and discrete variables were compared using ... Figure (open bars) and without acute exacerbations (gray bars) Changes 2in the SGRQ scores over months in subjects with Changes in the SGRQ scores over months in subjects with (open bars) and without ... scores on the SGRQ than subjects without exacerbations (Table 1) Seventy-nine subjects were on ICS, and acute exacerbations occurred in 26 < /b> of these subjects (32.9%) On the other hand, 77 subjects...
... numbers ofpatients Page of (page number not for citation purposes) Conclusions Based on available data, CYC treatment inpatientswith SScrelated ILD does not appear to result in clinically significant ... subtype of fibrosis) - Usual interstitial pneumonia (this is a suntype of fibrosis) Fibrosing alveolitis tion guidelines [8] The present article has been prepared in accordance with the QUOROM statement ... benefit of CYC on lung function as measured by pulmonary function tests by conducting a systematic review and meta-analysis of randomized clinical trials and prospective observational studies in patients...
... gender, sources of infection and type of specialties (Table 2) The two groups were not only comparable in their severity of sepsis at the points for interventions of the 6-< /b> hour sepsis bundle, assessed ... severe sepsis was progressing and organ function support was required (for example vasopressors, mechanical ventilation), patients were reassessed for the appropriateness of critical care admission ... sepsis bundles, modified from the SSC standard sepsis resuscitation bundle and sepsis management bundle, in our local hospitals There has so far been no information about compliance of sepsis...
... phosphodiesterase inhibition suppressed TNFα production in mononuclear cells [ 16,< /b> 17] These facts together are consistent with the possibility of a phosphodiesterase-specific effect, perhaps via inflammatory ... of to show improvements in apoptotic markers with milrinone infusion Page of (page number not for citation purposes) Journal of Translational Medicine 2009, 7 : 67 0 .6 < /b> 7URSRQLQ , QJ PO http://www.translational-medicine.com/content /7/ 1 / 67 ... Journal of Translational Medicine 2009, 7 : 67 http://www.translational-medicine.com/content /7/ 1 / 67 pathways such as inflammation and apoptosis Biomarkers may provide a glimpse into this pathophysiology...
... reductions in depressive symptoms being more robust inpatientswith baseline MADRS total scores ≥20 than in those with baseline CGI-BP-D severity scores of ≥4 or those experiencing a mixed episode ... regardless of baseline CGI-BP-D severity score † Data represent patientswith a CGI-BP-D severity score ≥4 at baseline regardless of baseline MADRS total score Montgomery-Asberg Depression Rating Scale-based ... with baseline CGI-BP-D severity scores ≥4; (C) patientswith a mixed episode at baseline CGI-BP-D = Clinical Global Impression for Bipolar Disorder-Depression; MADRS = Montgomery-Asberg Depression...
... IL -6 < /b> increased only in ICM while IL-1 b decreased only in NIDCM, both changes with respect to controls Previous study results on IL-1 b systemic level changes in heart failure have been inconsistent ... among NYHA III/IV ICM patients, but not among patientswith less severe chronic heart failure This would suggest that decreased levels of this cytokine are associated with disease progression ... Fisher s < /b> exact test Results Plasma cytokine profiles in ICM and NIDCM CHF patients vs controls Multiplex immunoassay screening for cytokine and growth factor protein expression, by means of the...
... IL -6 < /b> increased only in ICM while IL-1 b decreased only in NIDCM, both changes with respect to controls Previous study results on IL-1 b systemic level changes in heart failure have been inconsistent ... among NYHA III/IV ICM patients, but not among patientswith less severe chronic heart failure This would suggest that decreased levels of this cytokine are associated with disease progression ... Fisher s < /b> exact test Results Plasma cytokine profiles in ICM and NIDCM CHF patients vs controls Multiplex immunoassay screening for cytokine and growth factor protein expression, by means of the...
... GmbH JPP, SL, and JMP are co-authors of DMOAD patent applicate of Licofelone with Merckle GmbH Authors' contributions JPP, CB, JB, PR, SL, DL and JMP contributed to the study design JPP, CB, MB, ... MB, JB, FM, CG and JMP performed the acquisition of data JPP, CB, FM, PR, DL and JMP analyzed and interpreted the data JPP, CB, PR, DL and JMP prepared the manuscript JPP, CB, JB and JMP performed ... Huskisson EC, Berry H, Gishen P, Jubb RW, Whitehead J: Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee LINK Study Group Longitudinal investigation of nonsteroidal...
... trials have not been conducted However, a number of studies have supported the use of EBRT in populations with high-risk features for relapse and gross residual disease [5- 16]< /b> These studies have ... acute and chronic toxicities, and none ofpatients who developed locoregional recurrence were subsequently inoperable due to EBRT Discussion The role of EBRT inpatientswith nonanaplastic thyroid ... (22%) patients had a distant metastasis which was controlled with stable disease at pre-EBRT and these patients histologic type was all papillary AJCC Stage at initial diagnosis 10 (44) N 1b I-II...
... cord So, the aim of the present study is to explore the possible prophylactic effectof long-term administration of αTOL in spinal cord reperfusion injury against high oxidative stress induced by ... to sit without assistance; = able to sit but unable to hop; = weak hop; = complete recovery of hind limb function The placing/stepping reflex (SPR) was assessed by dragging the dorsum of the hind ... http://www.jbiomedsci.com/content/ 17/ 1/55 Page of Table 1: Effectof α-Tocopherol treatment in ischemic reperfusion injury model in rats for weeks on Motor function, Sensory response and Placing/Stepping...
... association between smoking and respiratory symptoms and diseases amongst HIV-positive subjects Methods Study design, setting and participants This was a cross-sectional study The study protocol was approved ... history of asthma and spirometry diagnosed asthma are also presented in Figure Respiratory diseases history A history of bronchitis was present in 38 (32%) subjects, pneumonia in 46 < /b> (39%) subjects, ... times the odds of a history of bronchitis compared to non-white subjects (p = 0.019) A history of other respiratory diseases was not associated with smoking status Subject classifications and...
... was identified Chronic respiratory failure was defined by the presence ofchronic obstructive pulmonary disease [7] or chronic restrictive pulmonary disease diagnosed on the basis of history, physical ... MSSA (5) Streptococcus pneumoniae (5) MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus Table Outcomes ofpatientswith (cases) and patients ... The patients included in the present study were also included in our previous prospective observational study of VAT [4], representing 5% of the 2128 patients included in the previous study Patients...
... Five patients (three patientsin the bolus group and two patientsin the infusion group) underwent surgical procedures during the study In two patients (one in the infusion group and one in the bolus ... patientsin the bolus group, and the corresponding value in the infusion group was 12 (50%) After five days, vasopressors were withdrawn in 20 patients (83%) in the bolus group and in 15 patients (63< /b> %) ... easily achieved if hydrocortisone therapy is given to septic shock patients by continuous infusion Key messages • In septic shock, continuous hydrocortisone infusion will reduce the number of...
... characteristics between open and closed model ICUs using student 's < /b> t-test, Wilcoxon rank-sum and chi-square test as appropriate We assessed the independent effectof staffing model on process of care ... Two studies indicate that increased intensivist staffing was associated with increased compliance with a number of evidence-based practices recommended inpatientswith ALI [ 16,< /b> 27] These studies ... obtain information about the structure, organisation, interactions among providers and process of care in KCLIP ICUs The surveys targeted both the nurse manager responsible for each ICU represented...
... example asthma, epilepsy, diabetes) The Children s < /b> Global Assessment Scale (CGAS) is a 100-point rating scale measuring the child s < /b> general level of functioning Scores above 70 indicate normal function ... including a subsample of children with CI The present study improves on previous studies by including a measure of intellectual function from a standardized test (WISC-III) [ 16]< /b> and measures of ... CI-group, and 63< /b> .5% and 36.< /b> 5% in the NCI-group Characteristics of the sample Statistical analyses For statistical analyses we used the SPSS version 15.0 Descriptive statistics were used to explore...
... Mechanisms of vascular dysfunction after subarachnoid hemorrhage J Physiol Pharmacol 20 06,< /b> 57( Suppl 11):145- 160< /b> Stein SC, Levine JM, Nagpal S,< /b> LeRoux PD: Vasospasm as the sole cause of cerebral ischemia: ... hypertension has the most consistent CBF increasing effect, if comparing baseline CBF to follow-up measurements • There is no consensus on how triple-H or its separate component should be applied Abbreviations ... components aim to influence perfusion pressure and blood viscosity in order to increase CBF [28] Whether induction of hypertension is successful in terms of raising blood pressure is easily controlled,...