... substrate C Eigenbrot et al cleavage site of pro-HGF is KQLR-VVNG (49 1 49 8) (P4–P4¢) and that of pro-MSP is SKLR-VVNG (48 7– 48 0) (P4–P4¢), indicating a preference for a P1 Arg The potential roles of ... [4] Other key attributes of the catalytically competent structure are the ‘oxyanion hole’ formed by the amide nitrogens of Ser195 and Gly193, and substrate-binding subsites (S1, S2, S3, and S4), ... domain recognizes misfolded protein and activates a protease Cell 117, 48 3 49 4 14 Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ & Romao MJ (2002) Crystal structure of a prostate kallikrein...
... residues K419–K423 and E425, giving a value of 3.1 34 ± 0 .43 5 for the G–H loop average (K419–I427) For CCP1, a high R2 ⁄ R1 value was observed for C 341 , D 344 , R 349 and A350 (R2 ⁄ R1 > 3 .4) and indicated ... exchange (Rex) was detected for residues E425, E421, G408, K423, T398 and K419 Distinct rapid local motion was indicated by the significant se of G4 24 and G401, for which residues the inclusion of ... the interfaces A–B (E300), D–E (Y325) and C–D (Y381), near the F–G turns of CCP2 (T411, C412, I417 and W418) and near the linker region (G360) For the tandem module, the model-free approach did...
... where Cys 14 makes a link with Cys28 in sheet and Cys43 of b4 connects Cys 54 of b5 in sheet In the same structure for the abcabc pattern, the 14 43 and 28– 54 Cbi–Cbj distances are 44 2 and 525 pm, ... Tyr3HN–Val45O Tyr3O–Val45HN Ala1O–Thr47HN Gly5HN 43 CysO Asp46O–Ala50HN Asp46HN–Ala51O Thr44O–Asp53HN Lys6O–Lys15NH Ala1NH–Tyr45OH Gly5O–Cys40HN Cys7HN–Ala38O Cys14HN–Ile26O Asp18HN–Lys22O Tyr16O–Thr24HN ... class of AFP [ 14] The 3D molecularstructure of PAF consists of five b-strands connected by three small loops involving b-turn motifs (loops 1, and 4) and the large loop (Fig 9) The b-strands create...
... lignin structureand monomeric composition have indeed been found and confirmed between plant species (Logan and Thomas, 1985), between plant organs and tissues grown either in vitro or in vivo and ... experiments by Bolker and Brener (1971) and by Yan et aL (19 84) According to these authors, the weak-bonds suggested by Freudenberg and Neish are mainly a-aryl ether linkintermolecular ages, respectively, ... detail, heterogeneity in lignin formation andmolecular structure, has been demonstrated in the case of gymnosperms (Terashima and Fukushima, 1988) and in the case of angiosperms (Higuchi, 19135;...
... in some low- and middle-income environments, are not present in others The sectoral and demand analyses of sections 4.4and4. 5 should detect the absence of key markets or services, and those analyses ... Claessens and Laeven 20 04and box 4. 2) In turn, ownership patterns are influenced by regulation and policy on entry, exit, and mergers and acquisitions Is the market structure segmented (with ... investors in securities, and the level and volatility of asset returns in the sectors depend on the microstructure and soundness of securities markets 10 11 12 A 4.4 .4 Securities Markets The...
... of and s, and then the average 15N-1H NOE was obtained Additional R1 values (20, 40 , 80, 140 , 240 , 40 0, 800, and 1200 ms with a delay of s) and R2 values (16.8, 33.5, 50.3, 67.0, 100.5, 1 34. 0, ... The total surface area of all these structures is very similar; XPCB–hHR23B, 41 nm2, XPCB–hHR23As from Waters et al and Kamionka and Feigon, 41 and 43 nm2, respectively The diverse hydrophobic ... 2 84 330 All atoms 717 241 33 121 41 89 1 242 70 42 28 A a Summation of energies defined by AMBER B C )3087.9 ± 12.3 15.1 ± 1.6 0.0 ± 0.0 )3103.1 ± 11.7 78.5 20.2 1.3 0.0 0.83 2.00 0.90 2 .43 0 .45 ...
... Ile12 and Thr15 were drastically reduced, and Asp 14 completely disappeared in Ó FEBS 20 04Structureand topology of TM4 of DMT1 (Eur J Biochem 271) 1 947 the presence of 0.2 mM Mn2+ (Figs and 7) ... medium-range NOEs and the Ó FEBS 20 04Structureand topology of TM4 of DMT1 (Eur J Biochem 271) 1 943 Table Structural statistics for DMT1-TM4 in the presence of SDS at pH 6.0 and in TFE SDS TFE ... Biochemistry 40 , 3 141 –3 149 56 Park, S.H., Kim, H.E., Kim, C.M., Yun, H.J., Choi, E.C & Lee, B.J (2002) Role of proline, cysteine and a disulphide bridge in the Ó FEBS 20 04Structureand topology of TM4...
... variants In detail, 14 Cys residues are present in C1R, all of which are involved in disulphide bonds (the Cys pairing being: 3–52, 32–65, 70–123, 100– 141 , 145 –271, 3 14 333 and 344 –3 74, numbered according ... Bioinformatics 23, 2 947 –2 948 Petrey D, Xiang Z, Tang CL, Xie L, Gimpelev M, Mitros T, Soto CS, Goldsmith-Fischman S, Kernytsky A, Schlessinger A et al (2003) Using multiple structure 5656 41 42 43 44 alignments, ... C1R (PDB code: 1GPZ [27]) and of the modelled structures of HPT1 and HPT2 HPT1 residue Cys15 and HPT2 residues Cys15 and Cys 74 are shown in spacefill representation This and the following figures...
... Proteins 41 , 46 047 4 34 Mandel AM, Akke M & Palmer AG III (1995) Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structureand function in an active enzyme J Mol Biol 246 , 144 163 ... the backbone dynamics of a 2035 Structureanddynamics of NSCP in solution 45 46 47 48 49 50 51 folded and unfolded SH3 domain existing in equilibrium in aqueous buffer Biochemistry 34, 868878 Krudy ... three categories, 1.82.9, 2.9 3.7 and 3.75.0 A except for daN(i,i +2) and dNN(i,i +2) distances in regular helical fragments which fall into 4. 24. 6 and4.04.4 A, respectively No restraints involving...
... Mesenchymal stem cells were dissociated from rat bone marrow and were marked by Brdu, and the expression of CD 44 CD 54 and double label of Brdu and CD 44 .The growth of rat mesenchymal stem cell under Seropharmacological ... of Nedd4 and Nedd4-2 mediate binding to SGK and that, despite their high homology, different WW domains of Nedd4 and Nedd4-2 are involved Our data also suggest that WW domains and of Nedd4-2 mediate ... mediated via Nedd4-2 and will decrease if competition between Nedd4 and Nedd4-2 for binding to SGK occurs We show that Nedd4 and Nedd4-2 are located in the same subcellular compartment and that they...
... Resonance assignments for D16W-D 24) 37 GGN4 in 500 mM SDS micelles at pH 4. 0 Table S4 NMR restraints and structural statistics of D 24) 37 GGN4 and D16W-D 24) 37 GGN4 ... of the D16W substitution, the solution structures of D 24) 37 GGN4 and D16W-D 24) 37 GGN4 were investigated by NMR spectroscopy The structure of the native GGN4 in 50% TFE/water consists of two a helices ... TFE/water mixture (A), D16W-D 24) 37 GGN4 in the 50% TFE/water mixture (B), and D16W-D 24) 37 GGN4 in SDS micelles (C), respectively In panel D, the set of D16W-D 24) 37 GGN4 structures in the 50% TFE/...