4 effects produced by the cholinergic nervous system
Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy on oligodendrocytes ... are planned that further reduce the dose of craniospinal radiation to 1,800 cGy, virtually no attention has been paid to the possible contribution of the chemotherapy to the cognitive decline ... support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity associated with very high doses of chemotherapy is...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... photon counting method to study the biophysical features of the plasma membrane It was first introduced in the 1970s by Magde et al [4] and further optimized in the 1990s by Rigler et al [5] This technique ... Subsequently, the z-position of the focal volume was adjusted towards the membrane to be measured by turning the fine knob of the microscope till the maximum brightness was found The maximum brightness ... was from the Bloomington Stock Center and the Baylor gene disruption project directed by H Bellen [80] The UASCeramidase (II) was generously provided by J Acharya and U Acharya [44 ] The flotillin-2...
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Tài liệu TRANSFER CREDIT SERVICES GUIDE: Produced by the Office of the Registrar ppt
... my.berklee.net by clicking on Student Services, then selecting View Transcript from the menu on the left You can then compare your transcript/earned credits to the Grids by Major link (also found in the ... file of the digital course manual or email the link to the school's official website with the PDF of the digital course manual to the Information Projects Coordinator in the Office of the Registrar ... Requirements section above Or contact the Information Projects Coordinator in the Office of the Registrar at transfercredits@berklee.edu, 617 747 8519, or stop by the Office of the Registrar (Uchida building,...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... 100 46 .0 100 41 .5 40 .9 100 43 .3 39.5 45 .4 100 33.6 35.7 37.5 41 .3 100 38.9 41 .0 47 .0 39.0 38.0 100 40 .0 36.7 40 .5 42 .3 39.3 38.7 100 40 .0 37.0 40 .5 42 .7 42 .3 38.7 93.8 100 41 .6 37.6 44 .4 42.3 41 .4 ... higher animals by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals ... domain binds the other copper (CuM, also termed as CuB) with two histidine Ne ligands (His 242 and His 244 ) and a methionine sulfur (Met3 14) [47 ] The two coppers ˚ are 11 A apart and face the interdomain...
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Báo cáo Y học: Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system docx
... (full length) (59– 344 ) ( 84 344 ) (1 14 344 ) (1–313) (1–273) GFP–Tob2 (2 84 344 ) prepared and subjected to SDS/PAGE and then to Western blotting as described above To analyze the stability of BTG1, ... (1– 141 ) GFP–BTG1 (111–171) BTG2 (full length) ( 34 158) (69–158) (1–129) GFP–BTG2 (98–158) Tob (full length) (59– 345 ) ( 84 345 ) (1 14 345 ) (1–315) (1–277) GFP–Tob (285– 345 ) Tob2 (full length) (59– 344 ) ... (285– 345 ) and GFP–Tob2 (2 84 344 ) fusion proteins, respectively (Fig 6A) We then transiently expressed the chimeric proteins, together with intact GFP, in HEK293 cells The stabilities of the respective...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... Journal of Neuroinflammation 2007, 4: 14 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Ransohoff RM, Bacon KB: Chemokine receptor antagonism as a new therapy for multiple sclerosis Expert ... disease Taken together, the results of the present study and from previous ones on the role of CCR1 and its ligand CCL3 in the pathogenesis of MS [39 ,40 ,42 ] and EAE [22 ,44 ,46 ], have provided ... and protein [43 ] The importance of CCR1 in the pathogenesis of EAE is emphasized by the fact that immunoneutralization of CCL3 [44 ], DNA vaccination [45 ], or genomic deletion of the CCR1 gene...
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Section III - Drugs Acting on the Central Nervous System docx
... the substance and the pathway inhibit or excite the target cell) More convincing is the demonstration that the ionic conductances activated by the pathway are the same as those activated by the ... Identifying the location of these receptors in the central nervous system (CNS), the function of pathways that incorporate them, and the behavioral and physiological changes induced by their interaction ... the anesthetic agent in inspired gas, (2) pulmonary ventilation delivering the anesthetic to the lungs, (3) transfer of the gas from the alveoli to the blood flowing through the lungs, and (4) ...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... mice Glia 2005, 49 : 542 -5 54 113 Tofilon PJ, Fike JR: The radioresponse of the central nervous system: a dynamic process Radiat Res 2000, 153:357-370 1 14 Hopewell JW, Withers HR: Late effects of radiation ... delayed neurological side effects have been observed for many other chemotherapeutic agents [9, 14, 23,26,27,29-31,33, 145 -1 54] , and it will be of interest to determine whether the pattern of degenerative ... contribute to the effects of chemotherapy on cognition The ability of irradiation to the CNS to suppress the generation of new neurons in the hippocampus has been suggested to be relevant to the understanding...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... vitro They also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus of the hippocampus and the corpus callosum in mice These ... standard dose systemic chemother apy in long-term survivors of breast cancer and lymphoma J Clin Oncol 2002, 20 :48 5 -49 3 Winocur G, Vardy J, Binns MA, Kerr L, Tannock I: The effects of the anti-cancer ... injury due to cancer treatment The knowledge gained from this and other studies will guide the development of translational clinical research to protect the nervous system from injury, to better...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... macrophages Eur J Immunol 19 94, 24, 1 941 -1 944 16 Reiling, N., Kroncke, R., Ulmer, A.J., Gerdes, J., Flad, H.D and Hauschildt, S Nitric oxide synthase: expression of the endothelial, Ca2+/calmodulin-dependent ... Cossart, P Entry of Listeria monocytogenes into neurons occurrs by cell-to-cell spread: an in vitro study Infect Immun 1998, 66, 44 6 144 68 Greenberg, S.S., Ouyang, J., Zhao, X and Giles, T.D Human ... from tissue, although the tissue was positive by immunohistochemistry [7] Two caprine brains were used as controls The control animals had no inflammation in the brain by histological examination...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... wrote the initial draft WY drew the pictures WZ revised the draft SL described the MRI features GL provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version ... central nervous system vasculitis: analysis of 101 patients Ann Neurol 2007, 62 :44 2 -45 1 MacLaren K, Gillespie J, Shrestha S, Neary D, Ballardie FW: Primary angiitis of the central nervous system: ... angiitis of the central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43 :599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... Begley DJ: Delivery of therapeutic agents to the central nervous system: The problems and the possibilities Pharmacology & Therapeutics 20 04, 1 04: 29 -45 29 Vinson SB: The role of the foreign surface ... known that the nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach ... and the roach’s nervous system In vivo studies showed that the nAuNPs were adapted by the roach and transferred inside the nerve cord within 17 days After that the nAuNPs were encapsulated by the...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... 43 2.13 DNA binding activity assay 43 2. 14 Cathepsin S activity assay 44 2.15 S-sulfhydration assay (modified biotin switch) 44 2.16 Glutamate uptake assay 45 ... and McGeer, 2007) Cholinergic hypothesis of AD 24 The cholinergic hypothesis of AD suggests that altered cholinergic pathway in the forebrain results into a reduction of cholinergic neurons, ... years (%) individuals) 20 14 (%) Western 5 .4 8.8 Europe 17 4. 9 102 Eastern Europe (regions with 3.8 7.7 169 3.9 8.1 1.8 84 6 .4 10.5 3 .4 172 4. 6 9.2 1.8 393 3.6 7.6 385 4. 3 1.5 189 336 low adult...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... Gliomas 77 4. 1 Introduction 78 VII 4. 2 Materials and Methods 83 4. 2.1 Cell lines and culture 83 4. 2.2 Baculovirus vectors 83 4. 2.3 Baculovirus transduction 85 4. 2 .4 Luciferase activity assay 85 4. 2.5 ... by combination of and sodium butyrate therapy 96 4. 4 Discussion 115 Chapter Concusion 126 Chapter References 131 VIII SUMMARY The structural and functional complicity of the central nervous system ... functional therapeutic effects to ameliorate the diseases The most ideal human gene therapy is the perfect combination of these three components to generate a safe and effective way for the delivery...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... particles were bound to the grid by incubating the samples at room temperature for 15 The samples were fixed with 4% paraformaldehyde for 20 at 4oC, followed by gentle rinse, the samples were stained ... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system ... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems...
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A study of the recombination activating gene 1 in the zebrafish nervous system
... recombination 5.1 .4. 3 Summary 144 144 5.2 The maturity and identity of the Rag1:GFP positive neurons in olfactory epithelium 145 5.2.1 GFP-positive olfactory neurons are mature 145 5.2.2 The Rag1:GFP ... 2001) These data indicate that the expression of Rag1 in the nervous system is conserved among vertebrate species and suggest a function 1.2.2 A brief overview of the nervous system The nervous system ... According to these functions, the nervous system is categorized as sensory system, integrating system and motor system respectively (Delcomyn, 1998) The structural organization of the nervous system...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... specificity of the therapeutic gene is primarily determined by the activity of the promoter at the transcriptional level, and the duration of the transgene expression can also be influenced by the selection ... expression in the brain 84 3 .4 Discussion 87 Chapter Hybrid Baculovirus-AAV Vector 91 4. 1 Introduction 92 4. 2 Materials and methods 94 4.2.1 Construction of hybrid baculovirus-AAV vectors 94 4.2.2 In ... 102 4. 4 Discussion 1 04 Chapter Conclusion 109 Chapter References 112 VIII SUMMARY Gene therapy is a promising approach for the treatment of neurological disorders in the central nervous system...
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Specificity and diversity in the vertebrate nervous system an analysis of two genes
... axons that they have reached their target neurons in the tectum The Recombination activating gene-1 (RAG1) is expressed in the vertebrate immune system and in the nervous system, including the zebrafish ... least at the molecular level there seems to be a link between the immune system and the nervous system Rag1 plays a key role in the initiation of this process of genomic rearrangement by recognizing ... plate The eye is covered with a melanin rich retinal pigmented epithelium (RPE) The RGCs in the eye project their axons to the optic tectum in the midbrain Apart from the major target, which is the...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... at the back of the head These proteins can potentially be a mixture of neurotoxins (which attack the nervous system) , hemotoxins (which attack the circulatory system) , cytotoxins and many other ... India The skin is either olive-green, tan, or black and it has faint, pale yellow cross bands down the length of the body The underbelly is cream or pale yellow, and the scales are smooth The head ... in the CNS, it is not clear whether their localization shown to be necessary in the physiological function (Chiappinelli, 1991) However, there is no direct evidence for their transport across the...
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