3— vasoactive intestinal peptide

Báo cáo khoa học: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells ppt

Ngày tải lên : 07/03/2014, 15:20

... Misra, H.P (1990) Vasoactive intestinal peptide, a singlet oxygen quencher J Biol Chem 265, 15371–15374 50 Pessina, F., Kalfin, R & Sgaragli, G (2001) Vasoactive intestinal peptide protects guinea-pig ... experiments Fig Vasoactive intestinal peptide (VIP) receptor-binding activity (A) and adenylate cyclase activation (B) with VIP and pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) ... effects of neuropeptides on the cigarette smoke extract (CSE)-induced cytotoxicity in L2 cells (A) Concentration-protective effect curves (10)15 to 10)5 M) for vasoactive intestinal peptide (VIP)...

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Báo cáo Y học: Transglutaminase-mediated polyamination of vasoactive intestinal peptide (VIP) Gln16 residue modulates VIP/PACAP receptor activity pdf

Ngày tải lên : 18/03/2014, 01:20

... cyclase-activating polypeptide I and II receptors, vasoactive intestinal peptide1 , and chimeric amino-terminal pituitary adenylate cyclase-activating polypeptide /vasoactive intestinal peptide1 receptors: ... novel receptor for vasoactive intestinal peptide Neuron 8, 811–819 10 Theriault, Y., Boulanger, Y & St Pierre, S (1991) Structural determination of the vasoactive intestinal peptide by two-dimensional ... study of vasoactive intestinal peptide by computational methods J Peptide Res 50, 55–64 12 Groossens, J.F., Cotelle, P., Chavatte, P & Henichart, J.P (1996) NMR study of the ﬁve N-terminal peptide...

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Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:23

... significance of vasoactive intestinal peptide in immunomodulation Pharmacol Rev 2004, 56:249-290 Delgado M, Martinez C, Pozo D, Calvo JR, Leceta J, Ganea D, Gomariz RP: Vasoactive intestinal peptide ... synovial cells from mice with collagen-induced arthritis (CIA) after vasoactive intestinal peptide (VIP) treatment intestinal peptide (VIP) treatment (a) EMSA results from nuclear extracts of synovial ... J: Vasoactive intestinal peptide, pituitary R1044 Arthritis Research & Therapy 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 R1045 Vol No Juarranz et al adenylate cyclase-activating polypeptide...

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Báo cáo y học: " Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands" docx

Ngày tải lên : 09/08/2014, 14:20

... acini and experimental pancreatitis has previously been reported [16] Vasoactive intestinal peptide (VIP) is a neuroimmunopeptide with several actions on exocrine glands In addition to inducing ... 56:3588-3600 Delgado M, Garrido E, Martinez C, Leceta J, Gomariz RP: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptides (PACAP27) and PACAP38) protect CD4+CD8+ thymocytes ... glucocorticoid-induced apoptosis Blood 1996, 87:5152-5161 Delgado M, Ganea D: Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit expression of Fas ligand in activated T lymphocytes...

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Báo cáo y học: " Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review" ppsx

Ngày tải lên : 12/08/2014, 13:22

... transport of vasoactive intestinal polypeptide (VIP) in nerves of the cat Acta Physiol Scand 1981, 112:427-36 44 Said SI: Vasoactive intestinal polypeptide (VIP): current status Peptides 1984, ... W: Vasoactive intestinal peptide gene alterations in patients with idiopathic pulmonary arterial hypertension Eur J Hum Genet 2007, 15:18-22 38 Opstad PK: The plasma vasoactive intestinal peptide ... JM, Pearse AG: Vasoactive intestinal peptide and waterydiarrhoea syndrome Lancet 1973, 2:14-6 41 Gyöngyösi M, Németh J, Várkonyi T: Elevated levels of plasma vasoactive intestinal peptide in human...

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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx

Ngày tải lên : 29/03/2014, 21:20

... Leibowitz SF (1985) Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion Peptides 6, 1205–1211 Mumford AD, Parry LJ & Summerlee AJ ... picomolar range and are similar to the effective doses of other orexigenic peptides such as ghrelin (30 pmol; intraPVN) and neuropeptide Y (NPY) (78 pmol; intraPVN) [45,46] Although RXFP3 and RXFP1 ... the group of neuropeptides that regulate energy homeostasis and reproduction (i.e modulate both appetite and the HPG axis) This group includes NPY, orexin and galanin-like peptides [51–54] Conclusions...

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Tài liệu Chương 3: Peptide - Cấu trúc và chức năng pptx

Ngày tải lên : 22/12/2013, 15:16

... cho chuỗi peptide cấu hình không gian có độ bền cao 1.2 Cách gọi tên phân loại peptide Căn vào số amino acid peptide để gọi tên peptide, có amino acid gọi dipeptide, amino acid gọi tripeptide, ... đoạn ngắn chuỗi polypeptide bỏ qua giai đoạn cắt chuỗi polypeptide thành peptide nhỏ mà tách phân lập phương pháp điện di hay sắc ký để tách riêng peptide Sau tách riêng peptide người ta tiến ... xác định peptide Có số phương pháp tách phân lập xác định thành phần, số lượng trình tự amino acid peptide Nguyên tắc chung phương pháp tách phân lập xác định peptide protein Tuy nhiên peptide...

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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx

Ngày tải lên : 21/02/2014, 03:20

... and peptides, 120 for RNase A), and were continually aerated After cessation of photolysis, catalase (Sigma, bovine liver, lgặmL)1 for BSA, 50 lgặmL)1 for lysozyme and RNase A, 250 lgặmL)1 for peptides) ... peroxides (Eur J Biochem 269) 1919 Fig Thermal decay of peptide peroxides over time at 37 C in the absence or presence of added GAPDH Peptide peroxide samples were generated as described in Fig ... peroxides was slower than that induced by the peptide peroxides at Fig Inhibition of glyceraldehyde-3-phosphate dehydrogenase on incubation with H2O2, and peptide- and protein-peroxides, in the presence...

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Báo cáo khoa học: Fowlicidin-3 is an a-helical cationic host defense peptide with potent antibacterial and lipopolysaccharideneutralizing activities ppt

Ngày tải lên : 07/03/2014, 11:20

... pleiotropic effects of antimicrobial peptides on various aspects of innate and adaptive immunity, these peptides have been proposed to be renamed as host defense peptides [6,7] Both antimicrobial ... 96-well cell culture plates, 10 lL peptides in serial twofold dilutions were added in duplicate The MIC value of each peptide was determined as the lowest peptide concentration that gave no visible ... was calculated as [1 ) (Fpeptide ) Fbackground) ⁄ (Facetic acid ) Fbackground)] · 100, where Fpeptide is the ﬂuorescence of cells exposed to different concentrations of peptides, Facetic acid is...

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Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells doc

Ngày tải lên : 23/03/2014, 12:20

... expressed in the apical membranes of intestinal (PEPT1) and renal (PEPT1 or PEPT2) epithelial cells Absorption of intact di- and tri-peptides and related mimetics at the intestinal epithelium or their ... requirements of H+ /peptide symporters It shows that phosphonodipeptides interact with mammalian PEPT1 and PEPT2 with high afﬁnity It does not necessarily mean that the phosphonodipeptide is actually ... antibacterial phosphonodipeptide alafosfalin interacts with both mammalian H+ /peptide symporters with high afﬁnity PEPT1 and PEPT2 not seem to differentiate very much between a dipeptide and its derivative...

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Báo cáo khoa học: Identiﬁcation of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles pdf

Ngày tải lên : 29/03/2014, 21:20

... speciﬁcity of E51 sequence in the peptide form (pepE51) To assess the reactivity and isozyme-speciﬁcity of E51 (PPPYSFYQSRWV) in peptide form, biotinylated peptides for E51 (pepE51) or E51 in ... gray 0.3 0.2 pepE51QN 0.1 0 Peptide (µM) Fig Analysis of the reactivity of E51 sequence in the peptide form (A) The time-dependent incorporation of lM biotinylated peptide E51 (pepE51) into spermine, ... substrate peptide for TGase A TGase B pepK5 Guinea pig liver TGase (TGase 2) 0.6 pepT26 Absorbance 0.5 0.4 0.3 0.2 pepE51 0.1 0.4 0.3 pepE51 0.2 0.1 pepE51QN 0 pepE51QN C Peptide (µM) Peptide (µM)...

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Báo cáo khoa học: Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3 pot

Ngày tải lên : 30/03/2014, 01:20

... Luo et al prepro-insulin-like polypeptide that contains a signal peptide, a B-chain, a C -peptide and an A-chain After removal of the signal peptide and the C -peptide, prepro-INSL3 is converted ... to secrete the peptide from the transformed yeast cells The single-chain INSL3 precursor was shown to possess near-full RXFP2 receptor activity The short, eight-residue linking peptide between ... molecular mass determined by MS Peptide mapping of the refolded single-chain INSL3 precursor The refolded INSL3 precursor was ﬁrst digested by trypsin (enzyme ⁄ peptide mass ratio : 10) at 37...

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Báo cáo khoa học: Effect of the -Gly-3(S)-hydroxyprolyl-4(R)-hydroxyprolyltripeptide unit on the stability of collagen model peptides ppt

Ngày tải lên : 30/03/2014, 02:20

... of this peptide and also produced several other peptides with 3(S)Hyp in the Xaa position All of these newly synthesized peptides formed a triple-helical structure We conﬁrmed that a peptide ... refolding of these model peptides in detail In order to evaluate the thermodynamic properties of 3(S)Hyp-containing collagen model peptides, a series of peptides with nine tripeptide units comprising ... transition curve for peptide Ac-(Gly3(S)Hyp-4(R)Hyp)10-NH2 (Fig 2) The ellipticity of the peptide was positive even after the transition at 95 °C Therefore, the characteristics of peptide Ac-(Gly-3(S)Hyp-4(R)Hyp)10-NH2...

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Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx

Ngày tải lên : 31/03/2014, 07:20

... grey N-BK peptide, C-BK peptide and the BK-containing peptide (BK -peptide) were ﬂanked by a donor-acceptor pair: a ﬂuorescent N-terminal Abz group and a C-terminal 3-NO2-Tyr quencher Peptides ... or Advanced Chemtech (Cambridge, UK) N-BK peptide, C-BK peptide and BKpeptide were prepared by Fmoc chemistry on an automated solid phase peptide synthesizer (ABI model 431 A, Applied Biosystems, ... C-terminal 3-NO2-Tyr quencher Peptides were synthesized as peptidyl-amides (B) N-BK peptide, C-BK peptide, BK -peptide and kinins (BK, Lys-BK, and des-Arg9BK) were incubated with the enzyme, and...

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Báo cáo y học: " Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis" ppt

Ngày tải lên : 12/08/2014, 14:22

... volume of ~80 μl Super-fusion was performed for Figure Immunohistochemistry of human neutrophil peptides 1-3 (HNP1-3) and human β-defensin (HBD 2) in the synovial lining and sublining area of ... The levels of HNP1-3 increased over time, Figure Double immunofluorescence of human neutrophil peptides 1-3 (HNP1-3) and human β-defensin (HBD 2) in synovial tissue of an RA patient Arrowheads ... defensins from synovial tissue/cells and density of synovial neutrophils (a) Levels of human neutrophil peptides 1-3 (HNP1-3) in superfusate of synovial tissue of two patients with rheumatoid arthritis...

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Báo cáo khoa học: "Clinical review: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock" ppsx

Ngày tải lên : 12/08/2014, 20:20

... decreases in macrocirculatory flow [6] In addition, intestinal villi perfusion is highly heterogeneous, as suggested by the wide range of intestinal surface oxygen saturation [7] In patients ... remained unaltered [26] Adrenergic drugs The choice of vasoactive drugs in sepsis and septic shock is controversial There is no evidence that any one vasoactive drug is more effective or safer than ... before it may be routinely used in septic shock Other vasoactive drugs Vasopressin and terlipressin Physiologically, vasopressin (a nonapeptide that is released from the neurohypophysis) plays...

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Báo cáo y học: "he adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation" ppt

Ngày tải lên : 13/08/2014, 11:23

... correlate to disturbed intestinal permeability and absorption capacity in septic patients is a modified and destroyed intestinal mucosal architecture that is quantifiable by intestinal mucosal damage ... results in: - Attenuated intestinal production of hypoxanthine (indicator of cellular energy failure); - Decreased intestinal lactulose/L-rhamnose ratio (measure of intestinal permeability); ... without EHNA application (LPS group), the intestinal production of hypoxanthine increased from 9.8 ± 90.2 μmol/l at baseline to 411.4 ± 124.6 Table Intestinal mucosal damage grading score Grade...

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Báo cáo y học: "The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study" pot

Ngày tải lên : 13/08/2014, 16:20

... Creutzfeldt W: Preserved incretin activity of glucagon-like peptide [7–36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus J Clin Invest ... this study was to determine whether exogenous GLP-1 attenuates the glycaemic response to small intestinal nutrient infusion in critically ill patients not previously known to be diabetic Materials ... mmol/l vs placebo 7.6 ± 0.6 mmol/l; P = not significant (NS)) Prior to the commencement of the small intestinal nutrient infusion (t = 30 min) GLP-1 had no effect on blood glucose On both days, there...

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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 3

Ngày tải lên : 14/09/2015, 23:32

... little higher peptide/ lipid ratio (1:2) compared with other peptides, considering that only less than 1% (0.77%) of active peptide, the peptide/ lipid ratio for V4 is low to 1:260 (peptide/ LUVs= ... antimicrobial peptides From a peptide concentration of 0.05 µM to µM, polymyxin B generated similar penetration Further addition of peptide induced slight increase in ∆π compared with the lower peptide ... penetration experiments, peptide was mostly present at higher amounts than lipids Antimicrobial peptides induced monolayer saturation at a certain peptide concentration Extra peptide kept the increased...

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Regulation of intestinal inflammation by mitogen activated protein kinase phosphatase 3

Ngày tải lên : 01/10/2015, 17:28

... Model of Colitis 5! 1.2.! The Role of Immune Response in Intestinal Inflammation 5! 1.3.! The Role of Intestinal Epithelium in Intestinal Inflammation 7! 1.4.! Mitogen-Activated Protein ... the shift in intestinal microbial content, breakdown of the protective barrier of the intestinal epithelia and/or a dysregulation in the immune system 4,11 The composition of the intestinal microflora ... contribute to its ability to spread within the intestinal mucosa and trigger chronic inflammatory response 13 Besides the intestinal microflora, the loss of intestinal epithelial integrity and function...

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