3 phát huy sức mạnh đại đoàn kết toàn dân tộc kết hợp sức mạnh dân tộc với sức mạnh thời đại trong bối cảnh hiện nay

Báo cáo khoa học: " Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response" potx

Ngày tải lên : 09/08/2014, 09:20

... supported by research grants from National Science Council(NSC 97 -31 11-B-075-001-MY3, NSC99-2811-B-016-007-MY3, 98- 232 0-B-075-003MY3), Taipei Veterans General Hospital (V97B1-006, E1-008, F-001), ... and nitrosoureas for the treatment of malignant glioma after surgery N Engl J Med 1980, 30 3( 23) : 132 3- 132 9 Stupp R, Dietrich PY, Ostermann Kraljevic S, Pica A, Maillard I, Maeder P, Meuli R, Janzer ... of DNA minor groovetargeted aniline mustard analogues of pibenzimol (Hoechst 33 258) J Med Chem 1994, 37 (25): 433 8- 434 5 Gourdie TA, Valu KK, Gravatt GL, Boritzki TJ, Baguley BC, Wakelin LP, Wilson...

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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc

Ngày tải lên : 20/06/2014, 04:20

... 0.82 ± 0. 03 0.82 ± 0. 03 0.75 ± 0.04 0. 73 ± 0.02 0.72 ± 0.04 0. 73 ± 0. 03 48 h 0.82 ± 0.04 0.81 ± 0.04 0.82 ± 0.02 0.80 ± 0.04 0.71 ± 0.02 0.71 ± 0.05 0.71 ± 0. 03 0.71 ± 0.04 72 h 0.81 ± 0. 03 0.80 ... Gynecol 2006, 45 :30 7 -31 2 30 Dempsey PW, Doyle SE, He JQ, Cheng G: The signaling adaptors and pathways activated by TNF superfamily Cytokine Growth Factor Rev 20 03, 14:1 93- 209 31 Rakshit DS, Ly ... Orthopaedic Surgery and Research 2010, 5: 83 http://www.josr-online.com/content/5/1/ 83 bone matrix that stimulate osteoblasts to promote or inhibit bone formation [32 ,33 ] This may have an impact on the...

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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot

Ngày tải lên : 20/06/2014, 07:20

... 0.82 ± 0. 03 0.82 ± 0. 03 0.75 ± 0.04 0. 73 ± 0.02 0.72 ± 0.04 0. 73 ± 0. 03 48 h 0.82 ± 0.04 0.81 ± 0.04 0.82 ± 0.02 0.80 ± 0.04 0.71 ± 0.02 0.71 ± 0.05 0.71 ± 0. 03 0.71 ± 0.04 72 h 0.81 ± 0. 03 0.80 ... Gynecol 2006, 45 :30 7 -31 2 30 Dempsey PW, Doyle SE, He JQ, Cheng G: The signaling adaptors and pathways activated by TNF superfamily Cytokine Growth Factor Rev 20 03, 14:1 93- 209 31 Rakshit DS, Ly ... Orthopaedic Surgery and Research 2010, 5: 83 http://www.josr-online.com/content/5/1/ 83 bone matrix that stimulate osteoblasts to promote or inhibit bone formation [32 ,33 ] This may have an impact on the...

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Báo cáo khoa học: "Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions" pptx

Ngày tải lên : 09/08/2014, 09:21

... migration [%] 100 80 60 40 20 U251MG U343MG B DMSO μM BA 10μM BA U251MG U343MG Figure Effects of BA on cell migration of glioma cells Migration rates of U251MG and U343MG cells treated with BA analyzed ... http://www.ro-journal.com/content/6/1/111 Page of clonogenic survival [%] 120 100 U251MG 80 U343MG 60 40 20 0 10 20 30 betulinic acid [μM] Figure Cytotoxicity in U251MG and U343MG cell lines after treatment with BA Both glioma cell ... (p = 0. 03) in U251MG cells and 87% (p = 0.15) or 82% (p = 0.07) in U343MG cells, respectively Under hypoxic conditions, an increased reduction in survival to 30 % (p = 0.01) or 9% (p = 0. 03) and...

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báo cáo khoa học: "Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251" pdf

Ngày tải lên : 10/08/2014, 10:21

... activities of basic fibroblast growth factor: potentiation of low-serum 25 26 27 28 29 30 31 32 33 34 35 36 37 38 growth mediated by natural or chimeric nuclear localization signals Mol Biol Cell ... 2004, 23: 330 8 -33 16 21 Ren W, Duan Y, Yang Y, Ji Y, Chen F: Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer Neurol Res 2008, 30 :297 -30 1 22 ... mouse model Oncogene 2004, 23: 330 8 -33 16 Lee H, Herrmann A, Deng JH: Persistently activated STAT3 maintains constitutive NF-kB activity in tumors Cancer Cell 2009, 15:2 83- 2 93 Brantley EC, Benveniste...

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molecular merchanisms underlying inhibitory effect of fuciodan on cytokine-induced inflammation in glioma cells

Ngày tải lên : 13/11/2014, 06:42

... regulates IFN-γ – induced JAK/STAT and p38 phosphorylation differently in C6 glioma cells and RAW264.7 macrophages ························· 72 iii 3. 3 Involvement of p38 and JAK/STAT in IFN-γ – induced ... astrocytoma cell line U3 73- MG, and mouse macrophage cell line Raw264.7 were purchased from the American Type Culture Collection (Manassas, VA, USA) C6 cells, SH-SY5Y cells, and U3 73- MG were cultured ... ································································ 36 12 Cell transfection and RNA interference ·························································· 38 13 Statistical analysis ··························································································...

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Báo cáo khoa học: "Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks" ppsx

Ngày tải lên : 07/08/2014, 18:20

... with 4(N-methyl-N-nitrosamino)-1- (3- pyridyl)-1-butanone and dibutyl phthalate enhanced ozone-induced genotoxicity in B6C3F1 38 5 mice Mutagenesis 2002, 17, 33 1 -33 6 22 Koren HS, Devlin RB, Graham ... Interact 1981, 34 , 233 - 238 11 Gray TJ, Beamand JA Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells Food Chem Toxicol 1984, 22, 1 23- 131 12 Harris ... µl of hprt-specific 5' primer (10 mM: 5GGC TTC CTC CTC AGA CCG CT -3) and 3' primer (10 mM: 5-GGC AAC ATC AAC AGG ACT CC -3) , 0 .3 µl of Taq DNA polymerase (5 U/µl) (Takara, Japan), and 22.7 µl of...

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Báo cáo khoa học: " Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress" pdf

Ngày tải lên : 07/08/2014, 20:23

... 2006, 33 , 211-220 32 Hausburg MA, Dekrey GK, Salmen JJ, Palic MR, Gardiner CS Effects of paraquat on development of preimplantation embryos in vivo and in vitro Reprod Toxicol 2005, 20, 239 -246 33 ... Cells 2004, 6, 38 6 -39 1 17 Cobb MH, Goldsmith EJ How MAP kinases are regulated J Biol Chem 1995, 270, 148 43- 14846 18 Cochrane CG Cellular injury by oxidants Am J Med 1991, 91, 23S -30 S 19 Du J, Daniels ... on cell survival Biochem J 1998, 33 3, 291 -30 0 59 Ward PA, Warren JS, Johnson KJ Oxygen radicals, inflammation, and tissue injury Free Radic Biol Med 1988, 5, 4 03- 408 60 Wolf R, Schönfelder G,...

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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps

Ngày tải lên : 07/08/2014, 23:22

... of the superoxide anion radical in the autoxidation of pyrogallol and a 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 convenient assay for superoxide dismutase Eur J Biochem 1974, 47, 469-474 ... 0.021b 0. 035 ± 0.004a 0.026 ± 0.009c 0. 031 ± 0.006a 0.015 ± 0.012c 0.028 ± 0.004a 0.014 ± 0.010c 3. 35 ± 0 .37 c 8.60 ± 0.55a 2. 93 ± 0.19c 5.50 ± 0.23a 2.71 ± 0.11c 8.75 ± 0.45a 2.59 ± 0.23c a a b ... (nmol.mL ) LPO (nmol of MDA 1 .35 ± 0 .31 a −1 −1 gm Hb h ) 30 days 35 .52 ± 6.18b Control 60 days 14. 53 ± 2.23a 45.25 ± 7.24b Control 19. 23 ± 2.64a 90 days Control 59.51 ± 13. 27b 19.42 ± 2.65a 120 days...

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Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine docx

Ngày tải lên : 10/08/2014, 05:21

... 148.1 ± 2.7 132 .3 ± 4.2** 121 .3 ± 3. 3*** 136 .4 ± 3. 7* Body weight of the offspring at birth (g) 6.8 ± 0.1 ± 0.1 6.6 ± 0.1 6.9 ± 0.1 Body weight of the offspring on day (g) 14.7 ± 0 .3 16 .3 ± 0.5* ... Neuropsychopharmacol Biol Psychiatry 20 03, 27 :38 1 -39 3 33 Zagon IS, McLaughlin PJ: Enhanced sensitivity to methadone in adult rats perinatally exposed to methadone Life Sci 1981, 29:1 137 -1142 34 He L, Kim J, Ou C, ... 0 .3 9.8 ± 0 .3 10.2 ± 0 .3 Fatality (%) 0.69 ± 0 .33 0 7.1 ± 2 .38 ** Fatality occurred in the offspring (%) (P2-P10) 0.21 ± 0.14 0.56 ± 0.56 12.14 ± 7.02* Body weight increase in the dams (g) (E3-E20)...

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Báo cáo y học: " A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre-exposed to H1N1 influenza virus" ppt

Ngày tải lên : 12/08/2014, 04:20

... inactivated split-virus Page of 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 influenza A (H5N1) vaccine in infants and children Vaccine 2008, 26: 638 3- 639 1 Treanor JJ, Campbell JD, Zangwill ... National 9 73 Project (2010CB 530 301), European Union Project (SSPE-CT-2006-44405), National Natural Science Foundation of China (30 9726 23) , National Key Technology R&D Program of China (2006BAD06A 03) , ... M1 DNA NP + M1 DNAs Pre-exposed to H1N1 Not done 22 .3 ± 1.15a, Unimmunized control 17.0 ± 1.0 b b Not done 12.7 ± 1.15a, 13. 3 ± 0.57a, b b 9 .33 ± 0.57 § Mice were grouped and treated as described...

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Báo cáo y học: " Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia" pps

Ngày tải lên : 12/08/2014, 13:22

... http://respiratory-research.com/content/12/1/68 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 basis for the predisposition to chronic lung inflammation in preterm newborns Pediatr Res 1996, 39 :966-975 Kwong KY, ... cells by 66% after 24 h and 36 h of hyperoxia (24 h-untreated = 5.74 ± 1.85 vs 24 h-treated = 2.06 ± 0 .39 ; p < 0.01; 36 huntreated = 9.47 ± 3. 17 vs 36 h-treated = 3. 30 ± 0.56; p < 0.01) (Figure ... 24 h of hyperoxia (untreated = 37 .0 ± 5.99 vs treated = 30 .8 ± 3. 56; p < 0.05) and by 27% after 36 h of hyperoxia (untreated = 54.5 ± 2 .30 vs treated = 39 .8 ± 3. 84; p < 0.01) respectively, when...

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Báo cáo y học: "Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study" pdf

Ngày tải lên : 12/08/2014, 15:20

... Total N.44 35 .5 (17) 49 (60) 21 16 (66) 52 (66) 30 26 (59) 26 (66) (34 ) (33 ) (100) (25) 13 (54) 11 (46) 11 (46) (89) (11) (11) 30 (68) 14 (32 ) 18 (41) (16) (33 ) (50) (20) (80) (29) (37 .) (33 ) (11) ... (100) (100) (100) (100) 14.2 ± 3. 4 31 .4 ± 2.5 16.4 ± 5.1 11.8 ± 3. 8 6.1 ± 17.1 ± 4.5 33 ± 3. 4 12 .3 ± 4.4 8.9 ± 3. 2 2.2 ± 0.5 17.5 ± 4.6 29 .3 ± 4.5 16 .3 ± 6.7 13. 5 ± 6.1 4.6 ± Ns Ns Ns Ns Ns Ns ... (100) (100) (100) (100) 9.9 ± 4 .3 27.4 ± 3. 1 21.1 ± 5.2 16.1 ± 4.5 7.5 ± 3. 3 8.6 ± 4.1 21.4 ± 4.9 19.5 ± 7.2 16 .3 ± 7.2 7.0 ± 4.7 12.1 ± 6.5 23. 5 ± 3. 8 20.2 ± 6.1 7 .3 ± 2.2 5.7 ± Ns Ns Ns Ns Ns...

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Báo cáo y học: "Modulation of the transcription regulatory program in yeast cells committed to sporulation" ppt

Ngày tải lên : 14/08/2014, 16:21

... cerevisiae Proc Natl Acad Sci USA 2002, 99:15 530 -15 535 Briza P, Bogengruber E, Thur A, Rutzler M, Munsterkotter M, Dawes 25 26 27 28 29 30 31 32 33 34 35 36 Genome Biology 2006, 7:R20 information ... Analysis of the kar3 meiotic arrest in Saccharomyces cerevisiae Cell Cycle 2004, 3: 3 63- 371 Cohen-Fix O: Meiosis: polo, FEAR and the art of dividing reductionally Curr Biol 20 03, 13: R6 03- R605 Lee BH, ... GEO [59] and are accessible through GEO Series accession numbers: GSE3814, GSE3815, GSE3816, GSE3817, GSE3818, GSE3819 and GSE3820 [57,58] (see also Additional data file 4) Calculating the correlation...

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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx

Ngày tải lên : 10/08/2014, 10:21

... activation [33 ] In our study, we evaluated the effect of Osthole on the PI3K/Akt Xu et al Journal of Experimental & Clinical Cancer Research 2011, 30 :33 http://www.jeccr.com/content /30 /1 /33 pathways ... of solid tumours Nature 2005, 435 :677-81 Xu et al Journal of Experimental & Clinical Cancer Research 2011, 30 :33 http://www.jeccr.com/content /30 /1 /33 Page of 30 Thees S, Hubbard GB, Winckler ... buffer(20 mM Xu et al Journal of Experimental & Clinical Cancer Research 2011, 30 :33 http://www.jeccr.com/content /30 /1 /33 Page of HEPES, pH 7.9, 20% glycerol, 200 mM KCl, 0.5 mM EDTA, 0.5% NP40,...

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Báo cáo y học: "Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R." pps

Ngày tải lên : 13/08/2014, 01:20

... p-Chk1-S345 γ-H2AX-S 139 Vpr β-actin B 10 11 12 13 G1/S G2/M 0h G1 Time S 5h S G1 8h G2 11 h Mock 30 60 90 120 150 30 Vpr HU Cell number Channels (FL2-A) 30 60 90 120 150 30 Channels (FL2-A) 30 60 ... Virology 2001, 287 :35 9 -37 0 34 Goh WC, Manel N, Emerman M: The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest Virology 2004, 31 8 :33 7 -34 9 35 Murakami H, Nurse ... 90 120 150 30 60 60 90 120 Channels (FL2-A) 120 150 30 Channels (FL2-A) 60 90 90 120 150 30 60 Channels (FL2-A) Channels (FL2-A) 150 30 60 90 120 150 30 60 Channels (FL2-A) 120 1500 30 Channels...

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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"

Ngày tải lên : 02/11/2012, 11:12

... on the protein expression of p21, p 53 and 14 -3- 3σ Actin was used as the internal control Control 0.25% 0.5% 1% 2.5% 5% 10% MW kDa p 53 53 Actin 43 14 -3- 3σ 30 p21 21 ... 2.7 2.9 4.0 4.7 5.0 5.0 p 53 Disscussion 0.8 2.5 3. 0 3. 4 5.0 14 .3 p21 Cell cycle checkpoints are important control 1.0 1.5 1.2 2.0 2.4 3. 3 14 -3- 3 mechanisms that ensure the proper execution of ... and 14 -3- 3 sigma negatively regulates cell cycle progression JBC 2000; 275: 231 06- 231 12 24 Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S Efp targets 14 -3- 3 sigma...

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Báo cáo Y học: Early growth response-1 gene (Egr-1 ) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro pot

Ngày tải lên : 17/03/2014, 17:20

... Cell 76, 1025±1 037 35 Wilhelm, D., van Dam, H., Herr, I., Baumann, B., Herrlich, P & Angel, P (1995) Both ATF-2 and c-Jun are phosphorylated by Ó FEBS 2002 36 37 38 39 40 41 42 43 44 45 stress-activated ... mainly triggered by ultraviolet light (UV-C) [34 36 ], ionizing radiation (reviewed in [37 ]), proin¯ammatory cytokines [30 ,31 ] and DNA damaging agents [37 ], whereas the Raf/ERK pathway is preferentially ... phosphorylated target proteins, i.e ERK1/2 (T202/Y204), SAPK/JNK (T1 83/ Y185), p38MAPK/SAPK2 (T180/Y182), ATF-2 (T71), c-Jun (S 73) and CREB (S 133 ) phosphospeci®c rabbit polyclonal Ig was applied Phosphorylation-state-indepen-...

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báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx

Ngày tải lên : 18/06/2014, 15:20

... mitochondrial cell death protein BNIP3 Oncogene 2005, 24:980–91 http://www.translational-medicine.com/content/7/1/ 13 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 Fulda S, Jeremias ... apoptosis signaling by retinoid CD 437 J Biol Chem 20 03, 278 :33 422 35 Kim HJ and Lotan R: Identification of protein modulation by the synthetic retinoid CD 437 in lung carcinoma cells using high ... for two minutes, 30 cycles including 95°C for 30 seconds, 57°C for 45 seconds, 72°C for 30 seconds For EGFR amplification: 95°C for two minutes, 32 cycles including 95°C for 30 seconds, 55°C...

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Báo cáo sinh học: " G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells" pot

Ngày tải lên : 19/06/2014, 08:20

... 104 104 1 03 10 10 102 100 1000 7. 43% 102 101 100 0. 63% 7-AAD 48h GFP 31 .57% 1 03 2 .39 % 7-AAD 10 0.49% 101 7.94% 100 104 Annexin V PE DNA Content EGFP expression 32 .17% 104 Annexin V PE p3b/EGFP-N1 ... coronavirus Science 20 03, 30 0: 139 9-1404 Oh JC, Jeong DL, Kim IK, Oh SH: Activation of calcium signaling by hepatitis B virus-X protein in liver cells Exp Mol Med 20 03, 35 :30 1 -30 9 Nakamichi K, Matsumoto ... 32 .17% 104 Annexin V PE p3b/EGFP-N1 (-) p3b/EGFP-N1 (+) b 104 GFP 101 101 0 1000 100 1. 73% 102 102 101 0.75% 1 03 0.29% 7-AAD 102 10 0.48% 1 03 7-AAD 32 .40% 1 03 48h 104 104 1.24% 10 104 DNA Content...

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