3 mechanism of action

Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"

Ngày tải lên : 26/10/2012, 09:39

... possible role of oxidative stress Metabolism 2002; 51: 134 0– 134 7 34 38 Ceriello A The possible role of postprandial hyperglycaemia in the pathogenesis of diabetic complications Diabetologia 20 03; 46: ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical ... been suggested that oxidative stress might be the mediator of damage to cellular components of insulin production (33 ,39 ) A major source of cellular reactive oxygen species is mitochondria, whose...

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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

Ngày tải lên : 19/02/2014, 07:20

... Journal 2 73 (2006) 72– 83 ª 2005 The Authors Journal compilation ª 2005 FEBS M Giudici et al 30 31 32 33 34 35 36 37 38 39 40 41 system in which to obtain patch-clamp recordings of ionic channels Biochemistry ... permeabilization [3, 16] To further explore the interaction of the most cytotoxic viscotoxin isoform, VtA3, with biological membranes and obtain information on its mechanism of action, we have applied ... studied the effects of FEBS Journal 2 73 (2006) 72– 83 ª 2005 The Authors Journal compilation ª 2005 FEBS 73 Analysis of the fungicidal effect of viscotoxin A3 M Giudici et al VtA3 on liposomes, both...

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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc

Ngày tải lên : 19/02/2014, 16:20

... 59 1 53 133 135 10 16 10 26 58 77 59 0.2 23 35 85 86 130 161 10 30 26 26 74 35 55 37 38 147 35 19 119 54 137 205 128 289 50 21 38 67 63 90 0.1 108 62 170 225 107 287 12 31 27 20 28 36 14 52 38 20 ... 10 15 3 0.1 5 15 2 1 2 2 1 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± SMB/acuA 10 10 1 0.1 3 10 10 2 2 1 0.5 2 .3 17 22 18 2 .3 3.5 29 31 30 0.6 24 26 71 67 82 11 44 33 24 64 63 57 ... (DmcsA) 5.8 12.7 2.4 5.1 < 0.5 0.9 38 41 12.4 14.7 4.4 5.8 78 115 24 46 9.6 11.7 49 63 15 16 5.6 7.1 86 109 32 28 9.6 8.7 65 1 43 25 54 5 .3 13. 3 Ó FEBS 2004 32 34 M Brock and W Buckel (Eur J Biochem...

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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

Ngày tải lên : 22/02/2014, 04:20

... Scheme shows the reactions of the two-step mechanism of action of TFPI It is shown in the Appendix that Scheme is equivalent to Scheme I of [8] within the area of the applicability of the latter In ... and found the values of the hypothetical reactions separately The model of the inhibitory action of the Xa–TFPI complex on the enzyme–substrate complex (model 3) The reaction of X–VIIa–TF inhibition ... its possible mechanism of action Blood 71, 33 5 34 3 Girard, T.J., Warren, L.A., Novotny, W.F., Likert, K.M., Brown, S.G., Miletich, J.P & Broze, G.J Jr (1989) Functional signiﬁcance of the Kunitz-type...

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báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx

Ngày tải lên : 10/08/2014, 22:20

... Leukemia 2001, 15(12):1950-61 http://www.jhoonline.org/content/2/1 /36 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 Teo SK: Properties of thalidomide and its analogues: implications for anticancer ... before treatment showed decreased expression of the set of the genes Figure Mechanism of action of lenalidomide Mechanism of action of lenalidomide Various mechanisms by which lenalidomide achieves ... transduction or a combination of all of these Figure summarizes the mechanism of action of lenalidomide as we know so far Future studies will assess these mechanisms as well as direct actions on the malignant...

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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt

Ngày tải lên : 11/08/2014, 03:20

... [5]: (δC1 38 ,6; δC2 23, 9; δC3 81,2; δC4 38 ,0; δC5 55,5; δC6 18,2; δ C7 34 ,4; δ C8 41,0; δ C9 50,5; δ C10 37 ,2; δ C11 21,1; δ C12 25,2; δC 13 38,2; δC14 43, 0; δC15 27,6; δC16 35 ,7; δC17 43, 0; δC18 ... ± 2.9 - 32 .6 ± 3. 9 - Morphine (7.5 mg/kg, i.p.) 23. 8 ± 2.8a 62.8 2.9 ± 1.6a 91.1 10 55.8 ± 3. 6 12.8 41.2 ± 5 .3 - 25 50 .3 ± 4.7a 21.4 13. 8 ± 3. 9a 57.6 50 36 .1 ± 2.2a 46.5 12.6 ± 2,2a 61 .3 (7.5 ... Garcia MD, Saenz MT, Villar A: New insights into the mechanism of action of the anti-inflammatory triterpene lupeol J Pharm Pharmacol 2001, 53: 1 533 -1 539 Soares DC, Andrade AL, Delorenzi JC, Silva JR,...

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Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf

Ngày tải lên : 12/08/2014, 23:21

... antiviral drug http://www.retrovirology.com/content/6/1/44 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 interaction between tenofovir, abacavir and lamivudine Antivir Ther 2005, 10:451-457 ... Kd (μM) Bmax (%) Bmax/Kd D20/D36 FTC-MP ddCMP NDa 16.9 ± 8.5 ND 38 .0 ± 4.4 ND 2.2 ND 445 ± 114 ND 15 .3 ± 2.7 ND 0. 034 1.54 ± 0 .33 1. 03 ± 0.25 5. 53 ± 1. 83 14.9 ± 0.8 3. 0 14.5 D27/D50 FTC-MP ddCMP ... Bmax/Kd D20/D36 TFV ddAMP 232 ± 12a 21.5 ± 9.8 18.5 ± 6.7 34 .2 ± 4.6 0.079 1.6 250 ± 11 171 ± 28 17.7 ± 3. 9 28.1 ± 4.7 0.071 0.16 0.70 ± 0.10 1.20 ± 0 .38 45.7 ± 10.0 16 .3 ± 3. 5 65 13. 6 D26/D50...

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Discovery and mechanism of action study of anti viral compounds for dengue virus

Ngày tải lên : 10/09/2015, 15:51

... 63 3.2 .3 Compound NITD448 inhibits E protein-mediated membrane fusion in liposomebased fusion assay 68 3. 2.4 Anti-viral activity of compound NITD448 73 3 .3 DISCUSSION ... overall helicase activity of NS3 by causing the dissociation of NS3 from singlestranded RNA (Umareddy et al 2006) 1 .3 PATHOGENESIS OF DENGUE INFECTION 1 .3. 1 The course of dengue infection There ... Identification of novel target sites and an inhibitor of the dengue virus E protein J Comput Aided Mol Des 23( 6) :33 3-41 Cell-cell fusion CLogP= 6 .36 7 MW = 469.40 Plaque reduction CLogP= 6. 638 MW = 414.86...

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Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway

Ngày tải lên : 11/09/2015, 09:08

... 42 43 51 52 57 63 71 72 75 75 79 82 83 84 Overall structure 84 3. 3.2 3. 3 .3 3 .3. 4 3. 3 Introduction Material and Methods 3. 2.1 Cloning, expression and purification 3. 2.2 Crystallization 3. 2 .3 Data ... 2.14 2.15 2.16 2.17 30 31 32 34 35 36 37 38 39 40 48 50 53 55 x 3. 3 Close-up view of the S6P binding site Superimposition of F6P-SPS and S6P-SPS complexes Ten docked models of UDP interacting ... 2 .3. 8 Putative ADP / UDP binding pocket 2 .3. 9 Mechanism of action Chapter 3: Mechanism of Action and Structure of Fructokinase from Halothermothrix orenii 24 24 24 25 25 26 26 27 27 28 28 34 39 ...

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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques

Ngày tải lên : 11/09/2015, 09:18

... 1 43 5 .3. 1 Significance of GEN‟s FLT3 inhibitory effect 1 43 5 .3. 2 High-throughput study and the story that it presents 144 5 .3. 3 The tale of two modes of “death” 149 5 .3. 4 ... 62 3. 9 Western Blot 63 3.10 Cell Cycle Analysis 65 3. 11 Caspase 3/ 7 Assay 65 3. 12 Annexin V-FITC apoptosis detection 66 3. 13 Measurement of ROS ... 1.4.4 Mechanism of action of rapa Rapamycin is a known inhibitor of the mammalian Target Of Rapamycin (mTOR) pathway The mechanism of this inhibition has been well established 1.4.4.1 Structure of...

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The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta

Ngày tải lên : 14/09/2015, 14:06

... interaction to associate with PKCδ 131 3. 3.9 3. 4 1 23 Summation 133 135 3. 4.1 PKCδ contributes to ERK1/2 activity 135 3. 4.2 Kinase activity of PKCδ is required for ERK1/2 phosphorylation 137 3. 4 .3 ... for its interaction with PKCδ 95 3. 2.6 Interaction between Spry2 and PKCδ is conformation dependent 98 3. 2.7 3. 3 95 106 Spry2 co-localizes with PKCδ Mechanism of action of Spry2 110 3. 3.1 Spry2 ... PKD1 128 3. 3.12 PKCδ-KD prevents the interaction between Spry2 and endogenous PKCδ 130 3. 3. 13 Increasing PKCδ-KD levels decrease the endogenous PKCδ-Spry2 interaction 132 3. 3.14 Interaction between...

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Understanding the mechanism of action of protein synthesis inhibitors against mycobacterium

Ngày tải lên : 13/10/2015, 16:41

... '149BA1" %1 33 '1A5BA1 33 33 $D 3 2 3 9F 36 E3 $D 33 9F 36 E3 $D 3 ?3DD 23 3' 1 34 56 738 9ABA3 9F 36 E3 $D 3 ?3DD 23 38 23 FFD 3 33 33 33 322 33 33 $D 3 1 33 '1A5BA1 33 33 $D 3 2 3 9F 36 E3 $D 3 9F 36 E3 $D 3 ?3DD 23 3' 1 34 56 738 9ABA3 9F 36 E3 $D 3 ?3DD 23 3' 1 34 56 738 9ABA3 33 33 33 ...

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Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

Ngày tải lên : 20/02/2014, 11:20

... derivatization of Cys31 and Cys32, the cysteine residues that form the intersubunit disuldes of BS-RNase Briey, MCM (monomeric bis-Cys31,Cys32-S-carboxymethylated-BS-RNase), MCA (monomeric bis-Cys31,Cys32-S-carboxyamidomethylatedBS-RNase), ... inhibitory action of CRI We tested the cytotoxic activity of the monomeric derivatives described above on malignant SVT2-3T3 broblasts by measuring cell survival after 48 h of growth in the presence of ... the absence of 10 or 50 mM ể FEBS 20 03 Disuldes and antitumor action of BS-RNase (Eur J Biochem 270) 1985 Fig Autoradiography of SDS/PAGE runs of the labelled monomeric derivative of BS-RNase...

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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc

Ngày tải lên : 24/03/2014, 04:21

... G4G4G3G and G4G3G were produced by digestion of barley glucan with a 1 ,3- 1,4-bglucanase and puriﬁed [26] The G3G3G3G3G3G, G3G3G3G3G, and G3G3G3G were prepared by formic acid hydrolysis of curdlan ... hydrolysis of laminarioligosaccarides effected by the exo-1 ,3- b-glucanase Substrate (Gn) Km (mM ) 1 03: Vmax (mmol:min21:mg21) 1 03: (Vmax/Km) (min21 : mg21) ln (Vmax/Km) G3G G3G3G G3G3G3G G3G3G3G3G G3G3G3G3G3G ... exo-1 ,3- b-glucanase from T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1 ,3- b-glucanase was studied using laminarin from L digitata with a ratio of 1 ,3- b-...

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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps

Ngày tải lên : 11/08/2014, 12:21

... CH3 CH H CH3 CH3 N C CH3 CH3 H CYP-enzyme CH3 CH CH3 CH O CH O CH3 CH3 CH3 CH3 S CH3 N C N C CH3 CH3 HO N C CH3 CH H CH3 CH3 N C CH3 CH3 H detoxication product toxic oxidation product H2O CH3 ... cytochrome b The reactions inhibited by strobilurin fungicides: OCH3 CH3O O O CH3 CH3 CH3 n CH3 ubiquinone (oxidized form) e- + H+ OCH3 CH3O OCH3 O HO e- + H+ CH3O R OH HO R CH3 CH3 semiquinone ubiquinone ... Stenersen CH3 O C CH2Cl N CH3 O O ofurace GSH CH3 O C CH2OCH2CH3 CH2CH3 acetochlor O CH2Cl N ©2004 by Jorgen Stenersen CH3 O C CH2OCH3 CH3 O N C CH2OCH3 N N CH3 CHCOC2H5 O CH3 CH3 O O oxadixyl...

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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 3

Ngày tải lên : 09/09/2015, 10:19

... of colonies formed in MDA-MB 231 cells, a 83% reduction in MCF-7 cells and only a 36 % down-regulation in T47D cells (Figure 14D) Interesetingly, the extent of inhibition on cologenic ability of ... reduction in the number of colonies formed by MDA-MB- 231 cells expressing the highest level of PPARγ receptor 112 Figure 14: PPARγ agonists reduce colony-forming ability of breast cancer cells ... computed from three experiments *, p

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A proteomics study of chemically induced cirrhosis in rat liver revealed the mechanism of thioacelamide hepatotoxicity 3

Ngày tải lên : 16/09/2015, 17:13

... SR64 CONTROL SR 63 3 ,3, 3,2 ,3, 3,2 ,3, 3,2 SR17 3, 3 ,3, 3 ,3, 3 ,3, 3 ,3, 2 SR18 3, 3 ,3, 3 ,3, 3 ,3, 3 ,3, 2 SR19 2 ,3, 2,2 ,3, 3 ,3, 2 ,3, 3 SR21 2,2,2 ,3, 2,2,1,2,2 ,3 SR22 4 ,3, 3 ,3, 4 ,3, 3 ,3, 2 ,3 84 Chapter 3 week control week ... 6.09e+0 13/ 25 (30 )/ 7 234 7 .3/ 5.07 b Protein Coverage / Sequence Covered 42% 50-60 61-74 82-96 82-97 102-1 13 124- 138 164-181 165-181 186-197 186-197 198-214 298 -30 6 30 7 -32 4 32 5 -33 6 32 5 -33 6 32 7 -33 6 35 3 -36 7 ... 15 (30 )/ 33 % 54459.0/ 7.95 4.748e+004/ 8(72)/ 68719/ 6.1 b Protein Coverage / Sequence Covered 33 % 1-16 23- 36 69-78 99-1 13 114-128 132 - 139 140-156 30 9 -32 1 30 9 -32 2 37 9 -39 5 37 9 -39 5 39 9-410 420- 435 ...

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Period 3: exercises of unit 10

Ngày tải lên : 01/06/2013, 08:47

... to learn! Where are the eggs… were in the fridge A who B where C when D which What was the name of the man….wife became ill and was taken to hospital A who B whom C whose D which I have a book ... which C whom D whose 10 Thank you very much for your letter…you told me a very interesting story of your holiday A on which B which C in which D to which Answers: A D A 10 C Homework (2m) - Ask...

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MECHANISM OF THE REACTION OF LiAlH4 WITH AN ESTER

Ngày tải lên : 07/06/2013, 01:26

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