3 in the skin
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... reflection index b 31 , 58, 59, 61, 67, 89 and 90 aa) The structurally homologous residues in Mglu (33 4, 33 6 -33 8, 34 4, 419, 420, 422 and 428 aa; nine aa in total) were located near the interface of the ... with the C-terminal domain residues (Asp345, Leu347, Thr352, Gly428 and Asp 435 ) in the physiological dimer in all the structures Therefore, the observed structural difference in the N-terminal ... differences in the interactions across the domain interface All the residues involved here seem to be unrelated to the Trisbinding site residues (including Arg2 23 and Ser227), either directly or indirectly...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... activate p38 MAP kinase in a human intestinal epithelial cell line, HT-29, and promote the transcription of the interleukin-8 gene [42] In line with previous studies, Fig 7A shows that Li induced the ... SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation of Ó FEBS 20 03 GSK -3 and glucose metabolism (Eur J Biochem 270) 38 33 strongly that targeted inactivation of GSK3, using either Li or SB-415286, ... glycogen synthesis in L6 muscle cells during oxidative stress: Evidence for cross-talk between the insulin and SAPK2/p38 MAP kinase signalling pathways J Biol Chem 274, 36 2 93 36 299 Ó FEBS 20 03 32 Bradford,...
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Báo cáo khoa học: Identification of preferred substrate sequences for transglutaminase 1 – development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin pot
... frequently observed in involucrin, trichohyalin and small proline-rich proteins, and has been implicated as a putative cross-linking site in these proteins [32 ,36 ,37 ] Sequences homologous to the motif ... 2, and 5) are expressed in keratinocytes [ 13 18], and are involved in cross-linking of the structural proteins to form the CE at distinct intracellular sites [8,18] In the current model of TGase ... CE comprises several proteins, including involucrin, loricrin, trichohyalin and small proline rich-proteins, that are preferred substrates for TGases in the skin Of the eight TGase isozymes,...
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Báo cáo khoa học: Identification of an antibacterial protein as L-amino acid oxidase in the skin mucus of rockfish Sebastes schlegeli pot
... glycoprotein consisting of 75-kDa subunits by SDS ⁄ PAGE, partly because of the scarcity of the protein of interest In this study therefore we isolated the antibacterial protein, SSAP, from the skin ... aplysianin A) [27], and the ink of the sea hare, A californica (termed escapin) [33 ] LAO family members possess in common flavin as a coenzyme and two motifs, a dinucleotide-binding motif comprising ... [22] 134 Determination of protein Protein was determined by the micro bicinchoninic acid method [39 ] using BSA as a standard protein Acknowledgements This study was partly supported by a Grant-in...
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Báo cáo khoa học: "Immunolocalization of anion exchanger 1 (Band 3) in the renal collecting duct of the common marmoset" pptx
... and in vesicles in the basolateral parts of the cytoplasm (A-C) The intensity of the band immunoreactivity of the basolateral plasma membrane in the CCD and OMCD cells is stronger than that in the ... immunolabeling of the basolateral plasma membrane was more intense in the CCD and OMCD, whereas immunolabeling of intracellular vesicles was more intense in the CNT In addition, we found that there ... immunolabeing in the mitochondria of type A interacted cells From these observations, we suggest that type A interacted cells of the CNT accumulate band protein in small transport vesicles in the inactivated...
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Báo cáo khoa học: " Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine" docx
... expressed in the intestinal epithelium The intense staining patterns of galectin -3 in the villous lamina propria (Fig 2D) largely overlapped with the acid-fast staining (Fig 2C) The rpoB DNA (36 8 bp) ... death In contrast to the increase of galectin -3 in macrophages during paratuberculosis, galectin -3 decreases in the intestinal epithelia of animals with intestinal bowel disease [19], suggesting ... granulation tissues in the intestines with a varying degree of inflammation The histological findings in three cases were similar Briefly, the lamina propria and submucosa of the small intestine was thickened...
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Báo cáo khoa học: "Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast" pdf
... staining with antibodies directed against fibrin-stabilizing factor XIII A, S-100 protein, smoothmuscle actin or cytokeratins AE1/AE3 On the other hand, the immunohistochemical profile of the ... cosmetic result, following this second resection The lesion was excised, including a wide cm margin of normal looking skin, under local anesthesia and the defect was closed primarily The histological ... positive for CD34 Additionally, immunostaining using CD34 as a marker is helpful in identifying tumor cells at the surgical margins, particularly when treating recurrent DFSP, in which tumor...
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báo cáo khoa học: "The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation" pps
... characteristic methyl bands shielding or to the dissolution of certain groups during the process of obtaining the nanoemulsion In the case of the bands group in the range of 1150-1250 cm-1, characteristic ... stretching), an increase in the intensity of the bands is observed, which is reflected in the decrease of its transmittance from 96% to 56% This is also explained by the increasing of the quantity ... v/v to 35 % v/v in the nanoemulsion High lycopene content of 35 % has the effect of increased intensity of certain bands at 1450 cm-1 (-CH3 and CH2 = strain) reflected in the decrease of the transmittance...
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Báo cáo y học: "Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis" pps
... CD1 63+ and CD204+ in SSc skin, without changing the total number of macrophages To answer the question why the infiltration of activated macrophage is increased in SSc skin, we then examined ... analysis We suggest that CD1 63+ or CD204+ macrophages in the skin and the CD14brightCD1 63+ CD204+ monocyte subset in the peripheral circulating blood are involved in the pathogenesis of SSc Page ... collagen bundles in the skin of SSc patients (Figure 1) When the cell number in randomly selected areas (per 10,000 μm2) was counted, the number of CD68+, CD1 63+ or CD204+cells in the skin of SSc patients...
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Báo cáo y học: "Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model" potx
... much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and destruction of bone and cartilage in the synovial joint [ 23] The present ... joints and if appropriately applied to patients with acute arthritic pain [32 ] There was significantly less bradykinin found in the crystal-induced arthritic joint after injection of HA [33 ] ... accumulation of inflammation-induced HIF-1a, iNOS, and MMP3 expressions in the synovium may be involved in the therapeutic mechanism of HA intervention used in the treatment of RA Further molecular studies...
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Expression pattern and functions of dihydropyrimindase like 3 in the rodent microglia
... 21 1. 13 Expression of Dpysl3 in different cell types 21 vi 1. 13. 1 Dpysl3 in the developing nervous system 21 1. 13. 2 Dpysl3 in adult nervous system 22 1. 13. 3 Dpysl3 in the peripheral ... developing rat brain 62 3. 2 Expression of Dpysl3 is increased in activated microglia 62 3. 2.1 In LPS injected rat brains 62 3. 2 .3 Activated microglial cultures 63 3 .3 Distribution ... Dihydropyrimidinase like -3 (Dpysl3) or Collapsin response mediator protein-4 (CRMP4) - Gene Ontology predictions The molecular function of Dpysl3 includes SH3 binding domain, chondroitin sulfate binding...
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Report Development Tools Building Custom Reports in the R/3 System
... 3 36 Consider Background Processing 3 37 Copy Before You Create 3 37 Use Variation 3 37 Naming Conventions 3 37 Review 3 38 ... 3 31 Display Periods of Quarter q 3 32 Display Periods of a Quarter Containing Period p 3 33 Display Variable Number of Columns for Periods p1 to p2 3 33 Working ... Interface 3 28 Background on Using the Report/Report Interface .3 30 Report/Report Interface 3 30 Working With Formula Variables 3 31 Rolling Periods: Fixed...
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Fill in the gaps 3
... could be used in place of the language shown in bold without changing the meaning of the sentence Remember that you may need to change the form or in some cases the grammatical class of the word: ... night to finish their work, but it is impossible to maintain this for very long and so it is not recommended _ One of the main causes of the increase in inner-city lawlessness is the number ... conform… The Pope in Rome is – according to the doctrine… Cars are not allowed to enter many civic… The police accompanied… The film was made on a very low budget, so all the minor… Mercury is the...
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Tài liệu Personal Web Usage in the Workplace: A Guide to Effective Human Resources Management Part 3 docx
... provided their employees Internet access in the workplace Forty-six of these companies were in the service sector, whereas the remaining were in the manufacturing sector These companies ranged in size ... work 831 151 -.04 1 43 814 111 137 04 784 122 229 130 778 164 206 1 13 692 130 09 194 034 808 036 195 099 792 171 092 157 759 147 010 027 749 0 43 325 105 08 781 2 53 140 03 767 118 133 126 636 252 ... 4 .30 1.74 1.86 4.14 1.82 3. 92 1.70 3. 89 3. 83 2.16 1.89 3. 70 1. 73 3.60 1.69 3. 55 1.65 3. 09 1.55 2.91 1.58 Copyright © 2004, Idea Group Inc Copying or distributing in print or electronic forms without...
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Tài liệu Color Atlas of Pharmacology (Part 3): Distribution in the Body docx
... conditions of license 30 Distribution in the Body Binding to Plasma Proteins Having entered the blood, drugs may bind to the protein molecules that are present in abundance, resulting in the formation ... drug-protein complexes Protein binding involves primarily albumin and, to a lesser extent, !-globulins and acidic glycoproteins Other plasma proteins (e.g., transcortin, transferrin, thyroxin-binding ... resupplied from binding sites on plasma proteins Binding to plasma protein is equivalent to a depot in prolonging the duration of the effect by retarding elimination, whereas the intensity of the effect...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory ... investigated whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound ... might in uence the disease process in AD 2 936 Role of the neurite growth-inhibitory properties of GIF in AD There have been extensive studies examining the role of GIF in AD, linked to its initial...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... 13 (green), the TF-interactive helix and the 170 loop (red), and the covalently attached inhibitor fFR-cmk (purple) The hydrogen bonds from Gly372(2 23) to Arg315(170C) and Ser -33 3(185) are indicated ... located in the vicinity of the active site and sensed by the peptidyl substrate are inuenced, in contrast to the remote exosites, e.g in the vicinity of the activation pocket, that affect FX binding, ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active...
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Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... 24 .3% }, 73 {[Si(CH3 )3] +, 98.4%} 31 1 (M+, 30 .6%), 296 (M+-CH3, 100%), 266 (M+-CH3 · 3, 39 .3% ), 238 [M+-Si(CH3 )3, 11.7%], 222 [M+, Si(CH3 )3- O, 62.7%], 194 [M+-COOSi(CH3 )3, 39 .3% ], 147 {[(CH3)2¼O-OSi(CH3 )3} +, ... (M+-CH3, 100%), 436 (M+-CH3 · 2, 0. 53% ), 421 (M+-CH3 · 3, 0. 53% ), 37 7 [M+-OSi(CH3 )3, 0.64%], 36 3 [M+-Si(CH3 )3- CH3 · 2, 4.8%], 299 (M+-C6F5, 65.1%), 195 ([C6F5N2]+, 8.7%), 147 {[(CH3)2¼O-OSi(CH3 )3] +, ... analysis, and the determination of released ammonia The coupled enzyme assay revealed the mechanism of the deamination reaction and the subsequent metabolism, including the deamination step The product...
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Tài liệu Báo cáo khoa học: Involvement of two positively charged residues of Chlamydomonas reinhardtii glyceraldehyde-3-phosphate dehydrogenase in the assembly process of a bi-enzyme complex involved in CO2 assimilation doc
... Chlamydomonas reinhardtii phosphoribulokinase in the information transfer between glyceraldehyde -3- phosphate 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 dehydrogenase and phosphoribulokinase Eur ... for the binding of CP12 The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic changes observed for the binding of the substrate when the wild-type recombinant ... Lys involvement in GAPDHCP12PRK formation (Eur J Biochem 271) 4 739 Rossman fold (residues 1147 and 31 333 4 in spinach GAPDH (accession code in PDB:1JN0), the other being the catalytic domain (residues...
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Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx
... though it did contain one ADPbinding motif This suggests the ADP-binding motif in the a1 subunit mediates the observed ATP binding, and FMN is likely situated at the interface between the a1 and b1 ... suggests that the ADP-binding motif in the b1 subunit mediates FAD binding On the other hand, FMN was not detected bound to either subunit (Fig 5B,C) We also extracted the flavin compounds from the native ... two ADP-binding motifs [6] spanning residues 120–149 and 271 30 0 (Fig 3) [3] The a1 subunit of PDH1, by contrast, contained only one ADP binding motif spanning residues 108– 136 (Fig 3) , which...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose