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2 13 bioluminescent images of tumor growth in representative animals the heat map represents the tumor area and color represents the intensity abbreviations d dorsal v ventral

Development of new neural stem cell based tumor targeted gene therapy approaches

Development of new neural stem cell based tumor targeted gene therapy approaches

Thạc sĩ - Cao học

... CD40L-blocking antibody LL48 abolished these antitumor effects in vitro and in vivo, indicating the dependence on CD40 in these treatments In contrast, - CD40L is ineffective in altering the growth ... constructed in our previous study The viruses were produced and propagated in Sf9 insect cells according to the manual of the Bac-to-Bac Baculovirus Expression System (Invitrogen) Budded viruses in the ... cassette of the CMV-driven VSV-G(H162R) gene was inserted into the pFastBac1 (Invitrogen) backbone plasmid This new construct was used to produce a baculovirus (BV.VSVG) that could mediate VSV-G(H162R)...
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WiX 3.6: A Developer''''s Guide to Windows Installer XML doc

WiX 3.6: A Developer''''s Guide to Windows Installer XML doc

Hệ điều hành

... ifdef ifndef Iterations Errors and warnings Preprocessor extensions Light.exe Command-line arguments (linking) 25 1 25 1 25 2 25 2 25 2 25 2 25 2 25 2 25 3 25 3 25 3 25 3 25 3 25 3 25 4 25 5 25 5 25 5 25 6 25 6 25 7 ... 25 7 25 8 25 8 26 4 26 5 -b 26 5 -bf 26 5 -binder 26 5 -cultures 26 6 -d 26 6 -dut 26 6 -ext 26 6 -loc 26 6 -nologo 26 6 -notidy 26 7 -o[ut] 26 7 -pedantic 26 7 -sadmin 26 7 -sadv 26 7 -sloc 26 7 -sma 26 7 -ss 26 8 ... 27 0 -cub 27 0 -dcl:level 27 0 -eav 27 0 -fv 27 0 -ice 27 1 -pdbout 27 1 -reusecab 27 1 -sa 27 1 -sacl 27 1 -sf 27 2 -sh 27 2 -sice: 27 2 -sl 27 2 -spdb 27 2 -sval 27 2...
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How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese

How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese

Quản trị kinh doanh

... reading them, children have an opportunity to better their understanding of different cultures, and they learn to appreciate precious humane and moral values Second, the innocence and naivety of ... such thing as a dead metaphor II .2. 3 .2. Metaphor and idiom 21 21 The Cambridge dictionary defines Idiom is a group of words whose meaning considered as a unit is different from the meanings of each ... books- of childrens favorites of all time with millions of copies have been sold over the world In other words, millions of 29 29 children of different generations have enjoyed reading the wonderful...
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Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt

Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt

Báo cáo khoa học

... D1 G 42 G8 02 G3*G3Š D2 Št ¼ D2 Š þ D2 G 42 Š þ D2 G 42 G8 02 Š þ D2 G 42 G 42 Š þ D2 G 42 G8 02 G 42 Š þ D2 G 42 G8 02 G 42 G8 02 Š þ D2 G 42 G8 02 G3*Š þ D2 G 42 G8 02 G3*G3*Š þ D2 G 42 G8 02 G3*G 42 Š þ D2 G 42 ...  D2 G 42 G8 02 G3*G 42 Š þ  D2 G 42 G8 02 G3*G3*G 42 Š þ  D2 G 42 G8 02 G 42 G8 02 Š þ  D2 G 42 G8 02 G3*Š þ  D2 G 42 G8 02 G3*G3*Š þ  D2 G 42 G8 02 G3*G 42 Š þ  D2 G 42 G8 02 G3*G3*G 42 G8 02 Š þ  D2 G 42 ...  D2 G 42 G8 02 G 42 Š þ  D2 G 42 G8 02 G 42 G8 02 Š þ  D2 G 42 G8 02 G3*Š þ  D2 G 42 G8 02 G3*G3*Š þ  D2 G 42 G8 02 G3*G 42 Š þ  D2 G 42 G8 02 G3*G3*G 42 Š þ  D2 G 42 G8 02 G3*G 42 G8 02 Š þ  D2 G 42 G8 02 G3*G3*G42...
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An integration of the four english skills in teaching reading texts to beginner learners at asemlink international language centre

An integration of the four english skills in teaching reading texts to beginner learners at asemlink international language centre

Khoa học xã hội

... the integration of Reading with other skills 26 2. 5 .2 The integration of reading with other skills 28 2. 5 .2. 1 Reading integrated with Listening 28 2. 5 .2. 2 Reading integrated with ... interesting, motivating and effective for the students 2. 5 .2 The integration of reading with other skills 2. 5 .2. 1 Reading integrated with Listening Reading and Listening are receptive skills They ... reading approach to reading and applying reading and writing components Jeanette and Moseley state it in the preface of their book as follow: “ today the idea of integrating writing and reading...
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How to get out of the friendzone: turn your  friendship into a  relationship

How to get out of the friendzone: turn your friendship into a relationship

Tâm lý - Nghệ thuật sống

... house in the Hollywood Hills Out by the infinity pool, a very intoxicated guy was loudly complaining about not getting a date We both started doling out advice, and by the end of the night, we had ... differently But then there you go again, doing the same thing day after day and wishing for a different ending You feel kind of addicted to your friend, like the way you’re addicted to curly fries, ... tired of hearing the same thing over and over again They cringe when you talk about your friend You’re the friend who needs an intervention They shake their heads and mouth the words “Friend Zone”...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Sức khỏe giới tính

... regarding the longevity of the Oarsmen of either University may be found 2 2 20 UNIVERSITY OARS in the Appendix These Tables are intended to shew by how many years each crew, and indeed every individual ... as landmarks in the history of their academic discipline Drawing from the world-renowned collections in the Cambridge University Library, and guided by the advice of experts in each subject area, ... county Directories Twenty-seven of the Oars had, however, gone abroad, or emigrated, and were either residing in our Colonies or in other parts of the world, and the only method I could discover of...
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A Review of Approaches to Mobility Telemonitoring of the Elderly in Their Living Environment potx

A Review of Approaches to Mobility Telemonitoring of the Elderly in Their Living Environment potx

Sức khỏe người cao tuổi

... to the decision-making process used when selecting a therapy The clinician examines the advantages and disadvantages of employing telemonitoring, and also examines the advantages and disadvantages ... remain unattended in the event of an accident The increasing use of telemonitoring to support independent living inside and outside of the home inevitably raises many ethical questions regarding ... worn under the subject’s armpit The data from this module is processed by embedded software and can distinguish between activity, a fall, and standing, lying, and bending postures The VTAM shirt...
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Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt

Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt

Báo cáo khoa học

... oligosaccharide-binding (OB) domain and the additional N- and C-terminal regions in PolC and DnaE, respectively The PolC proofreading 3¢–5¢ exonuclease domain is inserted into the PHP domain and is an integral ... OB domain may play a similar role in binding the incoming template in both PolC and DnaE The ability to bind single-stranded DNA has indeed been demonstrated for the E coli DnaE OB domain [ 12, 16] ... acid) involved in nucleic acid binding Two other profile-based methods, coma [22 ] and compass [23 ], also matched the second half of the PolC N-terminal region with PolIIIs -V and DnaA-I, producing...
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JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx

JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx

Du lịch

... however, and in doing so to confine attention to whether there is a sufficient link between the order and the main findings complained of in the Report, those in paragraph 377 At the beginning of ... obtain a setting aside of the findings under s (2) of the Judicature Amendment Act 1977 they have to show in addition that the findings were made in the exercise of a statutory power of decision ... would turn left in order to fly over Scott and McMurdo bases and in the vicinity of Ross Island so that a view would be obtained of Mt Erebus and the other three mountains there When the decision...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Báo cáo khoa học

... expression of p-Akt in vitro, consistent with the above in vivo findings PI3K/Akt is involved in PrPC-mediated MDR in gastric cancer In order to study whether activation of the PI3K/Akt signaling pathway ... added and the mixtures were incubated for h Dimethylsulfoxide was used for the negative control Cells were harvested, or cultured in drug-free medium for another 30 and then harvested The harvested ... were immunostained using SP-9000 Histostain-Plus kits The slides were deparaffinized, rehydrated, blocked and then primary antibody was added as described previously [7] Biotinylated goat anti-mouse...
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To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf

To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf

Ngân hàng - Tín dụng

... 12 10 -2 2006 20 07 20 08 20 09 20 10 20 11 20 00 20 12 Peru 20 01 20 02 2003 20 04 20 05 20 06 20 07 20 08 20 09 20 10 20 11 20 12 2011 20 12 12 20 02 2004 20 06 20 08 20 10 20 12 Uruguay 2 -3 -8 -1 -13 20 07 20 08 20 09 ... -2 -4 -6 20 00 20 02 2004 20 06 20 08 20 10 20 12 Colombia 20 00 20 02 2004 20 06 20 08 20 10 20 12 Mexico 20 00 20 02 2004 20 06 20 08 20 10 20 12 Peru 20 01 20 02 2003 20 04 20 05 20 06 20 07 20 08 20 09 20 10 20 11 20 12 ... shown by red dotted lines Source: Authors' calculations 20 12 20 02 2004 20 06 20 08 20 10 20 12 2004 20 06 20 08 20 10 20 12 2004 20 06 20 08 20 10 20 12 2004 20 06 20 08 20 10 20 12 Uruguay 20 00 20 02 Dominican Republic...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Báo cáo khoa học

... malonyl-CoA inhibition and highaffinity binding [20 ,22 ], indicating the presence of a different positive domain (residues 18 28 ) and the absence of a negative determinant, which correlates with the characteristic ... malonyl-CoA sensitivity J Biol Chem 28 1, 329 46– 329 52 22 Shi J, Zhu H, Arvidson DN & Woldegiorgis G (20 00) The first 28 N-terminal amino acid residues of human 21 8 23 24 25 26 27 28 29 30 31 32 heart muscle ... digested with ApaI and HindIII, taking advantage of the presence of the ApaI restriction site in the pGEMT polylinker and the HindIII site at position + 523 of pig CPT1B cDNA The inserts (548 and 518...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc

Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc

Báo cáo khoa học

... Wild-type D1 SD 2D3 D1 D2SD3 D1 D 2D3 S D1 SD 2D3 S D1 D2SD3S D1 SD2SD3 D1 SD2SD3S 151 178 109 163 138 137 173 54 100 123 96 104 90 1 12 123 52 3.1 2. 9 2. 1 2. 5 3.0 1.6 2. 5 3.0 2. 2 2. 1 1.9 1.6 2. 0 1.4 1.7 2. 9 ... constructed: D1 SD 2D3 , D1 D2SD3, D1 D 2D3 S, D1 D2SD3S, D1 SD2 D3 S, D1 SD2SD3 and D1 SD2SD3S (where the subscript S corresponds to the C fi S mutant and no subscript corresponds to a wildtype domain) Expression ... compilation ª 20 08 FEBS G G Hoffman et al compared with D1 D2SD3S and D1 SD2SD3, and the similar kcat values seen in D1 D2SD3S and D1 SD2SD3 Given the wealth of structural data available, it is surprising...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học

... PDZ3 SH3 DVRD255 QSVD397 Identification of hDlg caspase-cleavage sites B GUK YEVD747 Control Sorb UV-C hDlg(WT) Tubulin hDlg (D2 55A) Tubulin hDlg (D3 97A) Tubulin hDlg (D2 55A /D7 50A) Tubulin hDlg (D7 47A) ... attachment and (B) caspase activation were measured as indicated in Materials and methods, at the times indicated – (A) and h or (B) and h – in nontransfected and hDlg wild-type or hDlg D3 97A or hDlg D7 47A ... activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 Biochem J 339, 319– 328 29 Durocher Y, Perret S & Kamen A (20 02) High-level and...
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Report to the Congress on Practices of the Consumer Credit Industry in Soliciting and Extending Credit and their Effects on Consumer Debt and Insolvency pot

Report to the Congress on Practices of the Consumer Credit Industry in Soliciting and Extending Credit and their Effects on Consumer Debt and Insolvency pot

Ngân hàng - Tín dụng

... included MasterCard and Visa offline debit cards Includes general-purpose cards with a revolving feature issued with the Discover, MasterCard, and Visa brands For the years 1999 20 01, included MasterCard ... Technological advances are continually reducing the unit costs of data processing and telecommunications, and they have in turn greatly expanded the ability of creditors to offer Board of Governors of the ... issued with the Discover, MasterCard, and Visa brands; travel and entertainment cards with the American Express brand; and cards issued in the name of retail outlets For the years 1999 20 01, included...
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Report and Recommendations Pursuant to Section 133 of the Emergency Economic Stabilization Act of 2008: Study on Mark-To-Market Accounting doc

Report and Recommendations Pursuant to Section 133 of the Emergency Economic Stabilization Act of 2008: Study on Mark-To-Market Accounting doc

Kế toán - Kiểm toán

... study before the end of the 90-day period beginning on the date of the enactment of this Act containing the findings and determinations of the Commission, including such administrative and legislative ... advisable Such additional measures to improve the application should include addressing the need for additional guidance for determining fair value in inactive markets (including examining the ... financial information available to investors; (4) the process used by the Financial Accounting Standards Board in developing accounting standards; (5) the advisability and feasibility of modifications...
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Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx

Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx

Báo cáo khoa học

... synthesized d- Ala sulfamoyl adenylate analog in vitro and in vivo and show the efficiency of this molecule in blocking DltA activity in vitro and in vivo Characterization and inhibition of the Dlt system ... subtilis JH642DdltA (B) using vancomycin and the inhibitor The presence (+) and absence (–) of (I) and vancomycin (V) are indicated and the concentrations used are at mM and vancomycin at 0.4 nM ... and 25 .06 min; ACP, 21 . 02 and 21 .76 The amount of holo-DltC formed was determined by comparing the peak area of the holo-DltC formed with those of both apo- and holo-DltC and substracting the...
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Báo cáo sinh học:

Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx

Điện - Điện tử

... assisted in experimental work and drafting of the manuscript Abdel-Moneim conceived the study, designed and carried out the experimental work and drafted the manuscript All authors read and approved ... SOD in poxvirus-infected cells might disrupt the balance of oxidants and antioxidants Superoxide radicals arise during numerous oxidations in both living and nonliving systems and can act directly ... parvum and preparations of pox viruses in various in vivo and in vitro tests Zentralbl Veterinarmed B 1986, 33: 321 -339 Morel AS, Quaratino S, Douek DC, Londei M: Split activity of interleukin-10...
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