1—inventory the biological resources of the lagoons
Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
Ngày tải lên :
08/03/2014, 08:20
... structures of the b-amino acids that best fit are shown in Fig They all correspond to gauche(+) values of the h angle The methyl group of b2-HAla occupies a position close to that of CH2b of Pro or the ... Conversely, the methyl group of b3-HAla occupies a position similar to the pro R methyl of Aib, on the opposite side of the pyrrolidine ring of Pro A parallel can be drawn regarding the differences in biological ... of a-amino acids) has recently been applied to the syntheses of linear tetrapeptides of somatostatin [20] and of cyclic tetrapeptide and pentapeptide analogues of the RGD sequence [19] With the...
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THE LIVING MARINE RESOURCES OF THE WESTERN CENTRAL PACIFIC Volume 1. Seaweeds, corals, bivalves and gastropods
Ngày tải lên :
23/05/2014, 14:55
... axis of the shell whorls or columella may be hollow, forming at the base of the shell an opening, the umbilicus The base of shell is formed by the largest spiral turn or body whorl, while the other ... published for the Mediterranean and Black Seas in 1972 Both these publications were important compilations of the state of the art knowledge of the taxonomy of the major groups of marine organisms ... expansion of the dorsal part of a shell Equilateral - the condition of a valve when growth on either side of umbo is symmetrical Equivalve - the condition of a shell when valves are of the same...
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Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine
Ngày tải lên :
16/09/2015, 08:31
... Especially noteworthy is the convergent nature of this synthetic strategy and the incorporation of all the necessary functionalities in the early stages of the synthesis The procedure developed ... vascular system iv Screening of this library of simpler fragments obtained during the process of the total synthesis compounds has resulted in the discovery of other potent compounds This simple ... confirm the stereochemistries of C4 and C5 In our group, we have been working on the synthesis of the isomers of C4 and C5 as NOE studies of large rings is known to be unreliable.9 Later, the NMR...
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A STUDY ON THE RELIABILITY OF THE FINAL ACHIEVEMENT COMPUTER-BASED MCQS TEST 1 FOR THE 4TH SEMESTER NON - ENGLISH MAJORS AT HANOI UNIVERSITY OF BUSINESS AND TECHNOLOGY
Ngày tải lên :
10/04/2013, 14:46
... candidate for the degree of Master of Arts (TEFL) accept the requirements of the College relating to the retention and use of Master of Arts Thesis deposited in the library In terms of these conditions, ... reduce the reliability of the test scores On the basis of these results, the author provides some suggestions towards the improvement of the test quality The reliability of the final achievement ... Hc: the number of correct response in the high group Lc: the number of correct response in the low group The optimal size of each group is 28% of the total sample For very large samples of examinees,...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... conditions [22] In the traumatically injured brain, however, the synthesis of MT1 and MT2, as well as the synthesis of GIF, are up-regulated by reactive astrocytes in the vicinity of the lesion [23] ... processes of these cells Astrocytic synthesis of GIF is mainly found in the cortex, brainstem and spinal cord [6] Additionally however, there are also consistent reports of neuronal synthesis of GIF, ... partly explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory...
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Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
Ngày tải lên :
18/02/2014, 17:20
... conformation and biological function For example, only N-glycans located on either the b-propeller of a5 [55] or the I-like domain of b1 or b3 [68] contribute to the regulation of integrin function Therefore, ... Downregulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene Modulation of the biosynthesis of terminal ... modification of particular sites, which are involved in regulation of the conformation of integrin, determine the extent of cell migration Promoting cell migration P UD Asn P- UD V TGn Inability of synthesizing...
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Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx
Ngày tải lên :
19/02/2014, 07:20
... arrangement, and the side chain of Ser97 in VPRK is too short One side of the loop is involved in the binding of the P2–P4 residues of a substrate The other side of the loop is close to Arg94 (Lys ... a residue forming a part of the S2 site of the enzyme The disulfide bridge restricts the flexibility of a tight loop which is part of the S2 site The tight loop is further stabilized by a tight ... atoms of Thr3 Another interesting feature is that the direction of the main chain of the tripeptide is antiparallel to the naturally occurring inhibitors It was first speculated whether the C-terminal...
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Tài liệu Báo cáo khoa học: The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB pdf
Ngày tải lên :
19/02/2014, 16:20
... Fragments of HSQC and HMBC spectra of compound Labels illustrate assignment of the amide linkage between the amino group of Asp and the carboxyl group of GalA residue E Scheme The structures of oligosaccharides ... branching information [31] The charge state of a fragment ion is then identified by using the isotope profile, owing to the high resolution provided by the TOF mass analyser The product-ion spectrum ... 1436.42, owing to the loss of the branching xylose residues M and O, and of GlcA residue L The remaining linear sequence, consisting of K-B-F-I-D-N-Q, was confirmed by the observation of Ó FEBS 2004...
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Tài liệu Báo cáo khoa học: Moult cycle-related changes in biological activity of moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) in the crab, Carcinus maenas From target to transcript ppt
Ngày tải lên :
21/02/2014, 00:20
... investigated the biological activity of MIH and CHH during precisely timed stages of the moult cycle of Carcinus to determine changes in: (a) potency of these peptides in repressing ecdysteroid synthesis; ... levels in the XO, and peptide levels in the SG during these significant stages of the moult cycle, as these are of fundamental importance with regard to the currently accepted model of moult control ... products of the YO, ecdysone and 25-deoxyecysone Inhibition of 3-dehydroecdysone synthesis was not measured, but this is a minor secretory product of Carcinus YO [11] Loss of sensitivity of YO to the...
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Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx
Ngày tải lên :
22/02/2014, 04:20
... molecular mass of 62 000 in the lane with the wild-type extract that was absent from the lane corresponding to the mls1D mutant (arrow; Fig 1A), thereby con®rming the speci®city of the antibody ... involved in the glyoxylate cycle is attributed to the cytosolic isoform Mdh2p [7] The suggestion of an extra-peroxisomal location for the yeast glyoxylate cycle was further reinforced by the demonstration ... 5A) The results demonstrated that the mls1D mutant failed to grow on ethanol or acetate However, expression of either of the two Mls1p constructs complemented the mls1D mutant phenotype on these...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
Ngày tải lên :
07/03/2014, 05:20
... consisted of a linker (Glc-Kdo2)-lipid A structure The phenotype of this mutant was examined to investigate the roles of different moieties of the LOS molecule in biological activities of the M catarrhalis ... construction of the lgt3 mutant in M catarrhalis O35E Large arrows represent the direction of transcription; the site of the transposon insertion identified in the O35E is denoted as EN:TN, and the location ... groups Among the other ions m ⁄ z of 2654.8, 2694.8 and 2717.4 indicates the presence of the anhydro form and mono- and di-sodiated form of the molecular ion 2672.8 (Fig 4A) Among other characteristic...
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Báo cáo khoa học: A kinetic approach to the dependence of dissimilatory metal reduction by Shewanella oneidensis MR-1 on the outer membrane cytochromes c OmcA and OmcB potx
Ngày tải lên :
07/03/2014, 09:20
... characterized by IC50s of 10.7 lm and 81.4 lm for inhibition of OmcA and OmcB, respectively Modes of inhibition of either OmcA or OmcB by V(V) The modes of inhibition of either OmcA- or OmcBdependent ... anaerobic growth on either of the electron acceptors U(VI) and Se(VI) is due to the decaheme cytochromes c not recognizing either of these electron acceptors, we probed the relative affinities ... acceptor These results therefore provide evidence that there are differences between the electron transfer pathways towards chelated Fe(III) on the one hand and either U(VI) or Se(VI) on the other...
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Báo cáo khoa học: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals doc
Ngày tải lên :
07/03/2014, 11:20
... [40], indicating that the side effect of the activation of GAR-3 is limited Furthermore, the phenotype of gar-3 loss -of- function mutants is almost wildtype with the exception of a faster pharyngeal ... similar Ga in mammals The amino acid sequence of GOA-1 is 82.2% identical to that of Gao Although the similarity of the aA–aE region and the region upstream of a4 was relatively low, the N-terminal ... in the presence of 0.2 mM atropine; solid line, in the absence of atropine atropine (Fig 3A), suggesting that carbamylcholine induced the substitution for GTPcS in GOA-1 The IC50 value of the...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
Ngày tải lên :
07/03/2014, 21:20
... modifications of chromatin [9] Little is known, however, of the functional role of the remaining subclass members In this study, the yeast protein SPP1 (alias cps40), a member of the COMPASS complex ... constitute CGBP homologues The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII ... in the tree (Fig 1), the branch of the FEBS Journal 272 (2005) 3505–3511 ª 2005 FEBS A M Rojas et al fungal sequences is clearly distant from the other branches, which was indeed predicted The...
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Báo cáo khoa học: Conformational and functional analysis of the lipid binding protein Ag-NPA-1 from the parasitic nematode Ascaridia galli potx
Ngày tải lên :
16/03/2014, 18:20
... in cells of the inner hypodermis and the epithelium of the oviduct as well as extracellularly in the pseudocoelomic cavity of the worms Discussion A bundle of four a-helices constitutes the secondary ... staining of the pseudocoel (ps) especially in the vicinity of the uterus (ut) with developing eggs (C) Strong labeling of the oviduct (ovi) next to the unstained ovary (ov) in A suum (D) Section of the ... determined by the mutual spatial orientation of the transition dipole moments of the donor and acceptor As no data on the spatial orientation of the transition dipole moments of the chromophores...
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Báo cáo khoa học: Functional expression of the quinoline 2-oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P. putida 86-1 Dqor pUF1 and analysis of the Qor proteins doc
Ngày tải lên :
17/03/2014, 10:20
... estimated from Hanes plots Determination of the metal contents of the Qor proteins, and detection of the nucleotide moiety of the molybdenum cofactor The contents of molybdenum and iron were determined ... catalyse the synthesis and insertion of a cytidine dinucleotide cofactor into recombinant Qor as suggested by the release of CMP after hydrolysis of the enzyme, it appears that the assembly of intact ... microwave power of mW Trace B is multiplied by a factor of six to show the small signals of the rapid species in this sample The arrows indicate the position of contribution of the resting species...
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The Biological Basis of Nursing: Clinical Observations ppt
Ngày tải lên :
22/03/2014, 22:20
... existence of the individual The blood has the task of transporting: water and nutrients from the digestive system to the cells; oxygen from the lungs to the cells; carbon dioxide from the cells to the ... valve on the left and pulmonary valve on the right The aorta is the main artery taking blood from the left side of the heart for distribution around the body 31 THE BIOLOGICAL BASIS OF NURSING: ... the mitochondrion, an organelle at the centre of cellular respiration (i.e the powerhouse of the cell), produce ATP from the metabolism of glucose and fat Glucose Glucose is the end product of...
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Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx
Ngày tải lên :
23/03/2014, 11:20
... include identification of these lesions as a strand break, verification of the nature of the 3¢ end, and identification of a satisfactory pathway for repair The XRCC1 component of the XRCC1–DNA ligase ... period Approximately 80% of the repair of the substrate is achieved within at a point where the proteins are dissociating from the DNA Therefore, cross-linking of Pol b and the XRCC1–DNA ligase IIIa ... incubation for the times indicated, proteins involved in repair are cross-linked to the DNA and to each other by the addition of formaldehyde The beads are subsequently washed before reversal of the cross-links,...
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Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot
Ngày tải lên :
23/03/2014, 13:20
... is similar They all show a conformational variability at the tip portion of loop II, with the difference being that the length of the b-strands in NTX-1 is longer than in the others These neurotoxins ... the length of loop I is longer in short neurotoxins The NMR structure of NTX-1 is closest to that of the a-cobratoxin crystal The superposition of these two ˚ structures shows an RMSD value of ... structure is not observed in other long neurotoxins On the other hand, the absence of any NOE between residues 69–73 and other regions of the peptide indicates that there is no structural involvement...
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Báo cáo khoa học: A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin ppt
Ngày tải lên :
23/03/2014, 17:21
... half-time of the reaction (t1/2) that is 12.5fold longer than in the absence of TM, i.e 6810 and 545 s, respectively (Fig 1A) Because of the lower affinity of solulin for thrombin (due to the lack of the ... result in cleavage of the inhibitor and release of active enzyme A decreased overall inhibition rate can thus be the result of a shift of the rate constants of the branched part of mechanism, i.e ... In addition, the reduced affinity of TM for thrombin-VR1tPA is in agreement with the significant contribution of this part of the VR1 loop to the binding of TM by thrombin Binding of the carboxy-terminal...
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