1β cytokine level but enhanced tnf α and il 6 contents in the diabetic kidney without the involvement of nf κb signaling pathway
Báo cáo y học: "Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model" potx
... much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and destruction of bone and cartilage in the synovial joint [23] The present ... plasmocytic infiltration in the synovium and accumulation of HIF-1a, iNOS, and MMP3 were suppressed after intra-articular administration of HA at the early phase of adjuvant-induced inflammation The ... [14- 16] Under the inflammatory conditions of RA, the levels of HIF-1a, iNOS, and MMP3 are significantly higher in synovial fluids in previous studies and thus are implicated in the pathogenesis of...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... steps in the NF B pathway by modifying specific cysteine residues in IKKa and in the p50-subunit resulting in the inhibition of nuclear translocation and DNA-binding to the iNOS promoter Nevertheless ... vs h Furthermore, AS101 treatment attenuated p50 subunit DNA-binding abilities in the iNOS promoter Furthermore, the secretion of the inflammatory cytokine IL- 6, regulated by the NFkB pathway, ... Nevertheless these effects are exerted at different kinetics I At h, AS101 probably enters the nucleus and may interfere with the DNA-binding ability of the NF B complex resulting in the inhibition of iNOS...
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Báo cáo y học: "Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis." potx
... within the TNF and IL- 10 genes may influence mortality rates in patients with sepsis Polymorphisms in these genes may determine the concentrations of proinflammatory and anti-inflammatory cytokines, ... have yielded conflicting findings on the impact on outcome of the two TNF polymorphisms in septic patients In the case of the -308 (G/A) polymorphism, the frequency of TNF- 2 (containing 'A') was ... polymorphisms (the TNF- α- 308 promoter polymorphism, the polymorphism in the first intron of the TNF- β gene, and the IL1 0-1082 promoter polymorphism), after controlling for various confounding variables including...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... mutation of the VTY6 36 motif to AAA6 36 in MT5MMP did not affect the binding of the protease with GRASP55 Previous studies [66 ,67 ] have identified the EWV614 motif in MT5-MMP ICD as comprising an ... sequence for the interaction with the PDZ proteins: Mint-3, AMPA binding protein and glutamate receptor interacting protein (GRIP) It would therefore be interesting to determine whether this motif ... (Fig 6B, lanes 2, and 8) showed a clear interaction with GRASP55 We also tested whether the LLY 660 motif in MT2-MMP, the ILY598 motif in MT3-MMP or the VTY6 36 motif in MT5-MMP could also be involved...
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báo cáo hóa học: " All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2" potx
... rapidly in the spinal cord during sensitization, along with the production of prostaglandins like prostaglandin E2 (PGE2) [1] Interleukin -1β (IL -1β) is also up-regulated following inflammation and induces ... including the brain and the spinal cord [3,5] Retinoids are also present in the brain and spinal cord of adult rats and mice [6, 7] and are involved in functions such as spatial learning and memory ... 3. 46 ATRA 15´ 30´ 60 ´ 90´ Ratio 1.37 1.88 2. 96 3.31 IL -1β 15 30 μM COX-1 α- actin Ratio ATRA COX-1 α- actin Ratio b ATRA μM COX-2 α- actin 24 h COX-2 α- actin c 60 3 .60 90 COX-2 IL -1β 24 3.79 h 4.36...
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Báo cáo y học: "B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial" docx
... (1999) 360 8.0 (2824) 875 .6 (68 3- 260 1) 1008 .6 (3 56- 4038) 3141.8 (723 -66 82) 1580 .6 (1321 .6- 3280) 24 06. 2 (1534- 560 5) 3224.8 ( 168 4- 565 1) 360 8.0 ( 161 0- 560 5) BAFF pg/ml (mean (SD)) (median (range)) IL6 pg/ml ... increased levels of IL- 6 in the skin, serum, and bronchoalveolar lavage fluid of SSc patients suggest a role of this cytokine in promoting fibrosis by enhancing inflammation [11-13] Furthermore, ... suggest that IL- 6 might contribute to the active phase of the disease The decrease in IL- 6 at the systemic levels could be the biological premise of the improvement in skin fibrosis In fact, it...
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Báo cáo khoa học: " Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case of low pathogenicity" docx
... viral shedding and spread, which could inform the decision regarding whether to institute antiviral therapy and help in determining the pathogenicity of the virus, we measured the PLI in four consecutive ... Mallincrodt Diagnostica, Petten, The Netherlands), using a modified in vitro method Ten minutes after injection of the labelled RBCs, transferrin was labelled in vivo, following intravenous injection ... spill-over of 67 Ga into the 99mTc window, obtained by in vitro measurement of 67 Ga, and expressed as counts per minute (CPM) per lung field At 5, 8, 11, 15, 20, 25, 30, 40, 50 and 60 after 67 Ga...
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Báo cáo y học: " Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency" docx
... considerably improved the survival and quality of life of infected individuals (reviewed in [1]) However, the presence of cellular reservoirs that contain latent viruses capable of producing infectious particles ... obstacle to the eradication of HIV-1 in infected patients [3-5] Therefore, a greater understanding of the molecular mechanisms involved in establishment, maintenance and reactivation of viral latency ... expression in latently infected resting CD4+ T cells in viremic versus aviremic HIV-1 infected individuals [ 26] Recently, global gene expression changes in cell lines latently infected with HIV1 and induced...
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focuses on expressions of criticizing in American and Vietnamese e-newspapers in the light of Directness/Indirectness
... analysis and findings Structure of the articles Each of the three main part of an article (the headline, the lead and the body) has its own distinctive style and content 16 4.2.1.1 The headline The ... able to find out the subject and the main verb In this case, subject and main verb are together at the beginning of the sentence, but in other case, they are separated or the writer delays the appearance ... style They give the main points and state the criticism at the top in the headline and the lead paragraph(s) The body of the articles then adds details, statements, and comments from people involved...
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Factors influencing borrower’s behavior and decision making patterns in the success of a micro finance model
... debt financing On the other hand, the individual with low income and savings is more attracted towards debt financing The selection of income group and the means of income are very important The ... evaluate the level of knowledge and interest about micro financing prevailing in the lower income groups The awareness of micro financing may encourage the poor people to empower themselves and contribute ... income but to wait for their increment at the end of each year On the other hand, lower income group running their own businesses are encouraged by MFIs to obtain loans as the capacity building...
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Tài liệu PLEASE GIVE NORBERT WEINER (AND OTHER CURIOUS DEVELOPMENTS IN THE WORK OF JANET ZWEIG) doc
... documents the pattern of shifting individual actions, roles, and responsibilities in public space In all of these works, Arendt’s insistent appeal for thinking and seeing participation in the world ... visitors to the site, individual decisions of these members of the public, and the recycling of tiles placed in the grid, to determine possible life spans of Limited Edition If not incal- Sculpture ... characteristics of life in Minnesota chronicled in the musings of Garrison Keillor on his Prairie Home Companion, as well as in city branding initiatives The evolving collection of almost 200 audio and video...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding protein Targeting sequence Gelsolin Direct or indirect ... with liganded AR to the nucleus In the nucleus, FLNa( 16 24) disrupts interactions between the N- and C-termini of the AR, and interferes with the binding of the coactivator TIF2 267 6 Indirect ... F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ()) Cross-linking proteins Functions as scaffolds for signaling...
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Knowledge and Skill Chains in Engineering and Manufacturing: Information Infrastructure in the Era of Global Communications docx
... Methodologies and tools come available for the model driven building and deploying of information systems and information infrastructures The relevance of architecting for the infrastructure addressed in ... engineering information 22 Knowledge and Skill Chains in Engineering and Manufacturing infrastructure Engineering information infrastructure facilitates rationalized life cycle management of ... include these projects’ contributions, facilitating interchange of ideas within these projects and with others outside of the projects The information infrastructure supportive of improving the...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... neurons in the brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the ... SP9155) Decrease in vasopressin release Increase in the release of ACTH, oxytocin, vasopressin and prolactin Increase in the release of ACTH, oxytocin and prolactin ? ? No effects Increase [52,53] ... hypothalamus The administration of RFRP increases Fos expression in the hypothalamic paraventricular nucleus and in hypothalamic oxytocin neurons, and facilitates the release of ACTH and oxytocin into the...
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Báo cáo khoa học: Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin pptx
... G2 domain Footprint of G2 on gelsolin G4 6 domain Two sites within the G2 domain appear involved in the G2- G4 6 interface in the presence of EGTA (Fig 3) The interaction of these two sites (residues ... actin-binding sites, is in interaction with the C-terminal a-helix of G6 domain The sequence 159–193, including the second actin interface, appears also in interaction with G6 domain Therefore, ... other domains until the gelsolin is fully ÔopenÕ, then additional calcium ions are required to bind actin to G1 and to G4 for severing and capping The details of the latch helix structure in the...
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the mit ress vision and mind selected readings in the philosophy of perception sep 2002
... unaccustomed position of the ngers makes the synthesis of their perceptions impossible: the right side of the middle nger and the left side of the index not ordinarily work together, and if both are ... notion of the number six, the notion of side and that of equality, and link them together in a formula which is the denition of the cube But this denition rather puts a question to us than offers ... certain perspective, the house would not be posited as an autonomous being Thus the positing of one single object, in the full sense, demands the compositive bringing into being of all these...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... cells Cell 20 06, 125(2):315-3 26 Page 16 of 17 (page number not for citation purposes) Journal of Translational Medicine 2009, 7:20 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 Ramalho-Santos ... green I6, H9 and BG01v are names of hES cells lines P denotes the number of passages of the cell lines H9-EB denotes embryoid body (EB) prepared from cell line H9 and the day indicates the time in ... resulted in smaller embryos and immediate postnatal death of animals [67 ], which could due to the deficiency of their roles in the development of the heart, lung, and immune system [66 ] Additionally,...
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báo cáo hóa học: " Aging and selective sensorimotor strategies in the regulation of upright balance" docx
... segmental reflexes organized at the level of the spinal cord, but rather depend on the integration of proprioceptive, visual and vestibular information at many levels of the neuraxis [5-7] Head-based ... responses in both healthy young and old adults Aging affects the interaction of the somatosensory and visual systems on the ability of the CNS to resolve sensory conflicts and to maintain upright ... the decline in the integrity of many postural regulating systems [14- 16] , but its effect on the sensory inputs recalibration process remains to be determined One question of interest is whether...
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báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx
... for infants receiving breast milk for opportunistic infections • Infant feeding counselling • First pentavalent vaccine and other routine child health services and hepatitis B) and early infant ... progressive and marked decline in medication adherence across the perinatal period Although 82% of the mothers initiated medication during pregnancy, only 68 % of the mother-infant pairs ingested the ... group where mothers and infants initiated the intrapartum and postpartum prophylaxis doses, whereas it was 14.2% in the group where mothers, but not their infants, initiated the intrapartum dose...
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Báo cáo hóa học: " Cross-Layer Quality-of-Service Analysis and Call Admission Control in the Uplink of CDMA Cellular Networks" potx
... by [01234 566 666 666 666 665 4321] and illustrates this behavior The buffer is empty after the last packet in the buffer is removed until the arrival of next on-period In each on/off cycle, the buffer ... interfering mobiles MAI includes both intracell and intercell interference resulting from mobiles within and outside the reference cell SINR is a function of the received powers, spreading gains and number ... Compared to the results in [6] , the main contribution here is to calculate the outage probabilities in the environment with the GBN-ARQ scheme The computation of the lengthened activity factors will...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu