1α 25 dihydroxyvitamin d3 in prostate cancer cells effects on ap1 and creb mediated transcription

Báo cáo khoa học: "Calcium metabolism in cows receiving an intramuscular injection of 1,25-dihydroxyvitamin D3 combined with prostaglandin F2?? closely before parturition" doc

Ngày tải lên : 07/08/2014, 18:21

... 0.05 Table shows plasma 1 ,25( OH) D , Ca, iP and Mg concentrations around parturition in cows of 1 ,25( OH) D and control groups Plasma 1 ,25( OH) D concentrations in 1 ,25( OH) D group (391.4 ± 188.9 ... level in control group (57.4 ± 16.2 pg/ml; p < 0.05) 1 ,25( OH) D group showed a marked increase in plasma Ca and iP 2 3 3 3 2 3 3 2 Effect of 1 ,25- dihydroxyvitamin D3 and induced parturition in cows ... in plasma Mg concentration between two groups The increase in plasma Ca and iP concentrations following the 1 ,25( OH) D injection described here was similar to that observed by some previous investigations...

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Báo cáo y học: "1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss"

Ngày tải lên : 25/10/2012, 11:40

... apoptosis of embryonic renal cells (26), breast cancer cells (27, 28), ovarian cancer cells (29), and prostate cancer cells (30) In contrast, some studies also showed 1 ,25- (OH) 2D3 could inhibit apoptosis ... cytokine production by regulating Smad3 and TGF-β pathways and inducing HGF mRNA expression and HGF secretion in renal interstitial fibroblasts (40) So it was possible that 1 ,25- (OH) 2D3 could exert ... Podocyte injury is suppressed by 1 ,25- dihydroxyvitamin D via modulation of transforming growth factor-beta 1/bone morphogenetic protein-7 signalling in puromycin aminonucleoside nephropathy rats Clin...

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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx

Ngày tải lên : 18/06/2014, 18:20

... that A3G in resting CD4+ cells and monocytes are predominantly in its lowmolecular-mass (LMM) active form making these cells refractory to HIV-1 infection [24 ,25] Conversion of LMM to the inactive ... LNCaP cells with XMRV as the source of infectious XMRV Virus infections were performed using cells plated day before infection Cells were at 50% confluency at the time of infection On the day of infection, ... infection, fresh media containing µg/ml polybrene was added to the cells and virus was layered on the cells and incubated for h to allow virus adsorption Cells were then washed once with PBS, and...

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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot

Ngày tải lên : 09/08/2014, 09:20

... Results Antineoplastic efficacy of ionizing radiation and ErPC3 in prostate cancer cell lines In a first step, the anti-neoplastic effects of ErPC3 and ionizing radiation alone were analyzed in three ... combined treatment with ErPC3 and ionizing radiation PC3 cells (A), DU145 cells (B), and LNCaP cells (C) were treated with increasing concentrations of ErPC3 (1-100 µM) and ionizing radiation ... Radiation Oncology 2010, 5:108 http://www.ro-journal.com/content/5/1/108 Page of 12 Figure Combined effects of ErPC3 and ionizing radiation on apoptosis induction in prostate cancer cell lines PC3 and...

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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot

Ngày tải lên : 09/08/2014, 09:22

... irradiation and hormone incubation In combination with irradiation both tested hormones exhibited similar effects on clonogenic survival dependent on the investigated cell line In LNCaP, incubation ... represent one of three assays In controls incubated in FCS containing media and in controls incubated in media with FCS-withdrawal there was a induction of p21 expression The same was seen in cells ... hormonal incubation and control Estrogenic stimulation inhibits p21-induction after irradiation in LNCaP On protein level the expression of p21 was analyzed, as these proteins are involved in...

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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx

Ngày tải lên : 10/08/2014, 10:20

... protein by somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines ... Shandong University, Jinan, 250 012 P.R China 2Department of Urology, Qilu Hospital, Shandong University, Jinan, 250 012 P.R China Ageing Center, School of Nursing, Shandong University, Jinan, 250 012 ... phosphotyrosine phosphatases [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin and Octreotide on XAF1 expression...

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báo cáo khoa học: "Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells" pps

Ngày tải lên : 10/08/2014, 22:20

... postulated on conventional anticancer drugs being currently used [13] http://www.jhoonline.org/content/1/1 /25 Accordingly, we are interested in investigating whether the combination of IFN-α2b and PDF ... activating immune-competent cells such as natural killer cells and cytotoxic T -cells with a concomitant increase in interleukin-1 production [11], indicating stimulation of immune responses A ... citation purposes) Journal of Hematology & Oncology 2008, 1 :25 http://www.jhoonline.org/content/1/1 /25 Figureof combinations of IFN-α 2b and PDF on cell growth Effects Effects of combinations of...

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Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc

Ngày tải lên : 14/08/2014, 08:20

... potency against leukemic cancer cell lines harboring BCR-ABL mutations [9], the clear and imminent need for overcoming imatinib resistance, and the profound clinical benefit demonstrated in clinical ... correlation of its expression with dasatinib sensitivity in cell lines, and being a target of the drug, EphA2 appears to be a strong candidate biomarker for dasatinib in prostate cancer Down-regulation ... expression is not a consequence of cell growth inhibition Rationale for patient stratification in dasatinib prostate cancer trials Based on their differential expression, we reasoned that CK5, PSA, and...

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Báo cáo khoa học: "The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo" docx

Ngày tải lên : 09/08/2014, 09:20

... perifosine alone on survival The result of the colony formation assay was confirmed in the prostate cancer cell line PC-3 (Additional File 1, Figure S1) Perifosine on radiation induced apoptosis and ... http://www.ro-journal.com/content/6/1/39 Page of A Control IR B Perifosine Combined C Control IR Perifosine Combined Actin Cleaved Caspase Control IR Perifosine Combined Figure Effects of perifosine on radiation-induced ... combination therapy in clinical studies Additional material Additional file 1: Figure S1: Radiosensitization of perifosine in prostate cancer PC-3 cells Cells were irradiated in the absence (control)...

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Báo cáo y học: "Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells" ppt

Ngày tải lên : 10/08/2014, 05:21

... out on multiple sections from individual mice and three independent in vivo experiments (F) Hematoxylin and eosin stained sections of the Matrigel plugs (E, endothelial-like cells; T, tumor cells; ... that over-expression of STC-1 in ovarian cancer cells enhanced cell proliferation, migration, and tube formation in vitro and increased the growth of xenograft tumors in mice [29] In this study, ... http://www.jbiomedsci.com/content/18/1/39 Page of Figure Effects of STC-1 and VEGF on HUVEC cell migration (A) Effects of STC-1 on HUVEC migration HUVEC were seeded in triplicate on inserts, and incubated for...

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Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"

Ngày tải lên : 26/10/2012, 09:48

... delivery and targeting systems realizing high local TMZ concentrations in the nuclei of target cells To eradicate the target cells, without considering the HRPC cells resistance against therapeutic interventions ... (Becton & Dickinson, Germany) equipped with a 488nm argon laser and emission filter combinations for red fluorescence (610nm) using the Cell Quest acquisition and analyses software (Becton & Dickinson, ... analysis in metastatic hormone-refractory prostate cancer J Clin Oncol 2007; 25: 3965-3970 Garrett-Mayer E, Parmigiani G, Zhong X, Cope L, and Gabrielson E Cross-study validation and combined analysis...

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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974

Ngày tải lên : 26/10/2012, 09:48

... The study includes medical record examination and a ‘spectral analysis’ in remaining and non-remaining cases at the age of ten of asthma symptoms, signs and associated heredity, environmental ... reporting asthma or not reporting asthma at the age of 10) and least highly inter-correlated, were included in the final multiple logistic regression model Odds ratios and 95% confidence intervals ... correlation matrix was initially made for all independent variables in order to determine which indicators to be included in the final model For those variables that were inter-correlated and represented...

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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Ngày tải lên : 07/03/2014, 03:20

... nuclear-stained using 4¢,6-diamidino-2phenylindole (DAPI) The primary antibody combinations consisted of monoclonal antibody against p-Akt and monoclonal antibody against PrP SGC7901/ADR cells were incubated ... Fluorescence intensity analysis of intracellular adriamycin in gastric cancer cells (B) Adriamycin releasing index of gastric cancer cells The releasing index = (accumulation value ) retention value)/accumulation ... inhibition of the PI3K/Akt signaling pathway may lead to inhibition of the MDR induced by PrPC in gastric cancer cells The mechanism underlying PI3K/Akt -mediated PrPC-induced MDR in gastric cancer...

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Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer doc

Ngày tải lên : 22/03/2014, 17:20

... chemo-protection for normal human PBLs and B-lymphoid cells, by inducing mitotic catastrophe and erosion of telomeric DNA selectively in the cancer cells and by inducing cell proliferation in the normal cells ... brain cancers in vivo This might be achieved by the induction of telomere loss in cancer cells as shown in our in vitro experiments with glioma-derived brain cancer cells In contrast to conventional ... mitotic index (MI) and normal and abnormal metaphases of human brain cancer and B-lymphoid cells treated for 24 h with Ruta 6-high dose only, H2O2 only and in combination: A, human MGR1 brain cancer...

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Báo cáo khoa học: Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A ⁄sodium butyrate-induced and 5-aza-2¢-deoxycytidine-induced PTEN upregulation ppt

Ngày tải lên : 22/03/2014, 21:20

... melanoma cells, including those in myeloid leukemia, and breast, prostate, colon, skin and brain cancer [4– 8] Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was originally discovered ... chromatin structure to facilitate the binding of major 994 transcription factors on the promoter We were therefore interested in determining whether TSA ⁄ NaBu had any effects on promoting the binding ... was, on the basis of the above information, to determine whether vitamin D had any effects on gastric cancer cells, and to investigate the possible molecular processes involved in this action As...

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ADVANCES IN PROSTATE CANCER docx

Ngày tải lên : 22/03/2014, 22:20

... Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin Suyin, Joanne Louise Dickinson and Adele Frances Holloway Chapter 26 The Role of E-Cadherin-Catenin Complex in Prostate ... was integrated in tumour cells in regions surrounding potentially interest‐ ing/important genes, in two cases next to transcription factor genes (CREB and NFAT) and in the third, next to a hormone ... cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ lations (Figure 1) with...

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Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot

Ngày tải lên : 23/03/2014, 10:20

... acetate and evaluated for activity using select in vitro bioassays, including induction of quinone reductase with Hepa 1c1c7 cells and inhibition of transformation with JB6 cells [23,32] After in ... chemopreventive agents, including resveratrol [26,27], brassinin [28,29], and deguelin [30,31] Resveratrol is present in grapes, red wine and peanuts, brassinin is from Chinese cabbage, and deguelin is from ... that might account for the effects of IxoA in colon cancer cells, we investigated its effects on cell cycle distribution A noticeable accumulation of colon cancer cells in the G2 ⁄ M phase of the...

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Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot

Ngày tải lên : 24/03/2014, 00:21

... a common target of the growth factors and steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12–24 h and subsequent GPR30 and progestin (Eur ... a correlation between GPR30 upregulation and progestin-induced growth inhibition The ligand of GPR30 and its role in growth regulation are not known In amino acid sequence comparisons, GPR30 ... additional effect on p38 inhibitor-regulated GPR30 mRNA expression The fact that progestin [3–5] and p38 pathway inactivation [24 ,25] have the same kind of effect on proliferation of MCF-7 cells...

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Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx

Ngày tải lên : 30/03/2014, 02:20

... survival and motility [37] Usually, integrins avb3 and avb5 are involved in cell migration and attachment to the extracellular matrix proteins: vitronectin, fibronectin, fibrinogen, laminin, osteopontin, ... confirm the involvement of avb3 integrin in TPD52 mediated migration of LNCaP cells towards vitronectin Similar to breast cancer cells, prostate cancer cells metastasize to the bone, which consists ... Tumor protein D52 in prostate cancer R Ummanni et al Results A protein profiling study on prostate biopsies identified differentially expressed proteins in cancer containing several proteins that...

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