1considerations for optimal allergen specific immunotherapy

Báo cáo y học: "Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study" ppsx

Ngày tải lên : 08/08/2014, 21:20

... difficulties for allergen- specific immunotherapy (SIT) with fungal extracts arises from the variability and complexity of fungal organism, with the subsequent difference in composition and allergenic ... were asked not to take ICS for 12 hours, salbutamol for at least hours, oral antihistamines for at least 72 hours and intranasal antihistamines for at least 24 hours before each study visit Study ... several different allergens, Alt a1 represents by far the most important with greater than 90% of sensitized individuals having IgE antibody against this allergen[ 20] Therefore, immunotherapy with...

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Báo cáo y học: "Local Nasal Specific Immunotherapy for Allergic Rhinitis" potx

Ngày tải lên : 08/08/2014, 21:20

... the allergen through the sublingual mucosa occurs and that plasma radioactivity increases only after the allergen is swallowed This is also true for nasal administration Local Nasal Specific Immunotherapy ... studies performed with a mite extract, three with favourable results20,31,32 and one with negative results,24 but in this latter study, LNIT was admin- Local Nasal Specific Immunotherapy for Allergic ... Immunotherapy for Allergic Rhinitis — Passalacqua and Canonica 121 accounts for about 10% of immunotherapy sales Nevertheless, it remains a viable alternative to subcutaneous therapy The optimal candidates...

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Báo cáo y học: "Specific immunotherapy by the sublingual route for respiratory allergy" pot

Ngày tải lên : 08/08/2014, 21:20

... causes reported for noncompliance to allergen injections, having instead compliance problems similar to drug treatment Some studies not specifically designed for compliance (for instance safety ... of no need of visits for injections, higher savings, corresponding to € 3158 for dust mite and € 1708 for pollen allergy in adults and to € 3938 for dust mite and € 824 for pollen allergy in ... Malling HJ: Allergen immunotherapy: therapeutic vaccines for allergic diseases A WHO Position Paper J Allergy Clin Immunol 1998, 102:58-62 Canonica GW, Passalacqua G: Noninjection routes for immunotherapy...

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Báo cáo y học: " Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy" doc

Ngày tải lên : 13/08/2014, 13:22

... the amount of allergen, that results in 50% of maximal activation Generation of ROC curve The allergen concentration at which sensitivity and specificity were optimal for CD63 and for CD203c was ... controls The optimal final V vespula allergen concentration was 0,1 μg/ml The sensitivity and specificity were 88% and 78% for CD63 at 3,28% basophil activation For CD203c, the sensitivity and specificity ... E: Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy A statement of a World Allergy Organization (WAO) taskforce Allergy 2007,...

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An asthma allergen specific animal model for the study of responses to dust mite allergen induced asthma

Ngày tải lên : 15/09/2015, 21:56

... there is a need for more and better tools for which to study the responses to these allergens Clearly, mite allergens differ significantly from the model allergen ovalbumin Mite allergens possess ... (TCR) gene from a Der p specific CD8 T cell The TCR genes were cloned into expression cassettes for the generation of TCR transgenic mice with CD8 T cells specific for the HDM allergen, Der p We believe ... asthma had been performed using ovalbumin as a surrogate allergen This is mainly due to the greater availability of research tools for use in the ovalbumin model However, true asthma allergens had...

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Tài liệu Soft Computing for Optimal Planning and Sequencing of Parallel Machining Operations docx

Ngày tải lên : 25/12/2013, 19:15

... operation j performed by MUi on WLl in the kth time slot Deﬁne s ijl ϭ , if k k k ϭ 1; s ijl ϭ ϩϱ for infeasible i, j, k, l ; and s k ϭϩϱ if Σ x ijl ϭ for all j, k, l , i.e., for any ijl i particular ... performed by MUi on WLl in the kth time slot and deﬁne f ijl ϭϩϱ for infeasible i, j, k, l For example, let 1–3–2–6–4–7–8–5 be a feasible solution of a sequence of eight operations required for ... WL2 from the last cycle of operations For this partially completed workpiece, operations 1, 2, 3, 4, 5, 8, 9, 10, and 16 had been performed before it was transformed to WL2 At time 0, the machine...

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Tài liệu Practical mod_perl-CHAPTER 16:HTTP Headers for Optimal Performance doc

Ngày tải lên : 26/01/2014, 07:20

... imported when we use Apache:: File Refer to the Apache::File manpage for more information 530 | Chapter 16: HTTP Headers for Optimal Performance This is the Title of the Book, eMatter Edition Copyright ... nature (as in a “form page for submittal”) and the creator of the page wants to make sure that the page does not get submitted twice 540 | Chapter 16: HTTP Headers for Optimal Performance This is ... content; the content is the actual page, image, file, etc 532 | Chapter 16: HTTP Headers for Optimal Performance This is the Title of the Book, eMatter Edition Copyright © 2004 O’Reilly & Associates,...

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Tài liệu Problem-Oriented Guides for Police Problem-Specific Guides Series No. 48: Bank Robbery pptx

Ngày tải lên : 16/02/2014, 10:20

... Center for Problem-Oriented Policing Got a Problem? We’ve got answers! www.PopCenter.org Log onto the Center for Problem-Oriented Policing web site at www.popcenter.org for a wealth of information ... About the Problem -Specific Guides Series About the Problem -Specific Guides Series The Problem -Specific Guides summarize knowledge about how police can reduce the harm caused by specific crime and ... investigating offenses or handling specific incidents Neither they cover all of the technical details about how to implement specific responses The guides are written for police—of whatever rank or...

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Báo cáo khoa học: UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity potx

Ngày tải lên : 31/03/2014, 07:20

... Rousselle for mass spectrometry measurements, Dominique Douguet and Susan Michelson for constructive ´ ` criticism, Helene Munier-Lehmann for fruitful comments, and ´ Regine Lambrecht for excellent ... (correctness scores of 73% for UMP kinase from B subtilis vs 98% and 99% for the structures of NAGKec and CK-like CPSpf, respectively) Similar values were also obtained for various other UMP kinases ... both under Mg2+ complexed form or as a free nucleotide Mg2+-UTP, which is the major form of the nucleotide in the bacterial cell, is only a weak competitive inhibitor for ATP (Ki > mM), whereas...

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Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf

Ngày tải lên : 18/06/2014, 19:20

... accounted for approximately 50% to 55% of all cases, stage III accounted for 30%, and stage II for less than 20% For the year 2004, it is estimated that stage IV cancers will account for approximately ... vaccine) CBR of 45/142 (31.7%) for multi-peptide vaccines, 17/70 (28.6%) for autologous tumor cell vaccine, 46/163 (28.2%) for viral vector vaccine, 30/134 (22.4%) for dendritic cell-based vaccines ... SD rates Thus, for subset analysis, the CBR was calculated as the sum of CR, PR, MR, and SD based on the various vaccine formulations, the route of vaccination, and adjuvants [13] For the Meta-analysis...

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Báo cáo hóa học: " MAC Protocols for Optimal Information Retrieval Pattern in Sensor Networks with Mobile Access" pptx

Ngày tải lên : 23/06/2014, 00:20

... therefore, the best performance The performance under this scheduler can be used as a benchmark for performance comparison For a given sensor location realization xN and a fixed m, the optimal dmax is ... Besides the vector form as in (9) and (10), the input parameters of dmax (q) for both fields also take other forms in this paper for the ease of presentation The MAC design objective for the circular ... circular field is also to minimize E{dmax } MAC FOR OPTIMAL INFORMATION RETRIEVAL PATTERN 3.1 Optimal centralized scheduling Assume that the location information xN of all sensors is available to...

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Báo cáo y học: "Allergen-specific T cell quantity in blood is higher in allergic compared to nonallergic individuals" pptx

Ngày tải lên : 08/08/2014, 21:20

... between allergen- specific IgE obtained from FEIA and absolute count of allergenspecific Th and B cells Allergen- specific IgE vs Allergen- specific Th cells Allergen- specific IgE vs Allergen- specific ... between allergen- specific IgE and allergenspecific Th and B cells Since production of allergen- specific IgE is characteristic for allergic diseases, we determined serum concentration of allergen- specific ... allergen- specific IgE and allergenspecific Th cells but not allergen- specific B cells (specific for cat, Timothy and birch) were statistically significant (Table 2) Indices and absolute counts of allergenspecific...

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báo cáo khoa học: " The Rx for Change database: a first-in-class tool for optimal prescribing and medicines use" ppt

Ngày tải lên : 10/08/2014, 10:23

... [7] For the Rx for Change database, the CC&CRG is responsible for maintaining and updating the evidence on the effect of consumer-targeted interventions, such as providing consumers with information ... using a standardised data extraction form and a consensus process This ensures a consistent summary format for each review and ensures the accuracy of the information Analysis and synthesis We ... Agency for Drugs and Technologies in Health (CADTH), for making this project possible We also thank the Canadian Institutes for Health Research, KT Canada, and the National Prescribing Service for...

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báo cáo khoa học: "Split-Inteins for Simultaneous, site-specific conjugation of Quantum Dots to multiple protein targets In vivo" pptx

Ngày tải lên : 11/08/2014, 00:23

... initially demonstrated for C-terminus -specific modifications of recombinant proteins using artificially split Npu DnaE [45] and Ssp GyrB inteins [42] and more recently for N-terminus -specific modifications ... and specificity to bivalent metal atoms such as Ni2+ or Zn2+ and can therefore efficiently assemble on the QD surface with a well-defined orientation [13] Another approach exploits the highly specific ... vice versa, as the specific interactions that facilitate the splicing reaction, notably recognition of the complementary N- or Cintein and consequent non-covalent association for formation of an...

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Báo cáo y học: "Synthetic rabbit-human antibody conjugate as a control in immunoassays for immunoglobulin M specific to hepatitis E virus" ppsx

Ngày tải lên : 12/08/2014, 04:20

... engineered antibodies specific for epitope on a single antigen is different from those of antibodies produced in humans; which also encumbered the usage in immunoassays for different antigens ... immunoblot, and immunofluorescent assay (IFA), to detect the presence of IgM molecules specific for given antigens, for example, hepatitis A virus, T gondii, cytomegalovirus, herpes simplex virus, ... efficiency was calculated by the following equation: conjugation efficiency = (OD for the antibody conjugate/OD for the purified rabbit anti-HEV IgG) × 100% To determine whether the antibody conjugate...

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Báo cáo y học: "The SLC2A9 non-synonymous Arg265His variant and gout; evidence for a population-specific effect on severit" docx

Ngày tải lên : 12/08/2014, 15:23

... Caucasian cluster was 0.95 for the 505 Caucasian controls and 0.06 for the total 572 Māori samples, 0.95 and 0.06 for the 608 Eastern Polynesian samples and 0.98 and 0.05 for the 330 Western Polynesian ... frequencies for rs3733591 were in Hardy-Weinberg equilibrium (P > 0.01) for all case and control sample sets Twenty-five biallelic markers were used as genomic controls to account for differing ... isoforms with the long-form expressed on the basal side and short- form expressed on the apical side of the proximal renal tubule [17] Mice with overexpression of the long-form of SLC2A9 (also...

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Báo cáo y học: "Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders" pot

Ngày tải lên : 13/08/2014, 13:22

... approved the clinical protocol; all subjects signed informed consent For each subject, allergens were selected for study, with a preference for food allergens yielding the highest CFSE proliferation ... allergen proliferation EC50 Analyzable sigmoid curves were obtained for all subjects (Figure 2B), with subjects yielding data for two allergens and subjects having analyzable curves for one allergen ... omalizumab (B) Example of an allergen dose response to peanut Ag for subject 2, performed at baseline (circles) and at study completion (squares) (C) The EC50 for allergen proliferation was compared...

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Báo cáo y học: "In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker" ppt

Ngày tải lên : 13/08/2014, 16:20

... 37; 8347 bp at 5' end: thymopoietin isoform beta; 34500 bp at 3' end: similar to peptidylprolyl isomerase A isoform 1; inversin isoform a; inversin isoform b; 9890 bp at 5' end: hypothetical ... they may be ideal targets for research and development of mosquito -specific molecular biomarkers to employ in molecular entomology Specifically, DNA probes or retroposonspecific monoclonal antibodies ... the PLGA molecule respectively This possibly accounts for the generality of PLGA as a solvent MAbRST stands for monoclonal antibodies specific for a mosquito retroposon disease are preserved), which...

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lamp tools for creating application-specific fpga coprocessors

Ngày tải lên : 14/11/2014, 12:08

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