17β estradiol and progesterone control mammogenesis by stimulation of mammary epithelial cells proliferation regulation of gene expression and induction of autophagy
Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... These include the upregulation of the genes for apolipoprotein E [7], elastase [8] and tissue factor [9], as well as altered expression of several other genes [10] Within cells, lipid is stored ... is a marker of lipid accumulation and is among the lipid dropletassociated proteins present in a variety of cells such as hepatocytes, adipocytes, muscle cells, mammary epithelial cells, fibroblasts, ... endothelial cells and macrophages [15,16] Macrophage expression of adipophilin is upregulated by oxLDL [17], acetylated LDL (AcLDL) [18], enzymatically modified LDL [19] and by synthetic agonists of the...
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Báo cáo y học: " Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates " ppsx
... increases IL-8 gene expression in neutrophils Similar to what we have previously shown in human airway epithelial cells and mouse tracheal epithelial cells [13], Hsp72-induced IL-8 gene expression ... IL-8 expression (Figure 5A) Next, we asked whether Hsp72 regulated IκBα degradation Treatment of HL-60 cells with Hsp72 lead to rapid degradation of IκBα followed by resynthesis of IκBα by hours ... (TLR)-4, CD14, and MD-2 within the lipid raft and appear to be crucial in the regulation of the assembly and subsequent function of the TLR-4 receptor complex [4-7] Finally, the release of Hsp72 into...
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Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx
... performed but the cells are all recombined together and analyzed These combined cells should not give a variable pattern of gene expression This controls for perturbation of the culture by the selection ... experiments in terms of variation in the phase angles of peaking of gene expression in different individual cells Thus, given a particular variation in gene expression in different cells, one can account ... in gene expression: meaning and relevance to the cell cycle It is of interest to look at the basic data in Table of Liu, Gaido and Wolfinger [1] In Table they present results on the gene expression...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... result of the relocalization of the protein and not an increase of ASF ⁄ SF2 gene expression (Fig 4A) These data are further supported by the capacity of ASF ⁄ SF2 to migrate into SGs in cells ... regulate the stability and ⁄ or traductibility of 8% of all human mRNAs [2] RNAbinding proteins comprise other key components of the post-transcriptional regulation of gene expression These proteins ... expression As each step of the RNA metabolism is tightly regulated, the regulation of mRNA export, stability and translation rate is essential for the control of the expression of mRNAs coding for...
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Báo cáo sinh học: "Promoter architecture and the evolvability of gene expression" pdf
... a gene s expression is altered by the environment, and with expression noise [39,40], namely the extent by which a gene s expression differs among genetically identical cells [7,37] That is, genes ... evolvability of gene expression Science 2007, 317:118-121 38 Rando OJ, Verstrepen KJ: Timescales of genetic and epigenetic inheritance Cell 2007, 128:655-668 39 Raser JM, O’Shea EK: Noise in gene expression: ... quantitative model of transcription factor-activated gene expression Nat Struct Mol Biol 2008, 15:1192-1198 51 Choi JK, Kim YJ: Epigenetic regulation and the variability of gene expression Nat Genet 2008,...
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Báo cáo y học: "Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies" doc
... and bone resorption, also demand the identification of targets to directly inhibit destruction and/ or to induce regeneration and repair A deeper knowledge of pathophysiological networks and gene ... publication of results achieved with the current state of methodology is essential in the exchange and development of different approaches to gene expression profiling and in comparing selected candidates ... personal knowledge and investigative capacity of the scientists and is susceptible to misinterpretation In the face of our limited knowledge of the role and function of most of the genes that we discover...
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Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... in situ effect of licofelone on the gene expression and protein synthesis of the major collagenolytic enzymes (MMP-13 and cathepsin K) and aggrecandegrading proteases (ADAMTS-4 and ADAMTS-5) in ... the R1094 ADAMTS-4 and ADAMTS-5 gene expression and protein synthesis The level of gene expression of ADAMTS-5 in OA cartilage determined by PCR analysis was highly variable and, although sometimes ... score of 3.5 (0–10) and a safranin-O score of 0.4 (0–3) with the 2.5 mg dosage and a Mankin score of 4.2 (1.5–6.5) and a safranin-O score of 0.3 (0–1.5) with the 5.0 mg dosage MMP-13 gene expression...
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Global orchestration of gene expression by the biological clock of cyanobacteria Carl Hirschie Johnson pot
... of the transcription rates of all genes, accounting for the global regulation of gene expression [22] Gene- specific cis-regulatory elements that mediate rhythmic gene expression might therefore ... promoters: kaiAp (driving expression of KaiA) and kaiBCp (driving expression of a dicistronic mRNA encoding KaiB and KaiC) KaiA promotes the phosphorylation of KaiC and inhibits its dephosphorylation, ... basis of this global regulation? One possibility could be rhythmic control by RNA polymerase sigma subunits, which often determine the promoter specificity of the polymerase But studies of sigma...
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báo cáo khoa học: " Salivary a-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells" docx
... alter growth of mammary epithelial cells by using primary cultures of rat origin For this purpose, we used primary mammary epithelial cells from two inbred rat strains, Fischer 344 (F344) and Lewis, ... epithelial cells from female F344 and Lewis rats Preparation of the dissected mammary gland complexes produced comparable amounts of epithelial cells in F344 and Lewis rats Marked differences between cells ... rat mammary epithelial cells and human breast tumor cells On the one hand the effects on healthy rat breast cells indicate that endogenous a-amylase might be involved in the regulation of mammary...
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Báo cáo y học: "Inflammatory responses in epithelia: endotoxininduced IL-6 secretion and iNOS/NO production are differentially regulated in mouse mammary epithelial cells" pot
... inflammation and cancer in epithelial tissues The focus of this study was to investigate the regulation and coordination of IL-6 and iNOS by ET-induced NFB activation in mammary epithelial cells, and ... 15 of 17 [22], while the second emphasizes the importance of myoepithelial cells in maintaining epithelial cell polarity and the bilayered structure of epithelial cells and myoepithelial cells ... epithelium of the mammary gland SCp2 cells are responsive to ET by activation of the cytosolic transcription factor NFB, by secretion of inflammatory cytokines such as IL-6 and TNFa, and by reverting...
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Báo cáo y học: "A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells" potx
... representation of differences in gene expression of adult and cord blood monocytes in response to LPS Figure Heat map representation of differences in gene expression of adult and cord blood ... DFA analysis of phases of monocyte activation comparing cord and adult cells DFA analysis of phases of monocyte activation comparing cord and adult cells DFA identified a subset of genes (see Table ... identification of differentiallyexpressed genes Methods Cells and cellular stimulation Monocytes were purified from cord blood of healthy, term infants and from the peripheral blood of healthy adults by...
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Báo cáo y học: " 3′-coterminal subgenomic RNAs and putative cis-acting elements of Grapevine leafroll-associated virus 3 reveals ‘unique’ features of gene expression strategy in the genus Ampelovirus" potx
... size of CPm of GLRaV-3 is much larger than that of BYV and CTV In this study, we examined the gene expression strategy and cis-acting elements of GLRaV-3 in comparison to the other members of the ... sequence of p21 encompass 13 nt C-terminus of CPm ORF and 10 nt IGR between CPm and p21, the 95 nt leader sequence of p20A overlaps with the C-terminus of p21, and the 125 nt leader sequence of p20B ... sequence of the portion of the genomic RNA showing the TSS of sgRNAs specific to CP, p21, p20A and p20B and (b) the predicted secondary structure of the minus-strand sequences around the TSS of the...
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Báo cáo y học: "A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory network" pot
... Snail Figure Coexpression of genes in SMC cells Coexpression of genes in SMC cells Whole-mount in situ hybridization (WISH) analysis of examples of signaling and transcription factor genes identified ... serotonergic cellsGlass and Mox and immunohistochemical localization of WISH analysis of in normal and zinc-treated embryos WISH analysis of Glass and Mox and immunohistochemical localization of serotonergic ... minimal expression change of 1.3 and a significant reproducibility value (P value) of minimally e-3 from the set of all regulations We selected genes of good (P < e-5), medium (P = e-4 to e-3), and...
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Báo cáo y học: "Strategy for encoding and comparison of gene expression signatures" pps
... illustrating input of subject (Gene Expression Omnibus [GEO] dataset [GDS]) and query datasets, extraction of gene expression signatures, comparison with signature database, and generation of reports ... signature gene 'Concordant Similarity' is the number of concordant genes expressed as a percentage of the total number of genes in the signature 'Discordant Similarity' is the number of discordant genes ... individual expression signature, and significant genes within a signature The gene- level report contains alignments of significant gene triplets that were matched from within a pair of query and subject...
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Báo cáo y học: "The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression" ppt
... Downregulated expression and enrichment of cancer genes among highly targeted genes Downregulated expression and enrichment of cancer genes among highly targeted genes (a) In a comparison of highly ... only on housekeeping genes defined by Eisenberg and Levanon [42] This interactions Figure of Analysis site and gene features that affect miRNA repression Analysis of site and gene features that ... enrichment for a random set of genes targeted by any number of miRNAs is 1.0 (that is, no enrichment), shown by the dotted line (d) The enrichment of transcriptional regulators and nuclear genes among...
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Báo cáo sinh học: " Bootstrapping of gene-expression data improves and controls the false discovery rate of differentially expressed genes" ppsx
... Goddard treatment (1-20); and by gene- expression data not following a (Log-) Normal distribution [14] Because the number of genes on a microarray is often very large, and every gene is tested for its ... nnstedt and Speed [10] o and Efron et al [5] used the 90th percentile of the standard errors of all the genes, i.e., for 90% of the genes, a is larger than the usual denominator of the t-statistic ... any non-normality of the transformed gene- expression data [8] However, which of these methods is most appropriate for the analysis of gene- expression data is not clear The aim of this study is...
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Báo cáo y học: "Genome-wide patterns of carbon and nitrogen regulation of gene expression validate the combined carbon and nitrogen (CN)-signaling hypothesis in plants" pptx
... many of the genes involved in metabolism show less expression due to CN than expected The majority of the genes (28 out of 34) were repressed by carbon, induced by nitrogen and repressed by CN, and ... interactions between carbon and nitrogen, as it is induced only by CN, and not by carbon or nitrogen alone [36] Our studies of carbon and nitrogen regulation of gene expression in plants, combined ... First, single strands of the promoter sequences of the A thaliana genes were randomized 200 times, the reverse complement of the randomized strand was determined, and the number of times the 33...
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Báo cáo y học: "Consensus clustering and functional interpretation of gene-expression data" docx
... Output:Set of Robust Clusters RC Application of robust clustering Robust clustering was applied to both the ASC and B-cell lymphoma datasets and the partitioning of the gene- expression profiles observed ... combination of the previous observations plus some random noise For the synthetic dataset, each cluster was generated by a vector autoregressive model of order p = and size n equal to the number of genes ... robust and consensus clustering (CC) of gene- expression data and assign statistical significance to these clusters from known gene functions Our method is different from the approach of Monti...
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Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx
... from heritability weights Distribution of heritability of probe intensities and of probe-specific Distribution of heritability of probe intensities and of probe-specific weights derived from ... QTLs for gene expression can be classified according to the chromosomal location of the QTL relative to the location of the gene being expressed Those for which the location of the QTL and gene are ... human gene expression Nature 2004, 430:743-747 The GeneNetwork [http://www.genenetwork.org/search.html] Chesler EJ, Wang J, Lu L, Qu Y, Manly KF, Williams RW: Genetic correlates of gene expression...
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