1 progenitors isolated from diseased lungs display impaired in vitro regenerative potential
Báo cáo y học: "Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells" pptx
... decavanadate, 20 mM caffeine or 10 μM cyclosporine A (all were preincubated during 10 min) and after h incubation with 10 μM thapsigargin (TG) B Average of the line-scan images in A expressed as normalized ... http://respiratory-research.com/content/9 /1/ 70 Figure Flash photolysis of iso-Ins (1, 4,5)P3/PM induced release from internal stores in human tracheal gland cells Flash photolysis of iso-Ins (1, 4,5)P3/PM induced release from internal ... approved of the final manuscript http://respiratory-research.com/content/9 /1/ 70 10 11 12 13 14 15 16 17 Acknowledgements The authors thank Nathalie Bizard, Dr Sylvie Patri, and Dr Vincent Thoreau...
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... 15 4 C J Marsden et al (Eur J Biochem 2 71) A D75 D75 R180 R180 N78 E177 N78 E177 Y80 N122 Y123 R258 R134 Y80 N122 Y123 R258 R134 R 213 R 213 B D75 R180 E177 D75 R180 N78 Y80 E177 Y123 N78 Y80 Y123 ... 0 .15 4 (0 .15 4) 21 573 (720) 0.2 31 (0.257) 9 21 (24) 0 .15 7 24.8 2596 (including sulphate, acetate and 510 water molecules) 0 .17 7 (0 .17 6) 58 3 81 (4,486) 0. 214 (0 .19 2) 2,448 (18 8) 0 .17 9 19 .8 0.0 21 1.9 ... 21. 6 (4.7) 0.038 (0 .13 3) 85.6 (43.6) MAXLAB BL-I 711 MAR IP, 1. 0 213 a ¼ b ¼ 67.5, c ¼ 14 0.6 46 – 1. 4 (1. 436 1. 4) 274 010 60 829 43.2 (8 .1) 0.0 31 (0 .12 1) 93.9 (99.3) 2492 (including sulphate 406 water...
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Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... kcat/Km (M )1 min )1) 68 10 9 10 32 37 29 34 1. 8 0.3 ´ 10 3 3.8 0.7 ´ 10 3 0.9 0.2 ´ 10 3 71 32 15 2 10 8.5 19 10 8.3 1. 5 ´ 10 3 1. 7 0.4 ´ 10 3 15 .2 2.5 ´ 10 3 16 18 0.9 ... Fe(DoCPP) )13 G10 complexes at pH Without ImH Catalyst Fe(ToCPP) Fe(ToCPP) )13 G10 a,a -1, 2-Fe(DoCPP)) 13 G10 a,b -1, 2-Fe(DoCPP)) 13 G10 + 50 mM ImH kcat (min )1) Km (mM) kcat/Km (M )1 min )1) kcat (min )1) Km ... ´ 10 3 96 7 1 13.7 2.8 ´ 10 3 Ó FEBS 2002 Peroxidase-like Fe±porphyrin±antibody complexes (Eur J Biochem 269) 477 10 3 M )1 min )1 to 1. 7 0.4 ´ 10 3 M )1 min )1 with a,a -1, 2Fe(DoCPP)- and a,b -1, 2-Fe(DoCPP) )13 G10...
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báo cáo hóa học: " The effect of hip abduction on the EMG activity of vastus medialis obliquus, vastus lateralis longus and vastus lateralis obliquus in healthy subjects" pot
... Female 53.70 96.07 88. 31 119 . 61 75.70 10 3.98 Hip abduction at 0° Male female 69.05 87.09 11 0.62 10 0 .13 90.25 92.30 14 4. 91 c 16 5.97 b 11 5. 31 1 41. 30 14 6.72 d 16 2. 61 a MIVC at 90° of knee flexion Male ... subjects and in subjects with patellofemoral pain syndrome J Orthop Sports Phys Ther 19 96, 24 :16 0-5 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 Cowan SM, Bennell KL, ... of NeuroEngineering and Rehabilitation 2006, 3 :13 http://www.jneuroengrehab.com/content/3 /1/ 13 uting factor in the development of anterior knee pain [3942] 12 Ireland et al [39], using hand held...
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Investigations on the antiplasmodial activity of ferrocenyl chalcones
... Cl N Cl N 10 : n=3 14 : n=3 11 : n=4 15 : n=4 12 : n=5 16 : n=5 13 : n=6 17 : n=6 In another study, the methylene chain connecting N2 and N3 in was varied from n = to n = 3, 4, or (10 , 11 , 12 , 13 ) N3 was ... 11 8 6.4 .1. 1 Materials 11 8 6.4 .1. 2 Scavenging of ABTS radical cation 11 8 6.4 .1. 3 Spin trapping measurements .11 9 6.4.2 Results and discussion 12 0 6.4.2 .1 Scavenging ... 10 0 6.2 .1 Experimental methods 10 3 6.2 .1. 1 General experimental methods and materials 10 3 6.2 .1. 2 Binding to heme 10 4 6.2 .1. 3 Inhibition of β-hematin formation 10 4...
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 3
... 328 .13 11) 296 .14 21 (C19H20O3 = 296 .14 12) 319 .12 20 (C20H17O3N = 319 .12 08) 319 .12 14 (C20H17O3N = 319 .12 08) 10 1 10 2 10 3 A-3 11 2 (A) 83 (A) 89- 91 (B) 38.4 15 .9 10 .5 282 .12 48 (C18H18O3 = 282 .12 56) 16 42.09 ... 1H, 3’H), 3.89(s, 3H, OCH3), 3.87(s, 3H, OCH3), 3.03(s, 6H, N(CH3)2) 10 4 90-92 (A) 16 .5 10 5 11 5.3 -11 5.6 (A) 36.4 10 6 12 1.5 -12 1.8 (A) 72 .1 107e 11 2 -11 3 (A) 53.0 10 8e 13 0 -13 1 (C) 53.6 10 9 19 1 -19 2 ... 24.9 10 0.0 16 .1 16.0 24.8 19 .7 20.0 92.8 12 .3 39.9 41. 0 16 .3 51. 0 27.5 18 .4 17 .7 28.0 31. 0 29.5 Not Done 0.27 < 10
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 2
... 41. 0 16 .3 51. 0 27.5 Toxicity to macrophages (µM) c 30 30 30 30 30 10 30 10 10 30 ND 10 10 3 10 - Compound number 10 4 10 5 10 6 10 7 10 8 10 9 11 0d 19 22 23 31d 32d 38 11 1 11 2 11 3 11 4 11 5 11 6 11 7 13 5 ... 10 30 10 30 10 30 10 30 10 10 30 10 30 10 30 Compound number 39 12 1 12 2 12 3 12 4 12 5 12 6 12 7 13 6 41f 2 01 202d 203 204 205d 206 207d 208d 209d 210 d 211 245 212 d 213 d 214 d 215 d 216 d Ring B 4’-ethoxy ... 4.4 4 .19 4 .18 >30 2.6 >30 8 .13 4.39 4. 41 11. 74 >30 13 .16 6.82 12 .05 13 .16 10 .85 29. 31 29. 31 1.57 4.07 11 .73 12 .63 IC50 (µM) b 38.0 32.2 25.4 25.8 30.4 20.4 21. 7 18 .4 17 .70 24.50 29.6 35.45 18 8.00...
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 1
... 4-dimethylamino 2,4-dichloro H Compound No c 19 22 23 31a 32a 38 11 1 11 2a 11 3 11 4 11 5 11 6 11 7 13 5 25 26 33a 34a 39 12 1 12 2 12 3 12 4 12 5 12 6 12 7 13 6 2 01 202a 203 204 205a 206 207a 208a 209a 210 a 211 2 31 ... Compound No c 11 12 13 27a 28a 35 36 40 12 8 12 9 13 0 13 1 13 2 13 3 13 4 29a 30a 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0a 212 a 213 a 214 a 215 a 216 a 217 218 219 220 2 21 222 223 224 225 226 227 228 229 230 ... methemoglobin 10 2 6.3.2 Effects on falcipain-2 and associated changes in the food vacuole on incubation 10 3 6.3.3 Binding to heme 10 5 6.4 Discussion 11 0 6.5 Conclusion 11 1 SECTION SEVEN: CONCLUSION 11 3 -11 5...
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Tài liệu The Influence of Human Activity on the Environment ppt
... causing extinction of species Intensive Farming • Farming has become more intensive to provide a higher % yield from land • Many people regard intensive farming of animals to be cruel • In order ... diminishing fossil fuel reserves by using solar power or wind power Benefits of conserving endangered species • Ecotourism • Agricultural benefits • Species indicators • Maintaining diversity in ... Pesticides kill insects that will damage crops • They also kill harmless insects or can get washed into rivers and pollute the water • They may even end up in the food chain In the 19 60s, DDT in the food...
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Báo cáo khoa học: Effect of annealing time of an ice crystal on the activity of type III antifreeze protein pdf
... rates of 0. 01 °CÆmin )1 (closed circles) and 0.20 °CÆmin )1 (open circles) The TH activity obtained with a slow cooling rate (0. 01 °CÆmin )1) was significantly (1. 7-fold) higher than that obtained with ... (oC) 0. 01 oC/min (slow) 0.6 Thermal hysteresis (oC) B A 0.7 M Takamichi et al 0.7 0. 01 oC/min (slow) 0.6 0.5 0.4 0.3 0.2 0.20 oC/min (fast) 0 .1 0 0.05 0 .10 0 .15 0.20 Cooling rate (oC/min) 10 15 20 ... Annealing Temp = Tm - 0.05 °C 0.2 1. 4 1. 0 0 .1 0 1. 0 2.0 Annealing time (h) 3.0 Thermal hysteresis (°C) B 0.9 0.8 Annealing Time =2h 0.7 0.6 0.5 Discussion 0.4 0.3 0.2 Annealing Time = h 0 .1 0 10 15 ...
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Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
... KNA-26 > 10 0 (90%) > 10 0 (59%) K-52 > 10 0 (10 0%) 61 K-53 > 10 0 (10 0%) > 10 0 K-54 39 60 KNA-53 21 52 K -12 6 10 0 61 K- 61 > 10 0 ( 91% ) 14 K -11 1 > 10 0 (80%) > 10 0 (10 0%) K-49 13 12 EFV > 10 0.003 ... 61 60 52 61 14 12 0.003 0.0 01 > 10 0 (58%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (98%) 21 16 > 10 0 (10 0%) 16 ND 68 10 0 10 0 35 93 92 64 28 0.68 0.2 > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (10 0%) ... > 10 0 (86%) 22 16 > 10 0 (10 0%) > 10 0 (79%) ND > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (10 0%) > 10 0 (74%) > 10 0 (92%) > 10 0 (10 0%) > 10 0 (72%) > 10 0 (87%) 0.40 0 .1 NDe ND ND > 10 0 > 10 0 ND ND > 10 0...
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Báo cáo khoa học: Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase pdf
... heliquinomycin 17 To understand the mechanism by which heliquinomycin inhibits the activity of MCM4/6/7 helicase, we 10 nt 12 0 10 0 % 80 60 40 20 B 0.43 1. 4 4.3 HQ (μM) 14 0.43 1. 4 4.3 (μM) HQ 14 ... (BrdU) in the presence of increasing concentrations of heliquinomycin (Fig 1A) BrdU incorporated into DNA was detected by staining the cells with anti-BrdU Ig and Fig Effect of heliquinomycin (HQ) ... activity was also inhibited in the presence of heliquinomycin (Fig S5) These results suggest that heliquinomycin interferes with the interaction of + MCM4/6/7 A + Tag 1. 4 14 1. 4 14 0.43 4.3 43 0.43...
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Báo cáo khoa học: Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system pptx
... membrane potential sup- FEBS Journal 275 (2008) 616 8– 617 9 ª 2008 The Authors Journal compilation ª 2008 FEBS 617 7 Magnesium ions and cytosolic cytochrome c oxidation 10 11 12 13 14 15 16 17 G La ... molecules of endogenous cytoc present in the intermembrane space may have the additional function (proposed in 19 69 [14 ] and invoked in 19 81 [15 ] and 2002 [16 ]) to shuttle electrons between the ... 277, 17 7 51 17 757 Roman I, Figys J, Steurs G & Zizi M (2005) In vitro interactions between the two mitochondrial membrane proteins VDAC and cytochrome c oxidase Biochemistry 44, 13 192 13 2 01 Woo...
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Báo cáo khoa học: The ‘pair of sugar tongs’ site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity potx
... Enzyme kcat (s )1) Km (mgặmL )1) kcat Km (s )1 mLặmg )1) Y380A S378P AMY1 AMY2 NC 14 9 10 11 3 12 2 51 40 NC 96 23 73 15 18 8 26 0 .15 1 1. 547 1. 549 1. 338 kcat Km,app kcat Km ND 15 0 40 12 2 220 28 ... (mgặmL )1) 15 44 27 36 20 63 kcat Km (s )1 mL )1 mg )1) kcat (s )1) 0.363 0.3 51 0.3 91 0.203 0.208 0 .19 0 1. 074 2 61. 7 424.5 414 .3 802.9 692.3 973.7 6 71. 3 19 34 56 59 48 52 86 0.023 0.083 0 .14 6 ... starch-binding domain Curr Opin Microbiol 8, 260267 Giardina T, Gunning AP, Juge N, Faulds CB, Furniss CS, Svensson B, Morris VJ & Williamson G (20 01) Both binding sites of the starch-binding domain...
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Báo cáo khoa học: The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes doc
... DnsLK12(3.6) LK15(3.6) LK15(W14)(3.6) DnsLK15(3.6) DnsLK18(3.6) DnsLK19(3.6) DnsLK 21( 3.6) DnsLK22(3.6) 9 12 12 15 15 15 18 19 21 22 L5K3 L6K3 L6K3 L8K4 L8K4 L10K5 L9K5W L10K5 L13K5 L13K6 L15K6 L15K7 ... LK16(W15)(3.0) Scr-LK15(W14) DnsLK9(2.0) DnsLK 11( 2.0) DnsLK15(W14)(2.0) Melittin 10 0 10 0 50 25 3 .12 1. 56 1. 56 3 .12 50 25 0.78 3 .12 6.25 12 .5 12 .5 0.78 R R 10 0 50 12 .5 3 .12 3 .12 6.25 50 50 12 .5 12 .5 6.25 ... DnsLK 11( 2.0) DnsLK15(2.0) LK15(3.6) LK15(W14)(3.6) Scr-LK15(W14) LK16(W15)(3.6) Melittin No No No 0.05 0.05 10 0 .1 0. 01 No No No 0 .1 0 .1 50 0.2 0 .1 0 16 17 16 41 7 65 65 16 65 75 The 15 -residue ideally...
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Báo cáo khoa học: On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus pptx
... 306– 317 27 Rocha GB, Freire RO, Simas AM & Stewart JJ (2006) RM1: a reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I J Comput Chem 27, 11 01 11 11 28 Dundas J, Ouyang Z, Tseng J, Binkowski ... and R124W mutations in membrane protein This finding initially suggested that the observed antiviral activity could arise from bananin interference on a hypothetical helicase–membrane protein interaction, ... Hoffmann CE (19 64) Antiviral activity of 1- adamantanamine (amantadine) Science 14 4, 862– 863 17 Schwab RS, England AC, Poskanzer DC & Young RR (19 69) Amantadine in the treatment of Parkinson’s disease...
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Báo cáo khoa học: The two IQ-motifs and Ca2+/calmodulin regulate the rat myosin 1d ATPase activity pptx
... bound to Myo1d-IQ1 (1. 1) and Myo1d-IQ2 (0.24) This result indicates that CaM binds in a cooperative manner to the light chain binding domain of Myo1d The binding of CaM to IQ1 may induce a stabilization ... affected [18 20] For myosin 1c it has been demonstrated that binding of Ca2+ to the C-terminal pair of Ca2+-binding sites in CaM inhibits its actin-translocating activity [19 ] Myosin 1e, another ... of myosin I Biochim Biophys Acta 14 96, 2335 Wolenski JS (19 95) Regulation of calmodulin-binding myosins Trends Cell Biol 5, 310 316 Linse S, Helmersson A & Forsen S (19 91) Calcium binding to calmodulin...
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Báo cáo khoa học: Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4 doc
... that by 0 .1% Triton X -10 0 Molecular masses (in Da) are: Native, 3748; D16W, 3 819 ; N23, 2358; D16W-N23, 2429; D16F-N23, 2390; K15W-N23, 2 416 D16W N23 D16W-N23 D16F-N23 K15W-N23 Minimal inhibitory ... lines), 10 mM SDS micelles (gray lines), and mM DPC micelles (thin lines) B–E: CD spectra of D24)37 (thin, solid line), D16W-D24)37 (bold, solid line), D16F-D24)37 (bold, broken line), and K15WD24)37 ... channel-forming peptides: magainins, cecropins, melittin and alamethicin J Membr Biol 15 6, 19 7– 211 Gabay, J.E (19 94) Ubiquitous natural antibiotics Science 264, 373–374 Andreu, D & Rivas, L (19 98) Animal antimicrobial...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... activity 10 0 99.3 22 .1 18 .1 1 21 112 10 0 13 6 87.5 15 .5 10 0 ± 13 3 ± 4** ± ± ± ± ± ± ± ± ± ± 5.4 3.0*** 2.7*** 10 16 3 .1* 1. 0*** 38 .1 108 20.7 10 0 ± ± ± ± 1. 9*** 2.6*** 41. 9 ± 4.6** 34.9 ± 1. 6*** 18 .6 ... ± 4 .1 100 83.7 92.3 87.2 39.3 11 2 90.0 61. 3 11 7 ± ± ± ± ± ± ± ± ± 5.8 3.0 1. 9** 2.3*** 3* 2.8* 3 .1* ** 3** 39.5 10 0 10 4 96.4 10 1 96.2 10 8 99.4 96.3 13 6 ± ± ± ± ± ± ± ± ± ± 1. 3*** 3 .1 6.3 1. 4 4.4 ... Burns, R.D (19 93) Roles of cellular retinolbinding protein and cellular retinoic acid-binding protein in the metabolic channeling of retinoids In Retinoids Progress in Research and Clinical Applications...
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