... Refers to sensor position above; midpoint of lower esophageal sphincter TABLE Effect of Alterations in Bolus Osmolatity on Duration of Contraction (s) Esophageal Sensor Position* Water Mannitol 5%... Refers to segment position above midpoint of lower esophageal sphincter TABLE Effect ofAlterations in Bolus Osmolatity on Amplitude of Contraction (mm Hg) Esophageal Sensor Position* Water Mannitol... whether bolus osmolality modulates esophageal function Nasrallah and Hendrix (10) reported that a hypertonic glucose solution had no significant effects on the amplitude of esophageal contractions