http://etp.ciaa.b e Consumer life goals re food Be healthy for longer Be free from Health Problems Give Children a Good Start Huge global issues in nutrition 4bn people affected by malnutrition deserve the chance to develop physically & mentally to get more out of life 50% of world’s population have blood cholesterol that’s too high 30% of world’s population have blood pressure that’s too high A vision for improving population health Population numbers Target population for food industries & public healthcare Healthy Target population for pharma industries Unhealthy Green MR and van der Ouderaa F, Nature Pharmacogenomics - 2003 ETP Food for Life Vision An effective integration of strategically-focussed, trans-national, concerted research in the nutritional-, food- and consumer sciences and food chain management will deliver innovative, novel and improved food products for, and to, national, regional and global markets in line with consumer needs and expectations These products, together with recommended changes in dietary regimes and lifestyles, will have a positive impact on public health and overall quality of life (‘adding life to years’) Such targeted activities will support a successful and competitive pan- European agro-food industry having global business leadership securely based on economic growth, technology transfer, sustainable food production and consumer confidence European Technology Platform Food for Life Communication, Training & Technology Transfer Food & Health Food Quality & Manufacturing Food Safety Food & Consumer Food Chain Management Sustainable Food Production Stakeholders’ proposal for a Strategic Research Agenda April, 2006 The key innovation challenges  The development of this ETP has been driven by the activities of its eight Working Groups  To optimize the synergy of its internal interactions, the Stakeholders’ Strategic Research Agenda, SSRA, has been drafted according to the seven Key Challenges for Innovation facing the European agri-food sector  These Challenges map closely with the goals and deliverables of the individual Working Groups Healthy ageing: Goal Add life to years Well-being/ appearance Age Food & Health Delivering a healthy diet Working group:  Prof Wim Saris, DMS & Univ Maastricht, NL (chair)  Dr Jacqueline Castenmiller, WCFS, NL (fascilitator)           Prof Nils-Georg Asp, LU, SE Prof Robert-Jan Brummer, WCFS, NL Dr Irene Corthesy, CRN, Nestlé, CH Prof Hannelore Daniel, Techn Univ, München, D Dr Gerd Hazer, Kraft, D Dr Ian Johnson, IFR, Norwich, UK Prof Bertold Koletzko, Univ München, D Prof Ian Macdonald, Univ Nottingham,UK Dr Gert Meijer, Unilever, NL Dr Moïse Riboh, Danone, F Food & Health: priority research areas INFANT BRAIN FUNCTIONS IMMUNE- & INTESTINAL FUNCTIONS life - METABOLIC FUNCTIONS sta g e ELDERLY How did we work?  TOWARDS A STRATEGIC RESEARCH AGENDA FOR FOOD, NUTRITION & HEALTH • Please define research questions for each cell in the table • For each of the research questions, describe: – – – – - (Knowledge) deliverables; - When to reach these deliverables: 2010, 2015 or 2020; - Bottlenecks to solve the research questions; - The breakthrough potential on a scale from to (low to high potential)? This is about the potential of the research to contributing to breakthrough chances or opening up new horizons for application-inspired research How did we work?  Table Scientific targets Life cycle In-utero, newborns, infants and young children Metabolic function Immune function Cell plasticity Cell plasticity -To optimise development -Early disease prevention – minimising risk for later life -Physical activity -Programming and imprinting -Optimal weaning foods to maximise resistance and to minimise food allergy -Immune tolerance Brain function Cell plasticity -Nutrition and cognitive function -Brain conditioning (e.g., taste perception) How did we work N o Research question Which nutritional factors Basis for during pregnancy determine development optimal foetal development? of optimal foods/diets How important is caloric Refined excess and macronutrient recommendat imbalance for early risk ions on infant factor development? nutrition Knowledge deliverables Bottlenecks When Dietary survey methodology, ethical constraints limiting intervention studies Limited possibilities to perform intervention studies 2015 Breakthrough potenial 2015 Food & Health Delivering a healthy diet  Understanding brain function in relation to diet  Understanding dietary effects on immune and intestinal function  Understanding the link between diet and metabolic function (obesity and associated metabolic disorders)  Understanding consumer behaviour in relation to health and nutrition Goal 1: Understanding brain function in relation to diet  Diet and cognitive functions  Brain conditioning  Mood and optimal performance  Prevention of cognitive decline  Food intake regulation and hunger/satiety  Nutrition and interorgan signalling - esp gut-central nervous system interaction Goal Understanding dietary effects on immune and intestinal function  Modify systemic inflammatory activity by diet  Dietary factors that improve barrier functions  Biomarkers for intestinal health  Diet before and during pregnancy and lactation - immunefunction and allergy  Improved allergome database for foods Goal Understanding the link between diet and metabolic function (obesity and associated metabolic disorders  Early biomarkers of metabolic syndrome  Individual variations in metabolic energy efficiency  Food components that regulate food intake and increase termogenesis  Intervention strategies  Counteract age-associated muscle wasting  Low-grade inflammation - obesity/insulin resistance/metabolic syndrome  Epigenetic events - chronic disease  Maternal and infant recommendations for opt health  Meal composition and size - energy uptake, satiety Goal Understanding consumer behaviour in relation to health and nutrition  Key determinants of food habits  Biological determinants in food choice  Methodology to understand and quantify determinants  Perception and determinants of ”healthy lifestyle”  Better tools for effective communication  Consumer knowledge - consumer understanding of health schemes, health claims, simplified labelling - and personalised nutrition based on nutrigenomics Horizontal Activities The role of Horizontal Activities is to optimise the impact of the ETP through:  Ensuring internal complementarity: Minimising gaps or duplication across the SRA  Establishing effective links with nationally- and FP6- funded projects, and other ETPs Maximising the effectiveness of European food chain science  Establishing the Mirror Group: Effecting a dialogue with national funding bodies, policy makers and opinion formers, COST, EUREKA, ESF etc  Promoting the ETP: Gaining the support of all European stakeholders   Organising national and regional consultations: Ensuring that the SRA addresses the needs and opportunities of all of Europe Developing Scenario Studies Raising awareness of long-term challenges and opportunities for the food chain http://etp.ciaa.b e ... (chair)  Dr Jacqueline Castenmiller, WCFS, NL (fascilitator)           Prof Nils-Georg Asp, LU, SE Prof Robert-Jan Brummer, WCFS, NL Dr Irene Corthesy, CRN, Nestlé, CH Prof Hannelore