chemistry of cells sem1

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chemistry of cells sem1

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Chemistry of Cells Chapter 2, Section Objectives Describe the distinguishing characteristics of carbohydrates Describe the important biological functions of polysaccharides Explain what distinguishes lipids from other classes of biological macromolecules Describe the unique properties, building blocks and biological roles of fats, phospholipids and steroids Distinguish proteins from the other classes of macromolecules Objectives Cont List the biological functions which proteins perform Explain what determines protein conformation and why it is important Define denaturation and explain how proteins may be denatured Describe the characteristics that distinguish nucleic acids from the other classes of macromolecules 10 Summarize the functions of nucleic acids Objectives Cont 11 Briefly describe the three-dimensional structure of DNA 12 Evaluate the importance of energy to living things 13 Relate energy and chemical reactions 14 Describe the role of enzymes in chemical reactions 15 Identify the effect of enzymes on food molecules MacroMolecules • Macro = large • Molecules = or more atoms covalently bonded • Usually referred to as polymers – Like a chain • Made from several repeating subunits – The repeated subunits are called monomers – Like links in a chain • of the macromolecules are polymers of monomers Making or Breaking Polymers • The chemical mechanisms that cells use to make and break polymers are similar for all classes of macromolecules Making Polymers • Monomers are connected by covalent bonds via a condensation reaction or dehydration reaction – One monomer provides a hydroxyl group and the other provides a hydrogen and together these form water – This process requires energy and is aided by enzymes Breaking Down Polymers • The covalent bonds connecting monomers in a polymer are disassembled by hydrolysis – In hydrolysis as the covalent bond is broken a hydrogen atom and hydroxyl group from a split water molecule attaches where the covalent bond used to be – Hydrolysis reactions dominate the digestive process, guided by specific enzymes Types of Macromolecules There are four of them Carbohydrates Lipids Proteins Nucleic acids ☺ For each of these you will be expected to identify, describe, and differentiate between all four macromolecules ☺You will also be expected to describe the biological importance of each macromolecule Function of Carbohydrates Sugars, the smallest carbohydrates, serve as fuel and carbon sources Polysaccharides, the polymers of sugars, have storage and structural roles Phospholipids are major components of cell membranes • Phospholipids have two fatty acids attached to glycerol and a phosphate group at the third position • The “head” likes water • The “tail” hates water • The interaction of phospholipids with water is complex – The fatty acid tails are hydrophobic, but the phosphate group and its attachments form a hydrophilic head • When phospholipids are added to water, they selfassemble into aggregates with the hydrophobic tails pointing toward the center and the hydrophilic heads on the outside – This type of structure is called a micelle • What structure is this similar to? • At the surface of a cell phospholipids are arranged as a bilayer – the hydrophilic heads are on the outside in contact with the aqueous solution and the hydrophobic tails form the core – The phospholipid bilayer forms a barrier between the cell and the external environment • They are the major component of cell membranes Steroids include cholesterol and certain hormones • Steroids are lipids with a carbon skeleton consisting of four fused carbon rings – Different steroids are created by varying functional groups attached to the rings Proteins - Many Structures, Many Functions A polypeptide is a polymer of amino acids connected to a specific sequence A protein’s function depends on its specific conformation Introduction • Proteins are instrumental in about everything that an organism does – – – – – – – structural support, storage transport of other substances intercellular signaling movement defense against foreign substances Proteins are the main enzymes in a cell and regulate metabolism by selectively accelerating chemical reactions • Humans have tens of thousands of different proteins, each with their own structure and function • Proteins are the most structurally complex molecules known – Each type of protein has a complex threedimensional shape or conformation • All protein polymers are constructed from the same set of 20 monomers, called amino acids • Polymers of proteins are called polypeptides • A protein consists of one or more polypeptides folded and coiled into a specific conformation A polypeptide is a polymer of amino acids connected in a specific sequence • Amino acids consist of four components attached to a central carbon, the alpha carbon • These components include a hydrogen atom, a carboxyl group, an amino group, and a side chain • Polypeptides are made of amino acids – Amino acids CONTAIN NITROGEN (N) • The repeated sequence (N-C-C) is the polypeptide backbone • Attached to the backbone are the various R groups • Polypeptides range in size from a few monomers to thousands • The structural properties of silk are due to beta pleated sheets – The presence of so many hydrogen bonds makes each silk fiber stronger than steel Nucleic Acids • Contain genetic information – • • Provides instructions for making polypeptides Each monomer is a nucleotide Nucleotides are composed of carbon sugar   Deoxyribose ribose Phosphate group Nitrogenous base     Adenine (A) Thymine (T) in DNA, Uracil (U) in RNA Guanine (G) cytosine • Deoxyribonucleic acid (DNA) – Sugar is deoxyribose – Shape is a double helix • Ribonucleic acid (RNA) – Sugar is ribose – Uses a different nitrogenous base • Uracil (U) instead of thymine (T) – Shape may be a single or double helix [...]... other monomers, including those of amino acids (protein) and fatty acids (lipids) • in aqueous solutions monosaccharides form rings While often drawn as a linear skeleton, 2 Polysaccharides, the polymers of sugars, have storage and structural roles • Polysaccharides are polymers of hundreds to thousands of monosaccharides joined together (What is a polymer?) • One function of polysaccharides is energy... conformation • All protein polymers are constructed from the same set of 20 monomers, called amino acids • Polymers of proteins are called polypeptides • A protein consists of one or more polypeptides folded and coiled into a specific conformation A polypeptide is a polymer of amino acids connected in a specific sequence • Amino acids consist of four components attached to a central carbon, the alpha carbon... storage transport of other substances intercellular signaling movement defense against foreign substances Proteins are the main enzymes in a cell and regulate metabolism by selectively accelerating chemical reactions • Humans have tens of thousands of different proteins, each with their own structure and function • Proteins are the most structurally complex molecules known – Each type of protein has... assembled from smaller molecules by dehydration reactions • A fat is constructed from two kinds of smaller molecules, glycerol and fatty acids • Glycerol consists of a three carbon skeleton with a hydroxyl group attached to each • • A fatty acid consists of a carboxyl group attached to a long carbon skeleton, often 16 to 18 carbons long • The many nonpolar C-H bonds in the long hydrocarbon skeleton make...Structure of Carbohydrates • Monosaccharides generally have molecular formulas containing C,H and O in a 1:2:1 ratio – For example, glucose has the formula C6H12O6 – Most names for sugars end in -ose • Monosaccharides are also classified by the number of carbons in the backbone • Monosaccharides, particularly glucose, are a major fuel for cellular work • They are also building blocks for of other monomers,... different • Fatty acids may vary in length (number of carbons) and in the number and locations of double bonds • If there are no carbon-carbon double bonds, then the molecule is a saturated fatty acid - a hydrogen at every possible position • If there are one or more carbon-carbon double bonds, then the molecule is an unsaturated fatty acid - formed by the removal of hydrogen atoms from the carbon skeleton... – This type of structure is called a micelle • What structure is this similar to? • At the surface of a cell phospholipids are arranged as a bilayer – the hydrophilic heads are on the outside in contact with the aqueous solution and the hydrophobic tails form the core – The phospholipid bilayer forms a barrier between the cell and the external environment • They are the major component of cell membranes... needed • Other polysaccharides serve as building materials for the cell or whole organism • Starch is a storage polysaccharide composed entirely of glucose monomers – Great big chain of glucose molecules – What would this look like? (Draw it.) Biological Uses of Polysaccharides • Plants store starch within plastids, including chloroplasts • Plants can store surplus glucose in starch and withdraw it when... amounts of energy 2 Phospholipids are major components of cell membranes 3 Steroids include cholesterol and certain hormones Introduction • Lipids are an exception among macromolecules because they do not have polymers – Though lipid structure is easily recognized • Lipids all have little or no affinity for water • Lipids are highly diverse in form and function 1 Fats store large amounts of energy... the double bonds prevent the molecules from packing tightly together 2 Phospholipids are major components of cell membranes • Phospholipids have two fatty acids attached to glycerol and a phosphate group at the third position • The “head” likes water • The “tail” hates water • The interaction of phospholipids with water is complex – The fatty acid tails are hydrophobic, but the phosphate group and

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Mục lục

  • Chemistry of Cells

  • Objectives

  • Objectives Cont.

  • Slide 4

  • MacroMolecules

  • Slide 6

  • Slide 7

  • Breaking Down Polymers

  • Types of Macromolecules

  • Function of Carbohydrates

  • Structure of Carbohydrates

  • Slide 12

  • Slide 13

  • Slide 14

  • Slide 15

  • Slide 16

  • Slide 17

  • Lipids - Diverse Hydrophobic Molecules

  • Slide 19

  • Slide 20

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