Đánh giá sự ô nhiễm kim loại nặng trong thuốc đông dược và nghiên cứu đánh giá gốc và phân bố kim loại nặng trong một số

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Đánh giá sự ô nhiễm kim loại nặng trong thuốc đông dược và nghiên cứu đánh giá gốc và phân bố kim loại nặng trong một số

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DAI HOC QUOC GIA HA N Q I TRUONG DAI HOC KHOA HOC TUNHIEN BAG GAG TGNG KET DE TAI DANH CIA SU NHIEM KIM LGAI NANG TRGNG THUGC OGNG DUQC VA INGHIEN CUU OAINH GIA NGUGN GOC VA SU PHAN BO KIM LGAI NANG TRGNG MGT SG CAY THUGC Mas6: Chii tri dk tai: Cac can bo tham gia: QG-09-13 PGS.TS Ta Thi Thao Ths Nguyen Ngoc Son ThS Nguyen Thi Van Anh CN Nguyin Van ThuSn HANOI-2011 MyCLUC Trang Bao c^o tom tat ket qua thuc hien de tai Project's Summary Mo dau J Chucmg 1: Tong quan tai lieu 1.1 Tinh hinh bao che, sir dung dugc lieu va nhilm doc kim loai nang dugc lieu a Viet Nam hien 1.2 Cac phuong phap phan huy mau xac dinh lugng vet kim loai nang mau dat va mau thuc vat l,2.1.C^c phuang phap phan huy mau xac dinh lugng vet kim loai nang mau dat, tram tich 1.2.2 Cac phuang phap phan huy mau xac dinh lugng vet kim loai nang mau thuc vat 1.3 Phuong phap khoi plasma cao tan cam ung (ICP-MS) xac dinh lugng vet kim loai nSng 1.4 Phan tich thong ke da bien xac dinh nguon goc va su phan bo kim loai nSng 1.4.1 Khai niem phuang phap PCA va CA f ^ r \ f r n ^ Q IQ ^2 j^ fir 1.4.2 Mot so thong ke da bien xac dinh nguon goc chat nhiem 14 Chuang 2: Thuc nghiem jy 2.1 Dung cu va hoa chat jy 2.2 Lay mau va bao quan mau 19 2.2.1 Mau dugc lieu va thang thuoc dong y 1^ 2.2.2 Lay mau dat cay thuoc 24 2.2.3 Mau cay thuoc 26 2.3.Quy trinh xu ly mau dat va mau cay thuoc xac dinh kim loai nang 28 2.3.1 Quy trinh xu ly mau dat xac dinh kim loai nang 29 2.3.2 Quy trinh xu ly mSu cay thuoc va thang thuoc dong y 29 2.4.Phuang phap phan tich va xu ly so lieu phan tich 29 Chuang 3: Ket qua nghien cuu va thao luan 33 3.1 Nghien cuu t6i uu hoa cac di§u kien phan tich cua phuang phap ICP-MS 33 3.1.1 Chgn dong vi phan tich 33 3.1.2 Do sau mau 34 3.1.3 Cong suat cao tan 34 3.1.4 Luu lugng mang 34 3.1.5 Tom tat cac thong so toi uu 3.2 Danh gia phuang phap phan tich ICP-MS 3.2.1 Khoang tuyen tinh 3.2.2 Duong chuan xac dinh ham lugng 11 kim loai 3.2.3 Giai han phat hien va giai han dinh lugng 3.2.4 Danh gia chinh xac (do dung va chum) cua phep ICP-MS 3.3.Nghien cuu xay dung va danh gia quy trinh xu ly mau 3.3.1 Xay dung quy trinh xu ly mau thuoc dong y 3.3.1.1 Cac quy trinh xii ly mau khao sat 3.3.1.2.Danh gia hieu suat thu hoi cac qui trinh xu ly mau cay 3.3.1.3 Do chinh xac ciia phuong phap phan tich mau thuc te 3.3.1.4 Danh gia hieu suat thu hoi 11 kim loai nang vai quy trinh xu ly mau cay lua chgn 3.3.2 Lua chgn qui trinh xu ly mau dat 35 36 36 36 37 40 42 42 42 44 .« q 3.3.2.1.Danh gia hieu suat thu hoi r 3.3.22 Danh gia chum (qua lap lai ) ^I 3.3.3 Danh gia phuang phap phan tich thong qua mau chuan dugc chung nhan CRM 3.4 Ket qua phan tich mau thuc te 3.4.1 Ket qua phan tich ham lugng kim loai nang dugc lieu va thuoc dong y 3.4.2 Ket qua phan tich ham lugng kim loai nang mau cay thuoc va mau dat cay thuoc 3.5 Danh gia ham lugng kim loai nang dat va cay 53 c-^ ^^ ^Q 3.5.1 Danh gia ham lugng kim loai nang a dat ^-Q 3.5.2 Su phan bo ham lugng kim loai nang mot so cay thuoc ^^ 3.6 Buac dau khao sat su phat tan kim loai nang tu dugc lieu vao thuoc sac 3.7 Danh gia su tich luy kim loai nang dat va cay 3.7.1: ich luy kim loai nang theo thai gian thu hoach cay thuoc: ^^ 68 3.7.2 Phan bo ham lugng kim loai dat theo sau 68 ^g 3.7.3 rich luy kim loai cac bg phan cua cay thuoc ^Q 3.7.4 MANOVA danh gia anh huong ciia dia diem, thai gian thu hoach cay thuoc den ham luaim KL tronii cav thuoc 3.7.5 He s6 tich luy sinh hoc cac kim loai nang tCr dat len ca\ thuoc JQ 3.8 Phan tich thdng ke da bi^n danh gia nguon goc va sir phan bo nhiem kim loai nang mau dat ca\ thuoc va mot so cay thuoc dong dugc -j^ 3.8.1 Phan tich cau tur chinh (PCA) ^ ^ 3.8.2 Phan tich nh6m(CA) 73 76 DANH MyC CAC CHU VIET TAT AAS Phuang phap hap thu nguyen tir ANOVA Phan tich phucmg sai CA Phuang phap phan tich nhom CRM Mau vat lieu chuan dugc chung nhan CV-AAS Pho hap thu nguyen tii' diing ky thuat hoa hai lanh F-AAS Pho hap thu nguyen tu' nggn lua HSTLSH He so tich luy sinh hoc HVG-AAS Pho hap thu nguyen tii' dung ky thuat hidrua hoa ICP-AES Phuong phap phat xa nguyen tu- cao tan plasma cam ung ICP-MS Phuang phap khoi cao tan plamsa cam ung KLN Kim loai nang LOD Giai han phat hien LOO Giai han dinh lugng MANOVA Phan tich dong phuong sai PC Thanh phan chinh PCA Phuang phap phan tich phan chinh TB Trun" hinh BA O CAO TOM TAT KET QUA THlTC HIEN De t^i nghien ciru dac biet cSp Dai hoc Qu6c Gia Ten de tai: D^nh gia su' nhiem kim loai nang thuoc dong du'oc va nghien ciru d^nh gi^ nguon goc va su* phan bo kim ioai nang mot so cay thudc Ma s6: QG-09-13 Chu tri da tai: PGS.TS Ta Thi Thao Don vi cong tac: Khoa Hoa hgc- Truong Dai hgc Khoa hgc tu nhien Dia chi: 334- Nguyen Trai- Thanh Xuan- Ha Ngi S6 dien thoai: 84-4- 858.4287 So can bg tham gia: 03 Ths Nguyin Ngoc So*n- Khoa H6a hoc - Truong DHKHTN- DHQGHN ThS Nguyen Thj Van Anh- Hgc vien nghien cuu y Dugc co truyen Viet Nam m, r CN Nguyen Van Thuan- Hgc vien cao hgc K18 IMuc tieu va noi dung nghien cuu - De tai nghien cuu nham xay dung qui trinh phan tich, danh gia muc nhiem cac kim loai nang mot so loai thuoc dong dugc dang luu hanh tren thi truong Viet Nam hien nay, dong gop vao viec kiem soat chat lugng thuoc dong dugc hien dang dugc su dung rgng rai duai dang thuoc bo hoac thuoc dieu tri Ben canh viec danh gia sir phat tan kim loai nang vao thuoc uong sau sac se la co so ban dau da xay dung tieu chuan ham lugng kim loai nang thuoc dong dugc Cac ket qua danh gia ngu6n g6c ciia nhiem kim loai nang se dugc tien hanh tren doi tugng dat trdng nhieu vung khac va Ian truyen nhiem tu dat vao cac bo phan ciia cay dung lam thudc nhu re, than, la, qua, hat va danh gia Ian truyen du lugng kim loai nSng theo thai gian da xay dung khuyan cao va lugng kim loai nang co mat thudc dong dugc dung lam nguyan lieu dua tran diau kien tho nhuong, trong, cham soc v^ thu h^i, bao quan - De tai g6m nhijng ngi dung nghian cuu chii yau sau: f t , +T6i uu hoa cac diau kien phan tich dong thoi lugng vat va siau vat cac kim loai nSngnhuCu, Pb, Cd, Zn, Co, Ni, Cr, Mn bSngthiatbi phan tich ngudn cao tAn cam ung plasma- khoi (ICP-MS) co danh gia ham lugng hai nguyan t6 hay gay sai so phan tich bang phuang phap la As va Hg da rut co c4n thiat phai phan tich chung tren thiat bi hap thu nguyan tu, ap dung ky thuat hidrua hoa ( HVG- AAS) hoac hoa hoi lanh (CV-AAS) hay khong -fNghian cuu xay dung cac qui trinh xu ly mau thuoc dong dugc va xu ly mau dat + Danh gia su Ian truyan nhiam kim loai nang vao cay thudc dilu kien th6 nhuong, va cham soc, thu hai bao quan -I- Dung phan tich thong ka da bian danh gia nguon goc phat tan kim loai nang thuoc dong dugc trgt Cac ket qua dat duoc: 3.1 Ket qua l mau bang binh Kendal va qu\ trinh su dung 16 vi song va lira chgn dugc quy trinh xu ly mau phu hgp voi trang bi hien co la phuang phap kho u6l ket hgp hoac xu ly 16 \ i song dat hieu suat thu hoi tu 90-95% va lap t6t CV dugc thu thap tren dia ban quan Hoan Kiem va Ha Dong (Ha Ngi) Ket qua phan tich cho tha\ chua phat hien thay sir nhiem doc kim loai nang cac mau nghien cuu Nghien ciiu cung da buac dau danh gia su phat tan kim loai nang tu dugc lieu vao thuoc sac Su phat tiin thuoc vao tirng kim loai, mot so kim loai phat tan tuong doi nhieu (tran 30%) nhu Ni, Cu, Zn Ket qua phan tich ham lugng 1 kim loai nang dat cay thu6c va mot s6 ca\ thuoc tai hai dia diem la \ ucm thuoc cung cho thay c6 sir cao bk th\ibng mot s6 kim loai Viec sir dung chain th6ng ke Student dl danh gia cung cho thay co sir khac co nghTa v^ ham lugng trung binh m6i kim loai tai hai dia diem khac nhau, theo thai gian sinh song ciia cay va kha nang tich luy sinh hgc ciia cay theo tuoi * Dua tran kat qua dat dugc, bang phan tich thong ka da bian da danh gia dugc nguon goc phat tan kim loai nang cay thuoc dong dugc tran dAt nghian CUU, tu riit dugc nhan xat va diau kien tho nhuong va cham soc, ban chat tu nhian ciia chat dat gay sir khac c6 nghTa va ham lugng cua mot so kim loai nang khac Ngoai ra, muc tich luy kim loai nang khac voi timg loai cay va theo thai gian khac cung gay bian doi khac ve ham lugng trung binh Vi vay, can co nhung nghian cuu cu tha hon voi tung loai cay thuoc da danh gia muc anh huong cua kim loai nang tu co tha dua kat luan chinh xac 3.2 Ket qu^ ling dung: - Qui trinh phan tich dong thoi tong ham lugng 11 kim loai nang Cr, Mn, Fe, Co, Ni, Mn, Cu, Pb, Cd, Zn, Pb, As va Hg bang phuang phap ICP-MS voi nhay va chinh xac cao da dugc ung dung da phan tich ham lugng cac kim loai nang dat, cay thuoc va thang thuoc dong dugc cung nhu thuoc sac tran thiat bi ICP-MS tai khoa Hoa hgc- Truong Dai hgc Khoa hgc Tu nhian- Dai hgc Quoc Gia Ha Ngi - Da nghian cuu v^ ling dung phuong phap thong ka da bien da phan tich tap so lieu va ham lugng 11 kim loai nang cay thuoc va dat cay thuoc tai hai dia diam khac da kat luan \e phan bo ham lugng kim loai nang va nguon goc phat tan kim loai nang vao cay thuoc gop phan on dinh va kiam soat chat lugng dugc lieu tu goc So lieu thu dugc cung minh hga tot dang bai giang va phuong ph^p thong ka da bian chuyan da bat bugc day cho sinh vian cao hgc chuyan nganh Hoa phan tich cua khoa Hoa 33 Ket qu^ cong bo - Ba bai bao khoa hgc da dang tran tap chi khoa hgc chuyan nganh : Ta Thi Thao, Nguyen Thi Van Anh, Nguyen Nggc Son Nghian cuu danh gia ham lugng kim loai nang dong dugc bang phuang phap khoi plasma cam ung (ICP-MS) Tap chi khoa hoc va cong nghe Tap 48, s6 2A, (2010), trang 469477 2 Ta Thi Thao, Nguyin Van Thu4n, Nguyen Thi Huang Tham Nghien cuu danh gia nguon goc va phan bo kim loai nang mot s6 cay thudc va dit trdng cay thuoc bang phuang phap phan tich ICP-MS va th6ng ke da biln Tgp chi Hoa hoc T 48, 4C, (2010), trang 396-401 Ta Thi Thao, Nguyan Van Thuan Ung dung phuang phap khoi cao tan plasma cam ung (ICP-MS) da phan tich danh gia ham lugng kim loai nang mot SO cay thuoc va dat cay thuoc Tap chi Phan tich Hoa, Ly va Sinh hgc Viet Nam Tap 15, S6 (2010), trang 223-229 3.4 Ket qua dao tao 3.4.1 Cii' nhan: 02 - Nguyen Thj Thanh Dao Nghian cuu danh gia ham lugng asen va thuy ngan mot loai cay thuoc va phat tan vao thuoc sac Khoa luan tot nghiep- Khoa Hoa hgc- Truong DH KHTN, 2009 - Nguyen Thj Hong Phan tich ham lugng mot so kim loai nang thuoc dong dugc bang phuang phap hap thu nguyen tu Khoa luan tot nghiep- Khoa Hoa hgc- Trudng DH KHTN, 2011 3.4.2 Thac sT: 01 Nguyen Van Thuan Nghian ciiu danh gia nguon goc va su phan bo kim loai nang mot so cay thuoc.Truong Dai hoc Khoa hgc Tu nhien DHQG Ha Ngi, 2010 3.4.3 Ty dao tao: Nang cao tay ngha phan tich va xay dung cac qui trinh phan tich tran kim loai nang doi tugng dat, tram tich va thuc vat tran thiat bi phan tich hiendai ICP- MS Tinh hinh kinh phi ciia de tai: 100 trieu dong (mot tram trieu dong) 4.1 Thua khoan chuyen mon: 42.000.000 d -Chi phi nghiep vu chuyan mon: 54.000.000 d 4.2 Chi mua sam trang thiet bi: 4.3 Chi toan dich vu cong cong: 4.000.000 d Danh gia tinh thinh thuc hien nhiem vu nghien cuu: da hoan nhiem vu dugc giao Ha Noi, 24 thang nam 2011 Chii nhiem de tai Khoa quan ly V ?(^^^s, ^ t ^ - ^ ' ^^^ PCS TS Ta Thi Thao TRUONG DAI HOC KHOA HOC TU NHIEN •MOHI^UTtUONO PROJECT SUMMARY Project Title: ''Heavy metal contamination in traditional medicin and study on the sources and distribution of heavy metal contents in some herbal plants'' - Code Number: QG-09-13 - Project Leader: Ta Thi Thao, Assoc Prof Dr - Directing Institution: Department of Chemistry, University of Science, Vietnam National University, Hanoi r^articipatc members: 03 +Master of Science Nguyen Ngoc Son- Department of Chemistry, HUS, VNU ^Master of Science Nguyen Thi Van Anh- Vietnam Institute of Traditional Medicine and Pharmacy ^Bachelor [Nguyen Van Thuan- Master Student K 18 Project's Coals and studied methods: - Build up an analytical procedure and evaluation of the pollution of heavy metals in some oriental medicines that have been widel}' used as supplement or treatment drugs being circulated on the Vietnamese market The experimental results will contribute to the quality control medication - Assessing the release of heavy metals into cooked medicines will be the background for the establishment of standard amount o\^ heav\ metals in oriental medicines - The heavy metals pollution sources will be evaluated from the anal\lical results of soil in many different areas The spread of heavy metals from soil to parts of medicine plants such as root, body, leaves, fruits, grains will be also studied + Methods for study: The ICP-MS has been optimized to analyze traces of heav\ metals such as Cu, Pb, Cd, Zn, Co, Ni, Cr, Mn, As, Hg in several traditional medicine samples By applyzing the validation of an analytical method, the ICP- MS has been confirmed to be the applicable method for the determination of As and Hg instead of HVG-AAS The obtained data has also processed by multivariable statistic methods to evaluate the release of heavy metals into cooked medicines and the spread of heavy metals from soil to parts of medicine plants such as root, body, leaves, fruits, grains The preparation of medicine and soil samples are also needed to study to fmd out the best suitable methods with labaratory conditions in Vietnam Obtained results 3.1 Scientific Contributions: + Optimization and suitable analytical conditions had been studied to determine ultratrace amount of Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb using ICP-MS technique The procedure for validation of an analytical method also had been applied for evaluating LOD, LOQ, accuracy (precision and truness), recovery of the method with complex matrix and CRM The procedure for the analysis of total heavy metals in traditional medicines and soil had been figured out H- Six methods of medicine sample preparation (including methods in furnace, sample degition procedure using Kendal method and a method using microwave oven) had been studied and a best applicable procedure for the preparation of medicin, soil and herbal plant samples had obtained The recovery of the best one was 90-95% with CV < 5% -I-Thirty five herbal medicine samples collected in Hoankiem and Ha Dong districts (Hanoi) were analysed and the polution of heavy metals in studied samples were not recognized In this project, the releasing of heavy metals from traditional medicine to boiled water was given The degree of the heavy metals released into cooked medicines depended on each heavy metal (especially over 30% with Ni, Cu, Zn) +The trace amount of 11 heavy metals in soil samples and herbal plants in places in Northen Vietnam was analysed Using t-test, the significant difference of mean between different places, lifetime of plants and biology accumulate of plant was recognised + Multivariate analysis was also used to evaluate the sources of heavy metals in herbal plants to figure out the effect of geology, conditions of agricultures and the nature of soils to the accumulation of heavy metals in herbal plants The biological accumulation was also difTerent from each other and their lifetime The acumulation of heavy metals from soil to some parts of medicinal plants such as root, body, leaves, fruits, grains was much different to types of herbs Therefore, the detailed studied on each medicinal plant should be carried out to obtain the exact assessment of heavy metaPs effect to the medicinal plants and herbal medicines as well 3.2 Applied results: - The analytical procedure on ICP-MS equipment can be used as a standard method for the traditional medicine's quality control But the verification of the analytical method should be carried out before applying as a standard procedure in a lab - The multivarite analysis methods were applied to find out the distributions, sources of heavy metals contents based on the experimental data of 11 metal amounts in herb, medicine plants and soils collected at places The obtained results figured out the assessment of heavy metals content in herbal medicines These data have been being used as the good examples of multivariate analysis for the lectures in master education at Department of analytical chemistry 3.3 Results - Publications: 03 Ta Thi Thao, Nguyen I'hi Van Anh, Nguyen Ngoc Son Assessment of heavy metal contents in herbs using ICP-MS Journal of Science and Technology Vol 48, No 2A, (2010), pp 469-477 Ta Thi Thao, Nguyen Van Thuan, Nguyen Thi Huong Thorn Evaluation of distribution and sources of heav>' metals in some medicinal herbs and soils using ICPMS technique and multivariate analysis Journal ofChemisuy T 48 4C (2010), pp 396-401 3, Ta Thi Thao, Nguyen Van Thuan Evaluation of heavy metal contents in medicinal herbs and soils using ICP- MS technique Journal of Analytical Sciences Vol 15, No (2010) pp 223-229 3.4 Contribute to t r a i n i n g 3.4.1 Bachelor: 02 - Nguyen Thi Thanh Dao Assessment of arsenic and mercury contents in some kinds of medicinal herbs and releasing in to water of cooked medicinal herbs Bachelor thesis, Hanoi University of Science, I'NU, 2009 - Nguyen Thi Hong AnaKsis of some heav> metal contents in herbal medicines using AAS Bachelor thesis, Hanoi University of Science, I NU, 2011 3.4.2 Master thesis: 01 Nguyen Van Thuan Evaluation of distribution and sources of heavy metals in some medicinal herbs Master thesis Hanoi University of Science, VNU, 2009 Funding of the project: 100,000,000 VND MO DAU Hien nay, cung voi su phat trian cua khoa hgc cong nghe, nhiau tuu khoa hgc hien dai dugc van dung y hgc, gop phan nang cao chat lugng phong benh, chu'd benh, phuc hoi chuc nang, nhiau loai tan dugc dugc dua vao diau tri voi ch^t lugng cao nhung xu huong cua tha gioi van ua thich su dung cac phuang phap y hgc truyan thong, dac biet la y hgc co truyan phuong Dong Trong diau tri benh ben canh thuoc tay y dugc dung da diau tri cac can benh cap tinh thi thuoc dong y ngoai viec diau tri cac can benh man tinh duoc de cao vai tr6 viae chiJa banh tu soc Do tinh dac thu cua thuoc dong y la chuyan bian benh cham nan nguai benh phai uong thuoc thai gian dai Vi vay, nau chat lugng thuoc khong dugc kiam soat tot co tha dan tai nhung anh huong nghiam trgng doi voi co tha Mot cac yau to gay anh huong co hai den co tha nguai su dung thuoc dong dugc thai gian dai la ham lugng kim loai nang tran muc cho phep Khi vao CO the, lugng Ion kim loai nang tich tu cac mo, o cac co quan: gan, than, nao Co the cung co co che tu dao thai, nhung toe tich tu krn hon gap nhieu Ian Vi vay, kim loai nang co tha gay ngg doc cap tinh, tii' vong nhanh nhu nhiem doc cap tinh asen, chi nhung chu yau su tich luy dan kim loai nang co tha gay doc man tinh, nhieu can benh nguy hiam xuat hien, dac biet la benh ung thu Voi nguai benh, benh c6n nhe thuang tu tim thuoc va diau tri o cac thay lang, sau mai den cac nha thuoc dong y; phan nhieu so la dong y gia truyen va qua nhiau loai thuoc khac nen rat kho danh gia su nhiem doc thuoc, neu CO Gan day, cac xet nghiem tran hai benh nhan mot la phu niT trung nien bi ung thu te bao day va mot nam trung nian bi ung thu biu cho thay ham lugng asen toe va nuoc tieu rat cao co lian quan dan viec su dung nhiau thang thuoc bac co chua asen th6*i gian dai Viet Nam, asen v6 co thuc)iig dugc bo them vao cac thang thuoc bac hay thuoc nam nham dieu tri suyen va thuoc bo Benh nhan su dung cac loai thuoc co chua asen na\ thuang an ngon, ngu dugc len can \a benh suyan giam Ben canh vice them asen vao thuoc dong y da diau tri benh va gay nguy hiem cho benh nhan thi ban than thuoc dong dugc o Viet Nam hien na\ deu khong ro nguon g6c va chat lucmg Thuoc dugc thu mua cua dan tu hoac thu hai tren rung Toan bg qua trinh san xuat dong dugc nhu trong, cham soc, thu hai, che bien chu \eu tht^rc hien bang phuang phap thu cong, kern theo kinh nghiem thuc te tru\en mieng chu [...]... de cao vai tr6 trong viae chiJa banh tu soc Do tinh dac thu cua thuoc dong y la chuyan bian benh cham nan nguai benh phai uong thuoc trong thai gian dai Vi vay, nau chat lugng thuoc khong dugc kiam soat tot co tha dan tai nhung anh huong nghiam trgng doi voi co tha Mot trong cac yau to gay anh huong co hai den co tha nguai khi su dung thuoc dong dugc trong thai gian dai la ham lugng kim loai nang tran... loai nang tran muc cho phep Khi vao CO the, lugng Ion kim loai nang tich tu trong cac mo, o cac co quan: gan, than, nao Co the cung co co che tu dao thai, nhung toe do tich tu krn hon gap nhieu Ian Vi vay, kim loai nang co tha gay ngg doc cap tinh, tii' vong nhanh nhu nhiem doc cap tinh asen, chi nhung chu yau do su tich luy dan kim loai nang trong co tha gay doc man tinh, nhieu can benh nguy hiam... dong y; phan nhieu trong so nay la dong y gia truyen va qua nhiau loai thuoc khac nhau nen rat kho danh gia su nhiem doc do thuoc, neu CO Gan day, cac xet nghiem tran hai benh nhan mot la phu niT trung nien bi ung thu te bao day va mot nam trung nian bi ung thu biu cho thay ham lugng asen trong toe va nuoc tieu rat cao co lian quan dan viec su dung nhiau thang thuoc bac co chua asen trong th6*i gian... khoa hgc cong nghe, nhiau thanh tuu khoa hgc hien dai dugc van dung trong y hgc, gop phan nang cao chat lugng phong benh, chu'd benh, phuc hoi chuc nang, nhiau loai tan dugc dugc dua vao diau tri voi ch^t lugng cao nhung xu huong cua tha gioi van ua thich su dung cac phuang phap y hgc truyan thong, dac biet la y hgc co truyan phuong Dong Trong diau tri benh ben canh thuoc tay y dugc dung da diau tri cac... them vao trong cac thang thuoc bac hay thuoc nam nham dieu tri suyen va thuoc bo Benh nhan khi su dung cac loai thuoc co chua asen na\ thuang an ngon, ngu dugc len can \a benh suyan giam Ben canh vice them asen vao thuoc dong y da diau tri benh va gay nguy hiem cho benh nhan thi ban than thuoc dong dugc o Viet Nam hien na\ deu khong ro nguon g6c va chat lucmg Thuoc dugc thu mua cua dan tu trong hoac... cho benh nhan thi ban than thuoc dong dugc o Viet Nam hien na\ deu khong ro nguon g6c va chat lucmg Thuoc dugc thu mua cua dan tu trong hoac thu hai tren rung Toan bg qua trinh san xuat dong dugc nhu trong, cham soc, thu hai, che bien chu \eu tht^rc hien bang phuang phap thu cong, kern theo kinh nghiem thuc te tru\en mieng chu 1 ... lugng kim loai nang a dat ^-Q 3.5.2 Su phan bo ham lugng kim loai nang mot so cay thuoc ^^ 3.6 Buac dau khao sat su phat tan kim loai nang tu dugc lieu vao thuoc sac 3.7 Danh gia su tich luy kim. .. nhiem doc kim loai nang cac mau nghien cuu Nghien ciiu cung da buac dau danh gia su phat tan kim loai nang tu dugc lieu vao thuoc sac Su phat tiin thuoc vao tirng kim loai, mot so kim loai phat... qua phan tich ham lugng kim loai nang dugc lieu va thuoc dong y 3.4.2 Ket qua phan tich ham lugng kim loai nang mau cay thuoc va mau dat cay thuoc 3.5 Danh gia ham lugng kim loai nang dat va cay

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