DIRECTED DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS INTO HAEMATOPOIETIC AND DEFINITIVE ENDODERMAL LINEAGES ABRAHAM SUMAN MARY (M.Sc MICROBIOLOGY, UNIV OF MUMBAI, INDIA) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOCHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE 2009 ACKNOWLEDGEMENTS In all things I give YOU glory! You have always led me through amazing paths and given me gifts that I don’t deserve I thank you Lord for all the blessings you constantly shower on me Everything is possible with God! I thank Dr Alan Colman for being my guide and helping me to initiate the work contained in this dissertation His support and encouragement have been invaluable Thank you, Alan for your support through the years Dr Norris Ray Dunn took me under his wing and guided me through this endeavour He has been a true mentor, always willing to teach, and I have learned a lot from him Ray, thank you for showing me the way and helping me reach this juncture A significant part of the research was conducted at ES Cell International Pte Ltd to whom I would like to express my sincere gratitude Triona, Jacqui, Robert, Michael, Bruce, Chirag, Suzan and so many others have played important roles and encouraged me at all times Critical portions of this work were done at the Institute of Medical Biology, A*Star I would like to register my appreciation for the support and help provided by many people in IMB especially, members of the Ray Dunn lab, Mike Jones lab and Alan Colman lab Kee Yew, thank you for giving me your precious time and helping me with some of the most important data in this dissertation I would like to thank the staff at the Department of Biochemistry and Yong Loo Lin School of Medicine at the National University of Singapore for providing administrative support Through the years many colleagues and friends have expressed their concern, spoken encouraging words and pushed me to get to the finish I thank you all Varsha, Akila, Raj, Suzan and Thava, Chaaya, Ajith and Surinder– you have seen my struggles, listened to my problems and never hesitated to help Thank you My teachers through the years have influenced me in so many fantastic ways I remember you all and thank God that you were in my life Ms Susan, Mrs Chinnamma Kovoor, Mrs Phadnis, Mrs Shantini Nair, Mrs Vaidya, Mrs V.P.Kale and George– thank you None of this would have been possible but for the support system my family has been Thank you, Appa and Mummy for all the love and laughter and for inspiring me to follow my heart Sumitha, Aji and Tamanna, and Susan, thank you for the joy you bring to my life and my world Pappa and Mamma, thank you for your love and unconditional support My grandparents and the rest of my extended family have been encouraging me whole-heartedly and I sincerely thank all of them Ajit, you are my strength and joy You have been waiting patiently, working so hard not to distract me and making me smile even when things were tough Thank you for being by my side, egging me on and never losing faith in me You’re simply the best! i TABLE OF CONTENTS Summary………………………………………………………………………… ….v List of tables……………………………………………………………………… vii List of figures…………………………………………………………………… viii List of symbols……………………………………………………………………… x Chapter 1: General Introduction 1.1 Embryonic stem cells 1.2 Gastrulation– formation of mesoderm and endoderm in the embryo .8 1.3 Regenerative medicine and embryonic stem cells 10 1.3.1 Diabetes– a candidate disease for cell therapy 10 1.3.2 Transplantation tolerance of hESC-derived cell therapy 10 1.4 Haematopoiesis .18 1.4.1 Haematopietic development in the mouse 18 1.4.2 Haematopoiesis in the human embryo .25 1.4.3 Haematopoietic differentiation from mESCs .26 1.4.4 Haematopoietic differentiation from hESCs 29 1.5 Definitive endoderm formation in the vertebrate embryo 34 1.5.1 Differentiation of mESCs to endodermal derivatives 40 1.5.2 Endodermal differentiation from hESCs 45 Chapter 2: Materials and Methods 2.1 Cell culture 52 2.1.1 Human embryonic stem cell culture 52 2.1.2 Stromal feeder cells 53 2.2 Differentiation protocols .53 2.2.1 Haematopoietic differentiation: Co-culture with stromal cell lines 53 2.2.2 Haematopoietic differentiation: Use of cytokines 54 2.2.3 Endodermal differentiation: 3D Matrigel protocol 55 2.3 CFU assay .57 2.4 Flow Cytometry 58 2.5 Immunocytochemistry 58 2.6 Differential staining 59 ii 2.7 RNA extraction .60 2.8 Quantitative RT-PCR 61 2.9 Western blotting 61 2.10 Microarray 63 2.11 Whole Mount In Situ Hybridisation (WISH) 63 2.11.1 Cloning of genes 63 2.11.2 Riboprobe synthesis 64 2.11.3 Whole-mount In Situ Hybridisation (WISH) .65 Chapter 3: Haematopoietic Differentiation Introduction.………………………………………………………………………….67 Results……………………………………………………………………………… 70 3.1 hESC-derived embryoid bodies (EBs) give rise to haematopoietic-like cells when co-cultured with stromal cell lines……………………………………… 70 3.2 hESCs form haematopoietic-like cells when differentiated in presence of prohaematopoietic- cytokines 76 3.3 hESCs maintained on human feeder cells are amenable to haematopoietic differentiation 80 3.3.1 hESCs maintained on CCD919 cells 82 3.3.2 hESCs maintained on Ortec143 cells 85 Conclusion and Discussion………………………… …… .……………… 92 Chapter 4: Endodermal Differentiation Introduction.………………………………………………………………………….96 Results……………………………………………………………………………… 98 4.1 Formation of definitive endoderm within embryoid bodies derived from hESCs ……………………………………………………………………………98 4.1.1 Bmp4 enhances the endoderm-inducing potential of Activin A in Matrigel .99 4.1.2 Matrigel affects the extent, not the outcome of differentiation 102 4.1.3 Cells expressing FOXA2 and SOX17 are of definitive endodermal origin as visceral endoderm is suppressed during differentiation .107 4.2 Detailed analysis of the role played by Bmp4 in the formation of definitive iii endoderm in vitro .110 4.2.1 Activin A signaling leads to the expression of known target genes during differentiation 112 4.2.3 Bmp4 signaling and its downstream effects 118 4.2.4 Bmp4 does not generate cell types associated with its pleiotropic activities 123 4.2.5 No evidence of formation of alternate lineages during DE differentiation 128 4.2.6 Gene Expression Analysis of Differentiation Using Microarray Technology 131 Conclusion and Discussion…………………………………………………………153 Chapter 5– Future Direction Introduction ……………………………………………………………………….159 5.1 Haematopoietic Differentiation 160 5.2 Endoderm Differentiation 161 Bibliography……….………………………………………………………… … 164 Appendices…………………………………………… ………………………….187 iv SUMMARY Human embryonic stem cells (hESCs) are derived from the inner cell mass of a 5-day old blastocyst hESCs possess the cardinal properties of unlimited self-renewal and pluripotency which enable them to give rise to the approximately 220 different cell types that comprise the human body Theoretically, harnessing this property of hESCs could provide an inexhaustible source of cell therapy material for diseases like diabetes, Parkinson’s disease, etc In order to assess the usefulness of hESCs in regenerative medicine, I investigated the ability of two cell lines– hES2 and hES3– to generate derivatives of mesoderm and endoderm in vitro Differentiation into these particular lineages was of interest to me as hESC-derived β-like cells could be used as cell therapy for Type I Diabetes and haematopoietic cells from the same source could possibly be used to induce transplantation tolerance in a host receiving the allogeneic hESC-derived cell therapy graft To this end, I evaluated published strategies that used stromal cell support or cytokines to differentiate hESCs or hESC-EBs into haematopoietic-like cells Differentiation either on a cell layer of OP9 stroma or in the presence of cytokines like SCF, IL-4, TPO and Flt3L generated haematopoietic cells from both hES2 and hES3 EBs The haematopoietic identity of these cells was established by the expression of relevant markers like CD45, CD14, CD34, CD83 and CD86 and the formation of colony forming units in methylcellulose cultures The combination and concentrations of the cytokines used or the stroma itself seemed to bias the differentiation towards a granulocytic fate as no erythroid cells were formed at any stage This finding might also indicate the restricted differentiation potential of hES2 and hES3 Though not efficient, the differentiation achieved in this study provides proof-of-principle that these cells lines can be directed to a haematopoietic fate v A simultaneous investigation of the endodermal potential of these cells resulted in the development of a three-dimensional differentiation strategy in which hESC-EBs embedded in Matrigel were exposed to Activin A and Bmp4 to generate definitive endoderm Differentiation progressed in a developmentally relevant sequence with the formation of TBRA-expressing primitive streak-like cells followed by FOXA2- and SOX17-expressing endodermal cells These cells differentiated further in the presence of growth factors that promote pancreatic development and maturation to generate PDX1+ pancreatic progenitors which gave rise to insulin-secreting β-like cells albeit at a low efficiency The unexpected combinatorial effect of Activin A and Bmp4 on the formation of endoderm was investigated in detail using molecular techniques that dissected the individual role of these factors in the differentiation However, no clear mechanism of action was evident from these studies A global view of the differentiation was obtained using microarray technology which revealed expression of novel genes and novel expression patterns of known genes in this system Expression analysis of a few selected genes in the early mouse embryo showed hitherto uncharacterized expression domains some of which may be relevant to endoderm formation The significance of these genes in the specification of endoderm will be addressed in future studies employing other model systems like Xenopus and Zebrafish vi LIST OF TABLES Table 1.1 Marker genes expressed during the differentiation of mouse and human ES cells to Definitive Endoderm Table 3.1 Various stromal feeders used, their features and outcome of differentiation Table 3.2 Cytokines used in haematopoietic differentiation of hESC-derived EBs and their known functions Table 4.1 Genes expressed during gastrulation in the mouse and/ or associated with the formation of DE Table 4.2 Preliminary list of genes for detailed analysis Table 4.4 Summary of WISH genes expression domains in the mouse embryo Table 4.5 Novel genes involved in endoderm differentiation of hESCs Table 5.1 Available information on knock-out phenotypes in the mouse vii LIST OF FIGURES Figure 1.1 Embryonic origin of human embryonic stem cells and their in vitro characterisation Figure 1.2 Lineage tree of embryo-derived cells and cell lines Figure 1.3 Gastrulation and specification of the germ layers Figure 1.4 Pancreas and diabetes Figure 1.5 Haematopoietic development Figure 1.6 Pluripotent hESCs for cell replacement therapy Figure 1.7 Haematopoiesis in the mouse embryo Figure 1.8 A model for hemangioblast development Figure 1.9 Haematopoiesis in the human embryo Figure 1.10 Strategies for haematopoietic differentiation from ES cells Figure 1.11 Development of endoderm in the vertebrate embryo Figure 1.12 Nodal pathway Figure 3.1 Summary of various protocols tested Figure 3.2 hESC-EBs co-cultured with OP9 stromal cells give rise to haematopoietic colony forming units Figure 3.3 hESC-EBs treated with cytokines give rise to haematopoietic-like cells in culture Figure 3.4 hESC-EBs differentiated in presence of cytokines generate haematopoietic colony forming units in Methocult Figure 3.5 hESC grown on CCD919 human feeders differentiate in presence of cytokines to generate haematopoietic colonies Figure 3.6 hESCs cells grown on Ortec143 differentiated in presence of cytokines to give rise to haematopoietic-like cells Figure 3.7 hESCs grown on Ortec feeders differentiate in presence of cytokines to generate haematopoietic colonies Figure 4.1 Three dimensional differentiation in the presence of Activin A and Bmp4 viii Figure 4.2 Activin A and Bmp4 induce upregulation of endodermal markers and simultaneous downregulation of pluripotency markers Figure 4.3 Activin A and Bmp4 together are more effective in inducing endodermal differentiation than either growth factor alone Figure 4.4 Absence of Matrigel adversely affects the extent of endodermal differentiation Figure 4.5 Markers of visceral endoderm are suppressed during the definitive endoderm formation phase of differentiation Figure 4.6 Proposed model for synergistic activity of Activin A and Bmp4 Figure 4.7 Genes characteristic of Nodal/ Activin A signaling Figure 4.8 Phosphorylation of Smad2/3 in response to the Activin A signal Figure 4.9 Genes expressed in response to Bmp4 signaling Figure 4.10 Phosphorylation status of Smad1/5/8 in response to the Bmp4 signal Figure 4.11 Primordial Germ Cell markers are expressed transiently at extremely low levels Figure 4.12 Trophoblast markers are expressed at extremely low levels, mainly in response to Bmp4 Figure 4.13 Differentiation does not induce significant mesodermal gene expression Figure 4.14 No significant expression of neuronal markers during differentiation Figure 4.15 Samples loaded on Illumina BeadChip for microarray analysis Figure 4.16 Heat map shows global changes in gene expression corresponding to growth factor treatment Figure 4.17 Genes expressed in conditions that form DE were chosen for further analysis Figure 4.18 Quantitative PCR in mouse embryo samples for genes shortlisted from microarray Figure 4.19 Whole mount in-situ hybridisation in mouse embryos Figure 4.20 Expression of genes characterised by WISH during in vitro differentiation of hESCs ix AZIN1 PKIA MAN2A CHAC2 0.52 0.52 0.52 OAZI; OAZIN; ODC1L; MGC691; MGC3832 PRKACN1 MANA2; MANII NM_015878 NM_006823 NM_002372 antizyme inhibitor protein kinase (cAMP-dependent, catalytic) inhibitor alpha mannosidase, alpha, class 2A, member 0.519 LMBRD2 ChaC, cation transport regulator-like (E coli) ETV6 MGC33 926 ACP5 LFNG IL10RB 0.518 0.518 TEL MGC33926 NM_001008 708 NM_001987 NM_152390 0.516 0.516 0.516 TRAP; MGC117378 HLADMA ZNF589 SMTN DET1 PHLDB 0.515 0.515 0.515 0.515 0.515 CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2 DMA; HLADM; RING6; D6S222E NM_001611 NM_002304 NM_000628 ets variant gene (TEL oncogene) hypothetical protein MGC33926 acid phosphatase 5, tartrate resistant interleukin 10 receptor, beta NM_006120 major histocompatibility complex, class II, DM alpha NM_016089 NM_006932 NM_017996 NM_015157 zinc finger protein 589 smoothelin de-etiolated homolog (Arabidopsis) pleckstrin homology-like domain, family B, member NM_004237 NM_031209 TRIP13 QTRT1 0.515 0.514 SZF1 FLJ35365; FLJ38597 FLJ10103; MGC126156; MGC126157 LL5A; FLJ00141; FLJ90266; KIAA0638; MGC111531; DKFZp686H039; DKFZp686O24210 16E1BP TGT; FP3235 CDC14B ELOVL RPL41 MPP4 0.514 0.514 CDC14B3; Cdc14B1; Cdc14B2; hCDC14B ADMD; STGD2; STGD3 NM_003671 NM_022726 0.513 0.513 RPL41 DLG6; ALS2CR5 NM_021104 NM_033066 0.512 0.511 CSC-21K ALR; ALDR1; MGC1380; MGC12529 NM_003255 NM_006066 thyroid hormone receptor interactor 13 queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) CDC14 cell division cycle 14 homolog B (S cerevisiae) elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like ribosomal protein L41 membrane protein, palmitoylated (MAGUK p55 subfamily member 4) TIMP metallopeptidase inhibitor aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.511 MPP1; KRMP1; MPP-1; DKFZp434B0435; DKFZp434P0810 CP25; HOX3; HOX3C; HHO.C8 csl; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; IGKJRB1; MGC61669 SLC19A3 NM_016195 M-phase phosphoprotein NM_153693 NM_203284 homeobox C6 recombining binding protein suppressor of hairless (Drosophila) NM_025243 solute carrier family 19, member NM_203284 recombining binding protein suppressor of hairless (Drosophila) NM_032331 hypothetical protein MGC2408 NM_015895 NM_030755 NM_001005 290 NM_138410 NM_080911 geminin, DNA replication inhibitor thioredoxin domain containing proline/serine-rich coiled-coil CKLF-like MARVEL transmembrane domain containing uracil-DNA glycosylase NM_006845 NM_014802 kinesin family member 2C KIAA0528 TIMP2 AKR1A MPHOS PH1 HOXC6 RBPSU H SLC19A RBPSU H MGC24 08 GMNN TXNDC PSRC1 0.51 csl; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; IGKJRB1; MGC61669 MGC2408 0.509 0.508 0.508 Gem; RP3-369A17.3 TMX; TXNDC1; DKFZP564E1962 DDA3; FP3214; MGC1780; RP11-297O4.2 CMTM7 UNG 0.507 0.507 KIF2C KIAA05 28 RSU1 SKP2 IVD FAM113 B METRN L PLA2G4 C CENTB RBPMS 0.507 0.506 CKLFSF7; FLJ30992 DGU; UDG; UNG1; HIGM4; UNG15; DKFZp781L1143 MCAK; KNSL6 DKFZp779N2044 0.506 0.505 0.505 0.505 RSP-1; FLJ31034 FBL1; FLB1; FBXL1; MGC1366 ACAD2 MGC16044 NM_152724 NM_032637 NM_002225 NM_138371 Ras suppressor protein S-phase kinase-associated protein (p45) isovaleryl Coenzyme A dehydrogenase family with sequence similarity 113, member B 0.505 MGC99788 0.505 CPLA2-gamma; DKFZp586C0423 NM_001004 431 NM_003706 phospholipase A2, group IVC (cytosolic, calcium-independent) NDE1 LIAS PRIM1 RPL29 KPNA2 SCG2 DCC1 GOLPH RPUSD3 TFB2M CENPH EIF2S2 SLCO4 A1 RHOQ CD55 0.51 0.51 0.51 0.51 meteorin, glial cell differentiation regulator-like 0.505 ACAP1; KIAA0050 NM_014716 centaurin, beta 0.504 HERMES RNA binding protein with multiple splicing 0.504 0.503 0.503 0.502 0.502 0.502 0.502 0.502 NUDE; NUDE1; FLJ20101; HOM-TES-87 LAS; LIP1; HUSSY-01; MGC23245 p49; MGC12308 HIP; HUMRPL29; MGC88589 QIP2; RCH1; IPOA1; SRP1alpha SN; CHGC; SgII DCC1; MGC5528 GP73; PSEC0257 NM_001008 712 NM_017668 NM_006859 NM_000946 NM_000992 NM_002266 NM_003469 NM_024094 NM_016548 nudE nuclear distribution gene E homolog (A nidulans) lipoic acid synthetase primase, polypeptide 1, 49kDa ribosomal protein L29 karyopherin alpha (RAG cohort 1, importin alpha 1) secretogranin II (chromogranin C) defective in sister chromatid cohesion homolog (S cerevisiae) golgi phosphoprotein 0.502 0.501 0.501 0.5 FLJ34707; MGC29784 Hkp1; FLJ22661; FLJ23182 C12orf52 EIF2; EIF2B; MGC8508; EIF2beta; DKFZp686L18198 POAT; OATP1; OATP-E; OATP4A1; OATPRP1; SLC21A12 ARHQ; TC10; TC10A; RASL7A CR; TC; DAF NM_173659 NM_022366 NM_022909 NM_003908 RNA pseudouridylate synthase domain containing transcription factor B2, mitochondrial centromere protein H eukaryotic translation initiation factor 2, subunit beta, 38kDa NM_016354 solute carrier organic anion transporter family, member 4A1 NM_012249 NM_000574 0.5 0.5 0.499 PDE4B 0.499 COPS7A 0.499 TYSND C20ORF 72 LYPLA1 CD24 0.498 MGC34695; MGC131934 NM_173555 ras homolog gene family, member Q CD55 molecule, decay accelerating factor for complement (Cromer blood group) phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) trypsin domain containing 0.498 FLJ14597; bA504H3.4 NM_052865 chromosome 20 open reading frame 72 0.498 0.498 LPL1; APT-1; LYSOPLA CD24A NM_006330 NM_013230 lysophospholipase I CD24 molecule DPDE4; PDEIVB; MGC126529; DKFZp686F2182 MGC110877 NM_002600 NM_016319 264 TMEM3 0B LAP3 PHYH2 PAPSS2 0.498 CDC50B; MGC126775 0.498 0.498 0.497 LAP; PEPS; LAPEP HPCL; HPCL2; PHYH2; 2-HPCL SK2; ATPSK2 CUL1 PHF17 KCNG3 SNCA KLHL3 AKNA SRI PACSIN NFKB1 0.497 0.497 0.496 0.496 0.496 0.496 0.496 0.494 CDK6 JADE1; FLJ22479; KIAA1807 KV6.3; KV10.1 PD1; NACP; PARK1; PARK4; MGC110988 KIAA1129; MGC44594 KIAA1968; RP11-82I1.4 SCN; FLJ26259 SDPI; KIAA1379 0.494 GMDS LOC571 49 CBLC LTBP3 0.493 0.492 KBF1; EBP-1; MGC54151; NFKB-p50; NFKBp105; NF-kappa-B; DKFZp686C01211 GMD A211C6.1 0.492 0.492 PIAS2 0.492 LEPREL SPRYD3 RASIP1 MTHFD LOC139 886 C9ORF1 HSPA4L ALG3 cullin PHD finger protein 17 potassium voltage-gated channel, subfamily G, member synuclein, alpha (non A4 component of amyloid precursor) kelch-like (Drosophila) AT-hook transcription factor sorcin protein kinase C and casein kinase substrate in neurons NM_001500 NM_020424 nuclear factor of kappa light polypeptide gene enhancer in B-cells (p105) GDP-mannose 4,6-dehydratase LYR motif containing NM_012116 NM_021070 Cas-Br-M (murine) ecotropic retroviral transforming sequence c latent transforming growth factor beta binding protein NM_173206 protein inhibitor of activated STAT, NM_014262 leprecan-like 0.49 0.49 0.49 FLJ14800 RAIN; FLJ20401 MTHFC; MTHFD NM_032840 NM_017805 NM_005956 0.49 LOC139886; MGC133224 0.489 C9orf10; DNAPTP1; DNAPTP5; MGC111527; MGC133257 APG-1; Osp94 NM_001012 968 NM_014612 SPRY domain containing Ras interacting protein methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase hypothetical protein LOC139886 0.489 0.489 E3; ALDH4; ALDH7; ALDH9; TMABADH 0.488 DRAGON; FLJ90406; MGC86970 CYTL1 EPDR1 MCM7 0.488 0.487 0.487 0.487 C17 UCC1; MERP1; MERP-1 MCM2; CDC47; P85MCM; P1CDC47; PNAS146; CDABP0042; P1.1-MCM3 FLJ25416; FLJ13936 0.486 0.486 0.485 TM7SF3 amisyn; HSPC156; FLJ39638 MGC45840; MGC88858 KIAA19 14 EXOSC UGT3A CDR2 DYNLT AP1S1 MGST1 TNNC2 BID THYN1 leucine aminopeptidase 2-hydroxyacyl-CoA lyase 3'-phosphoadenosine 5'-phosphosulfate synthase 0.49 0.488 ARHGE F6 CHAF1 A EIF4E3 HMMR NM_003998 transmembrane protein 30B CBL-3; RNF57; CBL-SL LTBP2; LTBP-3; pp6425; FLJ33431; FLJ39893; DKFZP586M2123 miz; MIZ1; SIZ2; MGC102682; PIASX-BETA; PIASX-ALPHA GRCB; P3H3; HSU47926 ALDH9 A1 RGMB FLJ2541 TM7SF3 STXBP6 MGC45 840 HSPC11 UST EBNA1 BP2 WDR12 PCDH18 NCLN EDNRB VKORC MGST1 C1GAL T1C1 SSPN SDHA SERPIN B8 NLN SORBS1 NM_001017 970 NM_015907 NM_012260 NM_001015 880 NM_003592 NM_024900 NM_172344 NM_007308 NM_017415 NM_030767 NM_003130 NM_020804 family with sequence similarity 120A NM_014278 NM_001006 940 NM_000696 heat shock 70kDa protein 4-like NM_001012 761 NM_018659 NM_017549 NM_182776 RGM domain family, member B aldehyde dehydrogenase family, member A1 cytokine-like ependymin related protein (zebrafish) MCM7 minichromosome maintenance deficient (S cerevisiae) NM_145018 hypothetical protein FLJ25416 NM_016551 NM_014178 NM_173584 transmembrane superfamily member syntaxin binding protein (amisyn) EF-hand calcium binding domain 4A 0.485 HSPC111; HSPC185 NM_016391 hypothetical protein HSPC111 0.485 0.484 2OST P40; EBP2; NOBP NM_005715 NM_006824 uronyl-2-sulfotransferase EBNA1 binding protein 0.484 0.483 0.483 0.483 0.482 YTM1; FLJ10881; FLJ12719; FLJ12720 PCDH68L; KIAA1562; DKFZP434B0923 SCARB1 ETB; ETRB; HSCR; ABCDS; HSCR2 VKOR; MST134; MST576; VKCFD2; EDTP308; MGC2694; FLJ00289; IMAGE3455200 MGST; GST12; MGST-I; MGC14525 COSMC; C1GALT2; HSPC067; C1Gal-T2; MGC19947; c38h2-l1 KRAG; SPN1; SPN2 FP; SDH2; SDHF PI8; CAP2 NM_018256 NM_019035 NM_020170 NM_003991 NM_024006 WD repeat domain 12 protocadherin 18 nicalin homolog (zebrafish) endothelin receptor type B vitamin K epoxide reductase complex, subunit NM_020300 NM_001011 551 NM_005086 NM_004168 NM_001031 848 NM_020726 NM_015385 microsomal glutathione S-transferase C1GALT1-specific chaperone sarcospan (Kras oncogene-associated gene) succinate dehydrogenase complex, subunit A, flavoprotein (Fp) serpin peptidase inhibitor, clade B (ovalbumin), member NM_004840 Rac/Cdc42 guanine nucleotide exchange factor (GEF) NM_005483 chromatin assembly factor 1, subunit A (p150) NM_173359 NM_012485 eukaryotic translation initiation factor 4E member hyaluronan-mediated motility receptor (RHAMM) NM_001001 936 NM_020158 KIAA1914 exosome component 0.482 0.481 0.481 0.481 0.481 0.48 0.479 0.479 0.477 0.476 0.476 0.476 0.476 AGTBP; KIAA1226; DKFZp564F123 CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12; FLJ12406; KIAA1296; DKFZp451C066; DKFZp586P1422 PIXA; COOL2; MRX46; Cool-2; KIAA0006; alphaPIX; alpha-PIX CAF1; P150; CAF-1; CAF1B; CAF1P150; MGC71229 MGC39820; MGC86971 CD168; IHABP; RHAMM; MGC119494; MGC119495 XB130; FLJ14564 neurolysin (metallopeptidase M3 family) sorbin and SH3 domain containing 0.476 p12B; RRP46; RRP41B; Rrp46p; hRrp46p; MGC12901; MGC111224 MGC119426; MGC119429 NM_174914 UDP glycosyltransferase family, polypeptide A2 0.475 0.475 Yo; CDR62 RP3; TCTE1L; TCTEX1L NM_001802 NM_006520 cerebellar degeneration-related protein 2, 62kDa dynein, light chain, Tctex-type 0.474 0.474 0.473 0.473 0.473 AP19; CLAPS1; SIGMA1A MGST; GST12; MGST-I; MGC14525 TNNC2 MGC15319; MGC42355 MY105; THY28; MDS012; HSPC144; NM_057089 NM_020300 NM_003279 NM_001196 NM_199298 adaptor-related protein complex 1, sigma subunit microsomal glutathione S-transferase troponin C type (fast) BH3 interacting domain death agonist thymocyte nuclear protein 265 TPST2 0.473 THY28KD; MGC12187 TPST2 PBK GAJ GRAMD IRS1 RASL11 B TYK2 HEXB SRPK1 TEAD4 0.471 0.47 0.47 SPK; TOPK; Nori-3; FLJ14385 GAJ NS3TP2; FLJ21313 NM_001008 566 NM_018492 NM_032117 NM_023927 PDZ binding kinase meiotic nuclear divisions homolog (S cerevisiae) GRAM domain containing 0.47 0.47 HIRS-1 MGC2827; MGC4499 NM_005544 NM_023940 insulin receptor substrate RAS-like, family 11, member B 0.469 0.469 0.469 0.468 JTK1 ENC-1AS SFRSK1 RTEF1; TEF-3; EFTR-2; RTEF-1; TEFR-1; MGC9014; TCF13L1; hRTEF-1B KE6; FABG; HKE6; FABGL; RING2; H2-KE6; D6S2245E; dJ1033B10.9 V7-3; NTT73; hv7-3; FLJ10316; MGC87066; DKFZp761I0921 CFB ZNF483 NM_003331 NM_000521 NM_003137 NM_201441 tyrosine kinase hexosaminidase B (beta polypeptide) SFRS protein kinase TEA domain family member NM_014234 hydroxysteroid (17-beta) dehydrogenase HSD17B SLC6A1 GMPS ZNF483 0.468 0.467 0.466 PSAT1 ST7 0.465 0.465 BXDC1 ALDH4 A1 MCM7 0.465 0.465 0.464 FRAT2 INPP5D 0.464 0.464 ACYP1 KATNA L2 PARP9 0.464 0.462 XPC CXORF 12 MCCC2 DKK3 STRBP 0.461 0.461 0.461 0.461 0.46 LMO4 MFSD1 NME1 ABLIM1 0.46 0.459 0.457 0.457 PHB POLE2 SATB2 0.457 0.456 0.456 EPB41L 4B PARP1 0.454 0.467 0.462 0.455 NM_182767 solute carrier family 6, member 15 guanine monphosphate synthetase zinc finger protein 483 PSA; MGC1460 HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A1; DKFZp762O2113 RPF2; FLJ21087; bA397G5.4 P5CD; ALDH4; P5CDh; P5CDhL; P5CDhS NM_003875 NM_001007 169 NM_021154 NM_018412 NM_032194 NM_170726 brix domain containing aldehyde dehydrogenase family, member A1 MCM2; CDC47; P85MCM; P1CDC47; PNAS146; CDABP0042; P1.1-MCM3 MGC10562 SHIP; SHIP1; hp51CN; SIP-145; MGC104855; MGC142140; MGC142142 ACYPE MGC33211; DKFZP667C165 NM_005916 MCM7 minichromosome maintenance deficient (S cerevisiae) NM_012083 NM_001017 915 NM_203488 NM_031303 frequently rearranged in advanced T-cell lymphomas inositol polyphosphate-5-phosphatase, 145kDa NM_031458 poly (ADP-ribose) polymerase family, member NM_004628 NM_003492 xeroderma pigmentosum, complementation group C chromosome X open reading frame 12 MCCB REIC SPNR; MGC3405; FLJ11307; FLJ14223; FLJ14984; MGC21529; DKFZp434N214 LMO4 FLJ14153; UG0581B09 AWD; GAAD; NM23; NDPKA; NM23-H1 ABLIM; LIMAB1; LIMATIN; MGC1224; FLJ14564; KIAA0059; DKFZp781D0148 PHB DPE2 FLJ21474; FLJ32076; KIAA1034; MGC119474; MGC119477 CG1; EHM2; FLJ21596; DKFZp761N1814 NM_022132 NM_013253 NM_018387 methylcrotonoyl-Coenzyme A carboxylase (beta) dickkopf homolog (Xenopus laevis) spermatid perinuclear RNA binding protein NM_006769 NM_022736 NM_198175 NM_006720 LIM domain only major facilitator superfamily domain containing non-metastatic cells 1, protein (NM23A) expressed in actin binding LIM protein NM_002634 NM_002692 NM_015265 prohibitin polymerase (DNA directed), epsilon (p59 subunit) SATB family member NM_018424 erythrocyte membrane protein band 4.1 like 4B NM_001618 poly (ADP-ribose) polymerase family, member BAL; BAL1; FLJ26637; MGC:7868; DKFZp666B0810; DKFZp686M15238 XP3; XPCC ITBA1; DXS9878E TRAF3I P2 DAZAP TMEM5 CD74 0.452 PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1 ACT1; CIKS; C6orf4; C6orf5; C6orf6; MGC3581; DKFZP586G0522 MGC19907 0.452 0.452 HP10481 DHLAG; HLADG; Ia-GAMMA; protein 41 CSRP2 GPR160 TRAP1 NPFFR2 ACAT1 0.451 0.449 0.449 0.447 0.447 TXNDC 12 NOL6 VRK1 REEP5 WDSOF SYT1 NOX4 PHGDH 0.446 0.446 0.446 STAT1 PYGL 0.44 0.438 0.453 tyrosylprotein sulfotransferase phosphoserine aminotransferase suppression of tumorigenicity acylphosphatase 1, erythrocyte (common) type katanin p60 subunit A-like NM_147200 TRAF3 interacting protein NM_018959 DAZ associated protein CRP2; LMO5; SmLIM GPCR1; GPCR150 HSP75; HSP90L GPR74; NPFF2; NPGPR T2; MAT; ACAT; THIL NM_014254 NM_001025 158 NM_001321 NM_014373 NM_016292 NM_053036 NM_000019 0.446 ERP18; ERP19; TLP19 NM_015913 transmembrane protein CD74 molecule, major histocompatibility complex, class II invariant chain cysteine and glycine-rich protein G protein-coupled receptor 160 TNF receptor-associated protein neuropeptide FF receptor acetyl-Coenzyme A acetyltransferase (acetoacetyl Coenzyme A thiolase) thioredoxin domain containing 12 (endoplasmic reticulum) 0.446 NRAP; UTP22; FLJ21959; MGC14896; MGC14921; MGC20838; bA311H10.1 MGC117401; MGC138280; MGC142070 DP1; TB2; D5S346; C5orf18; MGC70440 Gm83; HSPC064; MGC126859; MGC138247; DKFZP564O0463 P65; SYT; SVP65; DKFZp781D2042 KOX; KOX-1; RENOX PDG; PGD; PGAD; PGDH; SERA; 3PGDH; 3PGDH; MGC3017 ISGF-3; STAT91; DKFZp686B04100 RB1 NM_022917 nucleolar protein family (RNA-associated) NM_003384 NM_005669 NM_015420 vaccinia related kinase receptor accessory protein WD repeats and SOF1 domain containing NM_005639 NM_016931 NM_006623 synaptotagmin I NADPH oxidase phosphoglycerate dehydrogenase NM_139266 NM_002863 signal transducer and activator of transcription 1, 91kDa phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) solute carrier family (cationic amino acid transporter, y+ system), member coagulation factor XII (Hageman factor) hypothetical protein FLJ20425 CCAAT/enhancer binding protein (C/EBP), delta chromogranin A (parathyroid secretory protein 1) pleiotrophin (heparin binding growth factor 8, neurite growthpromoting factor 1) translocase of inner mitochondrial membrane homolog A (yeast) 0.445 0.442 0.44 SLC7A1 0.436 ERR; ATRC1; CAT-1; HCAT1; REC1L NM_003045 F12 LYAR CEBPD CHGA PTN 0.435 0.434 0.433 0.432 0.432 HAF LYAR; FLJ20425 CELF; CRP3; C/EBP-delta; NF-IL6-beta CGA HARP; HBNF; HBGF8; NEGF1 NM_000505 NM_017816 NM_005195 NM_001275 NM_002825 TIMM8 A 0.431 DDP; MTS; DDP1; DFN1; MGC12262 NM_004085 266 SF3A3 EFNB2 0.431 0.431 NM_006802 NM_004093 splicing factor 3a, subunit 3, 60kDa ephrin-B2 0.431 0.43 0.43 PRP9; PRPF9; SAP61; SF3a60 HTKL; EPLG5; Htk-L; LERK5; MGC126226; MGC126227; MGC126228 CERK FLJ21841; Nbla00170 GTA; CD41; GP2B; HPA3; CD41B; GPIIb HHLA2 NES ITGA2B NM_007072 NM_006617 NM_000419 0.43 FLJ39106 NM_173629 HERV-H LTR-associating nestin integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) chromosome 18 open reading frame 26 C18ORF 26 LAD1 DPYSL2 WIPI1 OLFM1 0.43 0.43 0.428 0.427 NM_005558 NM_001386 NM_017983 NM_014279 ladinin dihydropyrimidinase-like WD repeat domain, phosphoinositide interacting olfactomedin 0.426 LadA; MGC10355 DRP2; CRMP2; DRP-2; DHPRP2 Atg18; WIPI49; FLJ10055 AMY; NOE1; OlfA; NOELIN; NOELIN1; NOELIN1_V1; NOELIN1_V2; NOELIN1_V4; NOELIN1_V5 CLIPINC; KIAA0925 NM_006091 coronin, actin binding protein, 2B 0.426 0.426 FBX22; FLJ13986 CDC46; MGC5315; P1-CDC46 NM_012170 NM_006739 ISOC2 NAP1L3 SEMA4 D BUB1B 0.425 0.425 0.425 TMEM101 MB20; NPL3; MGC26312 CD100; SEMAJ; coll-4; M-sema G; M-sema-G NM_024710 NM_004538 NM_006378 0.424 NM_001211 HSD11B AP1S1 C12ORF 24 RPS7 FLJ3120 RAI14 F2RL1 VAMP4 SLC24A ATP5G1 0.424 NM_181755 0.424 0.424 SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta HDL; 11-DH; HSD11; HSD11B; HSD11L; MGC13539; 11-beta-HSD1 AP19; CLAPS1; SIGMA1A HSU79274 F-box protein 22 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S cerevisiae) isochorismatase domain containing nucleosome assembly protein 1-like sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D BUB1 budding uninhibited by benzimidazoles homolog beta (yeast) hydroxysteroid (11-beta) dehydrogenase NM_001283 NM_013300 adaptor-related protein complex 1, sigma subunit chromosome 12 open reading frame 24 0.423 0.423 RPS7 FLJ31204; RP11-479E16.1 NM_001011 NM_174912 ribosomal protein S7 amidase domain containing 0.422 0.422 0.422 0.421 RAI13; NORPEG; KIAA1334; DKFZp564G013 PAR2; GPR11 VAMP24 NCLX; NCKX6; FLJ22233 NM_015577 NM_005242 NM_003762 NM_024959 0.421 ATP5A; ATP5G PANX1 EXTL3 0.421 0.419 MRPL24 ASPH ACO1 RIN2 HBA1 DBC1 ZNF206 LYN ARIH2 ASCC3 0.419 0.419 0.419 0.419 0.419 0.419 0.418 0.418 0.417 0.416 NM_024540 NM_020164 NM_002197 NM_018993 NM_000558 NM_014618 NM_032805 NM_002350 NM_006321 NM_006828 mitochondrial ribosomal protein L24 aspartate beta-hydroxylase aconitase 1, soluble Ras and Rab interactor hemoglobin, alpha deleted in bladder cancer zinc finger protein 206 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog ariadne homolog (Drosophila) activating signal cointegrator complex subunit MICB GLTP ASPHD GART 0.416 0.415 0.414 MRS1; UNQ2529; MGC21309 REG; RPR; REGR; botv; EXTR1; KIAA0519; DKFZp686C2342 MGC9831; MRP-L18; FLJ20917; MGC22737 BAH; HAAH; JCTN; junctin; CASQ2BP1 IRP1; IREB1; IREBP RASSF4 CD31; MGC126895; MGC126897 FAM5A; DBCCR1 ZSCAN10; FLJ14549 JTK8; FLJ26625 ARI2; TRIAD1; FLJ10938; FLJ33921 RNAH; HELIC1; ASC1p200; MGC26074; DJ467N11.1; dJ121G13.4 PERB11.2 GLTP ASPHD1 NM_001002 027 NM_015368 NM_001440 retinoic acid induced 14 coagulation factor II (thrombin) receptor-like vesicle-associated membrane protein solute carrier family 24 (sodium/potassium/calcium exchanger), member ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) pannexin exostoses (multiple)-like NM_005931 NM_016433 NM_181718 MHC class I polypeptide-related sequence B glycolipid transfer protein aspartate beta-hydroxylase domain containing 0.414 AIRS; GARS; PAIS; PGFT; PRGS; GARTF; MGC47764 NM_000819 DNAJB6 0.413 NM_005494 RAB7L1 SMS NQO1 LOXL3 ISG20L1 HK1 LCK BCAS4 CMTM8 RARRE S2 FLJ9023 MGC26 856 MGC41 72 CYP2S1 FKBP11 C3ORF2 PDGFR B ANK3 RPL8 CCRN4 L RAB31 PFS2 TPM2 GNG4 NSBP1 0.413 0.412 0.412 0.412 0.412 0.412 0.411 0.41 0.41 0.41 MRJ; HSJ2; HHDJ1; HSJ-2; MSJ-1; MGC1152; FLJ42837; MGC117297; DKFZp566D0824 RAB7L; DKFZp686P1051 SRS; SpS; MRSR; SPMSY DTD; QR1; DHQU; DIA4; NMOR1; NMORI LOXL AEN; pp12744; FLJ12484; FLJ12562 HKI; HXK1; HK1-ta; HK1-tb YT16; p56lck; pp58lck FLJ20495 CKLFSF8 TIG2; HP10433 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase DnaJ (Hsp40) homolog, subfamily B, member NM_003929 NM_004595 NM_000903 NM_032603 NM_022767 NM_033500 NM_005356 NM_017843 NM_178868 NM_002889 RAB7, member RAS oncogene family-like spermine synthase NAD(P)H dehydrogenase, quinone lysyl oxidase-like interferon stimulated exonuclease gene 20kDa-like hexokinase lymphocyte-specific protein tyrosine kinase breast carcinoma amplified sequence CKLF-like MARVEL transmembrane domain containing retinoic acid receptor responder (tazarotene induced) CORO2 B FBXO22 MCM5 0.41 NM_173581 0.409 PRO7434; ALKN2972; MGC26856 NM_152779 GLI pathogenesis-related like 0.409 MGC4172; ARPG836; FLJ39232 NM_024308 short-chain dehydrogenase/reductase 0.408 0.406 0.406 CYP2S1 FKBP19; MGC54182 MGC4308 NM_030622 NM_016594 NM_032359 cytochrome P450, family 2, subfamily S, polypeptide FK506 binding protein 11, 19 kDa chromosome open reading frame 26 0.406 JTK12; PDGFR; CD140B; PDGFR1; PDGF-Rbeta FLJ45464; ANKYRIN-G RPL8 NOC; CCR4L; MGC78549; MGC142054; MGC142060; MGC4120817 Rab22B PSF2; Pfs2; HSPC037 DA1; TMSB; AMCD1 VPS13B NSBP1 NM_002609 platelet-derived growth factor receptor, beta polypeptide NM_001149 NM_033301 NM_012118 ankyrin 3, node of Ranvier (ankyrin G) ribosomal protein L8 CCR4 carbon catabolite repression 4-like (S cerevisiae) NM_006868 NM_016095 NM_213674 NM_004485 NM_030763 RAB31, member RAS oncogene family GINS complex subunit (Psf2 homolog) tropomyosin (beta) guanine nucleotide binding protein (G protein), gamma nucleosomal binding protein 0.406 0.406 0.405 0.403 0.403 0.402 0.402 0.4 267 LAMC1 RNMTL ORC1L SULF1 0.4 0.399 LAMB2; MGC87297 HC90; FLJ10581 NM_002293 NM_018146 laminin, gamma (formerly LAMB2) RNA methyltransferase like 0.398 0.398 ORC1; PARC1; HSORC1 SULF-1; HSULF-1; FLJ38022; FLJ41750; KIAA1077 EPI; TFI; LACI NM_004153 NM_015170 origin recognition complex, subunit 1-like (yeast) sulfatase NM_006287 PA26; SEST1; MGC138241; MGC142129; RP11787I22.1 REV7; MAD2B NM_014454 tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) sestrin NM_006341 MAD2 mitotic arrest deficient-like (yeast) RAMP; L2DTL TN; HXB SD; AST; NSD; SLD; ISSD; SIASD; SIALIN; FLJ22227; FLJ23268 mGlu4; GPRC1D; MGLUR4 RIG; MGC111130 FLJ20701; HMFN2073 NM_016448 NM_002160 NM_012434 denticleless homolog (Drosophila) tenascin C (hexabrachion) solute carrier family 17 (anion/sugar transporter), member NM_000841 NM_001018 NM_017933 glutamate receptor, metabotropic ribosomal protein S15 hypothetical protein FLJ20701 TFPI 0.397 SESN1 0.395 MAD2L DTL TNC SLC17A GRM4 RPS15 FLJ2070 REXO2 0.394 0.393 0.392 0.392 0.391 0.391 0.391 0.39 GULP1 IDH3A SIX4 FKBP4 CALD1 MCEE AP1S1 PCNXL C3ORF5 SLC7A8 0.39 0.39 0.39 0.389 0.388 0.388 0.387 0.387 RFN; SFN; CGI-114; MGC111570; DKFZP566E144 CED6; GULP; CED-6; FLJ31156 PXDN AREC3; MGC119450; MGC119452; MGC119453 HBI; p52; Hsp56; FKBP52; FKBP59; PPIase CDM; H-CAD; L-CAD; NAG22; MGC21352 RPL12 AP19; CLAPS1; SIGMA1A FLJ11383; KIAA0435 NM_015523 REX2, RNA exonuclease homolog (S cerevisiae) NM_016315 NM_005530 NM_017420 NM_002014 NM_004342 NM_032601 NM_001283 NM_024938 GULP, engulfment adaptor PTB domain containing isocitrate dehydrogenase (NAD+) alpha sine oculis homeobox homolog (Drosophila) FK506 binding protein 4, 59kDa caldesmon methylmalonyl CoA epimerase adaptor-related protein complex 1, sigma subunit pecanex-like (Drosophila) 0.387 MGC20416 NM_203370 chromosome open reading frame 54 0.386 LAT2; LPI-PC1 NM_012244 BRP44 HNT CDCP1 WWC1 TRAM2 TNFRSF MAPRE JARID2 FAM98 A SLC25A 19 LRRC8 D PRPS1 SLC6A1 ADCY3 LNK H2AFJ IGSF1 0.385 0.384 0.382 0.382 0.382 0.381 MGC125752; MGC125753; DKFZP564B167 HNT; NTM; MGC60329 CD318; TRASK; SIMA135 KIBRA; FLJ10865; FLJ23369; KIAA0869 KIAA0057 CD30; KI-1; D1S166E NM_015415 NM_016522 NM_178181 NM_015238 NM_012288 NM_001243 solute carrier family (cationic amino acid transporter, y+ system), member brain protein 44 neurotrimin CUB domain containing protein WW, C2 and coiled-coil domain containing translocation associated membrane protein tumor necrosis factor receptor superfamily, member 0.379 EB1; EB2; RP1 NM_014268 microtubule-associated protein, RP/EB family, member 0.378 0.378 JMJ DKFZP564F0522; DKFZp686O03192 NM_004973 NM_015475 Jumonji, AT rich interactive domain family with sequence similarity 98, member A 0.376 DNC; MUP1; MCPHA NM_021734 0.376 LRRC5; FLJ10470; FLJ20403 NM_018103 solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 leucine rich repeat containing family, member D 0.375 0.375 NM_002764 NM_018057 phosphoribosyl pyrophosphate synthetase solute carrier family 6, member 15 NM_004036 NM_005475 NM_177925 NM_205833 adenylate cyclase SH2B adaptor protein H2A histone family, member J immunoglobulin superfamily, member 0.366 PRSI; PRS I; KIAA0967 V7-3; NTT73; hv7-3; FLJ10316; MGC87066; DKFZp761I0921 AC3; KIAA0511 LNK MGC921; FLJ10903 IGCD1; IGDC1; INHBP; PGSF2; KIAA0364; MGC75490 RIC; IWU1; KCT1; OIT2; IWU-1; dysad; HSPC113; PRO6241 FLJ33957; FLJ42845 MANSC3; FLJ14735; MGC39092; bA350J20.3 CSC-21K CRIK; STK21; KIAA0949 NET-4; TM4SF9; TSPAN-5 HREV107; HREV107-3; MGC118754; HREV107-1 FLJ23617 0.364 0.363 0.375 0.372 0.37 0.368 FXYD5 0.368 BTBD11 LRP11 TIMP2 CIT TSPAN5 HRASL S3 LOC134 147 MCM4 LOC387 882 HPRT1 0.367 0.367 0.366 0.366 0.366 0.366 NM_014164 FXYD domain containing ion transport regulator NM_152322 NM_032832 NM_003255 NM_007174 NM_005723 NM_007069 BTB (POZ) domain containing 11 low density lipoprotein receptor-related protein 11 TIMP metallopeptidase inhibitor citron (rho-interacting, serine/threonine kinase 21) tetraspanin HRAS-like suppressor NM_138809 carboxymethylenebutenolidase-like (Pseudomonas) CDC21; CDC54; hCdc21; MGC33310; P1-CDC21 LOC387882 NM_005914 NM_207376 MCM4 minichromosome maintenance deficient (S cerevisiae) hypothetical protein 0.363 HPRT; HGPRT NM_000194 FOS L2HGD H SYT6 CEBPZ MIMITI N FHL2 PLEKH F1 PARD6 A C13ORF SLC39A 10 PROK2 NASP 0.362 0.362 c-fos FLJ12618; C14orf160 NM_005252 NM_024884 hypoxanthine phosphoribosyltransferase (Lesch-Nyhan syndrome) v-fos FBJ murine osteosarcoma viral oncogene homolog L-2-hydroxyglutarate dehydrogenase 0.36 0.359 0.357 SYT6 CBF2; HSP-CBF MMTN; B17.2L; mimitin NM_205848 NM_005760 NM_174889 synaptotagmin VI CCAAT/enhancer binding protein zeta NDUFA12-like 0.357 0.355 DRAL; AAG11; SLIM3 APPD; MGC4090; PHAFIN1; ZFYVE15 NM_001450 NM_024310 0.352 PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha RAMA1; MGC4832 NM_016948 four and a half LIM domains pleckstrin homology domain containing, family F (with FYVE domain) member par-6 partitioning defective homolog alpha (C.elegans) NM_145061 chromosome 13 open reading frame NM_020342 solute carrier family 39 (zinc transporter), member 10 NM_021935 NM_002482 prokineticin nuclear autoantigenic sperm protein (histone-binding) PECI 0.346 NM_006117 peroxisomal D3,D2-enoyl-CoA isomerase 0.352 0.35 0.35 0.349 LZT-Hs2; MGC126565; MGC138428; DKFZp781L10106 BV8; PK2; MIT1 FLB7527; MGC2297; PRO1999; FLJ31599; FLJ35510; MGC19722; MGC20372; DKFZp547F162 DRS1; ACBD2; HCA88; dJ1013A10.3 268 LYSMD LRRN6 A P2RY5 CASP3 TCEAL2 PUNC FDXR SASH1 SCG3 FZD10 INHBE TIMP4 UBE2L6 PCOLC E PFTK1 TM4SF1 DPPA5 KCNN2 0.346 MGC35274; DKFZp686I2243 NM_153374 LysM, putative peptidoglycan-binding, domain containing 0.345 LERN1; LINGO1; UNQ201; FLJ14594; MGC17422 P2Y5; MGC120358 CPP32; SCA-1; CPP32B my048; MY0876G05 HsT18880 ADXR KIAA0790; dJ323M4.1; RP3-323M4.1 SGIII; FLJ90833 FzE7; FZ-10; hFz10 MGC4638 TIMP4 RIG-B; UBCH8; MGC40331 PCPE NM_032808 leucine rich repeat neuronal 6A 0.344 0.343 0.342 0.341 0.34 0.34 0.339 0.338 0.336 0.334 0.332 0.332 NM_005767 NM_032991 NM_080390 NM_004884 NM_024417 NM_015278 NM_013243 NM_007197 NM_031479 NM_003256 NM_004223 NM_002593 purinergic receptor P2Y, G-protein coupled, caspase 3, apoptosis-related cysteine peptidase transcription elongation factor A (SII)-like putative neuronal cell adhesion molecule ferredoxin reductase SAM and SH3 domain containing secretogranin III frizzled homolog 10 (Drosophila) inhibin, beta E TIMP metallopeptidase inhibitor ubiquitin-conjugating enzyme E2L procollagen C-endopeptidase enhancer 0.331 0.331 KIAA0834; PFTAIRE1 L6D NM_012395 NM_138786 PFTAIRE protein kinase transmembrane L six family member 18 0.331 Esg1 developmental pluripotency associated 0.33 SK2; hSK2; SKCA2; KCa2.2 NM_001025 290 NM_170775 0.327 S1R; ZPRO; CGI-119 NM_016056 potassium intermediate/small conductance calcium-activated channel, subfamily N, member transmembrane BAX inhibitor motif containing 0.325 0.325 FGF19 MGC24665 NM_005117 NM_152308 fibroblast growth factor 19 chromosome 16 open reading frame 75 0.324 0.324 0.323 0.323 0.323 BND7; EPB7; EPB72 MGC24837 EDR1; HPH1; RAE28 STEAP; PRSS24; MGC19484 DCLK; KIAA0369 NM_004099 NM_014587 NM_004426 NM_012449 NM_004734 stomatin SRY (sex determining region Y)-box polyhomeotic-like (Drosophila) six transmembrane epithelial antigen of the prostate doublecortin and CaM kinase-like 0.321 0.321 GRL; CHF1; HRT2; HERP1; HESR2; MGC10720 dUTPase; FLJ20622 hairy/enhancer-of-split related with YRPW motif dUTP pyrophosphatase ALG9 0.319 DIBD1; FLJ21845; DKFZp586M2420 NM_012259 NM_001025 248 NM_024740 PPP2R2 B 0.319 SEPHS1 FLJ2580 PSMB8 0.315 0.314 SCA12; MGC24888; PR55-BETA; PP2A-PR55B; PR2AB-BETA; PR2AB55-BETA; PR2APR55BETA SPS; SELD; SPS1; MGC4980 FLJ25801; MGC138164; MGC138166 NM_012247 NM_173553 selenophosphate synthetase hypothetical protein FLJ25801 0.314 LMP7; D6S216; RING10; D6S216E; MGC1491 NM_148919 CABC1 OCIAD2 0.312 0.312 COQ8; ADCK3; MGC4849 MGC45416; DKFZp686C03164 KCND2 0.309 NM_020247 NM_001014 446 NM_012281 proteasome (prosome, macropain) subunit, beta type, (large multifunctional peptidase 7) chaperone, ABC1 activity of bc1 complex like (S pombe) OCIA domain containing TMBIM FGF19 MGC24 665 STOM SOX8 PHC1 STEAP1 DCAMK L1 HEY2 DUT FLJ2266 GFPT2 FGD5 PAK1 ITGB1B P3 OAZ2 AKAP7 APCDD CTGF PRDM1 C7ORF2 NELL2 SMPDL 3B HSPA2 SCGB3 A2 ICAM3 UGP2 CHST7 OCIAD2 CXCL12 FAM57 B SMPDL 3B SEMA6 A FABP5 RTN4IP KIAA07 46 MT1A DIAPH2 CCND1 DNMT3 NM_181676 asparagine-linked glycosylation homolog (S cerevisiae, alpha1,2-mannosyltransferase) protein phosphatase (formerly 2A), regulatory subunit B (PR 52), beta isoform 0.309 RK5; KV4.2; KIAA1044; MGC119702; MGC119703 FLJ22662 NM_024829 potassium voltage-gated channel, Shal-related subfamily, member hypothetical protein FLJ22662 0.306 0.306 0.305 0.304 GFAT2; FLJ10380 ZFYVE23 PAKalpha; MGC130000; MGC130001 MIBP; NRK2; MGC126624 NM_005110 NM_152536 NM_002576 NM_170678 glutamine-fructose-6-phosphate transaminase FYVE, RhoGEF and PH domain containing p21/Cdc42/Rac1-activated kinase (STE20 homolog, yeast) integrin beta binding protein 0.303 0.3 0.296 OAZ2 AKAP18 B7323; DRAPC1; FP7019 NM_002537 NM_016377 NM_153000 ornithine decarboxylase antizyme A kinase (PRKA) anchor protein adenomatosis polyposis coli down-regulated 0.294 0.292 CCN2; NOV2; HCS24; IGFBP8; MGC102839 PFM11; MGC59730 NM_001901 NM_024504 connective tissue growth factor PR domain containing 14 0.29 MGC3077; FLJ11717 NM_024051 chromosome open reading frame 24 0.289 0.289 NRP2 ASML3B NM_006159 NM_014474 NEL-like (chicken) sphingomyelin phosphodiesterase, acid-like 3B 0.289 0.288 HSPA2 LU103; PNSP1; UGRP1 NM_021979 NM_054023 heat shock 70kDa protein secretoglobin, family 3A, member 0.286 0.284 0.281 0.277 0.275 0.269 CD50; CDW50; ICAM-R UDPG; UGPP2; UDPGP2; pHC379 C6ST-2 MGC45416; DKFZp686C03164 PBSF; SDF1; SDF1A; SDF1B; TPAR1; SCYB12; SDF-1a; SDF-1b; TLSF-a; TLSF-b FP1188; DKFZP434I2117 NM_002162 NM_006759 NM_019886 NM_152398 NM_001033 886 NM_031478 intercellular adhesion molecule UDP-glucose pyrophosphorylase carbohydrate (N-acetylglucosamine 6-O) sulfotransferase OCIA domain containing chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) family with sequence similarity 57, member B 0.268 ASML3B NM_014474 sphingomyelin phosphodiesterase, acid-like 3B 0.265 VIA; SEMA; HT018; SEMAQ; SEMA6A1; KIAA1368; sema VIa EFABP; E-FABP; PAFABP; PA-FABP NIMP; MGC12934 NM_020796 0.264 0.264 NM_001444 NM_032730 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A fatty acid binding protein (psoriasis-associated) reticulon interacting protein 0.264 KIAA0746; FLJ21629; DKFZp781J1697 NM_015187 KIAA0746 protein 0.261 0.26 0.259 0.256 MT1; MTC; MT1S; MGC32848 DIA; POF; DIA2; POF2; FLJ11167 BCL1; PRAD1; U21B31; D11S287E ICF; M.HsaIIIB NM_005946 NM_007309 NM_053056 NM_006892 metallothionein 1A (functional) diaphanous homolog (Drosophila) cyclin D1 DNA (cytosine-5-)-methyltransferase beta 269 B NANOG IQGAP2 CYP2S1 NFE2L3 ADAM1 MT1X DPPA2 DPPA4 ITGB1B P3 MMP9 HPCAL GLDC 0.255 0.25 0.249 0.243 0.241 FGA ARIH2 CYP2S1 NRF3 MDC15 NM_024865 NM_006633 NM_030622 NM_004289 NM_207195 Nanog homeobox IQ motif containing GTPase activating protein cytochrome P450, family 2, subfamily S, polypeptide nuclear factor (erythroid-derived 2)-like ADAM metallopeptidase domain 15 (metargidin) 0.241 0.237 0.234 0.23 MT1; MT-1l PESCRG1 FLJ10713; 2410091M23Rik MIBP; NRK2; MGC126624 NM_005952 NM_138815 NM_018189 NM_014446 metallothionein 1X developmental pluripotency associated developmental pluripotency associated integrin beta binding protein 0.228 GELB; CLG4B NM_004994 0.227 BDR1; HLP2; VILIP-3 NM_002149 matrix metallopeptidase (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) hippocalcin-like 0.226 NM_000170 glycine dehydrogenase (decarboxylating) 0.225 GCE; NKH; GCSP; HYGN1; MGC138198; MGC138200 CKMT; CKMT1; UMTCK CKMT1 B TERF1 CDCA7 L AASS DACT1 NM_020990 creatine kinase, mitochondrial 1B 0.223 0.223 TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS R1; RAM2; DKFZp762L0311 NM_017489 NM_018719 telomeric repeat binding factor (NIMA-interacting) cell division cycle associated 7-like 0.22 0.217 NM_005763 NM_016651 aminoadipate-semialdehyde synthase dapper, antagonist of beta-catenin, homolog (Xenopus laevis) SILV UBE2L6 PDPN 0.21 0.204 0.204 0.204 0.201 NM_006928 NM_004223 NM_001006 625 NM_003956 NM_001038 silver homolog (mouse) ubiquitin-conjugating enzyme E2L podoplanin CH25H SCNN1 A FLJ1250 FAH POU5F1 PTPRZ1 LKRSDH; LORSDH; LKR/SDH DPR1; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1 SI; SIL; ME20; gp100; PMEL17; D12S53E RIG-B; UBCH8; MGC40331 T1A; GP36; GP40; Gp38; OTS8; T1A-2; HT1A-1; PA2.26 C25H ENaCa; SCNEA; SCNN1; FLJ21883; ENaCalpha 0.199 FLJ12505; RP11-275G3.1 NM_024749 vasohibin 0.191 0.187 0.175 NM_000137 NM_203289 NM_002851 fumarylacetoacetate hydrolase (fumarylacetoacetase) POU domain, class 5, transcription factor protein tyrosine phosphatase, receptor-type, Z polypeptide FAM46 B HAS3 USP44 POU5F1 VSNL1 CKMT1 A SFRP2 0.175 FAH OCT3; OTF3; OTF4; Oct4; MGC22487 PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; RPTPbeta MGC16491; MGC20845; RP11-344H11.8 0.164 0.158 0.147 0.146 0.139 HAS3 FLJ14528; DKFZP434D0127 OCT3; OTF3; OTF4; Oct4; MGC22487 HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1 CKMT1; UMTCK 0.136 FRP-2; SARP1; SDF-5 cholesterol 25-hydroxylase sodium channel, nonvoltage-gated alpha NM_052943 family with sequence similarity 46, member B NM_005329 NM_032147 NM_002701 NM_003385 NM_001015 001 NM_003013 hyaluronan synthase ubiquitin specific peptidase 44 POU domain, class 5, transcription factor visinin-like creatine kinase, mitochondrial 1A secreted frizzled-related protein 270 d4AA only Gene Name CD1D C2ORF34 PPP2R2C Fold Change 2.844 2.622 2.4 VANGL1 IFRD1 HES1 SLC2A1 2.349 2.203 2.14 2.088 TMEPAI 2.024 NTS IL17RD 2.005 1.974 GPR64 1.974 PPT2 1.917 KAL1 1.902 ADAMTS18 1.9 SLC36A2 1.875 SHB 1.873 SON ZNF278 1.866 1.861 ANGPT1 KLF5 GDF3 CHRD C17ORF39 CROP 1.854 1.84 1.786 1.751 1.738 1.725 KIAA1944 1.704 NEBL 1.701 JOSD3 RNF44 GAD1 CLK2 SS18L1 1.697 1.692 1.68 1.673 1.66 MATR3 1.628 RBM35A BCOR 1.615 1.612 C10ORF47 C9ORF77 CCNG2 ZNF202 BTBD6 ZNF498 ANK2 1.609 1.607 1.606 1.605 1.604 1.603 1.601 EGLN1 1.591 NRIP1 NPY5R PPARGC1A 1.582 1.568 1.56 TNMD 1.553 NUDT10 1.541 ZNF435 1.54 ANP32C 1.505 GABBR1 1.492 Common Genbank Description R3; CD1A; MGC34622 FLJ23451 PR52; IMYPNO; IMYPNO1; MGC33570 LPP2; STB2; MGC5338 PC4; TIS7 HHL; HRY; HES-1; FLJ20408 GLUT; GLUT1; MGC141895; MGC141896 STAG1; PMEPA1 NM_001766 NM_024766 NM_181876 NM_006183 NM_017563 CD1d molecule chromosome open reading frame 34 protein phosphatase (formerly 2A), regulatory subunit B (PR 52), gamma isoform vang-like (van gogh, Drosophila) interferon-related developmental regulator hairy and enhancer of split 1, (Drosophila) solute carrier family (facilitated glucose transporter), member transmembrane, prostate androgen induced RNA neurotensin interleukin 17 receptor D NM_005756 G protein-coupled receptor 64 NM_138717 palmitoyl-protein thioesterase NM_000216 Kallmann syndrome sequence NM_199355 ADAM metallopeptidase with thrombospondin type motif, 18 solute carrier family 36 (proton/amino acid symporter), member Src homology domain containing adaptor protein B NN; NT; NT/N; NTS1; NMN-125 SEF; IL-17RD; IL17RLM; FLJ35755; MGC133309; DKFZp434N1928 HE6; TM7LN2; FLJ00282; MGC104454; MGC138738; MGC138739 G14; NG3; C6orf8; DKFZp564P1516 HHA; KAL; KMS; ADMLX; KALIG-1 ADAMTS21 PAT2; TRAMD1; FLJ16051; MGC119658; MGC119660 bA3J10.2; RP11-3J10.8 ZSG; MAZR; PATZ; RIAZ; ZBTB19; dJ400N23 AGP1; AGPT; ANG1 CKLF; IKLF; BTEB2 GDF3 MGC3048 CROP; LUC7A; OA48-18 MOLT; KIAA1944; MGC138770; MGC138771 LNEBL; bA56H7.1; MGC119746; MGC119747 MGC5306 KIAA1100 GAD hCLK2; MGC61500 CREST; LP2261; KIAA0693; MGC26711; MGC78386 MGC9105; KIAA0723; DKFZp686K0542; DKFZp686K23100 FLJ20171 MAA2; ANOP2; MCOPS2; FLJ20285; FLJ38041; KIAA1575; MGC71031; MGC131961 MGC35403 CGI-67; RP11-409O11.2 SCOTIN ZNF202 BDPL ZNF498 LQT4; FLJ38277; DKFZp686P0948; DKFZp686M09125 PHD2; SM20; ECYT3; SM-20; HIFPH2; ZMYND6; C1orf12; DKFZp761F179 RIP140 NPYR5 LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha) TEM; CHM1L; BRICD4; tendin; myodulin; CHM1-LIKE DIPP3a; hDIPP3alpha ZNF392; ZSCAN16; FLJ22191; dJ265C24.3 PP32R1 hGB1a; GPRC3A; GABABR1; GABBR1-3; GABAB(1e); NM_138959 NM_001550 NM_005524 NM_006516 NM_020182 NM_181776 NM_003028 NM_138926 NM_032051 NM_001146 NM_001730 NM_020634 NM_177978 NM_024052 NM_016424 NM_133448 zinc finger protein 278 angiopoietin Kruppel-like factor (intestinal) growth differentiation factor chromosome 17 open reading frame 39 cisplatin resistance-associated overexpressed protein transmembrane protein 132D NM_006393 nebulette NM_024116 NM_014901 NM_000817 NM_001291 NM_015558 NM_018834 Josephin domain containing ring finger protein 44 glutamate decarboxylase (brain, 67kDa) CDC-like kinase synovial sarcoma translocation gene on chromosome 18-like matrin NM_017697 NM_020926 RNA binding motif protein 35A BCL6 co-repressor NM_153256 NM_016014 NM_004354 NM_003455 NM_033271 NM_145115 NM_020977 chromosome 10 open reading frame 47 chromosome open reading frame 77 cyclin G2 zinc finger protein 202 BTB (POZ) domain containing zinc finger protein 498 ankyrin 2, neuronal NM_022051 egl nine homolog (C elegans) NM_003489 NM_006174 NM_013261 nuclear receptor interacting protein neuropeptide Y receptor Y5 peroxisome proliferative activated receptor, gamma, coactivator 1, alpha tenomodulin NM_022144 NM_153183 NM_025231 NM_012403 NM_021905 nudix (nucleoside diphosphate linked moiety X)-type motif 10 zinc finger protein 435 acidic (leucine-rich) nuclear phosphoprotein 32 family, member C gamma-aminobutyric acid (GABA) B receptor, 271 KIAA1468 ATF4 1.491 1.487 DOCK1 RYR2 ZSWIM3 TP53RK ZNF350 C20ORF10 FUT11 1.48 1.478 1.472 1.472 1.466 1.465 1.462 ATP7B SIAH1 1.454 1.454 NR2C1 1.443 ANKHD1 SNTB1 1.43 1.427 FGF12 C1ORF84 ZBED4 SCAND2 CRY1 FLJ22639 WDR19 1.427 1.42 1.42 1.417 1.415 1.401 1.399 COL4A4 KIAA1434 1.396 1.394 EDNRA JRK 1.388 1.387 PHF16 1.386 RCE1 1.386 CSAG2 1.382 PCF11 1.379 dJ271M21.1.1; dJ271M21.1.2 HsT885; HsT3308; FLJ33841 CREB2; TXREB; CREB-2; TAXREB67 ced5; DOCK180 ARVC2; ARVD2; VTSIP C20orf164 PRPK; Nori-2; Nori-2p; C20orf64 ZFQR; ZBRK1 CLG01; TP53TG5 MGC33202; MGC119338; MGC119339 WD; PWD; WC1; WND Siah-1; hSIAH1; HUMSIAH; Siah-1a TR2; TR2-11 MASK A1B; SNT2; BSYN2; 59-DAP; DAPA1B; SNT2B1; TIP-43; FLJ22442; MGC111389 FHF1; FGF12B FLJ34502; RP11-506B15.1 GON4L SCAND2 PHLL1 ORF26; PWDMP; FLJ23127; KIAA1638 CA44 KIAA1434; FLJ11085; MGC26147; RP5-1022P6.2 ETA; ETRA JH8; FLJ45729; DKFZp686C24207 JADE3; KIAA0215; MGC138748; MGC138749 FACE2; RCE1A; RCE1B NM_020854 NM_001675 NM_001380 NM_001035 NM_080752 NM_033550 NM_021632 NM_014477 NM_173540 NM_000053 NM_001006610 NM_001032287 NM_017747 NM_021021 fibroblast growth factor 12 chromosome open reading frame 84 zinc finger, BED-type containing SCAN domain containing cryptochrome (photolyase-like) NM_000092 NM_019593 collagen, type IV, alpha hypothetical protein KIAA1434 NM_001957 NM_003724 endothelin receptor type A jerky homolog (mouse) NM_014735 PHD finger protein 16 RCE1 homolog, prenyl protein peptidase (S cerevisiae) CSAG family, member NM_015885 NM_004909 1.373 PIF96; P96PIF NM_006582 FLJ14768 MARS2 1.365 1.365 ZNF798; FLJ14768 MetRS; mtMetRS NM_032836 NM_138395 MAN1A2 THAP1 1.359 1.343 MAN1B FLJ10477; MGC33014 NM_006699 NM_199003 HDHD3 1.34 NM_031219 ALDH1A3 CEP27 BRSK2 CTDSP1 1.338 1.337 1.332 1.331 C9orf158; MGC12904; 2810435D12Rik ALDH6; RALDH3; ALDH1A6 C15orf25; FLJ10460; HsT17025 SAD1; STK29; PEN11B; C11orf7 SCP1; NLIIF MRPL27 INPP5F 1.331 1.323 RET 1.319 ZNF16 ATF2 1.314 1.309 ZNF93 RNF170 ZNF233 WWOX 1.307 1.304 1.304 1.302 BTRC 1.302 MESDC1 NR2C2 1.301 1.298 1.298 ZNFN1A5 1.297 HNRPK IFRD1 YWHAZ 1.296 1.293 1.292 ZNF71 MAML3 1.29 1.288 ARL5B GLCCI1 1.287 1.287 IDDM1; CELIAC1; HLA-DQB; HLA DQB1 PEGASUS; ZNFN1A5; FLJ22973; DKFZp781B0249 CSBP; TUNP; HNRNPK PC4; TIS7 KCIP-1; MGC111427; MGC126532; MGC138156 EZFIT GDN; MAM2; CAGH3; ERDA3; MAM-2; TNRC3 ARL8 GIG18; FAM117C WD repeat domain 19 NM_001032279 GMEB1 HLA-DQB1 nuclear receptor subfamily 2, group C, member ankyrin repeat and KH domain containing syntrophin, beta (dystrophin-associated protein A1, 59kDa, basic component 1) NM_004113 NM_001012960 NM_014838 NM_033640 NM_004075 NM_024796 NM_025132 TRAG3; MGC149851; MGC149852 KIAA0824 L27mt; MGC23716 SAC2; hSAC2; MSTP007; MSTPO47; FLJ13081; KIAA0966; MGC59773; MGC131851 PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; RETELE1 KOX9 HB16; CREB2; TREB7; CREBP1; MGC111558 TF34; HPF34; HTF34; ZNF505 FLJ38306; DKFZP564A022 FLJ38032 FOR; WOX1; FRA16D; HHCMA56; PRO0128; WWOX v8; D16S432E FWD1; FBW1A; bTrCP; FBXW1A; bTrCP1; MGC4643; betaTrCP; BETA-TRCP MGC99595 TR4; TAK1; TR2R1; hTAK1 KIAA1468 activating transcription factor (taxresponsive enhancer element B67) dedicator of cytokinesis ryanodine receptor (cardiac) zinc finger, SWIM-type containing TP53 regulating kinase zinc finger protein 350 chromosome 20 open reading frame 10 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) ATPase, Cu++ transporting, beta polypeptide seven in absentia homolog (Drosophila) NM_000693 NM_018097 NM_003957 NM_182642 NM_148571 NM_198330 NM_020630 PCF11, cleavage and polyadenylation factor subunit, homolog (S cerevisiae) glucocorticoid modulatory element binding protein FLT3-interacting zinc finger methionine-tRNA synthetase (mitochondrial) mannosidase, alpha, class 1A, member THAP domain containing, apoptosis associated protein haloacid dehalogenase-like hydrolase domain containing aldehyde dehydrogenase family, member A3 centrosomal protein 27kDa BR serine/threonine kinase CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase mitochondrial ribosomal protein L27 inositol polyphosphate-5-phosphatase F NM_001029976 NM_001880 ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) zinc finger protein 16 activating transcription factor NM_001004126 NM_030954 NM_181756 NM_130844 zinc finger protein 93 ring finger protein 170 zinc finger protein 233 WW domain containing oxidoreductase NM_003939 beta-transducin repeat containing NM_022566 NM_003298 mesoderm development candidate nuclear receptor subfamily 2, group C, member major histocompatibility complex, class II, DQ beta IKAROS family zinc finger (Pegasus) NM_002123 NM_022466 NM_031263 NM_001007245 NM_003406 NM_021216 NM_018717 heterogeneous nuclear ribonucleoprotein K interferon-related developmental regulator tyrosine 3-monooxygenase/tryptophan 5monooxygenase activation protein, zeta polypeptide zinc finger protein 71 mastermind-like (Drosophila) NM_178815 NM_138426 ADP-ribosylation factor-like 5B glucocorticoid induced transcript 272 CDK10 ING3 FAM24B NOL9 1.286 1.284 1.281 1.274 1.26 1.257 PISSLRE Eaf4; ING2; p47ING3; FLJ20089 MGC45962; DKFZp667I0323 FLJ23323; MGC131821; MGC138483 FLJ20070 K13; kH2; KCNG; KV6.1; MGC12878 RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1; MGC20144; MGC111022 KHL4; DKELCHL; KIAA1687 P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388 CIS4; SSI4; SOCS4; STAI4; STAT4; STATI4; HSPC060 KIAA1625 KCR1; ALG10 ZNF586 KCNG1 1.274 1.274 PITX2 1.271 KLHL4 IL23A 1.266 1.265 SOCS6 1.263 SMURF1 KCR1 NM_052988 NM_198267 NM_152644 NM_024654 cyclin-dependent kinase (CDC2-like) 10 inhibitor of growth family, member family with sequence similarity 24, member B nucleolar protein NM_017652 NM_172318 zinc finger protein 586 potassium voltage-gated channel, subfamily G, member paired-like homeodomain transcription factor COX11 1.252 COX11P NM_004375 GTF2I 1.252 NM_033001 BTNL2 ACHE GOLPH3L ZNF607 GABRE 1.248 1.246 1.245 1.245 1.241 DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; BAP135 BTL-II; HSBLMHC1 YT; ARACHE; N-ACHE GPP34R; FLJ10687 FLJ14802; MGC13071 GABRE FLJ11171 ZNF675 SLC40A1 1.24 1.237 1.233 OR2A7 1.231 TMEM16J LOC112869 DSCR1L1 1.22 1.219 1.217 ZNF419 ZNF197 1.211 1.211 PLA2G6 1.211 RANBP2L1 KIAA1414 IFIT1L NM_000325 NM_057162 NM_016584 kelch-like (Drosophila) interleukin 23, alpha subunit p19 NM_004232 suppressor of cytokine signaling NM_181349 NM_001013620 SMAD specific E3 ubiquitin protein ligase asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase) COX11 homolog, cytochrome c oxidase assembly protein (yeast) general transcription factor II, i FLJ11171 TIZ; TBZF; FLJ36350 FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3 OR2A21; HSDJ0798C17 NM_018348 NM_138330 NM_014585 NM_001012302 NM_138414 NM_005822 NM_024691 NM_001024855 zinc finger protein 419A zinc finger protein 197 NM_003560 1.21 1.207 1.205 PIG5; TP53I5 FLJ32446 CSP2; RCN2; MCIP2; hRCN2; ZAKI-4 ZNF419; FLJ23233 P18; VHLaK; ZNF20; ZNF166; D3S1363E GVI; PLA2; INAD1; iPLA2; PNPLA9; CaI-PLA2 RGP5; BS-63; DKFZp686I1842 KIAA1414 bA149I23.6; DKFZp781M1841 butyrophilin-like (MHC class II associated) acetylcholinesterase (Yt blood group) golgi phosphoprotein 3-like zinc finger protein 607 gamma-aminobutyric acid (GABA) A receptor, epsilon hypothetical protein FLJ11171 zinc finger protein 675 solute carrier family 40 (iron-regulated transporter), member olfactory receptor, family 2, subfamily A, member transmembrane protein 16J coiled-coil domain containing 101 Down syndrome critical region gene 1-like NM_005054 NM_019024 NM_001010987 F7 1.202 F7 NM_000131 phospholipase A2, group VI (cytosolic, calcium-independent) RANBP2-like and GRIP domain containing KIAA1414 protein interferon-induced protein with tetratricopeptide repeats 1-like coagulation factor VII (serum prothrombin conversion accelerator) FTSJ2 AGPAT4 1.201 1.194 NUP43 GSTZ1 1.194 1.193 EPB41L5 MXD1 ZSWIM3 HIP2 PCGF6 1.192 1.191 1.19 1.189 1.187 GLUL 1.182 FBXO9 1.176 EIF5 LOC399900 TMPRSS3 1.175 1.174 1.169 ATG16L1 1.168 1-AGPAT4; dJ473J16.2; LPAATdelta; RP3-473J16.2 MAI; MAAI; GSTZ1-1; MGC2029 BE37; FLJ12957; KIAA1548 MAD; MAD1; MGC104659 C20orf164 LIG; HYPG; UBE2K MBLR; RNF134; MGC15678; MGC17541 GS; GLNS; PIG43 MLL4 1.167 C11ORF35 ZDHHC18 WASF1 1.167 1.164 1.164 LRP2 STARD4 MAPK14 1.164 1.164 1.163 ARHGAP29 ST14 1.16 1.159 KIF19 IFITM5 FLRT2 1.159 1.158 1.156 FBX9; VCIA1; KIAA0936; NYREN-57; dJ341E18.2; DKFZp434C0118 EIF-5A LOC399900 DFNB8; DFNB10; ECHOS1; TADG12 WDR30; APG16L; ATG16L; FLJ00045; FLJ10035; FLJ10828; FLJ22677 MLL4; HRX2; MLL2; TRX2; KIAA0304 MGC35138 DKFZp667O2416 WAVE; SCAR1; WAVE1; FLJ31482; KIAA0269 gp330 STARD4 RK; p38; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA PARG1; RP11-255E17.1 HAI; MTSP1; SNC19; MT-SP1; MTSP-1; PRSS14; TADG-15 KIF19A; FLJ37300 IFITM5 KIAA0405 NCOA2 1.151 TIF2; GRIP1; NCoA-2; NM_019602 NM_015831 NM_018178 NM_032689 NM_021990 NM_001005328 NM_177442 NM_001012733 NM_024647 NM_001513 NM_020909 NM_002357 NM_080752 NM_005339 NM_032154 NM_001033044 1-acylglycerol-3-phosphate O-acyltransferase (lysophosphatidic acid acyltransferase, delta) glutathione transferase zeta (maleylacetoacetate isomerase) erythrocyte membrane protein band 4.1 like MAX dimerization protein zinc finger, SWIM-type containing huntingtin interacting protein polycomb group ring finger NM_033481 glutamate-ammonia ligase (glutamine synthetase) F-box protein NM_183004 NM_001013667 NM_032401 eukaryotic translation initiation factor hypothetical gene supported by AK093779 transmembrane protease, serine NM_030803 ATG16 autophagy related 16-like (S cerevisiae) NM_014727 NM_173573 NM_032283 NM_003931 myeloid/lymphoid or mixed-lineage leukemia chromosome 11 open reading frame 35 zinc finger, DHHC-type containing 18 WAS protein family, member NM_004525 NM_139164 NM_139013 low density lipoprotein-related protein START domain containing 4, sterol regulated mitogen-activated protein kinase 14 NM_004815 NM_021978 Rho GTPase activating protein 29 suppression of tumorigenicity 14 (colon carcinoma) kinesin family member 19 interferon induced transmembrane protein fibronectin leucine rich transmembrane protein nuclear receptor coactivator NM_153209 NM_001025295 NM_013231 NM_006540 273 EPS8L1 1.15 SLA/LP GGA3 1.149 1.147 DKFZP686I15217 LPIN3 1.146 1.145 FANCC RET 1.141 1.14 C13ORF6 1.139 RFX4 MGC138808 DRC3; EPS8R1; MGC4642; PP10566; FLJ20258; MGC23164 SLA/LP KIAA0154 NM_133180 EPS8-like NM_016955 NM_138619 soluble liver antigen/liver pancreas antigen golgi associated, gamma adaptin ear containing, ARF binding protein hypothetical protein DKFZp686I15217 lipin 1.138 DKFZp686I15217 SMP2; LIPN3L; dJ450M14.2; dJ450M14.3; dJ620E11.2 FA3; FAC; FACC; FLJ14675 PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; RETELE1 C13orf6; FLJ14906; MGC27058; bA153I24.2; RP11-153I24.2 NYD-SP10 NM_213594 SUV39H2 1.133 FLJ23414 NM_024670 GPR12 1.132 NM_005288 LOC389118 ST6GALNAC1 1.131 1.131 GPCR12; GPCR21; MGC138349; MGC138351 LOC389118; PRO34300 SIAT7A; HSY11339; ST6GalNAcI PSD HTN3 RNPEPL1 1.13 1.126 1.122 TYL; KIAA2011 HIS2; HTN2; HTN5 FLJ10806; FLJ26675; MGC99544 NM_002779 NM_000200 NM_018226 TREML1 1.122 NM_178174 LGALS2 1.121 TLT1; TLT-1; PRO3438; GLTL1825; MGC119173; dJ238O23.3 HL14; MGC75071 HAAO WBSCR23 ARTN PSCDBP 1.119 1.118 1.118 1.116 EVN; NBN HE; B3-1; CASP; CYBR; CYTIP NM_012205 NM_025042 NM_057160 NM_004288 FAM91A1 1.115 FLJ23790; DKFZp666B104 NM_144963 PCDHA11 1.114 1.107 C8ORF37 SPTB 1.105 1.104 CNR7; CNRN7; CNRS7; CRNR7; PCDH-ALPHA11 HEMHC; SMHCE; MYHSE1; MYHC-EMB FLJ30600 HSpTB1 NM_031861 MYH3 NM_177965 NM_001024858 TSHB RFNG LOC390667 1.103 1.102 1.095 TSH-BETA RFNG LOC390667 NM_000549 NM_002917 NM_001013658 KA21 TAS2R4 MMP28 C1ORF157 1.094 1.093 1.091 1.09 NM_152349 NM_016944 NM_001032278 NM_182579 CRYM CLUL1 LTBP1 1.09 1.088 1.084 KA21; MGC45562 T2R4 MM28; MMP25 FLJ40343; MGC120329; MGC120330; MGC120332 THBP; DFNA40 RA337M LTBP1 NUP155 CMIP PLEC1 1.083 1.081 1.081 NM_153485 NM_198390 NM_201380 FLJ36492 GHRHR ARHGAP11A 1.08 1.078 1.078 PRKCABP FYTTD1 HIST1H2BI OR52A4 1.074 1.069 1.066 1.064 N155; KIAA0791 CMIP; KIAA1694 HD1; PCN; EBS1; EBSO; PLTN; PLEC1b FLJ36492; MGC126634 GRFR; GHRFR; GHRHRpsv KIAA0013; MGC70740; GAP (112) PRKCABP; MGC15204 DKFZp761B1514 H2B/k; H2BFK OR52A4 NM_012407 NM_001011537 NM_003525 NM_001005222 TIGD1 LOC400986 1.059 1.058 EEYORE LOC400986 NM_145702 NM_001010914 SPG7 1.057 SUCNR1 ELA2A MAP4 DLX3 KIAA0513 GLYAT KRTAP10-10 1.044 1.04 1.035 1.034 1.033 0.972 0.97 UNQ9217 KRTAP1-1 0.964 0.961 TSKS CC2D1A 0.944 0.941 SHOX 0.94 CAR; PGN; CMAR; MGC126331; MGC126332 GPR91 ELA2A; ELA1; PE-1 MGC8617; DKFZp779A1753 TDO KIAA0513 CAT; GAT; ACGNAT KAP10.10; KAP18.10; KRTAP18-10; KRTAP18.10 UNQ9217 HB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1 TSKS; TSKS1 MRT3; FREUD-1; FLJ20241; FLJ41160 SS; GCFX; PHOG; SHOXY HAO; 3-HAO NM_207495 NM_022896 NM_000136 NM_020975 NM_032859 NM_001007540 NM_018414 NM_006498 NM_002470 NM_001014444 NM_199167 NM_206943 NM_182568 NM_001009824 NM_014783 Fanconi anemia, complementation group C ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) abhydrolase domain containing 13 regulatory factor X, (influences HLA class II expression) suppressor of variegation 3-9 homolog (Drosophila) G protein-coupled receptor 12 VLLR9392 ST6 (alpha-N-acetyl-neuraminyl-2,3-betagalactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase pleckstrin and Sec7 domain containing histatin arginyl aminopeptidase (aminopeptidase B)like triggering receptor expressed on myeloid cells-like lectin, galactoside-binding, soluble, (galectin 2) 3-hydroxyanthranilate 3,4-dioxygenase artemin pleckstrin homology, Sec7 and coiled-coil domains, binding protein family with sequence similarity 91, member A1 protocadherin alpha 11 myosin, heavy polypeptide 3, skeletal muscle, embryonic chromosome open reading frame 37 spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) thyroid stimulating hormone, beta radical fringe homolog (Drosophila) similar to Neuronal pentraxin II precursor (NP-II) (NP2) keratin 222 pseudogene taste receptor, type 2, member matrix metallopeptidase 28 chromosome open reading frame 157 crystallin, mu clusterin-like (retinal) latent transforming growth factor beta binding protein nucleoporin 155kDa c-Maf-inducing protein plectin 1, intermediate filament binding protein 500kDa hypothetical protein FLJ36492 growth hormone releasing hormone receptor Rho GTPase activating protein 11A NM_033050 NM_033440 NM_030884 NM_005220 NM_014732 NM_005838 NM_181688 protein interacting with PRKCA forty-two-three domain containing histone 1, H2bi olfactory receptor, family 52, subfamily A, member tigger transposable element derived synonym: HEM1; Homo sapiens protein immuno-reactive with anti-PTH polyclonal antibodies (LOC400986), mRNA spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) succinate receptor elastase 2A microtubule-associated protein distal-less homeobox KIAA0513 glycine-N-acyltransferase keratin associated protein 10-10 NM_205548 NM_030967 AASA9217 keratin associated protein 1-1 NM_021733 NM_017721 testis-specific kinase substrate coiled-coil and C2 domain containing 1A NM_000451 short stature homeobox NM_199367 274 STAG3 TNPO1 GUCY1A2 MLL2 0.936 0.936 0.935 0.928 STAG3 MIP; TRN; IPO2; MIP1; KPNB2 GC-SA2; GUC1A2 ALR; AAD10 NM_012447 NM_002270 NM_000855 NM_003482 F11 0.92 FXI NM_000128 PPP1R14D 0.92 0.919 CIB3 0.919 ST8SIA4 0.919 ZDHHC9 LZTFL1 C20ORF135 FLJ42393 RDH8 FLJ23447 CUBN 0.918 0.917 0.914 0.913 0.912 0.91 0.907 EEFSEC 0.902 GBPI-1; FLJ20251; MGC119014; MGC119016; CPI17-like NUCLING; FLJ10128; KIAA1561; MGC141967; MGC141969 KIP3; MGC96922; MGC138405; MGC142151 PST; PST1; SIAT8D; MGC34450; MGC61459; ST8SIA-IV DHHC9; CGI-89; ZNF379 RAPH1 MGC42974; dJ591C20.1 FLJ42393 PRRDH SLRR5B; FLJ23447 IFCR; MGA1; gp280; FLJ90055; FLJ90747 SELB; EFSEC NM_017726 UACA Sep-06 0.901 TCP11 0.9 OSR2 PPFIA1 0.9 0.894 CATSPER2 ASCC3 0.893 0.891 FLJ42102 ZNF658 0.888 0.886 PROP1 ATR BICD1 POMZP3 KLHL4 BHMT MAP4K3 SEP2; KIAA0128; MGC16619; MGC20339; RP5-876A24.2 D6S230E; KIAA0229; MGC111103 FLJ90037 LIP1; LIP.1; LIPRIN; MGC26800 NM_018003 NM_054113 calcium and integrin binding family member NM_175052 ST8 alpha-N-acetyl-neuraminide alpha-2,8sialyltransferase zinc finger, DHHC-type containing leucine zipper transcription factor-like chromosome 20 open reading frame 135 FLJ42393 protein retinol dehydrogenase (all-trans) podocan-like cubilin (intrinsic factor-cobalamin receptor) NM_016032 NM_020347 NM_080622 NM_207488 NM_015725 NM_024825 NM_001081 NM_021937 NM_145799 eukaryotic elongation factor, selenocysteinetRNA-specific septin NM_018679 t-complex 11 (mouse) NM_053001 NM_177423 odd-skipped related (Drosophila) protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha cation channel, sperm associated activating signal cointegrator complex subunit NM_172097 NM_022091 0.884 MGC33346 RNAH; HELIC1; ASC1p200; MGC26074; DJ467N11.1; dJ121G13.4 FLJ42102 FLJ32813; MGC35232; DKFZp572C163 PROP1 0.882 0.88 0.877 0.876 0.875 0.874 FRP1; MEC1; SCKL; SCKL1 BICD POM121; MGC8359; POM-ZP3 KHL4; DKELCHL; KIAA1687 BHMT GLK; MAPKKKK3; RAB8IPL1 NM_001184 NM_001714 NM_012230 NM_019117 NM_001713 NM_003618 LOC51315 MAWBP SSH1 IGSF4B 0.87 0.868 0.866 0.865 PRKCB1 0.865 FLJ22333 MAWBP; FLJ35507 SSH-1; FLJ38102; KIAA1298 BIgR; NECL1; TSLL1; Necl-1; synCAM3; FLJ10698 PKCB; PRKCB; PRKCB2; MGC41878; PKC-beta AIP3; BAP1; WWP3; BAIAP1; MAGI-1; TNRC19 MOP4; PASD4; FLJ23138; MGC71151 FLJ11667; FLJ23571; DKFZp434B227 FLJ30681; MGC50861 ART-27 RSP3; dJ111C20.1 AAC2 MAGI1 0.862 NPAS2 0.861 IQCG 0.853 CCBE1 UXT RSHL2 NAT2 0.851 0.849 0.847 0.846 INSIG1 PRKAA1 0.845 0.844 ABCB4 0.843 BLOC1S2 0.84 GABRD stromal antigen transportin guanylate cyclase 1, soluble, alpha myeloid/lymphoid or mixed-lineage leukemia coagulation factor XI (plasma thromboplastin antecedent) protein phosphatase 1, regulatory (inhibitor) subunit 14D uveal autoantigen with coiled-coil domains and ankyrin repeats NM_001001680 NM_033160 FLJ42102 protein zinc finger protein 658 NM_006261 NM_016618 NM_001033083 NM_018984 NM_021189 prophet of Pit1, paired-like homeodomain transcription factor ataxia telangiectasia and Rad3 related bicaudal D homolog (Drosophila) POM (POM121 homolog, rat) and ZP3 fusion kelch-like (Drosophila) betaine-homocysteine methyltransferase mitogen-activated protein kinase kinase kinase kinase lysine-rich coiled-coil MAWD binding protein slingshot homolog (Drosophila) immunoglobulin superfamily, member 4B NM_212535 protein kinase C, beta NM_001033057 NM_002518 membrane associated guanylate kinase, WW and PDZ domain containing neuronal PAS domain protein NM_032263 IQ motif containing G NM_133459 NM_153477 NM_031924 NM_000015 NM_138928 collagen and calcium binding EGF domains ubiquitously-expressed transcript radial spokehead-like N-acetyltransferase (arylamine Nacetyltransferase) insulin induced gene protein kinase, AMP-activated, alpha catalytic subunit ATP-binding cassette, sub-family B (MDR/TAP), member biogenesis of lysosome-related organelles complex-1, subunit gamma-aminobutyric acid (GABA) A receptor, delta astrotactin retinoblastoma-like (p130) dynamin fatty acid 2-hydroxylase homeobox A11 carboxypeptidase Z NADH dehydrogenase (ubiquinone) beta subcomplex, 4, 15kDa methionine sulfoxide reductase B3 potassium voltage-gated channel, subfamily H (eag-related), member molybdenum cofactor synthesis NM_003847 NM_203347 NM_198468 peroxisomal biogenesis factor 11A MSFL2541 chromosome open reading frame 167 NM_006500 melanoma cell adhesion molecule 0.839 CL-6; MGC1405 AMPK; AMPKa1; MGC33776; MGC57364 MDR3; PGY3; ABC21; MDR2/3; PFIC-3 BLOS2; FLJ30135; MGC10120; RP11-316M21.4 MGC45284 NM_198336 NM_206907 NM_000815 ASTN2 RBL2 DNM1 FA2H HOXA11 CPZ NDUFB4 0.837 0.832 0.831 0.83 0.829 0.826 0.826 KIAA0634; bA67K19.1 Rb2; P130; FLJ26459 DNM FAAH; FAXDC1; FLJ25287 HOX1; HOX1I MGC99682 B15; CI-B15; MGC5105 NM_198188 NM_005611 NM_004408 NM_024306 NM_005523 NM_001014447 NM_004547 MSRB3 KCNH2 0.821 0.819 NM_001031679 NM_172056 MOCS1 0.818 PEX11A UNQ2541 C6ORF167 0.816 0.815 0.814 MCAM 0.814 FLJ36866; DKFZp686C1178 ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1 MIG11; MOCOD; MOCS1A; MOCS1B; KIAA0381 MGC138534; PEX11-ALPHA UNQ2541 FLJ46180; KIAA1900; dJ39B17.2; DKFZp781C2113; DKFZp686C20164 CD146; MUC18 NM_000443 NM_001001342 275 FAM112B 0.814 FLJ32942 NM_144594 PLEKHQ1 0.813 0.813 GATA2 EBF KLK7 NOX5 0.807 0.806 0.806 0.806 PP1628; pp9099; FLJ38884; DKFZp761K2312 MGC41939; bA425D10.6; dJ919F19.1 NFE1B; MGC2306 COE1; EBF1; OLF1; O/E-1 SCCE; PRSS6 NOX5A; NOX5B NM_025201 PPIL6 COL13A1 KARS USP48 0.805 0.802 0.802 DNTTIP2 0.8 SEZ6 BTN3A3 PTPRE 0.8 0.799 0.798 FLJ45121 C9ORF132 0.797 0.795 WDR63 0.793 DOK4 SELO SEZ6L2 HIST1H2BJ C3ORF34 RWDD2 0.793 0.792 0.785 0.784 0.782 0.781 COL13A1 KARS2; KIAA0070 USP31; RAP1GA1; MGC14879; MGC132556; DKFZp762M1713 ERBP; TdIF2; HSU15552; LPTSRP2; RP4-561L24.1 ZC3HC1 BTF3 PTPE; HPTPE; DKFZp313F1310; R-PTP-EPSILON FLJ45121 EEIG1; C9orf132; MGC50853; bA203J24.7 FLJ30067; NYD-SP29; RP11507C22.2 FLJ10488 SELO; MGC131879 PSK-1; FLJ90517 H2B/r; H2BFR MGC14126 MGC13523; MGC138208; dJ747H23.2 UGT; UGAT; UGT1; UGT2; UGTL; UGALT LPNA3; KIAA0654; MGC126567; MGC126569 NM_173672 NM_032638 NM_024007 NM_139277 NM_024505 NM_080805 NM_005548 NM_001032730 NM_014597 NM_178860 NM_006994 NM_006504 NM_207451 NM_203305 family with sequence similarity 112, member B pleckstrin homology domain containing, family Q member peptidylprolyl isomerase (cyclophilin)-like GATA binding protein early B-cell factor kallikrein (chymotryptic, stratum corneum) NADPH oxidase, EF-hand calcium binding domain collagen, type XIII, alpha lysyl-tRNA synthetase ubiquitin specific peptidase 48 deoxynucleotidyltransferase, terminal, interacting protein seizure related homolog (mouse) butyrophilin, subfamily 3, member A3 protein tyrosine phosphatase, receptor type, E NM_145172 FLJ45121 protein family with sequence similarity 102, member A WD repeat domain 63 NM_018110 NM_031454 NM_201575 NM_021058 NM_032898 NM_033411 docking protein selenoprotein O seizure related homolog (mouse)-like histone 1, H2bj chromosome open reading frame 34 RWD domain containing NM_005660 SLC35A2 0.78 PPFIA3 0.777 C14ORF28 CARS ACADS 0.774 0.773 0.772 DRIP1; c14_5270 CYSRS; MGC:11246 SCAD; ACAD3 NM_001017923 NM_001751 NM_000017 GRHL3 PPM1F 0.771 0.771 NM_021180 NM_014634 CYP51A1 0.768 KRT17 KCTD13 0.768 0.767 SOM; TFCP2L4; MGC46624 FEM-2; POPX2; hFEM-2; CaMKPase; KIAA0015 LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM PC; K17; PC2; PCHC1 PDIP1; FKSG86; POLDIP1 NM_000422 NM_178863 LOC196463 SLC25A20 0.766 0.766 LOC196463 CAC; CACT NM_173542 NM_000387 C1ORF33 ADC EGFL6 CRI1 0.766 0.765 0.762 0.761 NM_016183 NM_052998 NM_015507 NM_014335 WDR23 0.759 NM_025230 WD repeat domain 23 ZDHHC24 PNKD 0.759 0.755 NM_207340 NM_022572 zinc finger, DHHC-type containing 24 paroxysmal nonkinesiogenic dyskinesia CPA4 C1ORF24 0.755 0.755 dJ657E11.4 ODC-p; ODC1L; KIAA1945 W80; MAEG; DKFZp564P2063 EID1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; MGC138883; MGC138884 GL014; PRO2389; DKFZp779A1629 ZDHHC24 MR1; PDC; DYT8; FPD1; MR-1; BRP17; FKSG19; TAHCCP2; KIAA1184; KIPP1184; MGC31943; DKFZp564N1362 CPA3 C1orf24 solute carrier family 35 (UDP-galactose transporter), member A2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha chromosome 14 open reading frame 28 cysteinyl-tRNA synthetase acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain grainyhead-like (Drosophila) protein phosphatase 1F (PP2C domain containing) cytochrome P450, family 51, subfamily A, polypeptide keratin 17 potassium channel tetramerisation domain containing 13 hypothetical protein LOC196463 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 chromosome open reading frame 33 arginine decarboxylase EGF-like-domain, multiple CREBBP/EP300 inhibitor NM_016352 NM_022083 POU2F3 0.754 NM_014352 carboxypeptidase A4 synonyms: NIBAN, FLJ38228; isoform is encoded by transcript variant 2; cell growth inhibiting protein 39; Homo sapiens chromosome open reading frame 24 (C1orf24), transcript variant 2, mRNA POU domain, class 2, transcription factor RRAD KIAA1324 BICD2 HTR3A 0.751 0.75 0.748 0.747 NM_004165 NM_020775 NM_001003800 NM_000869 Ras-related associated with diabetes KIAA1324 bicaudal D homolog (Drosophila) 5-hydroxytryptamine (serotonin) receptor 3A ABCA8 0.747 NM_007168 ATP-binding cassette, sub-family A (ABC1), member chromosome open reading frame 83 C1ORF83 0.742 UPF3B 0.735 PRKCB1 0.73 RIPK5 0.723 KLHL13 0.721 GDF6 HSD17B2 ARL3 GSTM5 0.719 0.714 0.711 0.711 OCT11; PLA-1; Epoc-1; Skn-1a; FLJ40063; MGC126698 RAD; RAD1; REM3 RP11-352P4.1 KIAA0699; bA526D8.1 HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R KIAA0822 FLJ32112; FLJ39169; RP4758J24.3 UPF3X; HUPF3B; RENT3B PKCB; PRKCB; PRKCB2; MGC41878; PKC-beta RIP5; DustyPK; HDCMD38P; KIAA0472 BKLHD2; FLJ10262; KIAA1309; MGC74791 CDMP2 HSD17; EDH17B2 ARFL3 GTM5; GSTM5-5 NM_003660 NM_000786 NM_153035 NM_080632 NM_212535 UPF3 regulator of nonsense transcripts homolog B (yeast) protein kinase C, beta NM_015375 receptor interacting protein kinase NM_033495 kelch-like 13 (Drosophila) NM_001001557 NM_002153 NM_004311 NM_000851 growth differentiation factor hydroxysteroid (17-beta) dehydrogenase ADP-ribosylation factor-like glutathione S-transferase M5 276 NOXO1 0.709 0.702 0.7 P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5; MGC20258 gfg; bFGF; FGF-2; gfg-1; ASFGF2; FGF-AS; FGF2AS FLJ00131; KIAA1821; MGC11316; MGC126566; RAB11-FIP4 FAT; GP4; GP3B; GPIV; PASIV; SCARB3 APS EP1 NUDT6 0.707 RAB11FIP4 0.707 CD36 0.702 APS PTGER1 CRH AHNAK STARD8 FLJ10260 APBB1IP 0.7 0.699 0.698 0.692 0.69 CRF AHNAKRS; MGC5395 KIAA0189; DKFZp686H1668 SLFN3; FLJ10260 RIAM; INAG1; PREL1; RARP1 NM_000756 NM_024060 NM_014725 NM_018042 NM_019043 MGC31967 SERPING1 0.689 0.688 MGC31967; RP11-331F9.6 C1IN; C1NH; HAE1; HAE2; C1INH NM_174923 NM_000062 RARRES3 0.687 NM_004585 C4ORF18 0.685 TGFB1I1 0.684 RIG1; TIG3; HRASLS4; MGC8906 AD021; AD036; FLJ38155; DKFZp434L142 HIC5; ARA55; HIC-5; TSC-5 ETV1 0.684 NM_004956 ATG4A 0.679 ER81; MGC104699; MGC120533; MGC120534; DKFZp781L0674 APG4A; AUTL2 IL11RA C1ORF116 0.677 0.677 CNN1 SYAP1 0.674 0.666 DOC1 MYL9 0.664 0.663 MEIS2 0.659 C20ORF18 0.654 TNFRSF10A 0.652 GSTM3 0.652 F2RL2 0.652 FBXO32 0.645 DKFZP686A01247 0.643 PTGDS FLI1 AMPD3 0.638 0.637 0.633 CDKN1A 0.629 GNA15 0.628 HEXA ACPP CFH 0.626 0.626 0.616 BHMT2 AK5 ATP1B2 0.615 0.612 0.609 IDS HOXA10 0.607 0.605 ELLS1 PTMA DOC1 AHNAK MYEOV 0.604 0.602 0.601 0.598 0.597 LRP10 0.597 COL11A1 A4GALT 0.595 0.592 IL6ST 0.592 C9ORF89 0.589 MGC2146 SARG; MGC2742; MGC4309; FLJ36507; DKFZp666H2010 SMCC; Sm-Calp PRO3113; FLJ14495; FLJ44185; DKFZp686K221 DOC1; GIP90 LC20; MLC2; MRLC1; MYRL2; MGC3505 MRG1; MGC2820; HsT18361 XAP4; RBCK2; RNF54; ZRANB4; C20orf18; UBCE7IP3 DR4; APO2; CD261; MGC9365; TRAILR1; TRAILR-1 GST5; GSTB; GTM3; GSTM3-3; MGC3310; MGC3704 PAR3 Fbx32; MAFbx; ATROGIN1; FLJ32424; MGC33610 DKFZP686A01247; MGC72127; DKFZp434I0312; DKFZp686B2470; DKFZp686G2094; DKFZp781C1754; DKFZp781I1455; DKFZp686A01247; DKFZp686G18243 PDS; PGD2; PGDS; PGDS2 EWSR2; SIC-1 DUT NM_144603 NADPH oxidase organizer NM_198041 NM_032932 nudix (nucleoside diphosphate linked moiety X)-type motif RAB11 family interacting protein (class II) NM_001001548 CD36 molecule (thrombospondin receptor) NM_020979 NM_000955 SH2B adaptor protein prostaglandin E receptor (subtype EP1), 42kDa corticotropin releasing hormone AHNAK nucleoprotein (desmoyokin) START domain containing schlafen family member 12 amyloid beta (A4) precursor protein-binding, family B, member interacting protein coiled-coil domain containing 107 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) retinoic acid receptor responder (tazarotene induced) chromosome open reading frame 18 NM_016613 NM_015927 NM_052936 NM_004512 NM_023938 NM_001299 NM_032796 NM_182909 NM_006097 NM_020149 NM_006462 NM_003844 NM_000849 NM_004101 ATG4 autophagy related homolog A (S cerevisiae) interleukin 11 receptor, alpha chromosome open reading frame 116 calponin 1, basic, smooth muscle synapse associated protein 1, SAP47 homolog (Drosophila) downregulated in ovarian cancer myosin, light polypeptide 9, regulatory Meis1, myeloid ecotropic viral integration site homolog (mouse) RanBP-type and C3HC4-type zinc finger containing tumor necrosis factor receptor superfamily, member 10a glutathione S-transferase M3 (brain) NM_148177 coagulation factor II (thrombin) receptor-like F-box protein 32 NM_014988 hypothetical protein NM_000954 NM_002017 NM_001025389 prostaglandin D2 synthase 21kDa (brain) Friend leukemia virus integration adenosine monophosphate deaminase (isoform E) cyclin-dependent kinase inhibitor 1A (p21, Cip1) guanine nucleotide binding protein (G protein), alpha 15 (Gq class) hexosaminidase A (alpha polypeptide) acid phosphatase, prostate complement factor H P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 GNA16 NM_078467 TSD; MGC99608 PAP; ACP3; ACP-3 FH; HF; HF1; HF2; HUS; FHL1; CFHL3; MGC88246 FLJ20001 AK6; MGC33326 AMOG NM_000520 NM_001099 NM_001014975 MPS2; SIDS PL; HOX1; HOX1H; HOX1.8; MGC12859 Ells1; FLJ25903 TMSA; MGC104802 DOC1; GIP90 AHNAKRS; MGC5395 OCIM transforming growth factor beta induced transcript ets variant gene NM_002068 NM_017614 NM_174858 NM_001678 NM_000202 NM_153715 NM_152793 NM_002823 NM_014890 NM_024060 NM_138768 LRP9; MST087; MGC8675; MSTP087; MGC142274; MGC142276; DKFZP564C1940 STL2; COLL6; CO11A1 P1; PK; A14GALT; A4GALT1 NM_014045 NM_080629 NM_017436 CD130; GP130; CDw130; IL6Rbeta; GP130-RAPS BinCARD; MGC11115; NM_032310 NM_002184 betaine-homocysteine methyltransferase adenylate kinase ATPase, Na+/K+ transporting, beta polypeptide iduronate 2-sulfatase (Hunter syndrome) homeobox A10 chromosome open reading frame 41 prothymosin, alpha (gene sequence 28) downregulated in ovarian cancer AHNAK nucleoprotein (desmoyokin) myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas) low density lipoprotein receptor-related protein 10 collagen, type XI, alpha alpha 1,4-galactosyltransferase (globotriaosylceramide synthase) interleukin signal transducer (gp130, oncostatin M receptor) chromosome open reading frame 89 277 TGM2 0.578 MGC110898; bA370F5.1 TG2; TGC NM_198951 TRPM4 0.578 TRPM4B; FLJ20041 NM_017636 BMP1 ABCC3 PTPRN 0.577 0.574 0.566 PCP; TLD; PCOLC; FLJ44432 NM_006129 NM_020037 NM_002846 NRG1 0.557 H2AFY 0.542 ATP2B4 0.537 SGCE MYO1D ALCAM 0.526 0.518 0.517 TICAM1 0.515 IL1A STAT1 0.513 0.495 FLJ90166 0.493 CEECAM1 0.474 IL24 0.471 DHRS3 0.461 JAK1 DEGS1 0.46 0.457 NRP1 0.447 HSDL2 COMT DFNA5 THRA 0.426 0.417 0.407 0.404 GPR177 0.401 LIMA1 LOC388610 ECM1 S100A4 0.395 0.381 0.368 0.359 S100A4 0.358 FAP 0.351 EDG2 0.346 IA2; IA-2; ICA512; R-PTP-N; FLJ16131; IA-2/PTP GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF H2A.y; H2A/y; H2AFJ; mH2A1; H2AF12M; MACROH2A1.1; macroH2A1.2 MXRA1; PMCA4; ATP2B2; DKFZp686M088; DKFZp686G08106 ESG; DYT11 myr4; KIAA0727 MEMD; CD166; FLJ38514; MGC71733 TRIF; PRVTIRB; TICAM-1; MGC35334 IL1; IL-1A; IL1F1; IL1-ALPHA ISGF-3; STAT91; DKFZp686B04100 FLJ90166; MGC126807; MGC126809; RP4-685L9.2 CerCAM; GLT25D3; MGC149620; MGC149621 C49A; FISP; MDA7; ST16; IL-24; IL10B; Mob-5; mda-7 SDR1; RDH17; Rsdr1; retSDR1 transglutaminase (C polypeptide, proteinglutamine-gamma-glutamyltransferase) transient receptor potential cation channel, subfamily M, member bone morphogenetic protein protein tyrosine phosphatase, receptor type, N NM_013960 neuregulin NM_138609 H2A histone family, member Y NM_001684 ATPase, Ca++ transporting, plasma membrane NM_003919 NM_015194 NM_001627 sarcoglycan, epsilon myosin ID activated leukocyte cell adhesion molecule NM_182919 toll-like receptor adaptor molecule NM_000575 NM_139266 interleukin 1, alpha signal transducer and activator of transcription 1, 91kDa adenomatosis polyposis coli down-regulated 1-like cerebral endothelial cell adhesion molecule NM_153360 NM_016174 NM_006850 interleukin 24 NM_004753 dehydrogenase/reductase (SDR family) member Janus kinase (a protein tyrosine kinase) degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) neuropilin CCL20 0.333 SPARC 0.333 JAK1A; JAK1B MLD; DEGS; DES1; Des-1; FADS7; MIG15; MGC5079 NRP; CD304; VEGF165R; DKFZp781F1414; DKFZp686A03134 C9orf99; FLJ25855; MGC10940 COMT ICERE-1 AR7; EAR7; ERBA; ERBA1; NR1A1; THRA1; THRA2; THRA3; EAR-7.1; EAR-7.2; ERB-T-1; MGC43240; c-ERBA-1; MGC000261; ERBA-ALPHA; TR-ALPHA-1; c-ERBA-ALPHA2 MRP; WLS; C1orf139; FLJ23091; MGC14878; MGC131760 EPLIN; SREBP3; MGC131726 LOC388610 ECM1 42A; 18A2; CAPL; MTS1; P9KA; PEL98 42A; 18A2; CAPL; MTS1; P9KA; PEL98 FAPA; DPPIV; SEPRASE; DKFZp686G13158 LPA1; LPAR1; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3 CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20 ON NM_002227 NM_003676 TGM2 0.313 TG2; TGC NM_004613 HS3ST3A1 0.29 30ST3A1; 3OST3A1 NM_006042 CASP4 0.228 TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II NM_033306 NM_001024629 NM_032303 NM_000754 NM_004403 NM_003250 hydroxysteroid dehydrogenase like catechol-O-methyltransferase deafness, autosomal dominant thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) NM_024911 G protein-coupled receptor 177 NM_016357 NM_001013642 NM_004425 NM_002961 LIM domain and actin binding hypothetical LOC388610 extracellular matrix protein S100 calcium binding protein A4 NM_002961 S100 calcium binding protein A4 NM_004460 fibroblast activation protein, alpha NM_001401 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, chemokine (C-C motif) ligand 20 NM_004591 NM_003118 secreted protein, acidic, cysteine-rich (osteonectin) transglutaminase (C polypeptide, proteinglutamine-gamma-glutamyltransferase) heparan sulfate (glucosamine) 3-Osulfotransferase 3A1 caspase 4, apoptosis-related cysteine peptidase 278 ... endoderm differentiation of hESCs Table 5.1 Available information on knock-out phenotypes in the mouse vii LIST OF FIGURES Figure 1.1 Embryonic origin of human embryonic stem cells and their... CD86 and CD83 that enhance the activation of naive T cells 14 Figure 1.5 Haematopoietic development Pluripotent stem cells give rise to multipotent haematopoietic stem cells that differentiate into. .. studies on mouse and human embryos and mESCs, hESCs have been subjected to various differentiation strategies in order to develop and establish models of human embryonic and haematopoietic development