Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury

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Role of Cyclic AMP Signalling Mechanisms in Heart Protection Against Ischemia - Reperfusion Injury Dr Igor Khaliulin Coronary Artery Occlusion and Heart Attack Heart Attack Myocardium Atheroslcerosis Reperfusion Thrombosis Risk Zone IschaemiaReperfusion INJURY Experimental Protocol C IP TP SHP 10 20 30 40 50 60 70 80 90 100 110 120 Time (min) Perfusion 37oC Perfusion 26oC Global Ischemia % of Pre-Ischemic Values TP Hearts Demonstrated the Highest Haemodynamic Function Recovery 120 *** 100 # 80 ## ** * 60 Control IP TP SHP * P

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