CRC handbook of laboratory Safety - Chapter 1 docx

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CRC handbook of laboratory Safety - Chapter 1 docx

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Furr, A. Keith Ph.D. "Frontmatter" CRC handbook of laboratory Safety Edited by A. Keith Furr, Ph.D. Boca Raton: CRC Press LLC,2000 [...]... Biological Safety Officer (BSO) a Section IV-B-3-a b Section IV-B-3-b c Section IV-B-3-c 4 Section IV-B-7 Principal Investigator (P1) a Section IV-B-7-a General Responsibilities b Section IV-B-7-b Submissions by the Principal Investigator to NIH/ORDA c Section IV-B-7-c Submissions by the Principal Investigator to the Institutional Biosafety Committee d Section IV-B-7-d Responsibilities of the Principal... Section IV-B-7-e Responsibilities of the Principal Investigator During the Conduct of the Research H Section IV-D Voluntary Compliance 1 Section IV-D -1 Basic Policy - Voluntary Compliance 2 Section IV-D-2 Institutional Biosafety Committee Approval-Voluntary Compliance 3 Section IV-D-3 Certification of Host-Vector Systems-Voluntary Compliance 4 Section IV-D-4 Requests for Exemptions and Approvals - Voluntary... Section IV-D-5 Protection of Proprietary Data - Voluntary Compliance a Section IV-D-5-a General b Section IV-D-5-b Pre-submission Review F Appendices 1 Appendix A Exemptions Under Section III-f-5-Sublists of Natural © 2000 CRC Press LLC 2 3 4 5 Exchangers a Appendix A-I Sublist A b Appendix A-II Sublist B c Appendix A-III Sublist C d Appendix A-IV Sublist D e Appendix A-V Sublist E f Appendix A-VI Sublist... Rodents k Appendix C-VII-A and A -1 l Appendix C-VII-B m Appendix C-VII-C n Appendix C-VII-D o Appendix C-VII-E Appendix D Major Actions Taken under the NIH Guidelines Appendix E Certified Host-vector Systems © 2000 CRC Press LLC a Appendix E-I Bacillus subtilis b Appendix E-I-A Bacillus subtilis Host-Vector 1 Systems c Appendix E-I-B Bacillus subtilis Host-Vector 2 Systems d Appendix E-II Saccharomyces... Biosafety Committee Notice Simultaneous with Initiation h Section III-F Exempt Experiments G Section IV Roles and Responsibilities 1 Section IV-A Policy 2 Section IV-B Responsibilities of the Institution a Section IV-B -1 General Information 3 Section IV-B-2 Institutional Biosafety Committee (IBC a Section IV-B-2-a Membership and Procedures b Section IV-B-2-b Functions 4 Section IV-B-3 Biological Safety. .. (RG4) - Bacterial Agents o Appendix B-IV-B Risk Group 4 (RG4) - Fungal Agents p Appendix B-IV-C Risk Group 4 (RG4) - Parasitic Agents q Appendix B-IV-D Risk Group 4 (RG4) - Viral Agents r Appendix B-V Animal Viral Etiologic Agents in Common Use s Appendix B-V -1 Murine Retroviral Vectors Appendix C Exemptions Under Section III-F-6 a Appendix C-I Recombinant DNA in Tissue Culture b Appendix C-I-A Exceptions... Appendix B-II-D Risk Group 2 (RG2) - Viruses h Appendix B-III Risk Group 3 (RG3) Agents i Appendix B-III-A Risk Group 3 (RG3 )- Bacterial Agents Including Rickettsia j Appendix B-III-B Risk Group 3 (RG3) - Fungal Agents k Appendix B-III-C Risk Group 4 (RG3) - Parasitic Agents l Appendix B-III-D Risk Group 3 (RG3) - Viruses and Prions m Appendix B-IV Risk Group 4 (RG4) Agents n Appendix B-IV-A Risk Group... Appendix E-II-A Saccharomyces cerevisiae Host-Vector 2 Systems f Appendix E-III Escherichia coli g Appendix E-III-A Escherichia coli (EK2) Plasmid Systems h Appendix E-III-B Escherichia coli (EK2) Bacteriophage Systems i Appendix E-IV Neurospora crassa j Appendix E-IV-A Neurospora crassa Host-Vector 1 Systems k Appendix E-V Streptomyces l Appendix E-V-A Streptomyces Host-Vector 1 Systems m Appendix E-VI... Pseudomonas putida n Appendix E-VI-A Pseudomonas putida Host-Vector 1 Systems 6 Appendix F Containment Conditions for Cloning of Genes Coding for the Biosynthesis of Molecules Toxic for Vertebrates a Appendix F-I General Information b Appendix F-II Cloning of Toxin Molecule Genes in Escherichia coli K -1 2 c Appendix F-II-A d Appendix F-II-B e Appendix F-II-C f Appendix F-III Cloning of Toxic Molecule Genes... II, Safety Considerations 1 IIA -1 Risk Groups 2 IIA-2 Risk Assessment 3 IIA-3 Risk Assessment Factors E II-B Containment F Section III Experiments Covered by the NIH Guidelines 1 Section III-A.* Experiments that Require Institutional Biosafety Committee Approval, RAC Review, and NIH Director Approval Before Initiation a III-A -1 , Major Actions Under the Guidelines b Section III-A -1 - a 2 Section III-B . (BSO) a. Section IV-B-3-a. b. Section IV-B-3-b c. Section IV-B-3-c 4. Section IV-B-7. Principal Investigator (P1) a. Section IV-B-7-a. General Responsibilities b. Section IV-B-7-b. Submissions by. IV-B-2. Institutional Biosafety Committee (IBC a. Section IV-B-2-a. Membership and Procedures b. Section IV-B-2-b. Functions 4. Section IV-B-3. Biological Safety Officer (BSO) a. Section IV-B-3-a I-I. Levels of Biological Containment b. Appendix I-I-A. Host-Vector 1 Systems c. Appendix I-I-B. Host-Vector 2 Systems d. Appendix I-II. Certification of Host-Vector Systems e. Appendix I-II-B.

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  • 2523fm.pdf

    • CRC handbook of laboratory Safety

      • FOREWORD

      • THE EDITOR

      • THE CONTRIBUTORS

      • TABLE OF CONTENTS

      • DEDICATION

      • CRC Handbook of Laboratory Safety

        • Contents

        • Chapter 1: INTRODUCTION

          • I. LABORATORY SAFETY AS A COOPERATIVE RESPONSIBILITY

            • A. Human Resources

            • B. Legal Department

            • C. Purchasing Department

            • D. Facilities Department

            • E. Management

            • F. Organizational Structure

            • G. The Safety Department

              • 1. Functions Relevant to Laboratories for the Safety Department

              • H. Departmental Responsibilities

                • I. Laboratory Responsibilities

                • REFERENCES

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