Chapter 046. Sodium and Water (Part 3) Hypovolemia Etiology True volume depletion, or hypovolemia, generally refers to a state of combined salt and water loss exceeding intake, leading to ECF volume contraction. The loss of Na + may be renal or extrarenal (Table 46-1). Table 46-1 Causes of Hypovolemia I. ECF volume contracted A. Extrarenal Na + loss 1. Gastrointestinal (vomiting, nasogastric suction, drainage, fistula, diarrhea) 2. Skin/respiratory (insensible losses, sweat, burns) 3. Hemorrhage B. Renal Na + and water loss 1. Diuretics 2. Osmotic diuresis 3. Hypoaldosteronism 4. Salt-wasting nephropathies C. Renal water loss 1. Diabetes insipidus (central or nephrogenic) II. ECF volume normal or expanded A. Decreased cardiac output 1. Myocardial, valvular, or pericardial disease B. Redistribution 1. Hypoalbuminemia (hepatic cirrhosis, nephrotic syndrome) 2. Capillary leak (acute pancreatitis, ischemic bowel, rhabdomyolysis) C. Increased venous capacitance 1. Sepsis Note: ECF, extracellular fluid. Renal Many conditions are associated with excessive urinary NaCl and water losses, including diuretics. Pharmacologic diuretics inhibit specific pathways of Na + reabsorption along the nephron with a consequent increase in urinary Na + excretion. Enhanced filtration of non-reabsorbed solutes, such as glucose or urea, can also impair tubular reabsorption of Na + and water, leading to an osmotic or solute diuresis. This often occurs in poorly controlled diabetes mellitus and in patients receiving high-protein hyperalimentation. Mannitol is a diuretic that produces an osmotic diuresis because the renal tubule is impermeable to mannitol. Many tubule and interstitial renal disorders are associated with Na + wasting. Excessive renal losses of Na + and water may also occur during the diuretic phase of acute tubular necrosis (Chap. 273) and following the relief of bilateral urinary tract obstruction. Finally, mineralocorticoid deficiency (hypoaldosteronism) causes salt wasting in the presence of normal intrinsic renal function. Massive renal water excretion can also lead to hypovolemia. The ECF volume contraction is usually less severe since two-thirds of the volume lost is intracellular. Conditions associated with excessive urinary water loss include central diabetes insipidus (CDI) and nephrogenic diabetes insipidus (NDI). These two disorders are due to impaired secretion of and renal unresponsiveness to AVP, respectively, and are discussed below. . Chapter 046. Sodium and Water (Part 3) Hypovolemia Etiology True volume depletion, or hypovolemia, generally refers to a state of combined salt and water loss exceeding. tubule and interstitial renal disorders are associated with Na + wasting. Excessive renal losses of Na + and water may also occur during the diuretic phase of acute tubular necrosis (Chap. 2 73). also impair tubular reabsorption of Na + and water, leading to an osmotic or solute diuresis. This often occurs in poorly controlled diabetes mellitus and in patients receiving high-protein