[...]... to evaluate three factors: (1) actual abuse of the drug; (2) the clandestine manufacture of the drug; (3) trafficking and diversion of the drug or its precursors from legitimate channels into clandestine operations Pre-clinical abuse liability studies are then conducted on animals to evaluate physiological responses to the drug At this point, clinical abuse liability studies can be conducted with human... Alan Wayne Jones 6 Neurochemistry of Drug Abuse Edited by Deborah C Mash and Julie K Staley 6.1 The Dopamine Transporter and Addiction John W Boja and William M Meil 6.2 Neuropsychiatric Consequences of Chronic Cocaine Abuse Deborah C Mash 6.3 Neurochemical Adaptations and Cocaine Dependence Julie K Staley 6.4 The Neurobiology of Relapse David W Self Pathology of Drug Abuse Edited by Charles V Wetli 2.1... Prescribing Douglas Fraser 7.5 Management of Comorbidity Duncan Raistrick 7.6 Toxicologic Issues Alastair W.M Hay 8 Medical Complications of Drug Abuse Edited by Neal L Benowitz 8.1 Drug- Related Syndromes Shoshana Zevin and Neal L Benowitz 8.2 Emergency Management of Drug Abuse- Related Disorders Brett A Roth, Neal L Benowitz, and Kent R Olson 9 Sports Edited by Jordi Segura 9.1 Introduction Jordi Segura 9.2... pattern of abuse Scope, duration, and significance of abuse Risk to the public health Psychic or physiological dependence liability Immediate precursor The definition of potential for abuse is based upon an individual taking a drug of his own volition in sufficient amounts to cause a health hazard to himself or to others in the community Data is then collected to evaluate three factors: (1) actual abuse. .. Pharmacokinetics: Drug Absorption, Distribution, and Elimination Amanda J Jenkins, and Edward J Cone 4 Pharmacodynamics Edited by Stephen J Heishman 4.1 Effects of Abused Drugs on Human Performance: Laboratory Assessment Stephen J Heishman 4.2 Performance Measures of Behavioral Impairment in Applied Settings Thomas H Kelly, Richard C Taylor, Stephen J Heishman, and Dennis J Crouch 4.3 Effects of Abused Drugs on... Controlled Substances Analogue and Enforcement Act of 1986 1.4 CONTROLLED SUBSTANCES 1.4.1 HERION Whenever one thinks about drugs of abuse and addiction, heroin is one of the most recognized drugs Heroin is a synthetic drug, produced from the morphine contained in the sap of the opium poppy The abuse of this particular controlled substance has been known for many years The correct chemical nomenclature for heroin... Andollo 12.6 Interpretation of Postmortem Drug Levels Graham R Jones 13 Drug Law 13.1 Current Legal Issues of Workplace Drug Testing Theodore F Shults 13.2 DUI Defenses Alan Wayne Jones and Barry Logan 13.3 Fetal Rights Stephen M Mohaupt Appendices Ia Glossary of Terms in Forensic Toxicology Chip Walls Ib Common Abbreviations Chip Walls Ic References for Methods of Drug Quantitative Analysis II Sample Calculations... preference studies and epidemiology Accumulating scientific evidence of a drug s pharmacological effects involves examining the scientific data concerning whether the drug elicits a stimulant, depressant, narcotic, or hallucinogenic response A determination can then be made as to how closely the pharmacology of the drug resembles that of other drugs that are already controlled Evidence is also accumulated about... 3,4-methylenedioxy-amphetamine (MDA), and psilocybin mushrooms Progressesing from Schedule II to schedule V, abuse potential decreases Schedule II controlled substances also include drugs or other substances that have a high potential for abuse, but also have some currently accepted, but severely restricted, medical uses Abuse of Schedule II substances may lead to dependence which can be both physical and/or psychological... Program John Baenziger 10.3 Analytical Considerations and Approaches for Drugs Michael Peat and Alan E Davis 10.4 Urine Specimen Suitability for Drug Testing Ruth E Winecker and Bruce A Goldberger 10.5 The Role of the Medical Review Officer: Current Issues Steven St Clair 10.6 Alternative Drugs, Specimens, and Approaches for Non-Regulated Drug Testing Dennis Crouch 10.7 Implementation of Alcohol Testing: . Data Drug abuse handbook / editor-in-chief, Steven B. Karch. p. cm. Includes bibliographical references. ISBN 0-8493-2637-0 (alk. paper) 1. Drugs of abuse Handbooks, manuals, etc. 2. Drug abuse- -Handbooks,. pathologists interested in drug abuse. The sorry state of the DAWN report (Drug Abuse Warning Network) offers a hint of the importance our government accords to the investigation of drug- related deaths;. Hay 8 Medical Complications of Drug Abuse Edited by Neal L. Benowitz 8.1 Drug- Related Syndromes Shoshana Zevin and Neal L. Benowitz 8.2 Emergency Management of Drug Abuse- Related Disorders Brett