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UNDERSTANDING
TUBERCULOSIS –
DECIPHERING THE SECRET
LIFE OF THE BACILLI
Edited by Pere-Joan Cardona
Understanding Tuberculosis
–
Deciphering the Secret Life of the Bacilli
Edited by Pere-Joan Cardona
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
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Technical Editor Teodora Smiljanic
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First published February, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechweb.org
Understanding Tuberculosis – Deciphering the Secret Life of the Bacilli, Edited by Pere-
Joan Cardona
p. cm.
ISBN 978-953-307-946-2
Contents
Preface IX
Part 1 The "Quiet" Genome 1
Chapter 1 Molecular Biomarkers
for Ancient Tuberculosis 3
David E. Minnikin, Oona Y-C. Lee,
Houdini H.T. Wu, Gurdyal S. Besra
and Helen D. Donoghue
Chapter 2 Genomic Variability of Mycobacterium tuberculosis 37
María Mercedes Zambrano, Ginna Hernández-Neuta,
Iván Hernández-Neuta, Andrea Sandoval,
Andrés Cubillos-Ruiz, Alejandro Reyes
and Patricia Del Portillo
Chapter 3 IS6110 the Double-Edged Passenger 59
María del Carmen Menéndez, Sofía Samper,
Isabel Otal and María Jesús García
Chapter 4 Response of Mycobacterial Species
to an Acidic Environment 89
Beatrice Saviola
Chapter 5 Mycobacterium Tuberculosis Signaling via c-AMP 103
Mario Alberto Flores-Valdez,
Jeannette Barba and Angel H. Alvarez
Chapter 6 Mycobacterium tuberculosis RD-1 Secreted Antigens
as Protective and Risk Factors for Tuberculosis 117
Niladri Ganguly and Pawan Sharma
Chapter 7 Mycobacterium tuberculosis Transcriptome
In Vivo Studies – A Key to Understand the
Pathogen Adaptation Mechanism 129
Tatyana Azhikina and Timofey Skvortsov
VI Contents
Part 2 Resisting an Agressive Environment 147
Chapter 8 Morphological Characterization of
Mycobacterium tuberculosis 149
Ali Akbar Velayati and Parissa Farnia
Chapter 9 Mycobacterial Strains of Different Virulence
Trigger Dissimilar Patterns of Immune
System Activation In Vivo 167
Aaron Silva-Sanchez, Selene Meza-Pérez,
Fernando Muñoz-Teneria, Dulce Mata, Juana Calderon-Amador,
Sergio Estrada-Parra, Rogelio Hernández-Pando,
Iris Estrada-García and Leopoldo Flores-Romo
Chapter 10 Biofilms of Mycobacterium tuberculosis:
New Perspectives of an Old Pathogen 181
Anil K. Ojha and Graham F. Hatfull
Chapter 11 Cell Wall Deficiency in Mycobacteria:
Latency and Persistence 193
Nadya Markova
Chapter 12 Mycobacterium tuberculosis: Dormancy, Persistence
and Survival in the Light of Protein Synthesis 217
Ranjeet Kumar and Suparna Sanyal
Chapter 13 Lipid Surrounding of Mycobacteria:
Lethal and Resuscitating Effects 239
Alla A. Selishcheva, Galina M. Sorokoumova
and Evgeniya V. Nazarova
Chapter 14 Heat Shock Proteins in Mycobacterium tuberculosis:
Involvement in Survival and Virulence of the Pathogen 257
Divya Bajaj and Janendra K. Batra
Chapter 15 Mammalian Heme Peroxidases and
Mycobacterium tuberculosis 277
Amit K. Singh, Nisha Pandey, Mau Sinha,
Sujata Sharma and Tej P. Singh
Chapter 16 Thiol-Dependent Peroxidases in
Mycobacterium tuberculosis
Antioxidant Defense 293
Martín Hugo, Rafael Radi and Madia Trujillo
Chapter 17 Characteristic Conformational Behaviors of Representative
Mycolic Acids in the Interfacial Monolayer 317
Masumi Villeneuve
Preface
Mycobacterium tuberculosis has been the paradigm of genetic stability for years,
compared to other bacterial families or viruses, which is mainly related to its lack of
plasmid content. As recent investigations demonstrate, the bacillus has a complex
signaling expression, which allows its close interaction with the environment and one
of its most renowned properties: the ability to persist for long periods of time under a
non-replicative status. Although this skill is well characterized in other bacteria, the
intrinsically very slow growth rate of Mycobium tuberculosis, together with a very thick
and complex cell wall, makes this pathogen specially adapted to the stress that could
be generated by the host against them. In this book, different aspects of these
properties are displayed by specialists in the field.
Dr. Pere-Joan Cardona
Institut Germans Trias i Pujol (IGTP)
Catalunya, Spain
. UNDERSTANDING TUBERCULOSIS – DECIPHERING THE SECRET LIFE OF THE BACILLI Edited by Pere-Joan Cardona Understanding Tuberculosis – Deciphering the Secret Life of the. about the occurrence of tuberculosis in the pre-colonial Understanding Tuberculosis – Deciphering the Secret Life of the Bacilli 10 Far East (Spigelman & Lemma, 1993) and whether tuberculosis. lesions in the ribs arise by extension from spinal Understanding Tuberculosis – Deciphering the Secret Life of the Bacilli 6 lesions, from haematogenous spread from some remote soft tissue
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