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DIABETIC NEPHROPATHY
Edited by John S. D. Chan
Diabetic Nephropathy
Edited by John S. D. Chan
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors
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First published April, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Diabetic Nephropathy, Edited by John S. D. Chan
p. cm.
ISBN 978-953-51-0543-5
Contents
Preface IX
Section 1 Systemic and Local Intrarenal
Renin-Angiotensin-Aldosterone System in
the Development of Diabetic Nephropathy 1
Chapter 1 Up-Regulation of Renin-Angiotensin System
in Diabetes and Hypertension: Implications on the
Development of Diabetic Nephropathy 3
Dulce Elena Casarini, Danielle Yuri Arita, Tatiana Sousa Cunha,
Fernanda Aparecida Ronchi, Danielle Sanches Aragão,
Rodolfo Mattar Rosa, Nadia Sousa Cunha Bertoncello
and Fernanda Klein Marcondes
Chapter 2 Renal Angiotensinogen Gene Expression and
Tubular Atrophy in Diabetic Nephropathy 31
Brice E. T. Nouthe, Maya Saleh,
Shao-Ling Zhang and John S. D. Chan
Chapter 3 Diabetic Nephropathy:
Role of Aldosterone and Benefits of
Therapy with Aldosterone Receptor Blocker 41
Jayson Yap and Mohammad G. Saklayen
Chapter 4 Drug and Diabetic Nephropathy 57
Rozina Rani
Section 2 Novel Therapeutic Molecules in Diabetic Nephropathy 83
Chapter 5 Kidney ADP-Ribosyl Cyclase Inhibitors as
a Therapeutic Tool for Diabetic Nephropathy 85
Uh-Hyun Kim
Chapter 6 Significance of Advanced Glycation End-Products (AGE) and
the Receptor for AGE (RAGE) in Diabetic Nephropathy 97
Tarek Kamal, Yasuhiko Yamamoto and Hiroshi Yamamoto
VI Contents
Chapter 7 The Contribution of Fibronectin ED-A Expression to
Myofibroblast Transdifferentiation in
Diabetic Renal Fibrosis 109
Keisuke Ina, Hirokazu Kitamura,
Shuji Tatsukawa and Yoshihisa Fujikura
Chapter 8 Immunoinflammation in Diabetic Nephropathy:
Molecular Mechanisms and Therapeutic Options 127
Virginia Lopez-Parra, Beñat Mallavia,
Jesus Egido and Carmen Gomez-Guerrero
Chapter 9 Study of Diabetic Hypertensive Nephropathy in
the Local Population of Pakistan 147
Samreen Riaz and Saadia Shahzad Alam
Preface
The idea for publishing a book on diabetic nephropathy has been developed during
the last several years as my interest in studying diabetic complications has
increased. The need for a book that described the various novel and old molecules
involved in the development of diabetic nephropathy and the trend of future
research became apparent. The book describes the important role of intrarenal renin-
angiotensin-aldosterone system and immune system in the development of diabetic
nephropathy as well as provided data on the biochemical and pathological changes
in diabetic nephropathy. Relevant information on the treatments of diabetic
nephropathy is also provided.
The authors are internationally known for their work in diabetic nephropathy. Each
chapter has been peer-reviewed and edited and provide up-to-date information on
the topic.
I hope that the book will be useful for researchers working in the field of diabetic
nephropathy.
John S. D. Chan
Professor of Medicine at the Université de Montréal,
Chief of the Laboratory of Molecular Nephrology and Endocrinology,
Research Centre - Centre hospitalier de l’Université de Montréal (CRCHUM)
Montréal,
Canada
. DIABETIC NEPHROPATHY Edited by John S. D. Chan Diabetic Nephropathy Edited by John S. D. Chan Published by InTech Janeza Trdine 9, 51000 Rijeka,. developed during the last several years as my interest in studying diabetic complications has increased. The need for a book that described the various novel and old molecules involved in the development. these complications, diabetic nephropathy (DN), the most common etiology of chronic kidney disease (CKD) and common cause of end-stage renal disease (ESRD) in adults in the Western world (Choudhury
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