Kelley's Textbook of Internal Medicine 4th edition (August 15, 2000): by H. David Humes (Editor), Herbert L. Dupont (Editor) By Lippincott Williams & Wilkins Publishers By OkDoKeY Kelley's Textbook of Internal Medicine Table of Contents Editors Contributors Preface List of Clinical Decision Guides RAPID ACCESS GUIDE Paul L. Fine How to Use the Rapid Access Guide to Internal Medicine Cardiology Gastroenterology Nephrology Rheumatology Oncology and Hematology Infectious Diseases Pulmonary Medicine Endocrinology Neurology PART 1: PRINCIPLES OF MEDICAL PRACTICE SECTION I: HUMANISM AND ETHICS Chapter 1: Introduction to Internal Medicine as a Discipline William N. Kelley and Joel D. Howell Chapter 2: Clinical Medicine, Clinical Ethics and Physicians’ Professionalism Mark Siegler, Arthur L. Caplan, and Peter A. Singer SECTION II: BASIC MECHANISMS OF HEALTH AND DISEASE Chapter 3: The Genome Project and Molecular Diagnosis Leslie G. Biesecker, Barbara B. Biesecker, and Francis S. Collins Chapter 4: Cell Growth, Differentiation, and Death Max Wicha Chapter 5: Principles of the Immune Response Robert Winchester Chapter 6: Inflammation: Cells, Cytokines, and Other Mediators Zoltan Szekanecz and Alisa E. Koch Chapter 7: Mechanisms of Hormone Action Daryl K. Granner Chapter 8: Principles of Nutrition David H. Alpers Chapter 9: Principles of the Renal Regulation of Fluid and Electrolytes L. B. Gardner and H. David Humes Chapter 10: Pulmonary Gas Exchange John J. Marini and David R. Dantzker Chapter 11: Vascular Biology Elizabeth G. Nabel Chapter 12: Disorders of Lipid Metabolism Daniel J. Rader Chapter 13: Pathogenesis of Atherosclerosis Alan M. Fogelman, Franklin L. Murphy and Peter A. Edwards Chapter 14: Some Functional Pathways in the Central Nervous System John A. Kiernan Chapter 15: Biology and Genetics of Aging and Longevity Richard A. Miller Chapter 16: Clinical Physiology of Aging Lewis A. Lipsitz Chapter 17: Healthcare Implications of an Aging Society Joan Weinryb, Dennis Hsieh, Risa Lavizzo-Mourey Chapter 18: Host-Microbe Interaction Herbert L. DuPont and Liliana Rodriguez Chapter 19: Etiology of Malignant Disease William A. Blattner Chapter 20: Molecular and Cell Biology of Neoplasia Peter C. Nowell Chapter 21: Epidemiology of Malignant Disease David Schottenfeld Chapter 22: Prevention of Neoplasia Peter Greenwald Chapter 23: Transplantation Immunology Judith A. Shizuru SECTION III: APPROACH TO COMMON PRIMARY CARE ISSUES Chapter 24: Periodic Health Evaluation Albert G. Mulley, Jr. Chapter 25: Preoperative Medical Evaluation Judi M. Woolger Chapter 26: Immunizations Theodore C. Eickhoff Chapter 27: Infectious Disease Prevention in the International Traveler David O. Freedman Chapter 28: Cancer Screening and Early Detection Jhon K. Gohagan, Barnett S. Kramer, and William C. Black Chapter 29: Epidemiology and Prevention of Cardiovascular Disease Lori Mosca Chapter 30: Systemic Hypertension Myron H. Weinberger Chapter 31: Approaches to Hypercholesterolemia and Other Abnormal Lipid Profiles Daniel J. Rader Chapter 32: Approach to the Patient With Chest Pain (Cardiac and Non-Cardiac) Alberto A. Mitrani and Mark Multach Chapter 33: Smoking and Smoking Cessation Alfred Munzer Chapter 34: Approach to the Problem of Alcohol Abuse and Dependence Charles P. O’Brien Chapter 35: Approach to the Problem of Substance Abuse Charles P. O’Brien Chapter 36: Obesity Albert J. Stunkard and Thomas A. Wadden Chapter 37: Anorexia Nervosa and Eating Disorders Paul M. Copeland Chapter 38: Approach to the Patient With Unintentional Weight Loss Daniel M. Lichtstein and Robert L. Hernandez Chapter 39: Depression, Anxiety, and Other Psychiatric Disorders Maria D. Llorente Chapter 40: Care of the Dying Patient Joanne Lynn and Betty Ferrell SECTION IV: PRINCIPLES OF CLINICAL EVALUATION Chapter 41: The Clinical Approach to the Patient James O. Woolliscroft Chapter 42: Principles of Clinical Epidemiology Jay M. Sosenko Chapter 43: Evidence-Based Medicine Mark T. O’Connell Chapter 44: Computers in Support of Clinical Decision Making Edward H. Shortliffe Chapter 45: Quality Improvement and Clinical Outcomes Assessment David Shulkin Chapter 46: Assessment of Physician Performance in the New Century Health Care Environment Roberta Parillo, Mark Rivo, and Laurence B. Gardner Chapter 47: Medical Malpractice and Risk Management Kimberly A. Cook and Juan D. Reyes SECTION V: RELATED MEDICAL DISCIPLINES Chapter 48: Adolescent Medicine Gail B. Slap Chapter 49: Principles of Occupational Medicine Mark R. Cullen and Linda Rosenstock Chapter 50: Medical Ophthalmology Michele R. Piccone and Stuart L. Fine Chapter 51: Medical Otolaryngology Erica R. Thaler and David W. Kennedy Chapter 52: Principles of Women’s Medicine Erin N. Marcus Chapter 53: Principles of Sports Medicine Paul McCaffrey Ford and Gordon O. Matheson Chapter 54: Principles of Rehabilitation Medicine Kresimir Banovac, Debbie Fertel and Joseph Bauerlein Chapter 55: Principles of Clinical Pharmacology D. Craig Brater Chapter 56: Alternative Medicine: Prevalence, Cost, and Usefulness Mark Multach SECTION VI: SELECTED MEDICAL EMERGENCIES Chapter 57: General Principles in the Approach to the Patient with an Acute Emergency Sheldon Jacobson Chapter 58: Animal Bites and Stings Faith T. Fitzgerald Chapter 59: Near Drowning Leonard D. Hudson and Kenneth P. Steinberg Chapter 60: Treatment of Anaphylaxis Marc S. McMorris Chapter 61: Cardiopulmonary Resuscitation Kathleen S. Schrank Chapter 62: Hyperthermia and Hypothermia Faith T. Fitzgerald Chapter 63: Ionizing Radiation Injuries Brahm Shapiro PART 2: CARDIOLOGY SECTION I: APPROACH TO THE PATIENT WITH CARDIOVASCULAR DISORDERS Chapter 64: Essential Features of the Cardiac History and Physical Examination Elizabeth G. Nabel Chapter 65: Approach to the Patient With Chest Pain Elizabeth G. Nabel Chapter 66: Approach to the Patient With Heart Failure Robert J. Cody Chapter 67: Approach to the Patient With Cardiac Arrhythmias S. Adam Strickberger, Douglas P. Zipes and Fred Morady Chapter 68: Approach to the Patient With Heart Murmurs Jonathan Abrams Chapter 69: Approach to the Patient With Syncope Patrick T. O’Gara and Kristin Ellison Chapter 70: Approach to the Pregnant Patient With Heart Disease G. Michael Felker and Kenneth L. Baughman Chapter 71: Approach to the Patient With Hypotension and Shock Todd M. Koelling and Robert J. Cody SECTION II: DISORDERS OF THE CARDIOVASCULAR SYSTEM Chapter 72: Coronary Artery Disease Mihai Gheorghiade and Robert O. Bonow Chapter 73: Acute Myocardial Infarction Robert Roberts Chapter 74: Myocardial Diseases Michael R. Bristow, John B. O’Connell and Louisa Mestroni Chapter 75: Tumors of the Heart Joel S. Raichlen and Martin G. St. John Sutton Chapter 76: Cardiac Arrhythmias Bradley P. Knight, Douglas P. Zipes, and Fred Morady Chapter 77: Valvular Heart Disease David Bach and Kim A. Eagle Chapter 78: Congenital Heart Disease in the Adult Thomas J. Ryan and J. Kevin Harrison Chapter 79: Pericardial Diseases E. William Hancock Chapter 80: Pulmonary Hypertension and Cor Pulmonale Lewis J. Rubin Chapter 81: Vascular Medicine Mark A. Creager and Marie Gerhard-Herman Chapter 82: Genetics of the Cardiovascular System Craig T. Basson and Carl J. Vaughan SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN CARDIOVASCULAR DISEASES Chapter 83: Cardiovascular Radiology Robert D. Tarver, Dewey J. Conces, Jr., and Lynn S. Broderick Chapter 84: Electrocardiography, Exercise Stress Testing, and Ambulatory Monitoring Charles Fisch Chapter 85: Echocardiography William F. Armstrong Chapter 86: Radionuclide and Magnetic Resonance Techniques Mark A. Lawson and Gerald M. Pohost Chapter 87: Diagnostic and Therapeutic Catheterization Richard A. Lange and L. David Hillis Chapter 88: Electrophysiologic Testing Fred Morady Chapter 89: Principles of Cardiac Conditioning and Rehabilitation Victor F. Froelicher and Jonathan N. Myers Chapter 90: Clinical Pharmacology of Cardiovascular Drugs D. Craig Brater Chapter 91: Use of Anticoagulant Drugs Michael D. Ezekowitz Chapter 92: Principles and Applications of Cardiac Surgery John G. Byrne, Raymond H. Chen, and David H. Adams Chapter 93: Medical Management of the Cardiac Transplant Patient Keith Aaronson and Robert Cody PART 3: GASTROENTEROLOGY SECTION I: APPROACH TO THE PATIENT WITH DIGESTIVE AND HEPATOBILIARY DISORDERS Chapter 94: Approach to the Patient With Dysphagia Joel E. Richter Chapter 95: Approach to the Patient With Noncardiac Chest Pain Henry P. Parkman Chapter 96: Approach to the Patient With Abdominal Pain Robert B. Stein and Gary R. Lichtenstein Chapter 97: Approach to the Patient With Acute Abdomen Stewart C. Wang and Michael W. Mulholland Chapter 98: Approach to the Patient With Nausea and Vomiting William L. Hasler Chapter 99: Approach to the Patient With Diarrhea Carol E. Semrad and Eugene B. Chang Chapter 100: Approach to the Patient With Constipation, Fecal Incontinence, and Gas Jeffrey L. Barnett Chapter 101: Approach to the Patient With an Abdominal or Rectal Mass Ilias Scotiniotis and Michael L. Kochman Chapter 102: Approach to the Patient With Gastrointestinal Bleeding Grace H. Elta Chapter 103: Approach to the Patient With Jaundice Richard H. Moseley Chapter 104: Approach to the Patient With Abnormal Liver Chemistries Richard H. Moseley Chapter 105: Approach to the Patient With Complications of Chronic Liver Disease and Fulminant Hepatic Failure Charmaine A. Stewart and Michael R. Lucey SECTION IIA: DISORDERS OF THE ALIMENTARY TRACT Chapter 106: Diseases of the Esophagus Joel E. Richter Chapter 107: Gastroduodenal Ulcer Disease and Gastritis David C. Metz and John H. Walsh Chapter 108: Motor Disorders of the Gastrointestinal Tract Chung Owyang Chapter 109: Irritable Bowel Syndrome Yehuda Ringel and Douglas A. Drossman Chapter 110: Disorders of Digestion and Absorption Dennis J. Ahnen Chapter 111: Inflammatory Bowel Disease Lawrence S. Friedman and Daniel K. Podolsky Chapter 112: Mesenteric Vascular Diseases James C. Stanley Chapter 113: Gastrointestinal Infections C. M. Thorpe and Andrew G. Plaut Chapter 114: Gastrointestinal Diseases With an Immune Basis Charles O. Elson Chapter 115: Upper Gastrointestinal Neoplasms Anil K. Rustgi Chapter 116: Colorectal Neoplasia C. Richard Boland SECTION IIB: DISORDERS OF THE PANCREAS, LIVER, AND BILIARY TRACT Chapter 117: Pancreatitis James H. Grendell Chapter 118: Pancreatic Cancer and Gut Neuroendocrine Tumors Daniel G. Haller Chapter 119: Viral Hepatitis Frederick Nunes Chapter 120: Autoimmune Hepatitis and Primary Biliary Cirrhosis Gillian Ann Zeldin and Albert J. Czaja Chapter 121: Alcoholic Liver Diseases David W. Crabb and Lawrence Lumeng Chapter 122: Drug-Induced Hepatic Injury Shelly C. Lu and Lawrence S. Maldonado Chapter 123: Metabolic, Granulomatous, and Infiltrative Disorders of the Liver Bruce R. Bacon Chapter 124: Gallstones and Cholecystitis John H. Sekijima and Sum P. Lee Chapter 125: Biliary Tract Disease Jenny Heathcote Chapter 126: Hepatobiliary Neoplasms Andrew Stolz SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN DIGESTIVE AND HEPATOBILIARY DISORDERS Chapter 127: Endoscopic Diagnosis and Therapy Gregory G. Ginsberg Chapter 128: Abdominal and Alimentary Tract Imaging and Interventional Radiology Stephen W. Trenker Chapter 129: Diagnostic Tests in Gastrointestinal Motility and Physiology William L. Hasler Chapter 130: Parenteral and Enteral Nutrition William F. Stenson and Patti Eisenberg Chapter 131: Laparoscopic Surgery for Gastrointestinal Disorders C. Daniel Smith and Timothy M. Farrell Chapter 132: Liver Transplantation Christopher F. Schultz and Michael R. Lucey PART 4: NEPHROLOGY SECTION I: APPROACH TO THE PATIENT WITH RENAL AND ELECTROLYTE DISORDERS Chapter 133: Approach to the Patient With Renal Disease H. David Humes Chapter 134: Approach to the Patient With Hematuria John H. Galla Chapter 135: Approach to the Patient With Proteinuria and Nephrotic Syndrome Jeffrey R. Schelling and John R. Sedor Chapter 136: Approach to the Patient With Dysuria and Pyuria Eric W. Young Chapter 137: Approach to the Patient With Polyuria or Nocturia Robert M. A. Richardson and Sheldon Tobe Chapter 138: Approach to the Patient With Urinary Retention and Obstruction Nelson Leung, Amit K. Ghosh, and Karl A. Nath Chapter 139: Approach to the Patient With Nephrolithiasis Rebeca D. Monk and David A. Bushinsky Chapter 140: Approach to the Patient With Oliguria and Acute Renal Failure H. David Humes Chapter 141: Approach to the Patient With Chronic Renal Failure Fuad N. Ziyadeh Chapter 142: Approach to the Patient With Volume Depletion and Dehydration James A. Shayman Chapter 143: Approach to the Patient With Edema James A. Shayman Chapter 144: Approach to the Patient With Hyponatremia Lawrence S. Weisberg and Malcolm Cox Chapter 145: Approach to the Patient With Hypernatremia Harold M. Szerlip and Malcolm Cox Chapter 146: Approach to the Patient With Hypokalemia Manuel Martinez-Maldonado Chapter 147: Approach to the Patient With Hyperkalemia Manuel Martinez-Maldonado Chapter 148: Approach to the Patient With Altered Magnesium Concentration Anton C. Schoolwerth, George M. Feldman, and R. Michael Culpepper Chapter 149: Approach to the Patient With Acid-Base Abnormalities Thomas D. DuBose, Jr. SECTION II: DISORDERS OF THE KIDNEY Chapter 150: Immune-Mediated Glomerulopathies Ian R. Rifkin and David J. Salant Chapter 151: Tubulointerstitial Diseases Carolyn J. Kelly and Eric G. Neilson Chapter 152: Vascular Diseases of the Kidney William L. Henrich Chapter 153: Diabetes and the Kidney Frank C. Brosius III and Charles W. Heilig Chapter 154: Dysproteinemias and the Kidney Paul W. Sanders Chapter 155: Renal Tubular Acidosis and Fanconi Syndrome Peter C. Brazy Chapter 156: Renal Cysts and Cystic Diseases William D. Kaehny Chapter 157: Hereditary Nephropathies Martin C. Gregory Chapter 158: Obstructive Nephropathy Nelson Leung, Amit K. Ghosh and Karl A. Nath Chapter 159: Renal Lithiasis David A. Bushinsky Chapter 160: Tumors of the Kidney, Ureter, and Bladder Jia Bi and Derek Raghavan Chapter 161: Congenital Anomalies of the Kidney, Ureter, and Bladder Patrick Brophy and Jean E. Robillard Chapter 162: Pregnancy, the Kidney, and Hypertension Marshall D. Lindheimer and Adrian I. Katz SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN RENAL AND ELECTROLYTE DISEASES Chapter 163: Laboratory Evaluation of Renal Disorders Majd I. Jaradat and Bruce A. Molitoris Chapter 164: Renal Biopsy and Treatment of Glomerular Disease Ronald J. Falk Chapter 165: Renal Substitution Treatment in Acute and Chronic Renal Failure Paul Sakiewicz and Emil Paganini Chapter 166: Renal Transplantation Christopher Y. Lu, Miguel A. Vazquez, Mariusz Kielar, D. Rohan Jeyarajah, and Xin J. Zhou Chapter 167: Adjustment of Drug Dosage in Patients With Renal Insufficiency Suzanne K. Swan PART 5: RHEUMATOLOGIC, ALLERGIC, AND DERMATOLOGIC DISEASES Rheumatology and Allergy SECTION I: APPROACH TO THE PATIENT WITH RHEUMATOLOGIC AND ALLERGIC DISORDERS Chapter 168: Approach to the Patient With Musculoskeletal Complaints Eric L. Radin Chapter 169: Approach to the Patient With Pain in One or a Few Joints Alisa E. Koch Chapter 170: Approach to the Patient With Polyarthritis or Generalized Musculoskeletal Pain Theodore Pincus Chapter 171: Approach to the Patient With Back Pain Glen S. O’Sullivan Chapter 172: Approach to the Patient With Anergy Abba I. Terr Chapter 173: Approach to the Patient With Allergy Abba I. Terr SECTION II: DISORDERS OF THE RHEUMATOLOGIC AND ALLERGIC SYSTEMS Chapter 174: Rheumatoid Arthritis Gary S. Firestein Chapter 175: Osteoarthritis and Polychondritis Marc C. Hochberg Chapter 176: Spondyloarthropathies Frank C. Arnett Chapter 177: Crystal-Induced Synovitis Michael M. Ward Chapter 178: Systemic Lupus Erythematosus and Overlap Syndromes Ronald F. van Vollenhoven Chapter 179: Scleroderma and Raynaud’s Syndrome James R. Seibold Chapter 180: Idiopathic Inflammatory Myopathies Robert L. Wortmann Chapter 181: Vasculitis: Its Many Forms Gary S. Hoffman, Brian Mandell Chapter 182: Infectious Arthritis Mary M. Stimmler Chapter 183: Lyme Disease Leonard H. Sigal Chapter 184: Infiltrative, Neoplastic, and Endocrinologic Causes of Musculoskeletal Complaints Juan J. Canoso Chapter 185: Fibromyalgia (Fibrositis), Chronic Fatigue Syndrome, Bursitis, and Other Nonarticular Rheumatic Complaints Juan J. Canoso Chapter 186: Heritable Disorders of Connective Tissue Uta Francke Chapter 187: Inherited Deficiencies of Complement and Immunoglobulins George F. Moxley SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN RHEUMATOLOGIC AND ALLERGIC DISEASES Chapter 188: Use of Laboratory Tests in Rheumatic and Immunologic Diseases John A. Hardin Chapter 189: Arthroscopy William J. Arnold Chapter 190: Imaging Techniques for Rheumatologic Diagnosis Curtis W. Hayes and Avinash A. Balkissoon Dermatology SECTION I: APPROACH TO THE PATIENT WITH DERMATOLOGIC DISEASES Chapter 191: Approach to the Patient With Skin Lesions Christopher M. Barnard Chapter 192: Approach to the Patient With Alopecia or Balding Susan M. Swetter SECTION II: DISORDERS OF THE DERMATOLOGIC SYSTEMS Chapter 193: Psoriasis, Lichen Planus, and Pityriasis Rosea Christopher M. Barnard Chapter 194: Infections of Skin Gary L. Darmstadt Chapter 195: Bullous Diseases of Skin and Mucous Membranes Mark C. Udey Chapter 196: Atopic and Contact Dermatitis Teresa A. Borkowski and Mark C. Udey Chapter 197: Allergic Urticaria and Erythema Multiforme Christopher M. Barnard Chapter 198: Approach to the Management of Skin Cancer Susan M. Swetter Chapter 199: Cutaneous Reactions to Drugs Martin Vazaquez SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN DERMATOLOGIC DISEASES Chapter 200: Dermatologic Diagnosis: Fundamentals for the Internist Julie Anne Winfield PART 6: ONCOLOGY AND HEMATOLOGY SECTION I: APPROACH TO THE PATIENT WITH ONCOLOGIC AND HEMATOLOGIC DISORDERS Chapter 201: Approach to the Patient With Lymphadenopathy David J. Vaughn Chapter 202: Approach to the Patient With Splenomegaly Lynn M. Schuchter Chapter 203: Approach to the Patient With a Mediastinal Mass Kevin R. Fox Chapter 204: Approach to the Patient With Superior Vena Cava Syndrome Janice P. Dutcher Chapter 205: Approach to the Patient With a Palpable Breast Mass and/or An Abnormal Mammogram Helen Pass, Mark Helvie and Sofia D. Merajver Chapter 206: Approach to the Patient With a Testicular Mass Stephen D. Williams Chapter 207: Approach to the Patient With a Prostate Nodule or Elevated Prostate-Specific Antigen Level David C. Smith and James E. Montie Chapter 208: Approach to the Patient With an Adnexal Mass Ivor Benjamin and Stephen C. Rubin Chapter 209: Approach to the Patient With an Abnormal Papanicolaou Smear Andrew W. Menzin and Stephen C. Rubin Chapter 210: Approach to the Patient With a Pathologic Fracture Janice P. Dutcher Chapter 211: Approach to the Patient With Anemia Thomas P. Duffy Chapter 212: Approach to the Patient With Leukopenia Laurence A. Boxer Chapter 213: Approach to the Patient With Thrombocytopenia Douglas B. Cines Chapter 214: Approach to the Patient With Pancytopenia Joel M. Rappeport Chapter 215: Approach to the Patient With an Elevated Hemoglobin Level Eugene P. Frenkel Chapter 216: Approach to the Patient With Leukocytosis Stephen G. Emerson Chapter 217: Approach to the Patient With Thrombocytosis Alan M. Gewirtz Chapter 218: Approach to the Patient With Bleeding Keith R. McCrae Chapter 219: Approach to the Patient With Thrombosis Joel S. Bennett SECTION II: DISORDERS OF ONCOLOGY AND HEMATOLOGY Chapter 220: Breast Cancer Teresa Gilewski and Larry Norton Chapter 221: Gynecologic Malignancies Mark A. Morgan and Stephen C. Rubin Chapter 222: Germ Cell Malignancies in Men Stephen D. Williams Chapter 223: Prostate Cancer Kenneth J. Pienta and David C. Smith Chapter 224: Sarcomas of Soft Tissue and Bone J. Sybil Biermann and Laurence H. Baker Chapter 225: Epithelial Malignancies of the Head and Neck George J. Bosl and David G. Pfister Chapter 226: Cancer of Unknown Primary Origin John D. Hainsworth and F. Anthony Greco Chapter 227: Acute Leukemias Peter H. Wiernik Chapter 228: Chronic Leukemias George P. Canellos Chapter 229: Myelodysplastic Syndrome Frederick R. Appelbaum Chapter 230: Aplastic Anemia and Bone Marrow Failure Syndromes Joel M. Rappeport Chapter 231: Myeloproliferative Disorders: Polycythemia Vera, Thrombocythemia, and Myelofibrosis Eugene P. Frenkel Chapter 232: Hodgkin’s Disease Sandra J. Horning Chapter 233: Non-Hodgkin’s Lymphomas R. Gregory Bociek, Julie M. Vose, and James O. Armitage Chapter 234: Plasma Cell Disorders Phillip R. Greipp Chapter 235: Amyloidosis Robert A. Kyle Chapter 236: Waldenström’s Macroglobulinemia Robert A. Kyle Chapter 237: Inherited Disorders of Blood Coagulation David Ginsburg Chapter 238: Acquired Disorders of Blood Coagulation Alvin H. Schmaier Chapter 239: Disorders of Platelet Function Keith R. McCrae and Sanfod J. Shattil Chapter 240: Thrombotic Disorders Joel S. Bennett Chapter 241: Hemoglobinopathies George F. Atweh and Edward J. Benz, Jr. Chapter 242: Iron Deficiency and Iron Loading Anemias Kenneth R. Bridges Chapter 243: Megaloblastic Anemias Ralph Carmel Chapter 244: Hemolytic Anemias Joseph P. Catlett Chapter 245: Sickle Cell Anemia Bertram H. Lubin Chapter 246: Anemia of Chronic Disease Robert T. Means, Jr. Chapter 247: Paraneoplastic Syndromes Gregory P. Kalemkerian SECTION III: DIAGNOSTIC AND THERAPEUTIC MODALITIES IN ONCOLOGIC AND HEMATOLOGIC DISORDERS Chapter 248: Imaging in Oncology Stephen I. Marglin and Ronald A. Castellino Chapter 249: Pathology and Cytology Virginia A. LiVolsi and John E. Tomaszewski Chapter 250: Tumor Markers Daniel F. Hayes Chapter 251: Molecular Diagnosis of Cancer Jeffrey Sklar and Neal Lindeman Chapter 252: Principles of Surgical Oncology John M. Daly and Michael D. Lieberman Chapter 253: Principles of Radiation Oncology Allen S. Lichter Chapter 254: Principles of Chemotherapy and Hormonal Therapy Bruce A. Chabner, Michael Seiden, and Jeffrey Clark Chapter 255: Principles of Biologic Therapy John W. Smith II and Walter J. Urba Chapter 256: Hematopoietic Growth Factors Malcolm A.S. Moore Chapter 257: Blood Types, Tissue Typing, and Transfusion of Blood Products Frank T. Hsieh, Steven A. Mechanic, Edward Snyder, and Albert Deisseroth Chapter 258: Hematopoietic Stem Cell Transplantation Stephanie J. Lee and Joseph H. Antin Chapter 259: Anticoagulant and Fibrinolytic Therapy Bruce Furie Chapter 260: Cancer Pain Management Janet L. Abrahm Chapter 261: Antiemetic Treatment Richard J. Gralla Chapter 262: Design and Conduct of Cancer Clinical Trials Michael A. Friedman and Richard Simon PART 7: INFECTIOUS DISEASES AND AIDS Infectious Diseases SECTION I: APPROACH TO THE PATIENT WITH INFECTIOUS DISEASES Chapter 263: Approach to the Patient With Cellulitis and Other Soft-Tissue Infections Ronald T. Lewis Chapter 264: Intra-Abdominal Abscess: Diagnosis and Management Marianne Cinat and Samuel E. Wilson Chapter 265: Approach to the Patient With Osteomyelitis Layne O. Gentry Chapter 266: Approach to the Febrile Patient Philip A. Mackowiak Chapter 267: Approach Infection in the Immunocompromised Host Kenneth V. I. Rolston and Gerald P. Bodey Chapter 268: Approach to the Patient With Bacteremia and Sepsis Gary A. Noskin and John P. Phair Chapter 269: Approach to the Patient With Recurrent Infections Burke A. Cunha SECTION II: INFECTIOUS DISEASES Chapter 270: Endocarditis, Intravascular Infections, Pericarditis, and Myocarditis C. Glenn Cobbs and Michael Saccente Chapter 271: Approach to Infections of the Genitourinary Tract, Including Perinephric Abscess and Prostatitis Baldwin Toye and Allan R. Ronald Chapter 272: Sexually Transmitted Diseases and Genital Tract Infections William C. Levine Chapter 273: Surgical Infections, including Burns and Postoperative Infections E. Patchen Dellinger Bacterial Infections Chapter 274: Staphylococcal Infections Dennis R. Schaberg Chapter 275: Streptococcal Infections Monica M. Farley and Benjamin Schwartz Chapter 276: Anthrax Raymond A. Smego, Jr. Chapter 277: Listeria and Erysipeloid Infections Barry Zeluff, Marcia Kielhofner and Susan J. Burgert Chapter 278: Corynebacterial Infections Robert T. Chen and Charles R. Vitek Chapter 279: Meningococcal Infections Peter Densen Chapter 280: Gonococcal Infections Geo F. Brooks Chapter 281: Salmonellosis Sonja J. Olsen and Robert V. Tauxe Chapter 282: Shigellosis Karen Kotloff and Myron M. Levine Chapter 283: Infections Caused by Vibrio and Campylobacter Species J. Glenn Morris, Jr. and Martin J. Blaser Chapter 284: Infection Caused by Helicobacter pylori David Y. Graham Chapter 285: Brucellosis, Tularemia, Pasteurellosis, and Yersiniosis Edward J. Young Chapter 286: Infections Caused by Hemophilus and Bordetella Species Charles J. Schleupner and Kenneth M. Sosnowski Chapter 287: Legionellosis Emanuel N. Vergis and Robert R. Muder Chapter 288: Chancroid and Granuloma Inguinale George P. Schmid Chapter 289: Bartonellosis Norbert J. Roberts, Jr. Chapter 290: Clostridial Infections W. Lance George Chapter 291: Infections Caused by Nonclostridial Anaerobes Sydney M. Finegold and W. Lance George Chapter 292: Cat-Scratch Disease, Bacillary Angioimatosis, and Peliosis Hepatitis Thomas H. Belhorn Chapter 293: Rat-Bite Fever Ronald G. Washburn Mycobacterial Infections Chapter 294: Tuberculosis Lisa K. Fitzpatrick and Christopher Braden Chapter 295: Nontuberculous Mycobacterial Diseases David E. Griffith and Richard J. Wallace, Jr. Chapter 296: Leprosy [...]... M Helms, MD, PhD Professor of Medicine, Department of Internal Medicine, The University of Iowa College of Medicine, Iowa City, Iowa Mark A Helvie, MD Associate Professor of Radiology, Director, Division of Breast Imaging, University of Michigan Health System, Ann Arbor, Michigan William L Henrich, MD Professor and Chairman, Department of Medicine, University of Maryland School of Medicine, Baltimore,... Chair in Gastroenterology, Professor of Medicine, University of Alabama at Birmingham, Birmingham, Alabama Grace H Elta, MD Professor of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan Stephen G Emerson, MD, PhD Professor of Medicine, University of Pennsylvania School of Medicine, Chief, Hematology-Oncology Division, Hospital of the University of Pennsylvania, Philadelphia,... Aaronson, MD Assistant Professor of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan Janet L Abrahm, MD Associate Professor of Medicine, University of Pennsylvania School of Medicine, Attending Physician, Medicine/ Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania Jonathan Abrams, MD Professor of Medicine, University of New Mexico, Albuquerque,... University of Chicago Hospitals, Chicago, Illinois James W Kazura, MD, PhD Professor of Medicine and International Health, Case Western Reserve University, School of Medicine, University Hospitals of Cleveland, Cleveland, Ohio William N Kelley, MD Professor of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Carolyn J Kelly, MD Professor of Medicine, Department of Medicine, ... Schaberg, MD Professor and Chairman, Department of Medicine, University of Tennesee-Memphis, Memphis, Tennesee Jeffrey R Schelling, MD Assistant Professor of Medicine, Case Western University, Cleveland, Ohio Charles J Schleupner, MS, MD Professor of Internal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina Alvin H Schmaier, MD Professor of Internal Medicine and... Shayman, MD Professor of Internal Medicine and Pharmacology, Associate Chair for Research Programs, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan Judith A Shizuru, MD, Ph.D Assistant Professor of Medicine, Stanford University School of Medicine, Bone Marrow Transplant Program, Stanford, California Dolores M Shoback, MD Associate Professor of Medicine, Department of Medicine, ... Nephrology, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah James H Grendell, MD Professor of Medicine, Weill Medical College of Cornell University, Attending Physician, New York Presbyterian Hospital, New York, New York Phillip R Griepp, MD Professor of Medicine, Professor of Laboratory Medicine and Pathology, Department of Internal Medicine, Division of Hematology,... Division of TB Elimination, Atlanta, Georgia D Craig Brater, MD Chairman, Department of Medicine, Director of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiaina Glenn D Braunstein, MD Chairman, Department of Medicine, Cedars-Sinai Medical Center, Professor of Medicine, UCLA School of Medicine, Los Angeles, California Peter C Brazy, MD Professor of Medicine, University of. .. Calgary, Alberta, Canada Leonard D Hudson, MD Professor of Medicine, Head, Pulminary and Critical Care Medicine, University of Washington, Seattle, Washington Thomas Hyers, MD Clinical Professor of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri David H Ingbar, MD Professor of Medicine and Pediatrics, University of Minnesota School of Medicine, Director, Medical Intensive Care... Craig, MD Professor of Medicine, University of Wisconsin, Madison, Wisconsin Mark A Creager, MD Associate Professor of Medicine, Cardiovascular Division, Brigham & Women’s Hospital, Boston, Massachusetts William F Crowley, Jr., MD Professor of Medicine, Harvard School of Medicine, Boston, Massachusetts Mark R Cullen, MD Professor of Medicine and Public Health, Yale University School of Medicine, Occupational . MD, PhD Ensign Professor of Medicine, Chief, Section of Medical Oncology, Department of Internal Medicine, Yale University School of Medicine, New Haven,. Professor of Medicine, Division of Infectious Diseases, Wayne State University School of Medicne, Detroit, Michigan Thomas K. Aldrich, MD Professor of Medicine,