[...]... knowledge on the pancreas from international experts to readers everywhere The goal of this second edition of The Pancreas – An Integrated Textbook of Basic Science, Medicine, and Surgery is to provide the clinician with the most current data-based synthesis of understanding of pancreatic diseases, functional assessments, diagnostic and technical devices, and treatment options A major part of this edition... PhD Professor and Chair, Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA xiv Martin Zenker MD Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany Preface At the beginning of the 21st century, medicine is increasingly based on understanding the functions of genes and the molecular mechanisms of diseases In pancreatology,... brilliant cytoplasm… The cells lie together in considerable numbers diffusely scattered in the parenchyma of the gland.” In 1893, G.-E Laguesse (1861–1927) hypothesized their role in internal secretion and named them “d’îots de Langerhans” (islets of Langerhans) to commemorate the early tragic tuberculous death of Langerhans on the island of Madeira Plate 2.12 The relationship between observations in anatomy... identification of the human pancreas in 1642 in the dissecting room of Padua (bottom left) Sadly his blazon (top right) remains the only extant image of Wirsung who was tragically murdered by a student The small oblong folio drawing of the pancreas clearly distinguishes 21 branches of the pancreatic duct as well as the bile and pancreatic ducts, the duodenum, and spleen The medical cognoscenti of the time... proposal of the “common channel” hypothesis and the theory that bile reflux into the pancreatic duct would result in enzyme activation and culminate in acute pancreatitis Plate 2.16 In 1909, R Coffey (1869–1933) (right) reported experimental techniques utilizing pancreaticoenterostomy and established the possibility of pancreatectomy and pancreatic anastomosis (top) Although he considered the possibility of. .. Center, Ann Arbor, MI, USA Stephen Pandol MD Professor of Medicine and Director of Pancreatic Research Group, University of California at Los Angeles; Staff Physician, VA Greater Los Angeles Health Care System, CA, USA William F Regine MD Professor and Chairman, Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA Kaye M Reid-Lombardo MD Assistant Professor of Surgery, Department of. .. University of California at Los Angeles School of Medicine, CA, USA Chairman and Professor, The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan Stephen J.D O’Keefe MD MSc FRCP Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA Chung Owyang MD Professor of Surgery, A Alfred Taubman Health... Germany Chairman and Head and Professor of Surgery, Department of Surgery, Indiana University School of Medicine, IN, USA Clinic of Radiology, Charite Campus Virchow, University Medical Center Berlin, Germany Department of Surgery, New York Medical College, NY, USA Patrick Maisonneuve MD Director of Epidemiology, European Institute of Oncology, Milan, Italy Seiki Matsuno MD President of the Japanese Pancreas... understanding the pancreas, its normal and abnormal functions, and its morphological pathology has become an international focus of established scientists Medical sciences are not uniform around the world However, the impact of information technology, international data exchange, and global communications networks have resulted in a broadly increased level in the understanding and practice of pancreatology... Neoptolemos MA MB BChir MD FRCS FMedSci The Owen and Ellen Evans Chair of Cancer Studies; Head, Division of Surgery and Oncology; Head, School of Cancer Studies; Professor of Surgery, University of Liverpool, UK Bettina M Rau MD Coordinating Editor; Associate Professor of Surgery, Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Germany Kazuichi Okazaki MD PhD Howard . alt="" The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery 97 814 0 514 6647 _1_ pretoc.qxd 2/2/08 9: 41 AM Page i The Pancreas: An Integrated. the stomach and valve to close the pylorus. 97 814 0 514 6647_6_plate1.qxd 1/ 31/ 08 12 :26 PM Page 1 The Pancreas: An Integrated Textbook of Basic Science, Medicine,