... NRG-5¢_forNRG -a_ revTCTCCGGCGAGATGTCCGAGCTCCAGTGAATCCAGGTTG668b NRG-5¢_forNRG-Beta_revTCTCCGGCGAGATGTCCGAGGCAGCGATCACCAGTAAAC677GAPDH GAPDH_forGAPDH_revGAAGGGCTCATGACCACAGTCCATTCATTGTCGTACCAGGAAATGAGCTT450Fig. ... Universita¨t Darmstadt, Germany) was applied at a concentration of 2 lm . GM6001 (Calbiochem, San Diego,CA, USA) was used at a final concentration of 10 lm andphorbol 12-myristate 13-acetate (Sigma, ... NRG-1, on the other hand, wasimpaired in fibroblasts with catalytically inactiveADAM17 [30].b- and c-secretase are responsible for processing of the Alzheimer associated APP and its paralogues amy-loid...