... Effects of U 012 6, SB20 219 0 and SP60 012 5 on ICAM -1 synthesis induced by LPS. (A) Cells were pretreated with various concentrations of U 012 6 (10 , 20, 40 lM), SB20 219 0 (1, 10 , 20 lM) or SP60 012 5 (10 , ... Sar-tor RB (19 98) Mediation by NF-kappa B of cytokineinduced expression of intercellular adhesion molecule 1 (ICAM -1) in an intestinal epithelial cell line, a processblocked by proteasome inhibitors. ... U 012 6 (an MEK1⁄ 2 inhibitor), SB20 219 0 (ap38 MAPK inhibitor) and SP60 012 5 (an SAPK ⁄ JNKspecific inhibitor), the roles of MAPKs in LPS-induced ICAM -1 synthesis were examined. Pretreat-ment of...