Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
Báo cáo Y học: Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK potx
... the central cavity of the HsPII trimer, with the a helices at the periphery of the molecule (Fig. 1A). The bottom edge of the central cavity isnegatively charged (Fig. 2B, part i) owing to the ... by Phe in EcPII and Ala in EcGlnK. The entrance from the top is restricted by Thr31, whose lateralchain is oriented to the interior of the cavity. The interiorwall of the cavity is largely ... diagram of the structure of the trimericHsPII, each chain in a different colour. The b sheets of the bab motif line the central cavity of the trimer with the a helices at the periph-ery. (B)...
- 8
- 445
- 0
Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... score3 (1 to 8) 0 (0 to 2) 1 (0 to 4) 3 (1 to 6) 0.002ICU length of stay (days) 5 (3 to 10) 3 (2 to 5) 6 (2 to 10) 7 (4 to 11) 0.001Sites of infection (n (%))Respiratory tract 72 (60)Urinary tract ... participated in the acquisi-tion of data. AZ participated in the coordination of the study.AAZ participated in the design of the study, and performed thestatistical analysis. RA conceived of the study, participated ... because of thespecificity of our medical ICU. Finally, infections were micro-biologically documented in 58% of cases; this low percentagemay be explained by the frequency of respiratory tract...
- 10
- 597
- 0
Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following features: (a) the ability to deliver transgenes ... able to provide all of features (a-g) above. Indeed, some gene transfer systems are so thoroughly unsuited to human germline gene therapy that they are not considered here. Of the systems that offer ... The theoretical possibility of applying gene transfer methodologies to the human germline is explored. Transgenic methods for genetically manipulating embryos may in principle be applied to humans....
- 16
- 506
- 1
Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... cytopenias. The use of these agents is costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely ... combination therapy. Hepatology 2004;40:1450-8. 15. Crippin JS, McCashland T, Terrault N, Sheiner P, Charlton MR. A pilot study of the tolerability and efficacy of antiviral therapy in hepatitis ... Overall, improvement in both the inflammatory grade and histologic stage of disease were associated with therapy. Longer duration of therapy strengthened this association. Of the 153 cirrhotic patients...
- 4
- 460
- 0
Báo cáo Y học: Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4 pdf
... sequence of the 3¢ part of the gene encompassing17 kb. Three poly(A) signals were found after the stopcodon. Analysis of the four cosmid clones by PCR revealedthat they do not contain any sequence ... Contigs analysis of the Human GenomeProject did not reveal any other mucin on chromosome 3q29and, interestingly, our analysis allowed the determination of the genomic organization of the human MUC4 ... of the published cDNA and the evolving human draft sequence[20] is very close to that of the mouse Muc4 (Table 1). The size of intron 1 of the human MUC4 has been estimated to be 15 kb by restriction...
- 10
- 434
- 0
Báo cáo Y học: Novel regulatory regions found downstream of the rat B29/Ig-b gene docx
... activity to that of the B29-P promoter alone. The 30-bp deletions (4193 to 4222) unrelated to the footprinted region had activitysimilar to that of the control. The sequence responsible for the ... flanking genes may change. Recently, enhance-ment of H3 and H4 histone acetylation was observed from the promoter region of human GH gene to the upstreamregion present in the sodium channel gene ... immunoreceptortyrosine-based activation motif (ITAM), is located close to the N -terminal r egion of the cytoplasmic domain. K inasesin the Src family, such as Lyn phosphorylate tyrosineresidues...
- 10
- 332
- 0
Báo cáo y học: "Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats"
... proinflammatory cytokine levels, IL-1β and TNF-α, were found to be ameliorated by the adjuvant use of HBO and OT in the lung tissue when compared with the antibiotherapy only group. Histologic ... prevent the possible effects of biological rhythm. Sample collection At the end of 5th day of the study, general anaesthesia was administered to immobilize the rats [intraperitoneal ketamine ... morbid-ity and mortality. This study was designed to define the efficacy of OT as an adjuvant to antibiotherapy in an experimental rat model of sepsis. In terms of their similar mode of action, OT will...
- 8
- 672
- 0
Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"
... translation of B19 NS1 (18, 34), has lead us to examine the potential role of B19 NS1 in direct hepatocyte cytotoxicity. Our laboratory pre-viously demonstrated that B19 NS1 caused apoptosis in ... suicide, previously reported to be the mechanism of B19 NS1-induced cytotoxicity (34, 35). Further confirmation for the reduction of apop-tosis in the PathI transduced population of HepG2 cells ... Cell-Quest software (Becton-Dickson), and statistical analysis completed by FlowJo software (Tree Star, Inc, Ash-land, OR). Cytotoxicity Assay. Trypan blue dye exclusion was used to determine...
- 10
- 554
- 0
Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... disease.Unfortunately the quality of s ome of these syn uclein ROAspectra i s generally not as good as that of the caseins d ue inpart to the high concentrations of buffer salts.Figure 3 shows the backscattered ... 6 . The X-ray crystal structure 1 pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk inhibitor aredistributed fairly evenly over the b- and PPII-regions of the Ramachandran ... strands, they would be expected to readily undergo thistype of aggregation w ith each other and a lso with the edges of established bsheet. The m ore d ynamic type of disorderassociated with the...
- 9
- 667
- 0
Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... Perhaps, the negatively chargedcarboxyl moiety of TS is important for upregulation of PKC. Recently, Neuzil et al. reported the opposite findings to ours. They proposed that TS-induced apoptosis ... apoptosis inhepatopoietic and cancer cell lines is caused by the prevention of PKC activity due to activation of PP2A,similar to a-T activation of PP2A [13]. The reason for the inconsistency between ... by the stimulation of superoxide production due to the activation of NADPH oxidase [32]. As the activation of NADPH oxidase is reported to be associated with the activation of PKC [33,34], the...
- 6
- 494
- 0
Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenbáo cáo khoa học y họcbáo cáo y tế học đườngbáo cáo tuần sinh hoạt tập thể đầu năm họcmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămbáo cáo y tế học đường năm 2012báo cáo y tế học đường trường mầm nonbiểu mẫu báo cáo y tế trường họcbáo cáo y tế học đường trường tiểu họcbáo cáo y tế trường tiểu họcchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Chuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ