... lactis was split into a supply module, that produces ATP (glycolytic module or module 1), and a demand module, that consumes ATP(biomass production module or module 2). The inter-mediate is ... supply (module 1) oran increase in the activity of demand (module 2).Therefore, when the mean control coefficients areplotted against r (the factor by which the activity ofthe corresponding module ... single module is not effective to obtaining significant increa-ses in flux, simultaneously modulating both moduleswould be required [25,26]. In addition, we saw that therate of both modules...