... approximately ‡ 10-fold lower thanthose of primary hepatocytes. In particular, the enzymeactivity of CYP2C9 in AT-MSC-Hepa was remarkablyhigh compared to that in primary hepatocytes.CYP3A4 is ... region of 39 genes was hypermethylated and that of eightgenes was hypomethylated in AT-MSC-Hepa. It isnoteworthy that the promoter region of the Twist washypermethylated in AT-MSC-Hepa, indicating ... grade;TaKaRa, Kyoto, Japan).Microarray analysis and data mining (Aligentarray)A one-color microarray-based gene expression analysis sys-tem (Agilent Technologies, Tokyo, Japan) containing41 000...