... (Lanes 1, 2 and 3), BstXI (Lanes 4, 5, and 6), and BglII plus EcoRV (Lanes 7, 8, and 9). M, 1-kb DNA ladder. Lanes 1, 4, and 7, 293A cells; Lanes 2, 5, and 8, ADrBMP6 DNA; Lanes 3, 6, and 9, ADhBMP6 ... BMPs combine with type 1 (Alk2, Alk3, and Alk6) and type 2 (BR2, ActR2, and ActR2B) receptors, activate the Smad and p38/MAPK signal transduction pathways, and, finally, activate transcription ... [36, 44]. BMP2 and BMP4 combine with Alk3 and use Smad1, Smad5, or Smad8 to transduce signals [4, 31]. BMP6 and BMP7 may strongly combine with Alk2 and weakly combine with Alk3 and Alk6. Their...