... (2006) Host-defence peptides from the glandu-lar secretions of amphibians: structure and activity. NatProd Rep 23, 368–393.12 Fersht A (1985) Cooperative ligand binding and allos-teric interactions ... structure and mechanism.In Enzyme Structure and Mechanism, pp. 208–225. Free-man WH, New York, NY.13 Schon O, Friedler A, Freund S & Fersht AR (2004)Binding of p53-derived ligands to MDM2 ... chemicalshift changes occur for a large number of Ca2+-CaMresonances, and this can be seen from the selectedlabelled peaks shown in Fig. 3 (e.g. T5, G25, I27, T29,G61, G98, L116, T117, N137 and A147)....