... molecules that are implicated in immune and inflammatory responses [24,25]. Mitogen-activatedprotein kinases (MAPKs) are important mediators of cytokine expression; in particular, p38 and extra-cellular ... focalaccumulation and antigen-induced activation of T cellsin inflammatory demyelinating diseases of the PNS.As mentioned above, MAPKs were implicated in theactivation of NF-jB in SCs in response to ... the presence of cytokines.Natural ligands of ICAM- 1and LFA-1 are expressedon the surface of T and B lymphocytes, natural killercells, monocytes, macrophages and granulocytes [33], and interaction...