... lyso-somal proteins and recycling late Golgi proteins [13–16]. There are two mammalian isoforms of Vps4,VPS4A and VPS4B, which both function in endocytictrafficking [17] and virus budding [9,18–20].Members ... determinant forassembly and ATPase activity and has elements conservedin other members of the meiotic clade of AAA ATPasesParimala R. Vajjhala1,2, Chau H. Nguyen1,2, Michael J. Landsberg1, Carol ... are likely to be Vps4 orthologues and contain all three structural elements of the Vps4 oligo-merization domain (i.e. b sheets 7 and 8, the AAAdomain helix and the C-terminal helix). However,...