... Neuroscience and Neurology, Kuopio University Hospital, Kuopio University, Finland3 Department of Neurology and Neuroscience and Neurology, Kuopio University Hospital, Kuopio University, FinlandNeurofibrillary ... AD and 10 control brains. We found that levels of p-mTOR (Ser2481), and p-4E-BP1 (Thr70 and Ser65) dramatically increase in AD, and are positively sig-nificantly correlated with total tau and ... Ser424) and p-eIF4E, and total tau in AD and control brains [6,10]. In the cur-rent study, a significant correlation was seen betweenphosphorylation of 4E-BP1 at both Ser65 and Thr70sites, and...