... metabo-lite syndrome), including carbamazepine, phenytoin,phenobarbital, and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within ... patientsinclude nutrient intake and physical activity. In assessingthe nutrient intake of persons with bipolar disorder,Elmslie and colleagues found that they had increasedintake of carbohydrates and sweets, ... resulting in increased bioavailabil-ity of free, active highly protein-bound drugs. Accumula-tion of active hydroxylated metabolites of carbamazepinemay lead to symptoms of drug toxicity despite therapeuticdrug...