Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated George Chrysochoou1 and Scott R. Gunn2 1 Clinical Fellow, Department of Critical Care Medicine, University ... larger than anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% ... demonstrating a clear benefit for MET may take longer than the 6-month period of this study. Contamination of control hospitals also may have been an issue. Though they did not receive the study-based educational...
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Báo cáo y học: "Risk and Benefit of Drug Use During Pregnancy"
... Nevertheless, the vaginal use of the combination of these two drugs increased the risk for poly/syndactyly six fold [33]. Our analyses also demonstrated that it is necessary to differentiate the ... continually thinking of possible dangerous environmental factors and when asked about the history of their pregnancy, give a long list of supposed agents. On the other hand the mothers of healthy babies ... respiratory system [39] with high fever in early pregnancy are not treated by appropriate methods including drugs, therefore the teratogenic effect of hyperthermia can induce hyperthermic embryopathy...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... although the HGGG loop was acritical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not beattributed to the presence of the Gly cluster ... molecular model of the psychrophilicalkaline phosphatase was built [21] on the basis of the homology to the E.colienzyme the structure of which isknown [24]. For display of the model and for ... study [16], we explored the possibility of modifying the psychrophilic properties of an enzyme byintroducing, via mutagenesis, predictable flexibility changesto key active site residues of the...
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Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... the content of secondary structure only after the disruption of the native tertiary structure of RNase A(Figs 2–4). Interestingly, the preservation of the tertiarystructure coincides with the ... triflu-oroethanol the proteolytic susceptibility of RNase Astrongly increases, which coincides with the disruption of the tertiary structure of the RNase A molecule, in 20%trifluoroethanol the proteolytic ... hydro-chloride (GdnHCl), urea or elevated temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture of...
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Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... when studying the catalyticefficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-typeenzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functionscarried out by E301 in the wild-type enzyme [22]. In thiscontext, a special reactivity of the ... ascribed to the formation of the initial charge-transfer complex with regard to that of the wild-type (Table 4). The kinetics of reoxidation of the wild-type enzyme by NADP+produces an increase...
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Báo cáo Y học: Beyond the ABCs of CKC and SCC Do centromeres orchestrate sister chromatid cohesion or vice versa? potx
... complement of chromosomes. The fidelity of chromosome transmission is enhanced notonly by the geometry of stable centromere–MT interac-tions, but also by the action of a centromere-basedregulatory system ... redundancy between these two complexes, they arelikely to play distinct roles in meiosis. The most fascinatingproperty of Rec8 is its persistence at sister centromeres untilanaphase of meiosis ... activation of the mitotic checkpoint [5], it does soby indirectly inhibiting the degradation of the Scc1/Mcd1cohesin subunit (reviewed in [28–30]). Below we review infurther detail the nature of centromeric...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... acute goutyarthritis are predisposed to the development of polyartic-ular gouty arthritis [14]. Attacks can then occur in morethan one joint simultaneously, especially in the lowerextremity. This ... rise may be attrib-uted in part to the continuous aging of the population aswell as the widespread use of diuretics for treatment ofhypertension [4].Gout is a clinical syndrome caused by the deposition ... gout is of primeimportance. Clinicians should educate patients that gout may occur at any joint in the body not onlythe lower limb. Patients should be aware of the signs and symptoms of an acute...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... or themanagement of patients have a sound grasp of at least thebasics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on distant memories ofpoorly understood ... as to the most appropriate statistical methods to use and the theoryand assumptions behind them.Keywords data analysis, medical statisticsCritical Care February 2002 Vol 6 No 1 Whitley and ... Although some of the topics covered in this serieswill probably be familiar, it is hoped that there will still be usefullessons to be learned, for example the underlying assumptionsof a hypothesis test...
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Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"
... mesenchymal benign lesions origi-nating from the mature lipid tissue1. They constitute approximately 0.6% of the laryngeal and hypopha-ryngeal benign tumors4. Laryngeal and hypopharyn-geal ... the feeling of a mass in the throat without dysphagia was the only symptom of large pyriform sinus lipoma. The preferred method of treatment for laryngeal and hypopharyngeal lipogenic ... adults. They commonly occur in the neck and on the trunk, and are frequently located at the subdermal, while rarely at the dermal tissue layer. They are commonly found at the dorsal neck,...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... cells. By the age of 8 years, the top of the frontal sinuses is at the level of the orbital roof, and by the age of 10 years, the sinuses extend into the vertical portion of the frontal ... craniotomy because of the proximity of the sinus to the orbit and the anterior skull base [5]. The frequency of bilateral absence of the frontal sinus has been reported in 3-4% to 10% of ... life [4,8,9]. By the age of 4 years, the average cranial extent of the frontal sinus reaches half the height of the orbit and extends just above the top of the most-anterior...
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